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Search Results: 1 - 10 of 219251 matches for " Peter G. Pavlidakey "
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Erdheim-Chester Disease Associated with Marginal Zone Lymphoma and Monoclonal Proteinemia
Peter G. Pavlidakey,Alok Mohanty,Lisa J. Kohler,Howard J. Meyerson
Case Reports in Hematology , 2011, DOI: 10.1155/2011/941637
Abstract: Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis. We report a fatal case of ECD with extensive cardiac involvement associated with a marginal zone lymphoma and monoclonal proteinemia in a young man. This is the first reported association of ECD with a monoclonal gammopathy or a lymphoma.
Bonding Orthodontic Ceramic Brackets to Ceramic Restorations: Evaluation of Different Surface Conditioning Methods  [PDF]
Andreas Faltermeier, Claudia Reicheneder, Peter G?tzfried, Peter Proff
Materials Sciences and Applications (MSA) , 2013, DOI: 10.4236/msa.2013.47A2002

The purpose of this study was to compare the shear bond strength and Adhesive Remnant Index of four different veneering ceramic materials to ceramic brackets. Additionallly, a further aim of this study was to overcome the etching using hydrofluoric acid which is noxious and could seriously damage the corneas of the eyes. Two surface conditioning methods of four ceramic materials before bonding brackets were examined: in group 1 an air particle abrasion with 25 μm aluminium trioxide (4 seconds at a pressure of 2.5 bars) and subsequently a silane coupling agent (Espe Sil, 3M Unitek, Monrovia, USA) was applicated on one side of each ceramic specimen (10 per group). In group 2 one side of each sample (20 per group) was etched with 37.0 per cent orthophosphoric acid for two minutes and was followed by a silane application (Espe Sil, 3M Unitek, Monrovia, USA). After this procedure the self-ligating ceramic brackets Clarity SL (3M Unitek, Monrovia, USA) brackets were bonded to the ceramic blocks and a thermocycling process started (5°C - 55°C, 6000 cycles). Then, shear bond strength and Adhesive Remnant Index (ARI) were measured. To determine statistical differences Oneway-ANOVA and Tukey Post-hoc test were performed. Hydrofluoric acid seems not to be justifiable anymore for preparing the surface of dental ceramic restorations before bracket bonding. Sandblasting with 25 μm aluminium trioxide and the use of orthophosphoric acid (37.0 per cent) seem to prepare the surface of ceramic restoration sufficiently before ceramic bracket bonding. The found level of shear bond strength values seems to be sufficient for bonding ceramic brackets to ceramic restorations.

Consistent Condom Use among HIV Positive Women Attending Comprehensive Care Centre of Thika Level 5 Hospital, Kenya  [PDF]
Anne G. Macharia, Yeri Kombe, Peter Mwaniki
World Journal of AIDS (WJA) , 2015, DOI: 10.4236/wja.2015.53017
Abstract: Background: Condoms offer protection against human immunodeficiency virus (HIV) transmission when used correctly and consistently. Many HIV infected people do not use condom regularly, thus leading to new HIV infections and reinfections. In Kenya, condom use is considered to be low and HIV prevalence is high among women aged 15 - 49 years where utilization of condoms among HIV positive women has not been studied. Objectives: The study aimed at determining the prevalence of consistent condom use among HIV positive women aged 18 - 49 years and to investigate the variables associated with it. Methods: A mixed method of study design (qualitative and quantitative approaches) was employed. A total of 422 participants were selected randomly and interviewed using a pretested structured questionnaire. Three (3) focus group discussions with 8 participants in each group were conducted. Chi-square test (p < 0.05) and odds ratio with corresponding 95% confidence interval were computed to establish the association between consistent condom use and independent variables. Binary logistic regression model was used to identify variables independently associated with consistent condom use. Qualitative data were transcribed and coded and then analysed thematically. Results: Consistent condom use among sexually active HIV positive women was found to be 57.4% (95%CI: 52.7% - 62.1%). The stepwise logistic regression revealed that attending tertiary education [aOR = 2.54; 95%CI = 1.30 - 4.95; P = 0.006], disclosing HIV status [aOR = 2.27; 95%CI = 1.27 - 4.06; P = 0.005], having an HIV negative partner [aOR = 4.23; 95%CI = 1.99 - 8.98; P < 0.001], not taking alcohol [aOR = 1.72; 95%CI = 1.10 - 2.69; P = 0.017], never encountered resistance to use condom by partners [aOR = 1.87; 95%CI = 1.15 - 3.03; P = 0.011] and perceived risk of contracting STIs [aOR = 2.11; 95%CI = 1.12 - 3.97; P = 0.021] as factors independently associated with consistent condom use. Conclusion: This study shows that there is still low prevalence of consistent condom use among HIV positive women. More education, campaigning and sensitization should be tailored among HIV positive women during counseling so as to avoid re-infection and transmission of infections.
On Henig Regularization of Material Design Problems for Quasi-Linear p-Biharmonic Equation  [PDF]
Peter Kogut, Günter Leugering, Ralph Schiel
Applied Mathematics (AM) , 2016, DOI: 10.4236/am.2016.714134
Abstract: We study a Dirichlet optimal design problem for a quasi-linear monotone p-biharmonic equation with control and state constraints. We take the coefficient of the p-biharmonic operator as a design variable in \"\". In this article, we discuss the relaxation of such problem.
A Cohort Model for Ash Mortality Risk Due to Potential Emerald Ash Borer Infestation  [PDF]
Samuel G. Jenkins, Peter G. Oduor, Larry Kotchman, Michael Kangas
Open Journal of Biophysics (OJBIPHY) , 2016, DOI: 10.4236/ojbiphy.2016.62006
Abstract: Emerald ash borer (Agrilus planipennis Fairmaire) (Coleoptera: Buprestidae) is a phloem-feeding beetle native to Asia that is causing widespread mortality of ash trees in eastern North America. In this study, we quantify ash mortality risk associated with potential anthropogenic-induced introduction of Emerald Ash Borer (EAB) in North Dakota. The cohort model is calibrated with data from Ohio using weighting across factors—proximity to existing ash stands, campgrounds, roads and rails—to get a more accurate assessment of overall ash mortality risk. These factors are known to be associated with introduction of EAB to unaffected areas. Two protocols, a) “detection trees” and b) EAB traps are utilized to investigate EAB presence. Ash mortality risk maps such as the ones produced here may guide the placement of traps. Although North Dakota regions of high density ash tree stands are few, the resulting relative ash mortality risk map displays: a) very high risk areas around the Turtle Mountains and Theodore Roosevelt National Park and b) regions of high relative risk along the main riparian corridors. The applicability of risk maps such as the one developed may aid in assessing areas that may require significant monitoring.
The Zonal Structure of the Hadley Circulation

大气科学进展 , 2006,
Abstract: A discussion of the mass transport of the Hadley circulation is presented, with regard to its longitudinal structure. Data from the NCEP/NCAR reanalysis data set for the period 1948-2005 is examined,focusing on the solsticial seasons of June-August and December-February. Quantitative estimates have been extracted from the data to observe connections between the zonal mean of the upper tropospheric north/south mass transports and their relationship to the driving factor of tropical precipitation (implying latent heat release) and subsidence in the subtropical high pressure belts. The longitudinal structure of this flow is then examined with regard to these three main variables. The poleward upper tropospheric transport has four (JJA) or three (DJF) main branches, which link regions of major precipitation with corresponding regions of large subsidence, and one (June, July, August) or two (December, January, February) reverse branches. This structure has remained stable over the past sixty years. Although the total upper tropospheric transport in each season is less than the total sinking transport in the target subtropical high pressure belt, this does not apply to the individual branches, the balance being made up by the upper tropospheric reverse transports. An analysis of correlations between all of these various components shows, however, that the complete picture is more complex, with some precipitation regions being linked to subsidence regions outside their own branch.
Patient safety and acute care medicine: lessons for the future, insights from the past
Peter G Brindley
Critical Care , 2010, DOI: 10.1186/cc8858
Abstract: "All truth passes through three stages. First it is ridiculed. Second it is violently opposed. Third it is accepted as self-evident." [1]Arthur Schopenhauer 1788-1860It is estimated that approximately 40,000-100,000 Americans die annually from medical errors [2]. Thousands more suffer harm from medical errors. Still others are exposed to errors, but are lucky enough to suffer no obvious harm [3]. In fact, medical errors are now the eighth leading cause of death in the USA; data are no less alarming from other nations [4]. Regardless of the exact figures, it seems that patient safety is far from adequate. Crudely put, if medicine were a patient, we physicians would say it is time to admit there is a problem. We would expect urgent action, and we would welcome any ideas, rather than tolerate further delays. This chapter hopes to provide a call-to-arms, but most importantly a range of ideas, both new and old, to achieve the sort of care that our patients deserve.Albert Einstein stated that: "you can never solve a problem by using the same thinking that created it" [5]. As such, the first step is to emphasize that medical errors are rarely merely negligence, sloppiness, incompetence, or poor motivation. Instead, we should accept that health care is amongst the world's most complex social systems [3]. Coupled with the complexity of medical diagnosis, and the need to make decisions despite time pressure and incomplete information, the shocking patient safety figures make more sense. Perhaps the complexity of the task ahead is also a little clearer.The slogan states "Safety is no accident" [3]; stated another way, errors in healthcare are rarely random, unpredictable events. Some errors may ultimately be rooted in our organizations and perpetuated by our traditions. Like many complex systems, medicine has a double-headed Janus [6], where these traditions are both our greatest asset and our keenest shortfall. For example, the laudable tradition of self-reliance and patient-
Comments on “Ochratoxin A: In utero Exposure in Mice Induces Adducts in Testicular DNA. Toxins 2010, 2, 1428–1444”—Mis-Citation of Rat Literature to Justify a Hypothetical Role for Ochratoxin A in Testicular Cancer
Peter G. Mantle
Toxins , 2010, DOI: 10.3390/toxins2102333
Abstract: A manuscript in the journal recently cited experimental rat data from two manuscripts to support plausibility of a thesis that ochratoxin A might be a cause of human testicular cancer. I believe that there is no experimental evidence that ochratoxin A produces testicular cancer in rats or mice.
Medical simulation for severe sepsis: improving both factual knowledge and crisis management skills
Peter G Brindley
Critical Care , 2008, DOI: 10.1186/cc7034
Abstract: Following a didactic lecture on the key components of the Surviving Sepsis Campaign Guidelines, we trained 20 emergency medicine residents on a portable Laerdal Patient Simulator. Pre-programmed sepsis scenarios were developed following a needs assessment and modified Delphi technique. To maximize realism, this was performed in the acute care area of the Emergency Department and included a pre-briefed respiratory therapist and nurse. We videotaped resident performance and provided nonpunitive feedback, focusing on the comprehensiveness of therapy (for example, whether broad-spectrum antibiotics were given) and crisis resource management strategies (for example, whether help was asked for and tasks were appropriately allocated).Evaluation using a five-point Likert scale demonstrated that participants found this very useful (4.5/5), that lessons were complementary and supplementary to those learned from lectures (4.5/5) and that medical simulation was realistic (4/5). In addition, despite prior sepsis lectures, comparison of pre-tests and post-tests showed that more emergency medicine residents would: administer broad-spectrum antibiotics as soon as possible following hypotension (14/20 pre-test, compared with 16/20 post-test), administer low-dose corticosteroids for those with refractory shock (10/20 pre-test, compared with 13/20 post-test), and would favour norepinephrine as a vasopressor (8/20 pre-test, compared with 12/20 post-test). Participants specifically valued the chance to observe and practice crisis resource management skills, which they felt had not been previously addressed (19/20).Medical simulation appears to be an effective way to change both knowledge and behaviours in the treatment of severe sepsis. Many education and licensing boards also expect trainees to become not only content experts, but also effective communicators, collaborators, resource managers and advocates. These laudable goals are difficult to capture with traditional lectures but are
Safe using messages may not be enough to promote behaviour change amongst injecting drug users who are ambivalent or indifferent towards death
Peter G Miller
Harm Reduction Journal , 2009, DOI: 10.1186/1477-7517-6-18
Abstract: Qualitative, semi-structured interviews in Geelong, Australia with 60 regular heroin users recruited primarily from needle and syringe programs.Over half of the interviewees reported having previously overdosed and 35% reported not engaging in any overdose prevention practices. 13% had never been tested for either HIV or hepatitis C. Just under half reported needle sharing of some description and almost all (97%) reported previously sharing other injecting equipment. Many interviewees reported being indifferent towards death. Common themes included; indifference towards life, death as an occupational hazard of drug use and death as a welcome relief.Most of the interviewees in this study were indifferent towards heroin-related death. Whilst interviewees were well aware of the possible consequences of their actions, these consequences were not seen as important as achieving their desired state of mind. Safe using messages are an important part of reducing drug-related harm, but people working with IDUs must consider the context in which risk behaviours occur and efforts to reduce said behaviours must include attempts to reduce environmental risk factors at the same time.Injecting drug users (IDUs) experience higher rates of death and poorer health than their non-injecting peers. IDUs are between 6 and 20 times more likely to die than their non-heroin-using peers of the same age and gender [1]. Death due to suicide among heroin users occurs at 14 times the rate of matched peers [2]. The major type of heroin-related mortality and morbidity is heroin-related overdose. At the time of this study, the number of deaths attributed to opioid overdose in Victoria had risen from 49 in 1991 to 331 in 2000. In Australia, around a quarter of heroin users report having experienced an overdose in the past 6 months, and over 70% reporting having witnessed an overdose in the previous 12 months [3-5]. The other major cause of mortality and morbidity in IDUs is the transmission of blood-
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