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Search Results: 1 - 10 of 16 matches for " Perinetti "
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Inferencia y racionalidad en Hegel
Perinetti,Darío;
Revista latinoamericana de filosof?-a , 2009,
Abstract: hegel's logic is usually read as a book in metaphysics. against this reading, i will argue that it ought rather to be read as a philosophy of logic, the main feature of which is its critique of formalism. the following claims capture the core of hegel's anti-formalism: 1) formalism cannot explain logical validity; 2) logical properties cannot be reduced to grammatical properties; 3) the content of every concept can be accounted for in terms of the inferential relations it holds with other concepts; 4) logical validity can be accounted for in terms of the relations a reasoning maintains with some conceptual contents (ideas). this conception of logic results from a criradicalisation of a kantian thesis and aims at a normative theory of conceptual practices, not at an ontology.
Inferencia y racionalidad en Hegel
Darío Perinetti
Revista Latinoamericana de Filosofía , 2009,
Abstract: La Ciencia de la Lógica es, para una mayoría de intérpretes, un libro de metafísica. Aquí se sostiene que, por el contrario, ésta debe ser leída como una filosofía de la lógica. Su rasgo central es un antiformalismo que se caracteriza por las siguientes tesis: 1) el formalismo no puede explicar la validez lógica; 2) las propiedades lógicas no son reductibles a propiedades gramaticales; 3) el contenido de todo concepto se explica en términos de relaciones inferenciales a otros conceptos y 4) la validez lógica se explica en términos de la relación que un razonamiento mantiene con ciertos contenidos conceptuales (las Ideas). Esta concepción resulta de la radicalización de una idea kantiana y apunta a una teoría normativa de nuestras prácticas conceptuales, no a una ontología. Hegel's Logic is usually read as a book in metaphysics. Against this reading, I will argue that it ought rather to be read as a philosophy of logic, the main feature of which is its critique of formalism. The following claims capture the core of Hegel's anti-formalism: 1) formalism cannot explain logical validity; 2) logical properties cannot be reduced to grammatical properties; 3) the content of every concept can be accounted for in terms of the inferential relations it holds with other concepts; 4) logical validity can be accounted for in terms of the relations a reasoning maintains with some conceptual contents (Ideas). This conception of logic results from a Criradicalisation of a Kantian thesis and aims at a normative theory of conceptual practices, not at an ontology.
Aoste (Italie), Le complexe St. Ours – St. Laurent et le groupe épiscopal.
Renato Perinetti,Mauro Cortelazzo
Bulletin du Centre d’études Médiévales d’Auxerre , 2010, DOI: 10.4000/cem.11387
Abstract: Premesse.La sistemazione e l’apertura al pubblico dei siti archeologici realizzati dalla Soprintendenza regionale per i Beni e le Attività Culturali della valle d’Aosta, sono il risultato di collaborazioni, riflessioni e dibattiti svoltisi in questi ultimi decenni nei vari cantieri in cui si è operato e della particolare situazione amministrativa della nostra Regione .Le scelte e le soluzioni adottate tengono conto, oltre che delle specificità proprie di ogni scavo, anche delle particolari co...
A PCR-mutagenesis strategy for rapid detection of mutations in codon 634 of the ret proto-oncogene related to MEN 2A.
María Roqué, Eduardo Pusiol, Héctor Perinetti, Clara Godoy, Luis S Mayorga
BMC Medical Genetics , 2002, DOI: 10.1186/1471-2350-3-4
Abstract: DNA samples from MEN 2A patients were amplified by PCR. The products were incubated with the restriction enzyme Bst ApI or Bgl I.The samples were loaded in non-denaturing 10% Polyacrilamyde Gel and run at 120 volts for 40 min. The gels were stained with 10 μg/ml ethidium bromide, and the bands were visualized under a UV lamp.We developed a PCR-mutagenic method to check the integrity of the three bases of the cysteine 634 codon.The method can be used to detect inherited mutations in MTC patients without a clear family history. The method is relatively simple to use as a routine test in these patients to decrease the underdiagnosis of MEN 2A. In addition, the assay can be used to screen affected families with any mutation in cysteine 634.Multiple endocrine neoplasia type 2A (MEN 2A) is a dominantly inherited cancer syndrome, which involves the triad of medullary thyroid cancer (MTC), pheochromocytoma, and hyperparathyroidism. It is inherited as an autosomal dominant trait. Missense mutations in the codon encoding cysteine 634 of the ret proto-oncogene have been found in 85% of the reported families [1]. Other mutations in the same cysteine-rich domain of the protein can also cause MEN 2A. All these mutations lead to the replacement of a cysteine by an alternate amino acid.The ret gene is expressed in neural crest derived tissues [2]. It encodes a receptor with tyrosine kinase activity that is essential for the normal development of the kidneys and the intestinal nervous system [3]. This protein is considered a dependence receptor because it provokes proliferation in the presence of its ligand, and cell death in its absence [4,5]. The mutations associated with MEN 2A cause ligand-independent constitutive activation of the tyrosine kinase receptor by the formation of disulfide-bonded homodimers [6-9]. The main tumour type always present in MEN-2A is MTC, accompanied in 50% of the cases by pheocromocytoma and in 15–30% by parathyroid hyperplasia. MTC arises from the prol
Dental malocclusion and body posture in young subjects: A multiple regression study
Perinetti, Giuseppe;Contardo, Luca;Biasati, Armando Silvestrini;Perdoni, Lucia;Castaldo, Attilio;
Clinics , 2010, DOI: 10.1590/S1807-59322010000700007
Abstract: objectives: controversial results have been reported on potential correlations between the stomatognathic system and body posture. we investigated whether malocclusal traits correlate with body posture alterations in young subjects to determine possible clinical applications. methods: a total of 122 subjects, including 86 males and 36 females (age range of 10.8-16.3 years), were enrolled. all subjects tested negative for temporomandibular disorders or other conditions affecting the stomatognathic systems, except malocclusion. a dental occlusion assessment included phase of dentition, molar class, overjet, overbite, anterior and posterior crossbite, scissorbite, mandibular crowding and dental midline deviation. in addition, body posture was recorded through static posturography using a vertical force platform. recordings were performed under two conditions, namely, i) mandibular rest position (rp) and ii) dental intercuspidal position (icp). posturographic parameters included the projected sway area and velocity and the antero-posterior and right-left load differences. multiple regression models were run for both recording conditions to evaluate associations between each malocclusal trait and posturographic parameters. results: all of the posturographic parameters had large variability and were very similar between the two recording conditions. moreover, a limited number of weakly significant correlations were observed, mainly for overbite and dentition phase, when using multivariate models. conclusion: our current findings, particularly with regard to the use of posturography as a diagnostic aid for subjects affected by dental malocclusion, do not support existence of clinically relevant correlations between malocclusal traits and body posture
Detección de una mutación no estándar en el Proto-oncogen RET por mutagénesis dirigida Detection of a non-standard mutation in the ret protoncogene by site directed mutagenesis
Sebastián Real,Laura Gómez,Héctor Perinetti,Luis S. Mayorga
Medicina (Buenos Aires) , 2005,
Abstract: El síndrome de MEN2A es una enfermedad autosómica dominante que se caracteriza por el desarrollo de cáncer medular de tiroides, feocromocitoma e hiperplasia de paratiroides. Mutaciones en el ret proto-oncogén se asocian con MEN2A, con una penetrancia cercana al 100%. El gen se encuentra en el cromosoma 10q11.2 y codifica para una proteína transmembrana con función de receptor del tipo tirosina quinasa. Mutaciones que afectan el dominio extracelular de la proteína estimulan la dimerización espontánea del receptor y un aumento de la actividad de tirosina quinasa basal. El codón 634 codifica para una cisteína, y es considerado un sitio hot-spot por encontrarse mutado en el 85% de las familias con MEN2A. Para este sitio, nuestro grupo desarrolló en 2002 una metodología de detección indirecta y económica. Ante una familia sospechada de MEN2A, se aplicó esta estrategia, que reveló un codón 634 sano. Por posterior secuenciación se confirmó que el paciente índice portaba una mutación en el codón 611. Se desarrolló una nueva estrategia familia-específica por PCR mutagénica, que permitió diagnosticar en nuestro país a todos los integrantes de la familia con costos accesibles. Un ni o en el cual se halló la mutación, fue tiroidectomizado preventivamente, y a la fecha goza de buena salud. De esta manera, combinando la estrategia de detección de mutaciones en el sitio hot-spot y un posterior dise o de otra metodología familia-específica se pudo diagnosticar e intervenir preventivamente a la familia, sin enviar todas las muestras al extranjero. MEN2A is an autosomic dominant disease, characterized by medullary thyroid cancer, pheochromocytoma and parathyroid hyperplasia. Mutations in the ret proto-oncogene are associated with this disease, with almost 100% of pennetrance. The gene, situated on chromosome 10q11.2, codes for a transmembrane protein with a tirosinkinase-like receptor function. Mutations that affect its extracellular domain, stimulate spontaneous homodimerization and elevate the basal tirosinkinase activity. The codon 634 of the gene is considered a hot-spot site, since it is mutated in 85% of the MEN2A families. Our group developed in 2002 an indirect and costless strategy to detect alterations in this site. We present a family suspected of having MEN2A. We applied our PCR based indirect strategy on the DNA of the index patient and found that there was no mutation in that site. Posterior sequencing of exon 10 and 11 confirmed that the mutation affecting this family was in codon 611. Thus, we developed a new costless family-specific strategy based on mut
Detección de una mutación no estándar en el Proto-oncogen RET por mutagénesis dirigida
Real,Sebastián; Gómez,Laura; Perinetti,Héctor; Mayorga,Luis S.; Pusiol,Eduardo; Roque,María;
Medicina (Buenos Aires) , 2005,
Abstract: men2a is an autosomic dominant disease, characterized by medullary thyroid cancer, pheochromocytoma and parathyroid hyperplasia. mutations in the ret proto-oncogene are associated with this disease, with almost 100% of pennetrance. the gene, situated on chromosome 10q11.2, codes for a transmembrane protein with a tirosinkinase-like receptor function. mutations that affect its extracellular domain, stimulate spontaneous homodimerization and elevate the basal tirosinkinase activity. the codon 634 of the gene is considered a hot-spot site, since it is mutated in 85% of the men2a families. our group developed in 2002 an indirect and costless strategy to detect alterations in this site. we present a family suspected of having men2a. we applied our pcr based indirect strategy on the dna of the index patient and found that there was no mutation in that site. posterior sequencing of exon 10 and 11 confirmed that the mutation affecting this family was in codon 611. thus, we developed a new costless family-specific strategy based on mutagenic pcr and enzymatic cuts to diagnose all the family members. a seven-year old boy with this mutation was preventively thyroidectomized. in this way, combining the indirect methodology for codon 634 previously developed by our group, and a posterior family-specific mutation detection strategy, we were able to diagnose and intervene presymptomaticly the family members, avoiding sending all the samples to foreign centers.
Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease
Martins, Luciamare Perinetti Alves;Castanho, Roberto Esteves Pires;Nogueira, Adriano Barbosa;Silva, Otavio Turolo da;Gusm?o, Alex Silva de;
Brazilian Journal of Infectious Diseases , 2011, DOI: 10.1590/S1413-86702011000200004
Abstract: objective: to verify the incidence of t. cruzi transmission through breastfeeding during acute experimental chagas' disease. methods: fifteen female swiss mice were mated and, after pregnancy confirmation, placed in individual cages. a few hours after birth, the females were inoculated with 0.1 ml of blood containing approximately 3 x 105 trypomastigote forms of y strain of t. cruzi and continued breastfeeding for 25 days. results: in 142 offspring examined no infection through breast-feeding was observed. conclusions: the low number of trypomastigote forms ingested by the newborn mice combined with biological and biochemical characteristics of blood trypomastigotes may explain the lack of transmission in this experiment.
Caracteriza o biológica, histopatológica e análise de ácido nucléico de uma cepa Trypanosoma cruzi da regi o de Marília, SP
Martins Luciamáre Perinetti Alves,Castanho Roberto Esteves Pires,Rosa Jo?o Aristeu da,Silva Luiz Carlos da
Revista da Sociedade Brasileira de Medicina Tropical , 2003,
Abstract: Estudou-se o comportamento biológico e histopatológico de uma cepa genuínamente mariliense de Trypanosoma cruzi, isolada em 1997 através de xenodiagnóstico artificial. Vinte e cinco camundongos swiss foram infectados intraperitonealmente, sendo 11 utilizados para a realiza o da curva parasitêmica e observa o da morfologia dos tripomastigotas e 14 foram sacrificados após o 17, 23, 30, 60 e 180 dias pós-infec o e coletados cora o, es fago, fígado, cólon, e músculo esquelético (fragmento da coxa direita) para análise histopatológica. Cultura em meio LIT foi realizada para análise de DNA. Os resultados mostraram predomínio de formas largas, baixa parasitemia com picos médios de 860 tripomastigotas/5mil de sangue ao redor do 20o dia de infec o. Nenhum camundongo morreu na fase aguda da infec o. Exame histopatológico mostrou poucos ninhos de amastigotas em cora o, raros em músculo esquelético e cólon com discreto processo inflamatório. Comparada com a cepa Y, que foi isolada de uma paciente da mesma regi o, notamos diferentes características biológicas e comportamentais, porém a análise de DNA as coloca no mesmo grupo, demonstrando a proximidade dessas cepas.
Susceptibilidade de Rhodnius neglectus, Rhodnius robustus e Triatoma infestans (Hemiptera, Reduviidae, Triatominae) à infec o por duas cepas de Trypanosoma cruzi (Kinetoplastidae, Trypanosomatidae) utilizando xenodiagnóstico artificial
Martins Luciamáre Perinetti Alves,Rosa Jo?o Aristeu da,Castanho Roberto Esteves Pires,Sauniti Guilherme Lopes
Revista da Sociedade Brasileira de Medicina Tropical , 2000,
Abstract: A susceptibilidade de ninfas de 3o estádio de Rhodnius neglectus, R. robustus e Triatoma infestans às cepas Y e AMJM de Trypanosoma cruzi foi verificada utilizando xenodiagnóstico artificial. Para a leitura do xenodiagnóstico, as fezes dos triatomíneos foram examinadas a cada dois dias, a partir do 5o até o 31o dia pós infec o, pela técnica de compress o abdominal. Os resultados mostraram diferen as na susceptibilidade dos triatomíneos para as duas cepas estudadas e o período ótimo de leitura variou do 11o ao 19o dias para a cepa Y e do 11o ao 15o dias para a cepa AMJM. Também, p de-se concluir que para a cepa Y, as três espécies de triatomíneos demonstraram boa susceptibilidade, enquanto para a cepa AMJM, a melhor susceptibilidade foi observada com R. neglectus, seguida pelo T. infestans e R. robustus.
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