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Exploring the Impacts of Labor Migration and Job Satisfaction on Organizational Commitment of Foreign Workers in Taiwan’s Construction Industry: Employ Ability as a Moderator  [PDF]
Pei-Wen Liao
American Journal of Industrial and Business Management (AJIBM) , 2015, DOI: 10.4236/ajibm.2015.53016
Abstract: The purpose of this study is to understand employability into the moderator through which labor migration and job satisfaction are related to organizational commitment. A survey study was conducted on 440 Thai workers from construction industry in Taiwan. Using structural equation modeling (SEM), our analysis indicates that labor migration is significantly related to their feelings of satisfaction to the organizational commitment. After analyzing the survey questionnaires, we find the positive relationship among push migration, pull migration, interpersonal satisfaction, salary satisfaction, and organizational commitment. Furthermore, the result shows the positive significant moderating effects of employability on push migration and job satisfaction. However, the push migration has a significantly positive effect on job satisfaction in lower employability of foreign workers.
Does Internet-Based Survey Have More Stable and Unbiased Results than Paper-and-Pencil Survey?  [PDF]
Pei-Wen Liao, Jun-Yi Hsieh
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.51006
Abstract: This study designed to compare responses from an internet-based survey to those from a paper-and-pencil survey in terms of measurement reliability, validity, and equivalence using homogeneous demographic profiles of the undergraduates studying in Taiwan. Several similarities and differences were found between two types of survey in this study. For examples, contents of the survey items (i.e., internet-related vs. behavior-related) and survey environments significantly influence the distribution of responses. The normal distribution, internal consistency, in addition to construct, and convergent validity for individual construct are quite similar. However, the homological validity evidence was demonstrated through structural equation modeling across two survey modes. Implications and future research are also discussed.
Inhibitory Effects of Several Spices on Inflammation Caused by Advanced Glycation Endproducts  [PDF]
Su-Chen Ho, Pei-Wen Chang
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.327118
Abstract: Advanced glycation endproducts (AGEs) is implicated in the pathogenesis of diabetic complications. Inhibiting the formation of AGEs and interfering with AGEs-mediated inflammation are two practicable strategies for developing a dietary adjuvant against diabetic complications. This study evaluated the protective capacities against diabetic complications of several spices based on their inhibition of the formation of AGEs in an in vitro BSA/glucose system and on the AGEs-induced production of proinflammatory cytokine in RAW 264.7 macrophages. Among the tested spices, cinnamon exhibited most strongly inhibited both the formation of AGEs and the AGEs-induced production of nitric oxide, interleukin-6 and tumor necrosis factor-α. Additionally, correlative results revealed that the capacity of spices to inhibit the formation of AGEs is attributable to phenolic compounds and, in contrast, the capacity to inhibit AGEs-induced inflammation is attributable to condensed tannin. This investigation demonstrates the potential of cinnamon to serve as a dietary adjuvant against diabetic complications.
Lack of association between mutations of gene-encoding mitochondrial D310 (displacement loop) mononucleotide repeat and oxidative stress in chronic dialysis patients in Taiwan
Jin-Bor Chen, Tsu-Kung Lin, Shang-Chih Liao, Wen-Chin Lee, Lung-Chih Lee, Chia-Wei Liou, Pei-Wen Wang, Mao-Meng Tiao
Journal of Negative Results in BioMedicine , 2009, DOI: 10.1186/1477-5751-8-10
Abstract: Depending on alterations in the D310 mononucleotide repeat, subjects were categorized into 4 subgroups: 7-C, 8-C, 9 or 10-C, and T-to-C transition. Oxidative stress was higher in chronic dialysis patients, evidenced by higher levels of TBARS and mtDNA copy number, and a lower level of free thiol. The distribution of 7-C, 8-C, and 9-10C in dialysis and control subjects was as follows: 7-C (38% vs. 31.5%), 8-C (35.3% vs. 43.2%), and 9-10C (24.5% vs. 22.1%). Although there were significant differences in levels of TBARS, free thiol, and the mtDNA copy number in the D310 repeat subgroups (except T-to-C transition) between dialysis patients and control subjects, post hoc analyses within the same study cohort revealed no significant differences.Although oxidative stress was elevated in chronic dialysis patients and resulted in a compensatory increase in the mtDNA copy number, homopolymeric C repeats in the mtDNA region (D310), susceptible to ROS, were not associated with oxidative stress markers in these patients.Chronic kidney disease (CKD) is characterized by a state of increased oxidative stress [1]. This has been evidenced by changes in oxidative stress biomarkers in the blood and in tissue DNA. In our previous study, we demonstrated that, in continuous ambulatory peritoneal dialysis (CAPD) patients, the level of oxidative stress biomarkers in the blood was elevated, with an accompanying increase in the copy number of mitochondrial (mt) DNA [2]. mtDNA is a 16.6-kb double-stranded closed-circular DNA molecule. In humans, the mutation rate of mtDNA is at least 10 times higher than that of nuclear DNA. Most mutations in mtDNA accumulate in the displacement loop (D-loop) region. The D-loop functions as a promoter for both heavy and light strands of mtDNA and does not encode any functional proteins. A mononucleotide repeat sequence (CCCC...CCCTCCCCCC) between nucleotides 303 and 316-318 of mtDNA has been reported to be a hotspot of deletion or insertion mutation in primary
ACAP-A/B Are ArfGAP Homologs in Dictyostelium Involved in Sporulation but Not in Chemotaxis
Pei-Wen Chen,Paul A. Randazzo,Carole A. Parent
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008624
Abstract: Arfs and Arf GTPase-activating proteins (ArfGAPs) are regulators of membrane trafficking and actin dynamics in mammalian cells. In this study, we identified a primordial Arf, ArfA, and two ArfGAPs (ACAP-A/B) containing BAR, PH, ArfGAP and Ankyrin repeat domains in the eukaryote Dictyostelium discoideum. In vitro, ArfA has similar nucleotide binding properties as mammalian Arfs and, with GTP bound, is a substrate for ACAP-A and B. We also investigated the physiological functions of ACAP-A/B by characterizing cells lacking both ACAP-A and B. Although ACAP-A/B knockout cells showed no defects in cell growth, migration or chemotaxis, they exhibited abnormal actin protrusions and ~50% reduction in spore yield. We conclude that while ACAP-A/B have a conserved biochemical mechanism and effect on actin organization, their role in migration is not conserved. The absence of an effect on Dictyostelium migration may be due to a specific requirement for ACAPs in mesenchymal migration, which is observed in epithelial cancer cells where most studies of mammalian ArfGAPs were performed.
A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
Pei-wen Pan, Alejandra Rodriguez, Seppo Parkkila
BMC Molecular Biology , 2007, DOI: 10.1186/1471-2199-8-22
Abstract: The CAs expressed in all tissues were Car5b, Car7, and Car15, among which Car5b showed moderate and Car7 and Car15 extremely low expression levels. Car3, Car12, Car13, and Car14 were detected in seven out of eight tissues and Car2 and Car4 were expressed in six tissues. Importantly, Car1, Car3, and Car13 showed very high expression levels in certain tissues as compared to the other CAs, suggesting that these low activity isozymes may also participate in physiological processes other than CA catalysis and high expression levels are required to fulfil their functions in the body.A comprehensive mRNA expression profile of the 13 enzymatically active CAs in the murine gastrointestinal tract was produced in the present study. It contributes to a deeper understanding of the distribution of CA isozymes and their potential roles in the mouse digestive system.Mammalian α-carbonic anhydrases (CAs) are a large enzyme family containing 16 different isoforms, among which 13 (CA I, II, III, IV, VA, VB, VI, VII, IX, XII, XIII, XIV, and XV) are enzymatically active. The other three carbonic anhydrase-related proteins (CA-RP VIII, X, and XI) appear to lack CA activity because of substitutions in one or more of the functionally important histidine residues. In addition, the receptor-type protein-tyrosine phosphatases (RPTP) β and γ have been reported to contain 'CA-like' domains [1-3]. The enzymatically active CAs catalyze the reversible hydration of carbon dioxide in the reaction CO2 + H2O ? HCO3- + H+, and participate in various biological processes, including CO2 transport, regulation of pH homeostasis, bone resorption, ureagenesis, gluconeogenesis, production of body fluids, and fertilization [1,4]. Each isozyme also has a characteristic subcellular localization. CA I, II, III, VII, and XIII are cytosolic, CA IV, IX, XII, XIV, and XV are membrane-associated, CA VA and VB are mitochondrial, and CA VI is secreted. According to a recent bioinformatic analysis, CA XV may be the last
Explore the Molecular Mechanism of Apoptosis Induced by Tanshinone IIA on Activated Rat Hepatic Stellate Cells
Tai-Long Pan,Pei-Wen Wang
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/734987
Abstract:
Explore the Molecular Mechanism of Apoptosis Induced by Tanshinone IIA on Activated Rat Hepatic Stellate Cells
Tai-Long Pan,Pei-Wen Wang
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/734987
Abstract: Since the activated hepatic stellate cell (HSC) is the predominant event in the progression of liver fibrosis, selective clearance of HSC should be a potential strategy in therapy. Salvia miltiorrhiza roots ethanol extract (SMEE) remarkably ameliorates liver fibrogenesis in DMN-administrated rat model. Next, tanshinone IIA (Tan IIA), the major compound of SMEE, significantly inhibited rat HSC viability and led to cell apoptosis. Proteome tools elucidated that increased prohibitin is involved in cell cycle arrest under Tan IIA is the treatment while knockdown of prohibitin could attenuate Tan IIA-induced apoptosis. In addition, Tan IIA mediated translocation of C-Raf which interacted with prohibitin activating MAPK and inhibiting AKT signaling in HSC. MAPK antagonist suppressed ERK phosphorylation which was necessary for Tan IIA-induced expression of Bax and cytochrome c. PD98059 also abolished Tan IIA-modulated cleavage of PARP. Our findings suggested that Tan IIA could contribute to apoptosis of HSC by promoting ERK-Bax-caspase pathways through C-Raf/prohibitin complex. 1. Introduction Hepatic fibrosis characterized by excessive deposition of extracellular matrix (ECM) proteins results from chronic liver injury due to viral, autoimmune, drug-induced, cholestatic, and metabolic diseases [1–4]. During hepatic fibrosis progresses, various cytokines and molecules including transforming growth factor-β1 (TGF-β1) and platelet derived growth factor (PDGF) would in turn stimulate hepatic stellate cells (HSCs) which then undergo phenotypic transformation from quiescent cells into proliferative and fibrogenic cells [5–8]. Activated HSCs can also mediate release of proinflammatory cytokines and tissue inhibitor of metalloproteinases (TIMP), which could cause deposition of collagen and further fibrosis [9]. With ongoing liver damage, fibrosis may progress to cirrhosis, predisposing to liver failure and hepatocellular carcinoma [10]. Since HSCs are the major cause during the progression of hepatic fibrosis, therefore, removal of HSCs by apoptosis might effectively prevent or even reverse liver fibrosis [11]. The root of Salvia miltiorrhiza Bunge (Labiatae), commonly known as Dan-shen, has been used as a traditional Chinese medicine for treating microcirculatory diseases in Asia [12–14]. Salvianolic acid B, a water-soluble compound in Salvia miltiorrhiza, has been proven to attenuate cardiac fibroblast migration, collagen, and cytokine secretion [15]. In addition, water extract of Salvia miltiorrhiza has attracted increasing attention due to its antifibrotic effects
Dietary Uptake of Wedelia chinensis Extract Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice
Yuh-Ting Huang, Chih-Chun Wen, Yung-Hsiang Chen, Wen-Ching Huang, Li-Ting Huang, Wen-Ching Lin, Palanisamy Arulselvan, Jiunn-Wang Liao, Shu-Hui Lin, Pei-Wen Hsiao, Sheng-Chu Kuo, Ning-Sun Yang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064152
Abstract: Scope Traditional medicinal herbs are increasingly used as alternative therapies in patients with inflammatory diseases. Here we evaluated the effect of Wedelia chinensis, a medicinal herb commonly used in Asia, on the prevention of dextran sulfate sodium (DSS)-induced acute colitis in mice. General safety and the effect of different extraction methods on the bioactivity of W. chinensis were also explored. Methods and Results C57BL/6 mice were administrated hot water extract of fresh W. chinensis (WCHF) orally for one week followed by drinking water containing 2% DSS for nine days. WCHF significantly attenuated the symptoms of colitis including diarrhea, rectal bleeding and loss of body weight; it also reduced the shortening of colon length and histopathological damage caused by colonic inflammation. Among four W. chinensis extracts prepared using different extraction techniques, WCHF showed the highest anti-colitis efficacy. Analyses of specific T-cell regulatory cytokines (TNF-α, IL-4, IFN-γ, IL-17, TGF-β, IL-12) revealed that WCHF treatment can suppress the Th1 and Th17, but not Th2, responses in colon tissues and dendritic cells of DSS-induced colitis mice. A 28-day subacute toxicity study showed that daily oral administration of WCHF (100, 500, 1000 mg/kg body weight) was not toxic to mice. Conclusion Together, our findings suggest that specific extracts of W. chinensis have nutritional potential for future development into nutraceuticals or dietary supplements for treatment of inflammatory bowel disease.
catena-Poly[[diaqua(1,10-phenanthroline-κ2N,N′)nickel(II)]-μ-1H-benzimidazole-5,6-dicarboxylato-κ2N3:O6]
Wen-Dong Song,Hao Wang,Shi-Wei Hu,Pei-Wen Qin
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809019680
Abstract: In the title complex, [Ni(C9H4N2O4)(C12H8N2)(H2O)2]n, the NiII atom is hexacoordinated by one N and one O atom from two different 1H-benzimidazole-5,6-dicarboxylate ligands, two N atoms from one 1,10-phenanthroline ligand and two water molecules. The flexible 1H-benzimidazole-5,6-dicarboxylate ligands link the NiII centres, forming an infinite zigzag chain parallel to [001]. The crystal packing is governed by intermolecular hydrogen-bonding interactions of the O—H...O, N—H...O and C—H...O types.
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