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Search Results: 1 - 10 of 323481 matches for " Peter J. Conlon "
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Transplant Outcomes in Patients with Idiopathic Membranous Nephropathy
Claire Kennedy,Carol Traynor,Patrick O'Kelly,Anthony Dorman,Peter J. Conlon
International Journal of Nephrology , 2013, DOI: 10.1155/2013/818537
Abstract: Background. The natural history of idiopathic membranous nephropathy and recurrent disease in transplants is variable. We performed a retrospective cohort study of renal transplant recipients with a primary diagnosis of idiopathic membranous nephropathy. We aimed to establish patterns of disease recurrence and to identify factors associated with disease recurrence. Methods. We accessed the Irish renal transplant database to identify patients with biopsy-proven idiopathic membranous nephropathy in receipt of a renal transplant between 1982 and 2010. A detailed medical chart review was performed in all cases, and a senior renal histopathologist reviewed all histology specimens. Results. The outcomes of 32 patients, in receipt of 36 grafts, are reported. There was a male preponderance ( ). Significant graft dysfunction, directly attributable to recurrent disease, was evident in 31% of cases at 10 years. There was no significant association between time on dialysis, HLA mismatch, occurrence of rejection, and the development of recurrent membranous disease. One patient was retransplanted twice; all three grafts were lost to aggressive recurrent membranous disease. Conclusions. It remains difficult to identify those that will develop recurrent membranous nephropathy. Almost one third of patients in this cohort developed clinically significant recurrent disease at 10 years. 1. Introduction Idiopathic membranous nephropathy is a relatively common cause of nephrotic syndrome in nondiabetic adults. In our centre, 28% of native renal biopsies performed in the setting of nephrotic syndrome yielded a diagnosis of idiopathic membranous nephropathy [1]. The disease occurs most frequently in Caucasian adult males. In females, the diagnosis is more unusual and should prompt consideration of membranous lupus nephritis. An autoimmune basis for idiopathic membranous nephropathy has been established with the recent identification of the M-type phospholipase receptor (PLA2R) as the major antigen [2]. Characteristic histological features include diffusely thickened glomerular basement membranes on light microscopy. Immunofluorescence reveals diffuse granular IgG and C3 deposition along the glomerular basement membranes. Discrete subepithelial deposits are visualised on electron microscopy [3]. Histological findings which favour idiopathic membranous nephropathy over secondary disease include IgG4-positive immune complexes and exclusively subepithelial deposits [4]. The natural history of idiopathic membranous nephropathy is variable. Spontaneous remission occurs in a
Elites, eccentrics, and empowerments in the Maya area: implications for the interpretation of a peripheral settlement cluster near Cahal Pech, Belize
J. M. Conlon
Papers from the Institute of Archaeology , 1993, DOI: 10.5334/pia.44
Abstract: This paper focuses on the eccentric lithics recovered from the Tzinic group, a major settlement cluster located in the periphery of the larger site of Cahal Pech.
On the smoothability of certain K?hler cones
Ronan J. Conlon
Mathematics , 2014,
Abstract: Let $D$ be a Fano manifold that may be realised as $\mathbb{P}(\mathcal{E})$ for some rank $2$ holomorphic vector bundle $\mathcal{E}\longrightarrow Z$ over some Fano manifold $Z$. Let $k\in\mathbb{N}$ divide $c_{1}(D)$. We classify those K\"ahler cones of dimension $\leq4$ of the form $(\frac{1}{k}K_{D})^{\times}$ that are smoothable. As a consequence, we find that any irregular Calabi-Yau cone of dimension $\leq 4$ of this form does not admit a smoothing, leaving $K_{\mathbb{P}^{2}_{(2)}}^{\times}$ as currently the only known example of a smoothable irregular Calabi-Yau cone in these dimensions.
Comprehensive Investigation of the Caveolin 2 Gene: Resequencing and Association for Kidney Transplant Outcomes
Jennifer A. McCaughan, Seamus Duffy, Thomas O'Hagan, Aisling E. Courtney, Richard Borrows, Peter J. Conlon, Alexander P. Maxwell, Amy Jayne McKnight
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063358
Abstract: Caveolae are plasma membrane structures formed from a complex of the proteins caveolin-1 and caveolin-2. Caveolae interact with pro-inflammatory cytokines and are dysregulated in fibrotic disease. Although caveolae are present infrequently in healthy kidneys, they are abundant during kidney injury. An association has been identified between a CAV1 gene variant and long term kidney transplant survival. Chronic, gradual decline in transplant function is a persistent problem in kidney transplantation. The aetiology of this is diverse but fibrosis within the transplanted organ is the common end point. This study is the first to investigate the association of CAV2 gene variants with kidney transplant outcomes. Genomic DNA from donors and recipients of 575 kidney transplants performed in Belfast was investigated for common variation in CAV2 using a tag SNP approach. The CAV2 SNP rs13221869 was nominally significant for kidney transplant failure. Validation was sought in an independent group of kidney transplant donors and recipients from Dublin, Ireland using a second genotyping technology. Due to the unexpected absence of rs13221869 from this cohort, the CAV2 gene was resequenced. One novel SNP and a novel insertion/deletion in CAV2 were identified; rs13221869 is located in a repetitive region and was not a true variant in resequenced populations. CAV2 is a plausible candidate gene for association with kidney transplant outcomes given its proximity to CAV1 and its role in attenuating fibrosis. This study does not support an association between CAV2 variation and kidney transplant survival. Further analysis of CAV2 should be undertaken with an awareness of the sequence complexities and genetic variants highlighted by this study.
Host-Defense Peptides with Therapeutic Potential from Skin Secretions of Frogs from the Family Pipidae
J. Michael Conlon,Milena Mechkarska
Pharmaceuticals , 2014, DOI: 10.3390/ph7010058
Abstract: Skin secretions from frogs belonging to the genera Xenopus, Silurana, Hymenochirus, and Pseudhymenochirus in the family Pipidae are a rich source of host-defense peptides with varying degrees of antimicrobial activities and cytotoxicities to mammalian cells. Magainin, peptide glycine-leucine-amide (PGLa), caerulein-precursor fragment (CPF), and xenopsin-precursor fragment (XPF) peptides have been isolated from norepinephrine-stimulated skin secretions from several species of Xenopus and Silurana. Hymenochirins and pseudhymenochirins have been isolated from Hymenochirus boettgeri and Pseudhymenochirus merlini. A major obstacle to the development of these peptides as anti-infective agents is their hemolytic activities against human erythrocytes. Analogs of the magainins, CPF peptides and hymenochirin-1B with increased antimicrobial potencies and low cytotoxicities have been developed that are active (MIC < 5 μM) against multidrug-resistant clinical isolates of Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, Stenotrophomonas maltophilia and Klebsiella pneumoniae. Despite this, the therapeutic potential of frog skin peptides as anti-infective agents has not been realized so that alternative clinical applications as anti-cancer, anti-viral, anti-diabetic, or immunomodulatory drugs are being explored.
What should we be selecting for? A systematic approach for determining which personal characteristics to assess for during admissions
Conlon Peter,Hecker Kent,Sabatini Susan
BMC Medical Education , 2012, DOI: 10.1186/1472-6920-12-105
Abstract: Background Admission committees are responsible for creating fair, defensible, reliable, and valid processes that assess those attributes considered important for professional success. There is evidence for the continuing use of academic ability as a selection criterion for health professional schools; however, there is little evidence for the reliability and validity of measures currently in place to assess personal characteristics. The Ontario Veterinary College (OVC) initiated a review of its admissions criteria in order to implement an evidence-based method to determine which characteristics veterinary stakeholders consider important to assess for admission. Methods Eleven characteristics were identified by the OVC Admissions Committee and a survey was sent to all licensed veterinarians in Ontario (n=4,068), OVC students (n=450), and OVC faculty, interns and residents (n=192). A paired comparison method was used to identify the relative rank order of the characteristics, and multivariate analysis of variance with post hoc analyses was used to determine between group differences in the returned survey data. Results Surveys were returned from 1,312 participants (27.86% response rate; female 59.70%). The relative rank of the characteristics was reasonably consistent among participant groups, with ethical behaviour, sound judgment, communication, and critical and creative thinking being ranked as the top four. However, the importance of certain characteristics like communication and empathy were perceived differently by groups. For instance, females scored communication (F(1, 1289) = 20.24, p < .001, d = .26) and empathy (F(1, 1289) = 55.41, p < .001, d = 0.42) significantly higher than males, while males scored knowledge of profession (F(1, 1289) = 12.81, p < .001, d = 0.20), leadership (F(1, 1289) = 10.28, p = .001, d = 0.18), and sound judgment (F(1, 1289) = 13.56, p < .001, d = 0.21) significantly higher than females. Conclusions The data from the paired comparison method provide convergent evidence for the characteristics participant groups identify as most important in determining who should be admitted to a veterinary program. The between group analyses provides important information regarding characteristics most important to various subgroups; this has implications for what characteristics are selected for at admission as well as on who is selecting for them.
Constraining 3D Magnetic Field Extrapolations Using The Twin Perspectives of STEREO
Paul A. Conlon,Peter T. Gallagher
Physics , 2010, DOI: 10.1088/0004-637X/715/1/59
Abstract: The 3D magnetic topology of a solar active region (NOAA 10956) was reconstructed using a linear force-free field extrapolation constrained using the twin perspectives of \emph{STEREO}. A set of coronal field configurations was initially generated from extrapolations of the photospheric magnetic field observed by the Michelson Doppler Imager (MDI) on \emph{SOHO}. Using an EUV intensity-based cost function, the extrapolated field lines that were most consistent with 171\AA\ passband images from the Extreme UltraViolet Imager (EUVI) on \emph{STEREO} were identified. This facilitated quantitative constraints to be placed on the twist ($\alpha$) of the extrapolated field lines, where $\nabla \times {\bf B} = \alpha {\bf B}$. Using the constrained values of $\alpha$, the evolution in time of twist, connectivity, and magnetic energy were then studied. A flux emergence event was found to result in significant changes in the magnetic topology and total magnetic energy of the region.
Spin Dynamics in Pyrochlore Heisenberg Antiferromagnets
P. H. Conlon,J. T. Chalker
Physics , 2009, DOI: 10.1103/PhysRevLett.102.237206
Abstract: We study the low temperature dynamics of the classical Heisenberg antiferromagnet with nearest neighbour interactions on the pyrochlore lattice. We present extensive results for the wavevector and frequency dependence of the dynamical structure factor, obtained from simulations of the precessional dynamics. We also construct a solvable stochastic model for dynamics with conserved magnetisation, which accurately reproduces most features of the precessional results. Spin correlations relax at a rate independent of wavevector and proportional to temperature.
Absent pinch points and emergent clusters: further neighbour interactions in the pyrochlore Heisenberg antiferromagnet
P. H. Conlon,J. T. Chalker
Physics , 2010, DOI: 10.1103/PhysRevB.81.224413
Abstract: We discuss the origin of spin correlations observed in neutron scattering experiments on the paramagnetic phase of a number of frustrated spinel compounds, most notably ZnCr2O4. These correlations are striking for two reasons. First, they have been interpreted as evidence for the formation of weakly interacting hexagonal clusters of spins. Second, they are very different from those calculated for the nearest neighbour Heisenberg pyrochlore antiferromagnet, in which Coulomb phase correlations generate sharp scattering features known as pinch points. Using large-$n$ calculations and Monte Carlo simulations, we show that very weak further neighbour exchange interactions can account for both the apparent formation of clusters and the suppression of pinch points.
A 3.55 keV line from $\text{DM}\rightarrow a \rightarrow γ$: predictions for cool-core and non-cool-core clusters
Joseph P. Conlon,Andrew J. Powell
Physics , 2014, DOI: 10.1088/1475-7516/2015/01/019
Abstract: We further study a scenario in which a 3.55 keV X-ray line arises from decay of dark matter to an axion-like particle (ALP), that subsequently converts to a photon in astrophysical magnetic fields. We perform numerical simulations of Gaussian random magnetic fields with radial scaling of the magnetic field magnitude with the electron density, for both cool-core `Perseus' and non-cool-core `Coma' electron density profiles. Using these, we quantitatively study the resulting signal strength and morphology for cool-core and non-cool-core clusters. Our study includes the effects of fields of view that cover only the central part of the cluster, the effects of offset pointings on the radial decline of signal strength and the effects of dividing clusters into annuli. We find good agreement with current data and make predictions for future analyses and observations.
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