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Search Results: 1 - 10 of 79 matches for " Pejman Ghanouni "
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In vivo USPIO magnetic resonance imaging shows that minocycline mitigates macrophage recruitment to a peripheral nerve injury
Pejman Ghanouni, Deepak Behera, Jin Xie, Xiaoyuan Chen, Michael Moseley, Sandip Biswal
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-49
Abstract: Animal experiments were approved by Stanford IACUC. A model of neuropathic pain was created using the Spared Nerve Injury (SNI) model that involves ligation of the left sciatic nerve in the left thigh of adult Sprague–Dawley rats. Animals with SNI and uninjured animals were then injected with/without USPIOs (300?μmol/kg IV) and with/without minocycline (50?mg/kg IP). Bilateral sciatic nerves were scanned with a volume coil in a 7?T magnet 7?days after USPIO administration. Fluid-sensitive MR images were obtained, and ROIs were placed on bilateral sciatic nerves to quantify signal intensity. Pain behavior modulation by minocycline was measured using the Von Frey filament test. Sciatic nerves were ultimately harvested at day 7, fixed in 10% buffered formalin and stained for the presence of iron oxide-laden macrophages. Behavioral measurements confirmed the presence of allodynia in the neuropathic pain model while the uninjured and minocycline-treated injured group had significantly higher paw withdrawal thresholds (p?<?0.011). Decreased MR signal is observed in the SNI group that received USPIOs (3.3+/?0.5%) compared to the minocycline-treated SNI group that received USPIOs (15.2+/?4.5%) and minocycline-treated group that did not receive USPIOs (41.2+/?2.3%) (p?<?0.04). Histology of harvested sciatic nerve specimens confirmed the presence USPIOs at the nerve injury site in the SNI group without minocycline treatment.Animals with neuropathic pain in the left hindpaw show increased trafficking of USPIO-laden macrophages to the site of sciatic nerve injury. Minocycline to retards the migration of macrophages to the nerve injury site, which may partly explain its anti-nociceptive effects. USPIO-MRI is an effective in vivo imaging tool to study the role of macrophages in the development of neuropathic pain.
The Link between Dengue Incidence and El Ni?o Southern Oscillation
Pejman Rohani
PLOS Medicine , 2009, DOI: 10.1371/journal.pmed.1000185
Current state of existing project risk modeling and analysis methods with focus on fuzzy risk assessment – Literature Review
Pejman Rezakhani
Frattura ed Integrità Strutturale , 2012,
Abstract: Risk modeling and analysis is one of the most important stages in project success. There are many approaches for risk assessment and an investigation of existing methods helps in developing new models . This paper is an extensive literature survey in risk modeling and analysis methods with main focus on fuzzy risk assessment.
Dynamic Total Cost of Ownership Optimization for IPTV Service Deployment
Pejman Goudarzi
Journal of Applied Sciences , 2009,
Abstract: The Total Cost of Ownership (TCO) for developing communication services comprises from two parts; CAPital EXpenditure (CAPEX) and OPerational EXpenditure (OPEX). These two types of costs are interrelated and affect any service provider`s deployment strategy. In many traditional methods, selection of critical elements of a new service is performed in a heuristic manner aimed at reducing only the OPEX part of the TCO which is not necessarily optimal. In the current study, a mathematical modeling approach is developed for describing the cost of each Internet Protocol Tele Vision (IPTV) component. Then, based on the proposed models, the TCO optimization problem of the IPTV service is formulated as a nonlinear programming one. The solution of the proposed optimization problem can track the dynamic changes of the TCO and lead to a time-varying optimal solution. Numerical results associated with the developed method are presented.
Symmetry Protected Topological Order by Folding a One-Dimensional Spin-$1/2$ Chain
Pejman Jouzdani
Physics , 2015,
Abstract: We present a toy model with a Hamiltonian $H^{(2)}_T$ on a folded one-dimensional spin chain. The non-trivial ground states of $H^{(2)}_T$ are separated by a gap from the excited states. By analyzing the symmetries in the model, we find that the topological order is protected by a $\mathbb{Z}_2$ global symmetry. However, by using perturbation series and excluding thermal effects, we show that the $\mathbb{Z}_2$ symmetry is stable in comparison to a standard nearest-neighbor Ising model with a Hamiltonian $H_I$. We find that $H^{(2)}_T$ is a member of a family of Hamiltonians that are adiabatically connected to $H_I$. Furthermore, the generalizations of this class of Hamiltonians, their adiabatic connection to $H_I$, and the relation to quantum error-correcting codes are discussed. Finally, we show the correspondence between the two ground states of $H^{(2)}_T$ and the unpaired Majorana modes, and provide numerical examples.
Field Emission properties of nanocomposites of conducting polymers
Pejman Talemi
Physics , 2015,
Abstract: Nanocomposites based on graphene and carbon nanotubes dispersed in polypyrrole or poly(3,4ethylenedioxy)thiophene have been prepared and their performance as cold cathodes for field emission has been evaluated. It was found that the polymer matrix will degrade during the field emission process and result in unstable performance. Electropolymerization of the composites results in significantly better field emission performance, but the stability is still a major problem. Deposition of composites onto a stable membrane was proposed as a strategy for improving the performance of electrodes. The field emission data indicates that composites deposited on the surface of a membrane can limit the emission surface and result in lower maximum emission and higher Turn-On voltage. The lower emission current and consequently lower heat generation, in addition to the possible heat dissipation by the AAO membrane, can reduce the rate of the thermal degradation of the polymer. The membrane can also act as a physical barrier that holds nanotubes in place and allows electrons through. Thus, it can prevent shorting of the field emission cell. In this way higher emission and longer life time can be achieved.
Regularity of the density for a stochastic heat equation
Pejman Mahboubi
Mathematics , 2011,
Abstract: We study the smoothness of the density of the solution to the nonlinear heat equation u_t=Lu(t,x)+\sigma(u(t,x))W on a torus with a periodic boundary condition, where L is the generator of a Levy process on the torus, and W is white noise. We use Malliavin calculus techniques to show that the law of the solution has a density with respect to the Lebesgue measure for all t >0 and x in R.
Stochastic TCO minimization for Video Transmission over IP Networks
Pejman Goudarzi
Computer Science , 2012,
Abstract: From the viewpoint of service operators the Total Cost of Ownership (TCO) for developing a communication service comprises from two parts; CAPital EXpenditure (CAPEX) and OPerational EXpenditure (OPEX). These two types of costs are interrelated and affect any service provider's deployment strategy. In many traditional methods, selection of critical elements of a new service is performed in a heuristic manner aimed at reducing only the OPEX part of the TCO which is not necessarily optimal. Furthermore, exact cost modeling for such services is not always possible and contains some uncertainties. In the current work, after cost modeling of each video streaming element by capturing the effect of the model uncertainties, the TCO optimization problem for video streaming over IP networks is formulated as a stochastic optimization problem. The solution of the proposed optimization problem can cope with the cost modeling uncertainties and track the dynamism in the TCO and lead to a time-varying optimal solution. Numerical analysis results verify the developed method.
Crowd Evacuation for Indoor Public Spaces Using Coulomb’s Law
Pejman Kamkarian,Henry Hexmoor
Advances in Artificial Intelligence , 2012, DOI: 10.1155/2012/340615
Abstract: This paper focuses on designing a tool for guiding a group of people out of a public building when they are faced with dangerous situations that require immediate evacuation. Despite architectural attempts to produce safe floor plans and exit door placements, people will still commit to fatal route decisions. Since they have access to global views, we believe supervisory people in the control room can use our simulation tools to determine the best courses of action for people. Accordingly, supervisors can guide people to safety. In this paper, we combine Coulomb’s electrical law, graph theory, and convex and centroid concepts to demonstrate a computer-generated evacuation scenario that divides the environment into different safe boundaries around the locations of each exit door in order to guide people through exit doors safely and in the most expedient time frame. Our mechanism continually updates the safe boundaries at each moment based on the latest location of individuals who are present inside the environment. Guiding people toward exit doors depends on the momentary situations in the environment, which in turn rely on the specifications of each exit door. Our mechanism rapidly adapts to changes in the environment in terms of moving agents and changes in the environmental layout that might be caused by explosions or falling walls. 1. Introduction The gathering of a group of people at the same location and time is called a crowd. People who form the crowd often share a common activity. In order to study crowd evacuation, we need to have clear understanding of all their relevant attributes. Determining crowd dynamics based on their psychological identifications is one of the many ways that is broadly explored by previous researches. Crowd dispersion is unpredictable. There are many studies conducted that explore crowd behavior from different perspectives. One of the major crowd behaviors with psychological underpinnings is identified as deindividuation, which is the situation where antinormative individual behavior is exhibited in groups in which individuals are not seen as separate individuals. Simply put, deindividuation is blending in a group such that the individual decision making ceases to be observed separately. Submergence is largely acknowledged as the root of contemporary theories of deindividuation, [1]. Numerous studies have explored relationships between deindividuation and behavioral changes [1–6]. It is important to understand how individuals conceive themselves in the crowd since once being a member of a crowd they no longer act
Multi-Layer Substrate Integrated Waveguide E-Plane Power Divider
Pejman Mohammadi;Simsek Demir
PIER C , 2012, DOI: 10.2528/PIERC12042905
Abstract: A new multilayer power divider with Substrate Integrated Waveguide (SIW) technology is proposed. In this work, two-way and four-way power dividers realizations by two-layer and three-layer SIW, respectively, are presented. Considering the small size of the structure, extension of this method to -way power dividers and antenna feed networks are possible, and it has the potential for integration of compact multi-layer SIW circuits. Due to the lack of a multiport counterpart of the two-port thru-reflect-line (TRL) calibration, scattering matrix of an -way power divider must be reconstructed from measured data. A method is introduced for reconstruction of -parameters of the -port noncoaxial device with a two-port vector network analyzer (VNA). The two-way power divider is designed for 8.7-10.5 GHz band. Transmission coefficient about -3.5 dB and return loss below -10 dB has been measured for this two-way power divider. For four-way power divider, transmission about -7 dB in the 9.5-10.5 GHz has been achieved.
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