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Perfura??o do septo nasal: etiologia e diagnóstico
Fornazieri, Marco Aurélio;Moreira, Jemima Herrero;Pilan, Renata;Voegels, Richard Louis;
Arquivos Internacionais de Otorrinolaringologia , 2010, DOI: 10.1590/S1809-48722010000400015
Abstract: introduction: the nasal septum perforation is an occasional finding of rhinoscopy and most patients are asymptomatic. however, there are several possible etiologies of this condition, making necessary a thorough investigation. objective: to review the literature the main causes of septal perforation and describe the diagnostic tests currently used. method: a systematic literature review of journals indexed identifiable until december 2008. final comments: the main causes are the traumatic / iatrogenic nasal drug use, exposure to toxic gases, inflammatory and infectious diseases and neoplasms. the diagnosis is based on detailed medical history, focusing on occupation and origin of the patient, observation of the characteristics of mucosal injury on biopsy and collection of additional tests such as anca, guided by the main suspect.
Perforation of nasal septum: etiology and diagnosis
Fornazieri, Marco Aurélio,Moreira, Jemima Herrero,Pilan, Renata,Voegels, Richard Louis
International Archives of Otorhinolaryngology , 2010,
Abstract: Introduction: The nasal septum perforation is an occasional finding of rhinoscopy and most patients are asymptomatic. However, there are several possible etiologies of this condition, making necessary a thorough investigation. Objective: To review the literature the main causes of septal perforation and describe the diagnostic tests currently used. Method: A systematic literature review of journals indexed identifiable until December 2008. Final Comments: The main causes are the traumatic / iatrogenic nasal drug use, exposure to toxic gases, inflammatory and infectious diseases and neoplasms. The diagnosis is based on detailed medical history, focusing on occupation and origin of the patient, observation of the characteristics of mucosal injury on biopsy and collection of additional tests such as ANCA, guided by the main suspect.
Perfura o do septo nasal: etiologia e diagnóstico
Fornazieri, Marco Aurélio,Moreira, Jemima Herrero,Pilan, Renata,Voegels, Richard Louis
Arquivos Internacionais de Otorrinolaringologia , 2010,
Abstract: Introdu o: A perfura o do septo nasal é um achado ocasional da rinoscopia anterior e a maioria dos pacientes s o assintomáticos. Contudo, s o várias as etiologias possíveis dessa afec o, fazendo-se necessária uma investiga o criteriosa. Objetivo: Revisar na literatura as principais causas da perfura o septal e descrever os exames diagnósticos atualmente utilizados. Método: Revis o sistemática da literatura de periódicos indexados identificáveis até dezembro de 2008. Comentários Finais: Entre as principais causas, encontram-se as traumáticas/iatrogênicas, o uso de drogas nasais, a exposi o a gazes tóxicos, as doen as inflamatórias e infecciosas e as neoplasias. O diagnóstico se baseia na anamnese detalhada, com enfoque na ocupa o e procedência do paciente, na observa o das características mucosas da les o, na biópsia e na coleta de exames complementares, como o ANCA, guiada pelas suspeitas principais.
Performance of a radiatively cooled system for quantum optomechanical experiments in space
André Pilan-Zanoni,Johannes Burkhardt,Ulrich Johann,Markus Aspelmeyer,Rainer Kaltenbaek,Gerald Hechenblaikner
Physics , 2015,
Abstract: The performance of a radiatively cooled instrument is investigated in the context of optomechanical quantum experiments, where the environment of a macroscopic particle in a quantum-superposition has to be cooled to less than 20\,K in deep space. A heat-transfer analysis between the components of the instrument as well as a transfer-function analysis on thermal oscillations induced by the spacecraft interior and by dissipative sources is performed. The thermal behaviour of the instrument in an orbit around a Lagrangian point and in a highly elliptical Earth orbit is discussed. Finally, we investigate further possible design improvements aiming at lower temperatures of the environment of the macroscopic particle. These include a mirror-based design of the imaging system on the optical bench and the extension of the heat shields.
Avalia??o da antibioticoterapia na morbidade pós-adenotonsilectomia: estudo prospectivo randomizado
Guerra, Marja Michelin;Garcia, Eduardo;Pilan, Renata Ribeiro de Mendon?a;Rapoport, Priscila Bogar;Campanholo, Caio Barbosa;Martinelli, Eli Onivaldo;
Revista Brasileira de Otorrinolaringologia , 2008, DOI: 10.1590/S0034-72992008000300005
Abstract: tonsillectomy with or without adenoidectomy still is one of the most commonly performed surgical procedures in the world, mostly in the pediatric population. aim: to study the impact of amoxicillin for 7 days in post-adenotonsillectomy recovery, comparing results with a control group. study type: prospective, randomized, controlled study with 120 patients. patients and methods: the patients were randomized according to surgery time to receive 7 days of amoxicillin associated with pain killers, or analgesic alone. during the first week of postoperative, we assessed the level of pain, oral intake acceptance, nausea and vomits, fever and return to daily activities. results: it was only in the fourth post-operative day that the group receiving antibiotic agents showed a statistically significant difference as far as pain is concerned. there was no difference between the two groups for other data analyzed. conclusion: considering the results from our study and reviewing the literature on the use of antibiotic agents, we agree that there is no improvement in patient recovery after adenotonsillectomy with the use of amoxicillin for 7 days in the postoperative.
Avalia??o da qualidade de vida após septoplastia em pacientes com obstru??o nasal
Bezerra, Thiago Freire Pinto;Stewart, Michael G.;Fornazieri, Marco Aurelio;Pilan, Renata Ribeiro de Mendonca;Pinna, Fabio de Rezende;Padua, Francini Grecco de Melo;Voegels, Richard Louis;
Brazilian Journal of Otorhinolaryngology , 2012, DOI: 10.1590/S1808-86942012000300011
Abstract: nasal obstruction is a common complaint in the population. when caused by a deviated nasal septum, septoplasty is the procedure of choice for treating these patients. nose is a tool for assessing the disease-specific quality of life related to nasal obstruction. aim: to assess the impact of septoplasty on patients with nasal obstruction secondary to deviated nasal septum based on the disease-specific quality-of-life questionnaire. design: prospective. methods: patients undergoing septoplasty with/without turbinectomy after no clinical improvement with medical treatment were assessed by the nose questionnaire before and 3 months after surgery. we evaluated the surgical improvement based on total score, the magnitude of the surgery in the disease-specific quality of life and the correlation between the preoperative score and postoperatively improvement. results: fourty-six patients were included in the study. there was a statistically significant improvement in the preoperative nose score (md = 75, iqr = 26) and after three months (md = 10, iqr = 20) (p < 0.001.t-wilcoxon). the standardized response mean was 3.07. we found a strong correlation between the preoperative score in the nose questionnaire and improvements in the postoperative period (r = -0.789, p < 0.001, spearman). no difference was found in improvement scores by gender. (p = 0.668, u-mann-whitney). conclusion: septoplasty resulted in a statistically significant improvement in the disease-specific qol questionnaire.
Avalia??o da qualidade de vida após sinusectomia endoscópica para rinossinusite cr?nica
Bezerra, Thiago Freire Pinto;Piccirillo, Jay F.;Fornazieri, Marco Aurelio;Pilan, Renata Ribeiro de Mendon?a;Pinna, Fabio de Rezende;Padua, Francini Grecco de Melo;Voegels, Richard Louis;
Brazilian Journal of Otorhinolaryngology , 2012, DOI: 10.1590/S1808-86942012000200015
Abstract: chronic rhinosinusitis is a disease of undefined etiology that significantly impacts the quality of life of its patients. various studies carried out in countries other than brazil have shown endoscopic sinus surgery as an effective means of treating this condition. objective: this study aims to analyze, with the aid of snot-20, the association between endoscopic sinus surgery and disease-specific quality of life of brazilian patients treated for chronic rhinosinusitis accompanied or not by nasal polyps. materials and methods: this prospective study enrolled patients submitted to endoscopic sinus surgery after drug therapy failed to improve their symptoms. they were assessed based on questionnaire snot-20p before and 12 months after surgery. improvement on total scores and on the five items deemed more important by each patient were assessed. the study also looked into the correlation between preoperative scores and postoperative improvement and if there were any gender-related improvement differences. results: forty-three patients aged 44 (19), md (iqr), 65% of whom (26/43) were males. statistically significant improvement was seen on snot-20 and snot-20(5+) and a correlation was established between preoperative scores and postoperative improved scores (p<0.001). no gender-related differences were observed in quality of life. conclusion: endoscopic sinus surgery in patients with chronic rhinosinusitis is associated with statistically significant improvements in disease-specific quality of life.
Cross-Cultural Adaptation and Validation of SNOT-20 in Portuguese
Thiago Freire Pinto Bezerra,Jay F. Piccirillo,Marco Aurélio Fornazieri,Renata R. de M. Pilan,Tatiana Regina Teles Abdo,Fabio de Rezende Pinna,Francini Grecco de Melo Padua,Richard Louis Voegels
International Journal of Otolaryngology , 2011, DOI: 10.1155/2011/306529
Abstract: Introduction. Chronic rhinosinusitis is a highly prevalent disease, so it is necessary to create valid instruments to assess the quality of life of these patients. The SNOT-20 questionnaire was developed for this purpose as a specific test to evaluate the quality of life related to chronic rhinosinusitis. It was validated in the English language, and it has been used in most studies on this subject. Currently, there is no validated instrument for assessing this disease in Portuguese. Objective. Cross-cultural adaptation and validation of SNOT-20 in Portuguese. Patients and Methods. The SNOT-20 questionnaire underwent a meticulous process of cross-cultural adaptation and was evaluated by assessing its sensitivity, reliability, and validity. Results. The process resulted in an intelligible version of the questionnaire, the SNOT-20p. Internal consistency (Cronbach's alpha=0.91, <.001), reliability testing-retesting (=0.994, <.001), content validity, validity of discrimination of patients without chronic rhinosinusitis (=44, <.0001) and assessment of sensitivity to change (SRM=1.53 and 1.09) were evaluated. Conclusion. We conducted a successful process of cross-cultural adaptation and validation of the SNOT-20 questionnaire into Portuguese.
Cross-Cultural Adaptation and Validation of SNOT-20 in Portuguese
Thiago Freire Pinto Bezerra,Jay F. Piccirillo,Marco Aurélio Fornazieri,Renata R. de M. Pilan,Tatiana Regina Teles Abdo,Fabio de Rezende Pinna,Francini Grecco de Melo Padua,Richard Louis Voegels
International Journal of Otolaryngology , 2011, DOI: 10.1155/2011/306529
Abstract: Introduction. Chronic rhinosinusitis is a highly prevalent disease, so it is necessary to create valid instruments to assess the quality of life of these patients. The SNOT-20 questionnaire was developed for this purpose as a specific test to evaluate the quality of life related to chronic rhinosinusitis. It was validated in the English language, and it has been used in most studies on this subject. Currently, there is no validated instrument for assessing this disease in Portuguese. Objective. Cross-cultural adaptation and validation of SNOT-20 in Portuguese. Patients and Methods. The SNOT-20 questionnaire underwent a meticulous process of cross-cultural adaptation and was evaluated by assessing its sensitivity, reliability, and validity. Results. The process resulted in an intelligible version of the questionnaire, the SNOT-20p. Internal consistency (Cronbach's , ), reliability testing-retesting ( , ), content validity, validity of discrimination of patients without chronic rhinosinusitis ( , ) and assessment of sensitivity to change ( and 1.09) were evaluated. Conclusion. We conducted a successful process of cross-cultural adaptation and validation of the SNOT-20 questionnaire into Portuguese. 1. Introduction Rhinosinusitis (RS) is one of the most common complaints presented in physician office visits. About 31 million people are affected in the United States (USA) each year, with an annual cost of six billion dollars. It is one of the main reasons for prescribing antibiotics and lost worker productivity [1–3]. RS that lasts more than 12 weeks is called chronic rhionosinusitis. The Chronic rhinosinusitis is divided into with and without nasal polyps, distinguished by clinical examination, histopathology, and prognosis profile of interleukin [4]. The chronic RS is also a common reason for surgery, with more than 200,000 sinusectomies held each year in the USA [5]. Specific instruments to measure quality of life related to RS have been developed by the need to better assess the morbidity of a disease and the evolution and impact of treatments. Measures of quality of life related to RS with validity and reliability are crucial for assessing treatment outcomes of CRS [6]. In the past, some studies demonstrating the benefits of antibiotics presented as the primary endpoint only the descriptive report of improvement of symptoms of the patient, for example. Quality of life is seen in a different state of health. It is the only personal experience that reflects not only the health, but also other factors and circumstances in the patient's life that only he
Cirugía cardíaca reparadora en recién nacidos: Experiencia de 5 a?os en cirugía neonatal con circulación extracorpórea
Magliola,Ricardo; Althabe,María; Moreno,Guillermo; Lenz,Ana M.; Pilan,María L.; Landry,Luis; Balestrini,María; Charroqui,Alberto; Vassallo,Juan C.; Salgado,Gladys; Martín,Analía; Barretta,Jorge; Cornelis,Javier; García Delucis,Pablo; Suárez,José; Laura,Juan P.;
Archivos argentinos de pediatr?-a , 2009,
Abstract: introduction. four hundred newborns die every year in our country suffering from congenital heart disease. definitive surgical repair, whenever possible, is nowadays the optimal therapeutic strategy. our goal is to describe mortality and morbidity in neonatal surgery with cardiopulmonary bypass in a tertiary public hospital in argentina. patients and methods. descriptive, retrospective study. every patient, younger than 45 days, with cardiac surgery requiring cardiopulmonary bypass, at the garrahan hospital between 2004 and 2008 was included. demographic, surgical and postoperative data were collected. adjusted mortality risk analysis, and descriptive statistics from the most frequent diagnosis were performed. results are expressed as median and rank or percentage. results. 200 newborns were operated, 62% males. median age was 21 days (r 1- 45) and median weight 3.1 kg (r 1.6-6.2). total anomalous pulmonary venous return, transposition of great arteries an hypoplastic left heart syndrome diagnoses accounted for 75% of the procedures. median length of stay was 12 days (r 0-191), and 6 days of mechanical ventilation (r 0-180). eighteen percent of the patients required peritoneal dialysis. whole series mortality was 19% and fell to 14% in 2008. unstable preoperative condition and postoperative complications increased mortality, or= 2.23 (1.02-4.89) and or= 10 (3.6-33.4), respectively. conclusions. our postoperative mortality is similar to those reported in foreign countries databases. patients with unstable preoperative condition and post-operative complications had higher mortality.
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