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Search Results: 1 - 10 of 717 matches for " Pia Nyberg "
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Endogenous Matrix-Derived Inhibitors of Angiogenesis
Malin Sund,Pia Nyberg,Hans Petter Eikesdal
Pharmaceuticals , 2010, DOI: 10.3390/ph3103021
Abstract: Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM) surrounding cells. Many matrix-derived inhibitors of angiogenesis, such as endostatin, tumstatin, canstatin and arresten, are bioactive fragments of larger ECM molecules. These substances become released upon proteolysis of the ECM and the vascular basement membrane (VBM) by enzymes of the tumor microenvironment. Although the role of matrix-derived angiogenesis inhibitors is well studied in animal models of cancer, their role in human cancers is less established. In this review we discuss the current knowledge about these molecules and their potential use as cancer therapeutics and biomarkers.
Can ELISPOT Be Applied to A Clinical Setting as A Diagnostic Utility for Neuroborreliosis?
Marika Nordberg,Pia Forsberg,Dag Nyman,Barbro H. Skogman,Clara Nyberg,Jan Ernerudh,Ingvar Eliasson,Christina Ekerfelt
Cells , 2012, DOI: 10.3390/cells1020153
Abstract: The aim of this prospective study was to investigate the diagnostic performance of Borrelia (Bb)-induced interferon (IFN)-γ secretion detected by ELISPOT modified to be feasible for clinical laboratories as a supplementary test to the laboratory diagnosis of Lyme neuroborreliosis (LNB) in an endemic setting. Between 2002 and 2004, patients with symptoms of suspected clinical LNB were included in a study conducted on the ?land islands in the Finnish archipelago, which is a hyper-endemic area for Lyme borreliosis (LB). Fourteen patients with confirmed LNB and 103 patients with non-LNB were included, and the numbers of spontaneous and Bb-induced IFN-γ-secreting cells were assayed by the ELISPOT test. The ELISPOT assay showed a weak diagnostic performance with a sensitivity of 36% and a specificity of 82%. The findings in this study show that this ELISPOT-assay modified to be feasible in clinical routine laboratories is not useful as a supplementary diagnostic tool in the laboratory diagnosis of patients with clinically suspected LNB.
Arresten, a Collagen-Derived Angiogenesis Inhibitor, Suppresses Invasion of Squamous Cell Carcinoma
Mari Aikio, Ilkka Alahuhta, Sini Nurmenniemi, Juho Suojanen, Riitta Palovuori, Susanna Teppo, Timo Sorsa, Carlos López-Otín, Taina Pihlajaniemi, Tuula Salo, Ritva Heljasvaara, Pia Nyberg
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051044
Abstract: The turnover of extracellular matrix liberates various cryptic molecules with novel biological activity. Among these are the collagen-derived anti-angiogenic fragments, some of which are suggested to affect carcinoma cells also directly. Arresten is an endogenous angiogenesis inhibitor that is derived from the non-collagenous domain of the basement membrane collagen IV α1 chain. As the mere prevention of tumor angiogenesis leads to hypoxia that can result in selection of more aggressive cell types and reduces the efficacy of chemotherapy, we aimed here to elucidate how arresten influences the aggressive human carcinoma cells. Arresten efficiently inhibited migration and invasion of HSC-3 tongue carcinoma cells in culture and in an organotypic model. Subcutaneous Arr-HSC xenografts grew markedly more slowly in nude mice and showed reduced tumor cell proliferation, vessel density and local invasiveness. In the organotypic assay, HSC-3 cells overproducing arresten (Arr-HSC) showed induction of cell death. In monolayer culture the Arr-HSC cells grew in aggregated cobblestone-like clusters and, relative to the control cells, showed increased expression and localization of epithelial marker E-cadherin in cell-cell contacts. Application of electric cell-substrate impedance sensing (ECIS) further supported our observations on altered morphology and motility of the Arr-HSC cells. Administration of a function-blocking α1 integrin antibody abolished the impedance difference between the Arr-HSC and control cells suggesting that the effect of arresten on promotion of HSC-3 cell-cell contacts and cell spreading is at least partly mediated by α1β1 integrin. Collectively, our data suggest novel roles for arresten in the regulation of oral squamous carcinoma cell proliferation, survival, motility and invasion through the modulation of cell differentiation state and integrin signaling.
ADVICE FROM A PROFESSIONAL: The DNA of a Technical Communicator
Mette Nyberg
Communication & Language at Work , 2013,
Abstract: Unlike our peers in the US or UK, the technical communicators in the Danish/Scandinavian region have not had the luck of easy access to formal education within the field of technical communication. I claim that most of us technical communicators in the Danish/Scandinavian region do not have a formal technical communication degree. We have learned on the job – spiced with relevant courses (such as Information Mapping), and we have kept ourselves up to date by attending conferences, reading books and articles. For the past 10 years or so we have been blessed with the growing wealth of information on the Internet to keep us in the loop and the social media to exchange views and experiences. This article discusses the evolution of a technical communicator profile as known in the Danish/Scandinavian region and what it takes to become a good technical communicator. What is indeed the skill set of a good technical communicator? Is there at all a future for technical communicators - and is it a promising career path?
Scalar Curvature and Stability of Toric Fibrations
Thomas Nyberg
Mathematics , 2012,
Abstract: We study fibrations $\cV$ of toric varieties over the flag variety $G/T$, where $G$ is a compact semisimple Lie group and $T$ is a maximal torus. From symplectic data, we construct test configurations of $\cV$ and compute their Futaki invariants by employing a generalization of Pick's Theorem. We also give a simple form of the Mabuchi Functional.
Human Bone Marrow Mesenchymal Stem Cells Induce Collagen Production and Tongue Cancer Invasion
Sirpa Salo, Carolina Bitu, Kalle Merkku, Pia Nyberg, Ibrahim O. Bello, Jussi Vuoristo, Meeri Sutinen, Hannu V?h?nikkil?, Daniela E. Costea, Joonas Kauppila, Petri Lehenkari, Dan Dayan, Marilena Vered, Juha Risteli, Tuula Salo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077692
Abstract: Tumor microenvironment (TME) is an active player in carcinogenesis and changes in its composition modify cancer growth. Carcinoma-associated fibroblasts, bone marrow-derived multipotent mesenchymal stem cells (BMMSCs), and inflammatory cells can all affect the composition of TME leading to changes in proliferation, invasion and metastasis formation of carcinoma cells. In this study, we confirmed an interaction between BMMSCs and oral tongue squamous cell carcinoma (OTSCC) cells by analyzing the invasion progression and gene expression pattern. In a 3-dimensional myoma organotypic invasion model the presence of BMMSCs inhibited the proliferation but increased the invasion of OTSCC cells. Furthermore, the signals originating from OTSCC cells up-regulated the expression of inflammatory chemokines by BMMSCs, whereas BMMSC products induced the expression of known invasion linked molecules by carcinoma cells. Particularly, after the cell-cell interactions, the chemokine CCL5 was abundantly secreted from BMMSCs and a function blocking antibody against CCL5 inhibited BMMSC enhanced cancer invasion area. However, CCL5 blocking antibody did not inhibit the depth of invasion. Additionally, after exposure to BMMSCs, the expression of type I collagen mRNA in OTSCC cells was markedly up-regulated. Interestingly, also high expression of type I collagen N-terminal propeptide (PINP) in vivo correlated with the cancer-specific mortality of OTSCC patients, whereas there was no association between cancer tissue CCL5 levels and the clinical parameters. In conclusion, our results suggest that the interaction between BMMSC and carcinoma cells induce cytokine and matrix molecule expression, of which high level of type I collagen production correlates with the prognosis of OTSCC patients.
Cathepsin K Is Present in Invasive Oral Tongue Squamous Cell Carcinoma In Vivo and In Vitro
Carolina C. Bitu, Joonas H. Kauppila, Andréia Bufalino, Sini Nurmenniemi, Susanna Teppo, Meeri Kein?nen, Suvi-Tuuli Vilen, Petri Lehenkari, Pia Nyberg, Ricardo D. Coletta, Tuula Salo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070925
Abstract: Objectives Cathepsin K, a lysosomal cysteine protease, is expressed in the tumor microenvironment (TME) of skin carcinoma, but nothing is known about cathepsin K in oral tongue squamous cell carcinoma (OTSCC). Our aim was to describe the expression of cathepsin K in invasive OTSCC in vitro and in a series of clinical cancer specimens. Materials and Methods OTSCC invasion in vitro was studied using invasive HSC-3 tongue carcinoma cells in 3D organotypic models. In total, 121 mobile tongue OTSCCs and 10 lymph node metastases were analyzed for cathepsin K expression. The association between cathepsin K expression and clinicopathological factors was evaluated. Results Cysteine protease inhibitor E64 and cathepsin K silencing significantly (p<0.0001) reduced HSC-3 cell invasion in the 3D models. Cathepsin K was expressed in a majority of carcinoma and metastatic cells, but the expression pattern in carcinoma cells did not correlate with clinical parameters. Instead, the weak expression of cathepsin K in the invasive TME front correlated with increased overall recurrence (p<0.05), and in early-stage tumors this pattern predicted both cancer recurrence and cancer-specific mortality (p<0.05 and p<0.005, respectively). Conclusions Cathepsin K is expressed in OTSCC tissue in both carcinoma and TME cells. Although the diminished activity and expression in aggressive tongue HSC-3 cells reduced 3D invasion in vitro, the amount of cathepsin K in carcinoma cells was not associated with the outcome of cancer patients. Instead, cathepsin K in the invasive TME front seems to have a protective role in the complex progression of tongue cancer.
Mobile MSN Messenger: Still a Complement?
Marcus Nyberg,Didier Chincholle
International Journal of Interactive Mobile Technologies (iJIM) , 2008,
Abstract: In order to understand how mobile instant messaging services can fit into the users’ current communication behavior, Ericsson Research performed a qualitative user study in Sweden in May 2007. The results showed that the respondents were positive towards (free of charge) mobile MSN Messenger and perceived it as an ex tension of the computer-based version that could be used anywhere. However, although MSN Messenger on the com puter definitely was considered as a ‘must-have’ application, the mobile version was only perceived as a ‘nice-to-have’ application and a complement to text mes saging (SMS). Almost one year later, in April 2008, Ericsson Research performed a short qualita tive follow-up study with the same set of respondents to un derstand if and how the mobile MSN Messenger usage had changed. The results actually revealed that none of the re spondents used mobile MSN Messenger anymore as the application no longer was free of charge. On a general level, the study highlights important considera tions when intro ducing computer-based concepts and Internet services in a mo bile environment.
一般論述研究/The Case of the Royal School of Library and Information Science: A European iSchool/Pia Borlund
Pia Borlund Pia Borlund
Journal of Library and Information Science , 2011,
Abstract: The present paper forms the basis of the invited talk given by the author at the International Symposium on the Transformation and Innovation of Library and Information Science, November 16-17, 2010, Taipei, Taiwan. The paper introduces the Royal School of Library and Information Science, Denmark, as a European School of Library and Information Science and a member of iSchool Caucus. The paper outlines some of the current challenges of the Royal School of Library and Information Science and how these challenges are met, including how the membership of the iSchool movement is considered beneficial with respect to the mentioned challenges. The paper also touches upon some of the challenges, which the iSchool movement is facing – at least from the perspective of the author. 本文為作者受邀於2010 年11 月16-17 日,在臺灣師大舉辦的「圖書資訊學蛻變與創新國際研討會」上所發表的文章。本文介紹丹麥皇家圖書資訊學院為歐洲圖書資訊科學校院,並為iSchool Caucus 成員。本文概述丹麥皇家圖書資訊學院面臨的挑戰,以及如何面對這些挑戰,包括iSchool 的成員活動如何有益於這些挑戰。作者也探討一些其他iSchool 運動正面臨的挑戰。頁次:11-17
Influences of Age and Length of Education on rCBF-SPECT in Healthy Elderly: Diagnostic Implications for Dementia  [PDF]
Torbj?rn Sundstr?m, Anne Larsson, Lars Nyberg, Katrine Riklund
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.22026
Abstract: Background: Few previous studies have described other than age- and gender related changes in regional cerebral blood flow (rCBF) in healthy elderly. What is the influence of other common clinically relevant variables such as ache, education, MMSE, and smoking history? Purpose: To study rCBF in Swedish healthy elderly by single-photon emission computed tomography (SPECT) and evaluate the influence on rCBF of age, gender, education, MMSE, ache, and smoking with a focus on education in relation to the ‘cognitive reserve’. Methods: Healthy subjects (n = 45, 50 -75 y), sampled from a large longitudinal aging study took part in an extensive examination of health and memory, including cognitive testing and socio-economic survey. After injection of 99 mTc-hexamethylpropylene amine oxime (HMPAO) followed by SPECT the rCBF-SPECT images were analyzed using statistical parametric mapping (SPM). Results: Age-related decreases in uptake were seen in interhemispheric and interlobar regions. There was a positive rCBF correlation with education in the inferior frontal lobe and a higher uptake in the left temporal lobe in an age-gender-matched high education subgroup. Conclusion: The localization of the age related findings except for the medial temporal lobe differs markedly from typical dementia related findings. A reduction close to interhemispheric or interlobar space should always be related to chronological age. Education seems to have an influence on basal brain function at a resting-state condition. Knowledge of normal rCBF variations for variables such as age and education should be considered when making clinical diagnosis. The findings could be interpreted as further support for the theory of cognitive reserve.
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