oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 8 )

2019 ( 422 )

2018 ( 632 )

2017 ( 663 )

Custom range...

Search Results: 1 - 10 of 328066 matches for " Pilar; López-K?stner "
All listed articles are free for downloading (OA Articles)
Page 1 /328066
Display every page Item
Síndrome de Lynch: Caracterización genético clínica. Caso clínico
Zárate,Alejandro; álvarez,Karin; Wielandt,Ana María; Hevia,Montserrat; De la Fuente,Marjorie; Carvallo,Pilar; López-Kstner,Francisco;
Revista médica de Chile , 2008, DOI: 10.4067/S0034-98872008000600011
Abstract: hereditary non-polyposis colorectal cancer (hnpcc) or lynch syndrome is an autosomic dominant syndrome involving 596-1096 of colorectal cancer patients. mutations in mlh1 and msh2 genes account for most cases. these two genes particípate in the dna mismatch repair pathway. therefore mutation carriers show microsatellite instability (msi) in tumors. this syndrome is characterized by the early development of colorectal cancer (before 50 years) and an increased incidence of cancer in other organs. we report four siblings from a family diagnosed with hnpcc. all of them were subjected to colonic surgery for colorectal cancer moreover, one patient developed an ampulloma after her colon surgery. the molecular-genetic analysis revealed three brothers with microsatellite instability in the tumor tissue, the absence of the mlh1 protein, and the presence of a germ une mutation localized in introm 15 ofthe mlh1 gene
Cáncer colorrectal hereditario: análisis molecular de los genes APC y MLH1
Bellolio R,Felipe; álvarez V,Karin; Fuente L,Marjorie De la; León G,Francisca; Fullerton M,Demian A; Soto D,Gonzalo; Carvallo de SQ,Pilar; López-Kstner,Francisco;
Revista médica de Chile , 2006, DOI: 10.4067/S0034-98872006000700006
Abstract: background: among colorectal cancer hereditary variants, two syndromes show a predisposition to the disease based on germline mutations: familial adenomatous polyposis (fap) and hereditary nonpolyposis colorectal cancer (hnpcc). aim: to screen mutations in fap and hnpcc families in chile. materials and methods: two fap and one hnpcc families were studied. the apc gene (for fap patients) and the mlh1 gene (for hnpcc patients), were screened for mutations on genomic dna. the molecular analysis was performed through polymerase chain reaction, single strand conformer polymorphism (sscp) and dna sequencing. mutations were defined as changes in the dna sequence leading into a stop codon and a truncated protein. results: in the two fap families the analysis revealed a mutation consisting in the deletion of five nucleotides named c.3927_3931delaaaga. the genetic study of the hnpcc family demonstrated the insertion of one adenine in codon 168 of exon 6, named c.504insa. discussion: germ-line mutations were identified in the three families. the relevance of these studies in a better knowledge of cancer susceptibility, and the possibility of identifying in relatives in risk by molecular diagnosis
Proctocolectomía restauradora con reservorio íleoanal laparoscópica sin ileostomía de protección
LóPEZ-KSTNER,FRANCISCO; ZáRATE C,ALEJANDRO;
Revista chilena de cirugía , 2008, DOI: 10.4067/S0718-40262008000100014
Abstract: the aim of this paper is to present the result of the first laparoscopic proctocolectomy with neo anal pouch, without loop ileostomy, made in the clinical hospital of the pontificia universidad católica de chile. the operation was made in a patient of 34 years old, with adenomatous familial polyposis. the patient had a clinical presentation of a month and a half with abdominal pain and change of abdominal bowel evacuation. the colonoscopic study reveal the presence of multiples polyps in the colon (>100 polyps), and rectal compromise. in order to the intraoperative findings we decided made a laparoscopic proctocolectomy with an ileal j pouch, without protection ileostomy, and surgical specimen was extracted through pfannensteil's incision. the surgery was made without difficulties, with an operative time of 340 minutes. the patient was feed with liquid diet in the 5° postoperative day, and was discharge the 9° postoperative day, without complications. there were not complications in the early follow up (<30 days since the operation). after 6 months, the patient presents 4-6 bowel movements per day, without urgency and use loperamida sporadically
Proctocolectomía restauradora con reservorio íleoanal laparoscópica sin ileostomía de protección Restorative proctocolectomy with ileal pouch anal anastomosis without loop ileostomy
FRANCISCO LóPEZ-KSTNER,ALEJANDRO ZáRATE C
Revista Chilena de Cirugía , 2008,
Abstract: El objetivo de este trabajo es presentar el resultado de la primera proctocolectomía laparoscópica con reservorio íleo-anal, sin ileostomía de protección, practicada en el Hospital Clínico de la Pontificia Universidad Católica de Chile. La operación se realizó en un paciente de 34 a os con poliposis adenomatosa familiar. El paciente tuvo un cuadro clínico de un mes y medio de evolución, caracterizado por dolor abdominal y cambio del hábito intestinal. El estudio colonoscópico reveló la presencia de múltiples pólipos en colon (>100 pólipos), así como también, compromiso rectal. Dado los hallazgos intraoperatorios se decidió efectuar una proctocolectomía laparoscópica más un reservorio ileal en J, sin ileostomía de protección; la pieza operatoria se extrajo mediante una incisión de Pfannenstiel. La cirugía se realizó sin dificultades en un tiempo de 340 minutos. El paciente se realimentó con líquidos al 5o día y se dio de alta al 9o día postoperatorio, sin complicaciones. No se registraron complicaciones en el seguimiento temprano a 30 días del alta hospitalaria. Luego de 6 meses desde su operación, el paciente presenta 4-6 deposiciones diarias, sin urgencia y utiliza loperamida en forma esporádica The aim of this paper is to present the result of the first laparoscopic proctocolectomy with Neo anal pouch, without loop ileostomy, made in the Clinical Hospital of the Pontificia Universidad Católica de Chile. The operation was made in a patient of 34 years old, with adenomatous familial polyposis. The patient had a clinical presentation of a month and a half with abdominal pain and change of abdominal bowel evacuation. The colonoscopic study reveal the presence of multiples polyps in the colon (>100 polyps), and rectal compromise. In order to the intraoperative findings we decided made a laparoscopic proctocolectomy with an ileal J pouch, without protection ileostomy, and surgical specimen was extracted through Pfannensteil's incision. The surgery was made without difficulties, with an operative time of 340 minutes. The patient was feed with liquid diet in the 5° postoperative day, and was discharge the 9° postoperative day, without complications. There were not complications in the early follow up (<30 days since the operation). After 6 months, the patient presents 4-6 bowel movements per day, without urgency and use loperamida sporadically
Prevalencia de la incontinencia fecal en centros de salud y casas de reposo
Zárate,Alejandro J; López-Kstner,Francisco; Vergara,Flavia; Badilla,Nathalia; Viviani,Paola;
Revista médica de Chile , 2008, DOI: 10.4067/S0034-98872008000700007
Abstract: background: fecal and urinary incontinence (fi and ui) are psychologically and socially debilitating and embarrassing conditions. aim: to determine the prevalence of fi and associated factors in patients assessed in health centers (hc) and nursing home (nh) residents. material and methods: prospective, multicentric survey carried out in 3 hc and 16 nh of santiago. patients and residents of nh were interrogated about fi between march and july 2004. results: the questionnaire was answered by 618 patients attending health centers aged 18 to 87 years (75% females) and 128 nursing home residents aged 40 to 103years (80% females). the prevalence of liquid or solid fi in hc and nh was 2.7 and 45%, respectively. among the latter, the incontinence for liquids and solids was 19% and 42%, respectively. the prevalence of ui was 30.1 and 62.7% in hc patients and nh residents, respectively. among patients attending hc, multivariable analysis showed a relation between older age and urinary incontinence with liquid or solid fi among nh residents, multivariate analysis showed a relation between urinary incontinence and motor disabilities with liquid or solid fi conclusions: the prevalence of liquid or solid fi among patients assessed in health center is 2.7%. this figure increases in older people, those with ui and in nh residents
Resultados y eventos adversos de la sigmoidectomía por cáncer: laparoscopia versus laparotomía Results and complications in patients with sigmoid cancer: laparoscopic versus laparotomy
ALEJANDRO ZáRATE C,FRANCISCO LóPEZ-KSTNER,CAROLINA LOUREIRO P,GEORGE PINEDO M
Revista Chilena de Cirugía , 2008,
Abstract: Objetivo: Comparar resultados y complicaciones inmediatas al realizar una sigmoidectomía lapa-roscópica (SL) versus abierta (SA) en pacientes con cáncer de colon sigmoides. Material y método: Inclusión prospectiva y consecutiva, mediante protocolo de estudio de pacientes operados mediante SL entre el 2000 y el 2006. Análisis comparativo caso-control, mediante pareo según edad, sexo y ASA entre pacientes operados mediante SL con SA. Análisis por intención de tratamiento, mediante test t de Student, chi cuadrado, Mann-Withney y exacto de Fischer; consideramos estadísticamente significativo p <0,05. Resultados: Treinta y dos pacientes por grupo fueron comparados. Los grupos (SL v/s SA) fueron similares estadísticamente en edad (65,6 v/s 67,3 a os), sexo (femenino 31,25%), y ASA (p> 0,05). La mediana del tiempo operatorio fue mayor en SL (220 v/s 172 minutos, p <0,01). Un 9,3% se convirtió a técnica abierta en SL. El tiempo medio a la expulsión de gases y realimentación con líquidos fue menor en SL (2 v/s 4 días, p<0,01 y 3 v/s 5 días, p< 0,01). La estadía media postquirúrgica (5 v/s 8 días p<0,01) fue menor en SL. Las complicaciones postoperatorias médicas, fueron menores en SL (9,3% v/s 37,5% p<0,01), pero las quirúrgicas fueron iguales (6,25% cada grupo). Los linfonodos resecados y tama os de piezas operatorias fueron similares (SL v/s SA: 22,7 v/s 22,1 linfonodos p= 0,9 y 21,8 v/s 19,3 cm. p= 0,2). Conclusión: El desarrollo de la cirugía laparoscópica colorrectal mediante un protocolo, permite realizar la SL por cáncer con resultados quirúrgicos similares a la SA Background: The laparoscopic surgery for colorectal cancer is an alternative to the laparotomy. The aim of this study is to compare results and early complications after a laparoscopic sigmoidectomy (LS) versus open surgery (OS) in patients with sigmoid cancer. Material and Method: Prospective and consecutive inclusion, by a study protocol of patients operated on for LS between 2000 and 2006. Comparative case-control design, the LS group was match with the OS group by age, sex, and ASA classification. Statistical analysis: Results were analyzed with intention to treat. The variables were analyzed with T Student, Chi-square, Mann-Withney and Fischer exact test, considering statistically significant a P value < 0.05. Results: Thirty-two patients by group were compared. The groups (LS vs OS) were statistically similar in age (65.6 v/s 67.3 years), gender (31.25% females each group), and ASA (p > 0.5). The mean operative time was higher in LS group (220 v/s 172 minutes, p <0.01). Conversion rate wa
Estudio endoscópico en familiares de primer grado de pacientes operados por cáncer colorrectal Screening colonoscopy among first degree relatives of patients with colorectal carcinoma
Francisco López-Kstner,Demian A Fullerton,Udo Kronberg,Gonzalo Soto D
Revista médica de Chile , 2006,
Abstract: Background: First degree relatives of patients with colorectal carcinoma are at a higher risk of having the disease than the general population. Therefore, they should be subjected to screening colonoscopy. Aim: To assess the effectiveness of colonoscopy among first degree relatives of patients with colorectal carcinoma. Material and methods: A free colonoscopy was offered to first degree relatives of patients operated on for colorectal cancer between 1998 and 2000. As inclusion criteria, subjects had to be asymptomatic, older than 40 years or less than 10 years younger than the index case. Each subject was contacted twice, inviting him/her to have a colonoscopy performed. Results: Two hundred forty three relatives were contacted for the study and in 76, a colonoscopy was performed. Among the latter, a neoplasm was found in 13 (17%): One adenocarcinoma and 12 adenomas. Three of these lesions were located in the right colon. The main reason given by the 176 subjects that did not agree to have a colonoscopy was lack of interest. Conclusions: Screening colonoscopy is effective to detect adenoma and adenocarcinomaamong first degree relatives of patients with colorectal carcinoma, however only 31% of all potential relatives agreed to undergo a colonoscopy (Rev Méd Chile 2006; 134: 997-1001)
Diagnóstico y tratamiento de la perforación de colon durante la colonoscopia Diagnosis and management of colon perforation after colonoscopy
Eduardo García,Francisco López-Kstner,Antonio Rollan,Rodrigo Mu?oz
Revista médica de Chile , 2008,
Abstract: Background: Colon perforation is an uncommon but feared complication of colonoscopy. The treatment is usually surgical but occasionally it does not require an operation. Aim: To report our experience in the diagnosis and management of colon perforation after colonoscopy. Material and methods: Retrospective review of the database of 11,720 colonoscopies. The medical records of those patients that had a perforation were reviewed. Results: Twelve perforations in patients aged 26 to 92 years (six women), were identified with a global perforation rate of 0.1%. Five occurred during diagnostic and seven during therapeutic procedures. All perforations were confirmed by a plain X ray or CT scan of the abdomen. Four patients, without signs of initial diffuse peritoneal irritation, were medically treated. One of these, finally required surgery. Among operated patients, a primary suture was done in five, a primary excision without colostomy in three and a Hartmann procedure due to a severe peritoneal contamination in one. No patient died. Conclusions: There is a higher risk of colon perforation during therapeutic colonoscopies. Selected cases may be safely treated without surgery
Resultados de la cirugía laparoscópica en el tratamiento electivo de la enfermedad diverticular de colon Results of laparoscopic surgery for the treatment of diverticular disease of the colon
Francisco López-Kstner,Alejandro Zárate,George Pinedo,María E Molina
Revista médica de Chile , 2008,
Abstract: The laparoscopic approach is an alternative for the elective treatment of diverticular colon disease (DCD). Aim: To analyze the results of patients electively operated for DCD using a laparoscopic technique. Material and Methods: Data of patients with DCD operated using laparoscopy at the Catholic University of Chile Clinical Hospital were prospectively recorded from January 1999 to August 2006. Indications for surgery were repetitive crises of acute diverticulitis, the persistence of the symptoms or anatomic deformity after the first crisis and complicated diverticulitis (Hinchey 1-2) that responded to the medical treatment. The laparoscopic technique used five ports and the surgical specimen was extracted through a suprapubic approach. Results: One hundred and six patients aged 32 to 82 years (49% females) were operated in the study period. Fifty five percent had a previous abdominal surgery. The mean operative time was 213 minutes (range: 135-360). Four patients were converted to open surgery (3.7%). One or more early post-operative complications were observed in five patients (4.7%). The mean time for passing gases and reinitiate liquid diet was 1.7 and 2.4 days respectively. The median post operative stay after surgery was 4 days. There was no operative mortality. Mean follow-up time was 27 months and only one patient (0.9%) had a new episode of acute diverticular disease, with a satisfactory response to medical treatment. No patient has developed bowel obstruction. Conclusions: The laparoscopic approach is a safe alternative in the elective surgical treatment of DCD
Prevalencia de la incontinencia fecal en centros de salud y casas de reposo Prevalence of fecal incontinence in health centers and nursing home residents
Alejandro J Zárate,Francisco López-Kstner,Flavia Vergara,Nathalia Badilla
Revista médica de Chile , 2008,
Abstract: Background: Fecal and urinary incontinence (FI and UI) are psychologically and socially debilitating and embarrassing conditions. Aim: To determine the prevalence of FI and associated factors in patients assessed in health centers (HC) and nursing home (NH) residents. Material and Methods: Prospective, multicentric survey carried out in 3 HC and 16 NH of Santiago. Patients and residents of NH were interrogated about FI between March and July 2004. Results: The questionnaire was answered by 618 patients attending health centers aged 18 to 87 years (75% females) and 128 nursing home residents aged 40 to 103years (80% females). The prevalence of liquid or solid FI in HC and NH was 2.7 and 45%, respectively. Among the latter, the incontinence for liquids and solids was 19% and 42%, respectively. The prevalence of UI was 30.1 and 62.7% in HC patients and NH residents, respectively. Among patients attending HC, multivariable analysis showed a relation between older age and urinary incontinence with liquid or solid FI Among NH residents, multivariate analysis showed a relation between urinary incontinence and motor disabilities with liquid or solid FI Conclusions: The prevalence of liquid or solid FI among patients assessed in health center is 2.7%. This figure increases in older people, those with UI and in NH residents
Page 1 /328066
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.