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Search Results: 1 - 10 of 3300 matches for " Pilar Gilardi "
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La reconfiguración del tiempo en la narración historiográfica según Paul Ricoeur
Gilardi, Pilar;
Estudios de historia moderna y contemporánea de México , 2011,
Abstract: this article seeks to deal with the issue of historical time in the thinking of paul ricoeur, particularly within the horizon of time and narration. from this point onwards the french philosopher realizes the need to deal with the issue of time in general and historical time in particular through narration. so time is configured through three fundamental phenomena in the historical work on which the author will focus: calendar, generation and traces. this analysis of historical time forces one to distinguish it from the time configured in the narration characteristic of fiction, regarding which the author will show his differences and possible confluences.
La reconfiguración del tiempo en la narración historiográfica según Paul Ricoeur The reconfiguration of time in historiographic narration by Paul Ricoeur
Pilar Gilardi
Estudios de historia moderna y contemporánea de México , 2011,
Abstract: Este artículo aborda la cuestión del tiempo histórico en el pensamiento de Paul Ricoeur, en particular dentro del horizonte de Tiempo y narración. A partir de este momento se hace patente, a ojos del filósofo francés, la necesidad de abordar la cuestión del tiempo en general y del tiempo histórico en particular a través de la narración. Así el tiempo se configura a partir de tres fenómenos fundamentales en el quehacer historiográfico en los que el autor se detendrá: el calendario, la generación y la huella. Este análisis del tiempo propiamente histórico obliga a distinguirlo del tiempo configurado en la narración característica de la ficción, respecto de la cual el autor mostrará sus diferencias y posibles confluencias. This article seeks to deal with the issue of historical time in the thinking of Paul Ricoeur, particularly within the horizon of Time and narration. From this point onwards the French philosopher realizes the need to deal with the issue of time in general and historical time in particular through narration. So time is configured through three fundamental phenomena in the historical work on which the author will focus: calendar, generation and traces. This analysis of historical time forces one to distinguish it from the time configured in the narration characteristic of fiction, regarding which the author will show his differences and possible confluences.
Refractory recurrent bleeding as a late mortal complication of chest wall irradiation
Gilardi Leonardo
Annals of Thoracic Medicine , 2011,
Abstract: Radiation therapy is used to treat breast malignancies. Old external radiotherapy protocols included high-dose schedules and were associated with late complications. We describe the case of a 72-year-old woman who was admitted with recurrent bleeding from chest wall. Arteriovenous fistulae were diagnosed. Embolization therapy was initially successful, even though the bleeding episodes became recurrent. Arteriovenous fistulae should be included among differential diagnosis of thoracic bleeding in patients with history of local radiation therapy. The prognosis is poor and endovascular treatment may be considered a first-line treatment.
STUDIARE IN ITALIANO: ELABORAZIONE DI ESERCIZI SU TESTI UNIVERSITARI DI GEOGRAFIA
Thomas Gilardi
Italiano LinguaDue , 2010, DOI: 10.6092/2037-3597/644
Abstract: Nella prospettiva indicata dal CLIL (Content and Language Integrated Learning) l'articolo presenta un modello di unità didattica in cui si collocano esercizi per lo sviluppo della capacità di lettura per l'apprendimento disciplinare destinati a studenti universitari stranieri con l'obiettivo di sviluppare un livello di competenza linguistico-comunicativa corrispondente ai livelli B1 e B2 del Quadro Comune Europeo di Riferimento per le Lingue. Gli esercizi proposti sono finalizzati alla comprensione di testi, tratti da manuali di geografia, di cui viene indicato il livello di difficoltà in base all'indice di difficoltà Gulpease. Following the CLIL (Content and Language Integrated Learning) guidlines, this article presents a model for a didactic unit which includes reading skills exercises in a specific field of study for foreign university students. The aim for the students was to reach a B1 linguistic and a B2 comunicative language level according to the Common European Framework of Reference for Languages. The reading comprehension exercises utilize texts from Geography textbooks, which are marked with the level of difficulty based on the Gulpease difficulty index.
Reflexiones sobre el debate de la difusión de políticas
Meseguer, Covadonga;Gilardi, Fabrizio;
Política y gobierno , 2008,
Abstract: this paper surveys what is new in the study of the international diffusion of policies. we critically review the most recent contributions on the topic, trying to identify the substantive and methodological novelties in this literature. regarding mechanisms, we argue that whereas there is acknowledgement that they overlap, there is hardly any attention to the way in which they interact (either with other mechanisms of diffusion or with domestic factors). more generally, mechanisms are studied separately and are not integrated into a coherent model of diffusion. regarding empirics, we argue that existing studies have concentrated on policies that seem to have diffused in an explosive way despite the fact that both theory and methods are appropriate to study any type of diffusion. we argue that new empirical work should tackle the difficult issue of how to better operationalize alternative diffusion mechanisms. more attention should also be given to modeling diffusion processes to account for the fact that causal patterns may be highly heterogeneous in time and space. finally, we show that the last wave of studies on diffusion may have had the unintended consequence of opening up new questions. some of these questions are about the mechanisms that initiate vs. accelerate the diffusion of policies and institutions, why policies diffuse in clusters rather than globally, why some policies diffuse faster than others, and why some policies do not diffuse at all.
Improvement of Biocatalysts for Industrial and Environmental Purposes by Saturation Mutagenesis
Francesca Valetti,Gianfranco Gilardi
Biomolecules , 2013, DOI: 10.3390/biom3040778
Abstract: Laboratory evolution techniques are becoming increasingly widespread among protein engineers for the development of novel and designed biocatalysts. The palette of different approaches ranges from complete randomized strategies to rational and structure-guided mutagenesis, with a wide variety of costs, impacts, drawbacks and relevance to biotechnology. A technique that convincingly compromises the extremes of fully randomized vs. rational mutagenesis, with a high benefit/cost ratio, is saturation mutagenesis. Here we will present and discuss this approach in its many facets, also tackling the issue of randomization, statistical evaluation of library completeness and throughput efficiency of screening methods. Successful recent applications covering different classes of enzymes will be presented referring to the literature and to research lines pursued in our group. The focus is put on saturation mutagenesis as a tool for designing novel biocatalysts specifically relevant to production of fine chemicals for improving bulk enzymes for industry and engineering technical enzymes involved in treatment of waste, detoxification and production of clean energy from renewable sources.
Collective Action in Common Pool Resource Management, Including Heterogeneity of Opportunities and Exit Options  [PDF]
Pilar Useche
Natural Resources (NR) , 2013, DOI: 10.4236/nr.2013.48059
Abstract:

The mechanism through which exit options and outside opportunities affect cooperation outcomes has not been well studied in the resource management literature, since a deep analysis of the concepts of exit options and outside opportunitiesis missing. This article analyzes these concepts across the common pool resource management literature, investigates the factors that underlie opting out decisions, and reviews potential ways to operationalize these concepts for empirical analysis. It also explores how the relationship of cooperation and exit options may be influenced by broad economic processes, such as economic integration.

Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites
Giovanna Di Nardo,Gianfranco Gilardi
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms131215901
Abstract: Drug metabolism in human liver is a process involving many different enzymes. Among them, a number of cytochromes P450 isoforms catalyze the oxidation of most of the drugs commercially available. Each P450 isoform acts on more than one drug, and one drug may be oxidized by more than one enzyme. As a result, multiple products may be obtained from the same drug, and as the metabolites can be biologically active and may cause adverse drug reactions (ADRs), the metabolic profile of a new drug has to be known before this can be commercialized. Therefore, the metabolites of a certain drug must be identified, synthesized and tested for toxicity. Their synthesis must be in sufficient quantities to be used for metabolic tests. This review focuses on the progresses done in the field of the optimization of a bacterial self-sufficient and efficient cytochrome P450, P450 BM3 from Bacillus megaterium, used for the production of metabolites of human enzymes. The progress made in the improvement of its catalytic performance towards drugs, the substitution of the costly NADPH cofactor and its immobilization and scale-up of the process for industrial application are reported.
Relationship between 18F-FDG PET SUV with Partial Volume Correction and Histology in Gastric and Gastro-Oesophageal Cancer  [PDF]
Francesca Gallivanone, Carla Canevari, Paola Mapelli, Maria Picchio, Luigi Gianolli, Maria Carla Gilardi, Isabella Castiglioni
Open Journal of Medical Imaging (OJMI) , 2012, DOI: 10.4236/ojmi.2012.23017
Abstract: In vivo molecular imaging techniques is increasingly used in the management of oncological patients, allowing different aspects of oncological pathologies to be assessed (e.g. metabolism, hypoxia) non invasively. The possibility to extract indexes of disease from in vivo biomedical images and to associate them with their biological drivers opens new pro-spective on the role of in vivo molecular imaging and expedites the translation of novel biomarkers from the bench to the clinical environment. In this work we investigate the relationship between 18F-FDG uptake measured by Body- Weight Standardized Uptake Value (SUVBW) as index of cell glucose metabolism, and histological indices for gastric and gastro-oesophageal cancer. For this purpose, Partial Volume Effect Correction (PVC) has been properly compen- sated prior to the measurement of the PET index (PVC-SUVsub>BW). The correlation of 18F-FDG PVC-SUVBW with histol- ogy data was evaluated by bivariate and multivariate statistical analysis. Although obtained in a limited number of pa- tients, our results suggest that correlations can be found when PVC is applied to SUVBW and that 18F-FDG PET can provide information on biological characteristics of gastric and gastro-oesophageal cancer lesions.
Parrots Eat Nutritious Foods despite Toxins
James D. Gilardi, Catherine A. Toft
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038293
Abstract: Background Generalist herbivores are challenged not only by the low nitrogen and high indigestibility of their plant foods, but also by physical and chemical defenses of plants. This study investigated the foods of wild parrots in the Peruvian Amazon and asked whether these foods contain dietary components that are limiting for generalist herbivores (protein, lipids, minerals) and in what quantity; whether parrots chose foods based on nutrient content; and whether parrots avoid plants that are chemically defended. Methodology/Principal Findings We made 224 field observations of free-ranging parrots of 17 species in 8 genera foraging on 102 species of trees in an undisturbed tropical rainforest, in two dry seasons (July-August 1992–1993) and one wet season (January-February1994). We performed laboratory analyses of parts of plants eaten and not eaten by parrots and brine shrimp assays of toxicity as a proxy for vertebrates. Parrots ate seeds, fruits, flowers, leaves, bark, and insect larvae, but up to 70% of their diet comprised seeds of many species of tropical trees, in various stages of ripeness. Plant parts eaten by parrots were rich in protein, lipid, and essential minerals, as well as potentially toxic chemicals. Seeds were higher than other plant materials in protein and lipid and lower in fiber. Large macaws of three species ate foods higher in protein and lipids and lower in fiber compared to plant parts available but not eaten. Macaws ate foods that were lower in phenolic compounds than foods they avoided. Nevertheless, foods eaten by macaws contained measurable levels of toxicity. Macaws did not appear to make dietary selections based on mineral content. Conclusions/Significance Parrots represent a remarkable example of a generalist herbivore that consumes seeds destructively despite plant chemical defenses. With the ability to eat toxic foods, rainforest-dwelling parrots exploited a diversity of nutritious foods, even in the dry season when food was scarce for other frugivores and granivores.
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