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Search Results: 1 - 10 of 219306 matches for " Peter G. Furth "
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Multi-Stage Pedestrian Crossings and Two-Stage Bicycle Turns: Delay Estimation and Signal Timing Techniques for Limiting Pedestrian and Bicycle Delay  [PDF]
Peter G. Furth, Yue (Danny) Wang, Michael A. Santos
Journal of Transportation Technologies (JTTs) , 2019, DOI: 10.4236/jtts.2019.94031
Abstract: Signalized intersections sometimes involve multistage pedestrian crossings, in which pedestrians cross to one or more islands and then wait there for a signal to continue. When signals are timed without attention to pedestrian progression, pedestrian delay at multistage crossings can be very long. This paper addresses two issues. First, pedestrian delay at multistage crossings is rarely evaluated because there are no tools in the industry for that purpose except microsimulation. We present a numerical method for determining crossing delay with any number of stages and with the possibility of multiple WALK intervals per cycle. The same method can be applied to single stage crossings, to diagonal two-stage crossings where pedestrians may have path choice, and bicycle two-stage turns. This method has been implemented in a freely available online tool. Second, we describe several signal timing techniques for improving pedestrian and bicyclist progression, and thus reducing their delay, through multistage crossings. They include reservice for selected crossing phases, left turn overlaps, having pedestrian phases overlap each other, and bidirectional bicycle crossings which create path options for two-stage turns. Examples show the potential for large reductions in pedestrian delay, often with little or no increase in vehicular delay. In one example, the addition of a short pedestrian overlap phase reduced average pedestrian delay at a 3-stage crossing by 82 s while average vehicular delay increased by only 0.5 s.
Frank Morton Carpenter (1902–1994): Academic Biography and List ofPublications
David G. Furth
Psyche , 1994, DOI: 10.1155/1994/46462
Secondary Sexual Characteristics in the Galerucinae (Sensu Stricto) (Coleoptera: Chrysomelidae)
M. S. Mohamedsaid,D. G. Furth
ISRN Zoology , 2011, DOI: 10.5402/2011/328670
Abstract: A list of 1298 species and 172 genera of Chrysomelidae from the subfamily Galerucinae (sensu stricto) with the males having at least one form of secondary sexual characteristic (SSC) is presented. The number of species amounts to 24% of the total Galerucinae presently known from all over the world—a very significant amount. The SSCs comprise various types of modified structures found on all parts of the body—head, thorax, and abdomen. They are not variable but species specific. Illustrations from selected 87 species that include 84 images and 15 line drawings showing various types of SSC are provided. The amazing array of SSCs from the Galerucinae offers a large and taxonomically diverse set of data that are not comparable with other subfamilies in the Chrysomelidae and may be useful in phylogenetic analysis of the family. 1. Introduction Galerucinae (sensu stricto) is the second largest subfamily within the Chrysomelidae (Coleoptera), represented by about 520 genera and between some 5000 species [1], 5500 species [2], and 6300 species [3] and its most diverse distribution concentrated mainly in the tropical and subtropical regions. The classification of the Chrysomelidae proposed by Lawrence and Newton [4] lumped together the Galerucinae and Alticinae into a single subfamily Galerucinae (sensu lato). Consequently, the Galerucinae (sensu stricto) was placed in the Tribe Galerucini and the Alticinae (sensu stricto) as the Tribe Alticini. Since then, some workers have continued to separate the two subfamilies as in the Seeno and Wilcox [5]. There has been support for Alticinae as a monophyletic group with metafemoral spring as the main character [6]. Likewise, Galerucinae has been considered paraphyletic with Alticinae as a subordinated clade [7]. On the other hand, Kim et al. [8] in their molecular and morphological-based phylogenetic studies showed that there is molecular data to support Alticinae as a tribal ranking (Alticini) within the Galerucinae and neither as a separate subfamily. They suggested that more independent characters are needed. More recently, Gillespie et al. [1] claimed to have the most comprehensive phylogeny estimation and showed consistency with previous molecular phylogenetic reconstruction of Galerucinae, but at the same time agreed that there was a lack of taxon representation from the Old World. There is no doubt that more characteristics need to be utilised from a more complete range of taxa selected from the Old and New Worlds, that is, better taxon sampling, including secondary sexual characteristics. In this study, we refer
Discovery and Designation of Type Specimens of Chrysomelidae(Coleoptera) From Argentina Described by E. von Harold in 1875
David G. Furth,Ingolf S. Askevold,Catherine N. Duckett
Psyche , 1994, DOI: 10.1155/1994/69032
Cumulative Gains Model Quality Metric
Thomas Brandenburger,Alfred Furth
Advances in Decision Sciences , 2009, DOI: 10.1155/2009/868215
Abstract: This paper proposes a more comprehensive look at the ideas of KS and Area Under the Curve (AUC) of a cumulative gains chart to develop a model quality statistic which can be used agnostically to evaluate the quality of a wide range of models in a standardized fashion. It can be either used holistically on the entire range of the model or at a given decision threshold of the model. Further it can be extended into the model learning process.
FDG-PET Response Prediction in Pediatric Hodgkin’s Lymphoma: Impact of Metabolically Defined Tumor Volumes and Individualized SUV Measurements on the Positive Predictive Value
Amr Elsayed M. Hussien,Christian Furth,Stefan Schnberger,Patrick Hundsdoerfer,Ingo G. Steffen,Holger Amthauer,Hans-Wilhelm Müller,Hubertus Hautzel
Cancers , 2015, DOI: 10.3390/cancers7010287
Abstract: Background: In pediatric Hodgkin’s lymphoma (pHL) early response-to-therapy prediction is metabolically assessed by (18)F-FDG PET carrying an excellent negative predictive value (NPV) but an impaired positive predictive value (PPV). Aim of this study was to improve the PPV while keeping the optimal NPV. A comparison of different PET data analyses was performed applying individualized standardized uptake values (SUV), PET-derived metabolic tumor volume (MTV) and the product of both parameters, termed total lesion glycolysis (TLG); Methods: One-hundred-eight PET datasets (PET1, n = 54; PET2, n = 54) of 54 children were analysed by visual and semi-quantitative means. SUVmax, SUVmean, MTV and TLG were obtained the results of both PETs and the relative change from PET1 to PET2 (Δ in %) were compared for their capability of identifying responders and non-responders using receiver operating characteristics (ROC)-curves. In consideration of individual variations in noise and contrasts levels all parameters were additionally obtained after threshold correction to lean body mass and background; Results: All semi-quantitative SUV estimates obtained at PET2 were significantly superior to the visual PET2 analysis. However, ΔSUVmax revealed the best results (area under the curve, 0.92; p < 0.001; sensitivity 100%; specificity 85.4%; PPV 46.2%; NPV 100%; accuracy, 87.0%) but was not significantly superior to SUVmax-estimation at PET2 and ΔTLGmax. Likewise, the lean body mass and background individualization of the datasets did not impove the results of the ROC analyses; Conclusions: Sophisticated semi-quantitative PET measures in early response assessment of pHL patients do not perform significantly better than the previously proposed ΔSUVmax. All analytical strategies failed to improve the impaired PPV to a clinically acceptable level while preserving the excellent NPV.
Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence
Maddalena T Tilli, Priscilla A Furth
Breast Cancer Research , 2003, DOI: 10.1186/bcr614
Abstract: Cancer is a multistage process. Cells are selected after accumulating successive genetic lesions in oncogenes and tumor suppressor genes, resulting in independence from the normal restraints that regulate growth, proliferation, survival, differentiation and migration [1-5]. Conditional transgenic mouse models expressing oncogenes involved in human cancer pathways have revolutionized the way in which we define the contributions that these oncogenes lend to the process of tumorigenesis. Adaptation of the tetracycline-responsive gene expression system to transgenic mice [6-9] prepared the way for development of conditional models in which precise timing of oncogene exposure in specific tissues initiated events that model those that occur during the stepwise progression of human oncogenesis [10-18].A first application of these models was to study the potential for reversal of a dysplastic or malignant phenotype when expression of an initiating oncogene was downregulated. Determining the effect of loss of expression of the initiating oncogene establishes the requirement of the initiating oncogene for maintenance of preneoplasia and/or neoplasia. Experiments to date reveal provocative differences in preneoplastic or neoplastic reversal between different initiating oncogenes and target tissues. Reversibility of salivary oncogenesis initiated by expression of the complex oncoprotein Large Simian Virus 40 T antigen, which disrupts both pRB-related and p53 tumor suppressor pathways, is interrupted at a preneoplastic stage in a time-dependent manner [11]. In contrast, melanomas initiated by H-Ras [12], lung carcinomas initiated by K-Ras [13], and leukemia initiated by BCR-ABL [14] remain reversible through the neoplastic stage after expression of the initiating oncogene is downregulated. Reversibility in different tissues following downregulation of the single initiating oncogene c-myc can be compared in mammary adenocarcinomas [15] and in lymphomas [16]. Whereas 90% of the ly
Rolle neuer Schnittbildtechniken bei Diagnose und Verlaufskontolle von chronisch entzündlichen Darmerkrankungen
Seidensticker M,Ricke J,Furth C
Journal für Gastroenterologische und Hepatologische Erkrankungen , 2010,
Abstract: Bei der Diagnostik und Verlaufskontrolle von chronisch entzündlichen Darmerkrankungen (CED) konnten sich neben den Basismethoden der Endoskopie, des Ultraschalls und der kontrastmittelgestützten Durchleuchtung neue Bildtechniken etablieren, die neben der Komplettierung der Basisdiagnostik insbesondere in der Verlaufskontrolle und der Komplikationsdiagnostik einen hohen Stellenwert erlangt haben. Neben der Computertomographie, die in der akuten Komplikationsdiagnostik (Abszess, Perforation) sicher nicht wegzudenken ist, ist hier die Magnetresonanztomographie (MRT) zu erw hnen. Mittels dieser strahlenfreien Technik ist durch neue Sequenztechniken eine komplement re Diagnostik des gesamten Abdomens zu erzielen, wobei durch orale Aufnahme von Kontrastmitteln eine Distension und Beurteilbarkeit des Dünn- und Dickdarms erzielt wird. Mit der MRT konnte eine Sensitivit t von 80 % in der Detektion von entzündlichen Darmabschnitten erreicht werden. Da Patienten mit einer CED in der Regel auf repetitive Untersuchungen im Krankheitsverlauf angewiesen sind und die Erkrankungen h ufig bereits im Kindesalter beginnen, ist der strahlungsfreie Charakter der MRT hervorzuheben. Der Beitrag wird durch Fallbeispiele aus der Praxis im Anhang abgerundet.
Bonding Orthodontic Ceramic Brackets to Ceramic Restorations: Evaluation of Different Surface Conditioning Methods  [PDF]
Andreas Faltermeier, Claudia Reicheneder, Peter G?tzfried, Peter Proff
Materials Sciences and Applications (MSA) , 2013, DOI: 10.4236/msa.2013.47A2002

The purpose of this study was to compare the shear bond strength and Adhesive Remnant Index of four different veneering ceramic materials to ceramic brackets. Additionallly, a further aim of this study was to overcome the etching using hydrofluoric acid which is noxious and could seriously damage the corneas of the eyes. Two surface conditioning methods of four ceramic materials before bonding brackets were examined: in group 1 an air particle abrasion with 25 μm aluminium trioxide (4 seconds at a pressure of 2.5 bars) and subsequently a silane coupling agent (Espe Sil, 3M Unitek, Monrovia, USA) was applicated on one side of each ceramic specimen (10 per group). In group 2 one side of each sample (20 per group) was etched with 37.0 per cent orthophosphoric acid for two minutes and was followed by a silane application (Espe Sil, 3M Unitek, Monrovia, USA). After this procedure the self-ligating ceramic brackets Clarity SL (3M Unitek, Monrovia, USA) brackets were bonded to the ceramic blocks and a thermocycling process started (5°C - 55°C, 6000 cycles). Then, shear bond strength and Adhesive Remnant Index (ARI) were measured. To determine statistical differences Oneway-ANOVA and Tukey Post-hoc test were performed. Hydrofluoric acid seems not to be justifiable anymore for preparing the surface of dental ceramic restorations before bracket bonding. Sandblasting with 25 μm aluminium trioxide and the use of orthophosphoric acid (37.0 per cent) seem to prepare the surface of ceramic restoration sufficiently before ceramic bracket bonding. The found level of shear bond strength values seems to be sufficient for bonding ceramic brackets to ceramic restorations.

Consistent Condom Use among HIV Positive Women Attending Comprehensive Care Centre of Thika Level 5 Hospital, Kenya  [PDF]
Anne G. Macharia, Yeri Kombe, Peter Mwaniki
World Journal of AIDS (WJA) , 2015, DOI: 10.4236/wja.2015.53017
Abstract: Background: Condoms offer protection against human immunodeficiency virus (HIV) transmission when used correctly and consistently. Many HIV infected people do not use condom regularly, thus leading to new HIV infections and reinfections. In Kenya, condom use is considered to be low and HIV prevalence is high among women aged 15 - 49 years where utilization of condoms among HIV positive women has not been studied. Objectives: The study aimed at determining the prevalence of consistent condom use among HIV positive women aged 18 - 49 years and to investigate the variables associated with it. Methods: A mixed method of study design (qualitative and quantitative approaches) was employed. A total of 422 participants were selected randomly and interviewed using a pretested structured questionnaire. Three (3) focus group discussions with 8 participants in each group were conducted. Chi-square test (p < 0.05) and odds ratio with corresponding 95% confidence interval were computed to establish the association between consistent condom use and independent variables. Binary logistic regression model was used to identify variables independently associated with consistent condom use. Qualitative data were transcribed and coded and then analysed thematically. Results: Consistent condom use among sexually active HIV positive women was found to be 57.4% (95%CI: 52.7% - 62.1%). The stepwise logistic regression revealed that attending tertiary education [aOR = 2.54; 95%CI = 1.30 - 4.95; P = 0.006], disclosing HIV status [aOR = 2.27; 95%CI = 1.27 - 4.06; P = 0.005], having an HIV negative partner [aOR = 4.23; 95%CI = 1.99 - 8.98; P < 0.001], not taking alcohol [aOR = 1.72; 95%CI = 1.10 - 2.69; P = 0.017], never encountered resistance to use condom by partners [aOR = 1.87; 95%CI = 1.15 - 3.03; P = 0.011] and perceived risk of contracting STIs [aOR = 2.11; 95%CI = 1.12 - 3.97; P = 0.021] as factors independently associated with consistent condom use. Conclusion: This study shows that there is still low prevalence of consistent condom use among HIV positive women. More education, campaigning and sensitization should be tailored among HIV positive women during counseling so as to avoid re-infection and transmission of infections.
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