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Search Results: 1 - 10 of 8604 matches for " Pietro Paolo Bacciu "
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Association between Human Plasma Chondroitin Sulfate Isomers and Carotid Atherosclerotic Plaques
Elisabetta Zinellu,Antonio Junior Lepedda,Antonio Cigliano,Salvatore Pisanu,Angelo Zinellu,Ciriaco Carru,Pietro Paolo Bacciu,Franco Piredda,Anna Guarino,Rita Spirito,Marilena Formato
Biochemistry Research International , 2012, DOI: 10.1155/2012/281284
Abstract: Several studies have evidenced variations in plasma glycosaminoglycans content in physiological and pathological conditions. In normal human plasma GAGs are present mainly as undersulfated chondroitin sulfate (CS). The aim of the present study was to evaluate possible correlations between plasma CS level/structure and the presence/typology of carotid atherosclerotic lesion. Plasma CS was purified from 46 control subjects and 47 patients undergoing carotid endarterectomy showing either a soft or a hard plaque. The concentration and structural characteristics of plasma CS were assessed by capillary electrophoresis of constituent unsaturated fluorophore-labeled disaccharides. Results showed that the concentration of total CS isomers was increased by 21.4% (<0.01) in plasma of patients, due to a significant increase of undersulfated CS. Consequently, in patients the plasma CS charge density was significantly reduced with respect to that of controls. After sorting for plaque typology, we found that patients with soft plaques and those with hard ones differently contribute to the observed changes. In plasma from patients with soft plaques, the increase in CS content was not associated with modifications of its sulfation pattern. On the contrary, the presence of hard plaques was associated with CS sulfation pattern modifications in presence of quite normal total CS isomers levels. These results suggest that the plasma CS content and structure could be related to the presence and the typology of atherosclerotic plaque and could provide a useful diagnostic tool, as well as information on the molecular mechanisms responsible for plaque instability.
Association between Human Plasma Chondroitin Sulfate Isomers and Carotid Atherosclerotic Plaques
Elisabetta Zinellu,Antonio Junior Lepedda,Antonio Cigliano,Salvatore Pisanu,Angelo Zinellu,Ciriaco Carru,Pietro Paolo Bacciu,Franco Piredda,Anna Guarino,Rita Spirito,Marilena Formato
Biochemistry Research International , 2012, DOI: 10.1155/2012/281284
Abstract: Several studies have evidenced variations in plasma glycosaminoglycans content in physiological and pathological conditions. In normal human plasma GAGs are present mainly as undersulfated chondroitin sulfate (CS). The aim of the present study was to evaluate possible correlations between plasma CS level/structure and the presence/typology of carotid atherosclerotic lesion. Plasma CS was purified from 46 control subjects and 47 patients undergoing carotid endarterectomy showing either a soft or a hard plaque. The concentration and structural characteristics of plasma CS were assessed by capillary electrophoresis of constituent unsaturated fluorophore-labeled disaccharides. Results showed that the concentration of total CS isomers was increased by 21.4% ( ) in plasma of patients, due to a significant increase of undersulfated CS. Consequently, in patients the plasma CS charge density was significantly reduced with respect to that of controls. After sorting for plaque typology, we found that patients with soft plaques and those with hard ones differently contribute to the observed changes. In plasma from patients with soft plaques, the increase in CS content was not associated with modifications of its sulfation pattern. On the contrary, the presence of hard plaques was associated with CS sulfation pattern modifications in presence of quite normal total CS isomers levels. These results suggest that the plasma CS content and structure could be related to the presence and the typology of atherosclerotic plaque and could provide a useful diagnostic tool, as well as information on the molecular mechanisms responsible for plaque instability. 1. Introduction Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in medium and large arteries. Plaque rupture and thrombosis are the most important clinical complication in the pathogenesis of acute coronary syndromes and peripheral vascular disease [1, 2]. Although numerous risk factors such as hypertension, diabetes, and hyperlipidemia are thought to play a role in the development and progression of this pathology [3], the mechanisms underlying plaque formation and progression are still largely unknown. Abnormal expression and structural modifications of arterial chondroitin sulfate proteoglycans (CS-PGs) have been implicated in atherosclerosis progression [4–6]. Arterial CS-PGs are markedly increased in early atherosclerotic lesions, participating in lipid retention, modification, and accumulation. Furthermore, CS-PGs play a key role in inflammation processes
Numerical Simulation of the Behavior of Cracked Reinforced Concrete Members  [PDF]
Pietro Croce, Paolo Formichi
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.512090
Abstract: Refined non-linear static or dynamic analyses of reinforced concrete structures require the knowledge of the actual force-displacement or bending moment-rotation curves of each structural member, which depend on the crack widths and on the crack pattern, and after all on the slip between concrete and reinforcing steel. For this reason the definition of improved local models taking into account all these local aspects is a fundamental prerequisite for advanced assessment of r.c. structures. A numerical procedure which allows to predict the relative displacement between steel reinforcement and the surrounding concrete in a reinforced concrete element, once assigned the stress in the naked steel bar and the bond-slip law is discussed. The method provides as final outcomes the sequence of crack openings and the individual crack widths, regardless of the particular bond-slip correlation adopted. The proposed procedure is implemented referring to two relevant experimental case studies, demonstrating that it is able to predict satisfactorily actual strain fields and slips along the investigated reinforced concrete elements.
In reply
Lanzetta Paolo,Monaco Pietro
Indian Journal of Ophthalmology , 2004,
Abstract:
Major ocular complications after organ transplantation.
Lanzetta Paolo,Monaco Pietro
Indian Journal of Ophthalmology , 2004,
Abstract:
Generalized Crossover in multiparameter Hamiltonians
Pietro Parruccini,Paolo Rossi
Physics , 2001, DOI: 10.1103/PhysRevE.64.047104
Abstract: Many systems near criticality can be described by Hamiltonians involving several relevant couplings and possessing many nontrivial fixed points. A simple and physically appealing characterization of the crossover lines and surfaces connecting different nontrivial fixed points is presented. Generalized crossover is related to the vanishing of the RG function $Z_t^{-1}$. An explicit example is discussed in detail based on the tetragonal GLW Hamiltonian.
Rituximab ameliorated severe hearing loss in Cogan's syndrome: a case report
Jelka G Orsoni, Bruno Laganà, Pierangela Rubino, Laura Zavota, Salvatore Bacciu, Paolo Mora
Orphanet Journal of Rare Diseases , 2010, DOI: 10.1186/1750-1172-5-18
Abstract: a 25-year-old Italian woman was referred with conjunctival hyperaemia, interstitial keratitis, moderate bilateral sensorineural hearing loss accompanied by tinnitus, dizziness, nausea and vertigo, poorly responsive to oral and topical steroidal therapy. Diagnosis of typical CS was made. The administration of a combined immunosuppressive treatment resolved ocular inflammation, dizziness, nausea, and vertigo but gave little results in controlling progressive hearing loss. A noticeable improvement in hearing function was documented by pure tone audiometry after infusion of Rituximab.in CS, hearing function is often the most difficult parameter to control with therapy. A positive effect of Rituximab on was observed in our case. The drug also allowed to significantly reduce the number of adjuvant immunosuppressive medications.Rituximab is a chimeric human-mouse monoclonal antibody against lymphocyte CD20 surface antigen, and treatment induces depletion of B lymphocytes by various mechanisms. These antibodies are thought to act in vivo mostly through activation of antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, although direct growth inhibition and/or induction of apoptosis may also take place [1]. Rituximab is presently approved for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis. Here is the first report of the use of this drug in a case of severe Cogan's syndrome (CS).A 25-year-old Italian woman developed severe bilateral sensorineural hearing loss over the course of 12 months from her first acute inflammatory episode characterized by conjunctival hyperaemia, interstitial keratitis and tinnitus. Before the admission, the patient had already experienced a 3-week regimen of oral prednisone (50 mg/day at regressive dosage) and dexametasone eye-drops with poor response. After the patient had been screened for a possible infectious origin of her symptoms and all other known causes of interstitial keratitis had been exclu
QA/QC Procedures for in-Situ Calibration of a High Altitude Automatic Weather Station: The Case Study of the AWS Pyramid, 5050 m asl, Khumbu Valley, Nepal  [PDF]
Elisa Vuillermoz, Gian Pietro Verza, Paolo Cristofanelli, Paolo Bonasoni, Guido Roggero, Andrea Merlone
Atmospheric and Climate Sciences (ACS) , 2014, DOI: 10.4236/acs.2014.45070
Abstract:

In-situ calibrations of weather stations are usually performed by positioning standard instruments close to the station under calibration and comparing the obtained results. This procedure could be useful to evaluate the proper functioning of the monitoring equipments, but do not allowed the determination of a calibration curve that allow the corrections of the acquired parameters. Thus, the development of a dedicated facility for in-situ calibration of weather stations, enabling simultaneous generation of a wide range of temperatures and pressures could offer important improvements in this framework, particularly if this facility is applied to high mountains monitoring stations where the weather stations calibrations could be very difficult. This paper will present the calibration chamber developed in the framework of the EMRP-METEOMET (Metrology for Meteorology) Project, which aims is to bring metrological traceability to high altitude meteorological instruments and through this experience will provide a general overview on the importance of the application of this methodology at different levels.

2-dimensional Regge gravity in the conformal gauge
Pietro Menotti,Pier Paolo Peirano
Physics , 1995, DOI: 10.1016/0920-5632(96)00138-7
Abstract: By restricting the functional integration to the Regge geometries, we give the discretized version of the well known path integral formulation of 2--dimensional quantum gravity in the conformal gauge. We analyze the role played by diffeomorphisms in the Regge framework and we give an exact expression for the Faddeev--Popov determinant related to a Regge surface; such an expression in the smooth limit goes over to the correct continuum result.
Faddeev-Popov determinant in 2-dimensional Regge gravity.
Pietro Menotti,Pier Paolo Peirano
Physics , 1995, DOI: 10.1016/0370-2693(95)00603-I
Abstract: By regularizing the singularities appearing in the two dimensional Regge calculus by means of a segment of a sphere or pseudo-sphere and then taking the regulator to zero, we obtain a simple formula for the gauge volume which appears in the functional integral. Such a formula is an analytic function of the opening of the conic singularity in the interval from $\pi$ to $4\pi$ and in the continuum limit it goes over to the correct result.
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