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Search Results: 1 - 10 of 22516 matches for " Pedro Pimentel Nunes "
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Permeabilidade Intestinal, Endotoxemia e Inflama o na Cirrose: Que Rela o? Intestinal Permeability, Endotoxemia and Inflammation in Cirrhosis: What Relationship?
Pedro Pimentel-Nunes
Jornal Português de Gastrenterologia , 2011,
Abstract:
Tenofovir como 1a op o terapêutica na hepatite B Tenofovir as first therapeutical option of hepatitis B
Pedro Pimentel Nunes
Jornal Português de Gastrenterologia , 2012,
Abstract:
Toll-Like Receptors as Biomarkers of Gastric Carcinogenesis: Implications for Diagnosis, Prognosis and Treatment  [PDF]
Pedro Pimentel-Nunes, Jo?o Bruno Soares, Mário Dinis-Ribeiro
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.45117
Abstract:

Toll-like receptors (TLR) are essential for Helicobacter pylori (Hp) recognition and subsequent innate and adaptive immunity responses. TLR2 appears to be the receptor responsible for most of the immunologic reaction against Hp infection. However, TLR4, TLR9 and eventually TLR5 may also have a synergic effect with TLR2 against Hp. It has been shown that gastric Hp infection increases TLR expression in the gastric mucosa. Moreover, recent studies have shown that human gastric carcinogenesis is associated not only with increased expression of TLR but also with decreased expression of their inhibitors such as Toll-Interacting Protein (TOLLIP) and peroxisome proliferator-activated receptor (PPAR)-g. Indeed, gastric dysplasia and adenocarcinoma are associated with high expression levels of TLR and low levels of TOLLIP and PPAR-g, suggesting increased activation of these receptors throughout human gastric carcinogenesis. In this article we discuss how these novels findings could be used not only for the diagnosis and prognosis of gastric lesions associated with Hp infection but also for their treatment. Specifically, we discuss the potential use of TLR agonists in addition to antibiotics to improve eradication rates of Hp and of TLR antagonists to slow the progression of gastric preneoplastic lesions. We also discuss the potential value of TLR signalling blockers and quantification of tumoral TLR expression, respectively, in the treatment and prognosis of gastric cancer. In conclusion, TLRs can be an important link between Hp and the sequence of gastric carcinogenesis and they can be used as biomarkers of gastric carcinogenesis. In this article, future lines of investigation related with these novel scientific findings are proposed and discussed.

Apresenta o da Doen a de Whipple como Linfoma Whipple Disease Presenting as Abdominal Lymphoma
Pedro Pimentel-Nunes,Elisabete Cardoso,Catarina Brand?o,Hálio Duarte
Jornal Português de Gastrenterologia , 2011,
Abstract: A doen a de Whipple é uma doen a rara, provocada por uma bactéria Gram-positiva intracelular Tropheryma whipplei. é um diagnóstico difícil de fazer e, apesar de se poder apresentar com uma clínica muito variada, a sintomatologia gastrointestinal está quase sempre presente. O diagnóstico é estabelecido pela identifica o de inclus esPAS-positivas em macrófagos da lamina própria da mucosa duodenal. Os autores descrevem o caso de um doente que se apresenta com um quadro clínico muito sugestivo de doen alinfoproliferativa, na ausência de sintomas gastrointestinais, cujo diagnóstico foi estabelecido pela análise histológica de fragmento de umaadenopatia retroperitoneal obtida por pun o guiada por tomografia computorizada Whipple’s disease is a rare disease caused by Tropheryma whipplei, a Gram-positive intracellular bacterium. It’s a difficult diagnosis to do and although gastrointestinal manifestations are almost always present, it can be present with a great diversity of symptoms. The diagnosis is made by the identification of PAS-positive inclusions in the macrophages of duodenal mucosa. The authors describe a case of a patient presenting with a clinical picture suggestive of alymphoproliferative disease, in the absence of gastrointestinal symptoms, with diagnosis of Whipple’s disease being made by pathological analysis of a fragment obtained by computer tomography guided biopsy of a retroperitoneal adenopathy
Apresenta??o da Doen?a de Whipple como Linfoma
Pimentel-Nunes,Pedro; Cardoso,Elisabete; Brand?o,Catarina; Duarte,Hálio; Lobo,Cláudia Rodrigues; Henrique,Rui; Moreira-Dias,Luís;
Jornal Português de Gastrenterologia , 2011,
Abstract: whipple?s disease is a rare disease caused by tropheryma whipplei, a gram-positive intracellular bacterium. it?s a difficult diagnosis to do and although gastrointestinal manifestations are almost always present, it can be present with a great diversity of symptoms. the diagnosis is made by the identification of pas-positive inclusions in the macrophages of duodenal mucosa. the authors describe a case of a patient presenting with a clinical picture suggestive of alymphoproliferative disease, in the absence of gastrointestinal symptoms, with diagnosis of whipple?s disease being made by pathological analysis of a fragment obtained by computer tomography guided biopsy of a retroperitoneal adenopathy
Genetic Variability in Key Genes in Prostaglandin E2 Pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and Their Involvement in Colorectal Cancer Development
Carina Pereira, Sara Queirós, Ana Galaghar, Hugo Sousa, Pedro Pimentel-Nunes, Catarina Brand?o, Luís Moreira-Dias, Rui Medeiros, Mário Dinis-Ribeiro
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092000
Abstract: The pro-carcinogenic effects of prostaglandin E2 (PGE2) in colonic mucosa are not only regulated by the rates between Cyclooxygenase-2 (COX-2) biosynthesis and 15-Hydroxyprostaglandin Dehydrogenase (15-PGDH)-dependent degradation but also the steady-state levels of PGE2 in extracellular microenvironment, maintained by key specific prostaglandin transporters, the Multidrug Resistance Protein (MRP4) (efflux carrier) and Prostaglandin Transporter (PGT) (influx carrier). To understand the contribution of genetic variability in genes coding for COX-2/15-PGDH/MRP4/PGT proteins in CRC development, we conducted a hospital-based case-control study involving 246 CRC patients and 480 cancer-free controls. A total of 51 tagSNPs were characterized using the Sequenom platform through multiplexed amplification followed by mass-spectrometric product separation or allelic discrimination using real-time PCR. Seven tagSNPs were implicated in CRC development: the rs689466 in COX-2 gene, the rs1346271 and rs1426945 in 15-PGDH, the rs6439448 and rs7616492 in PGT and rs1751051 and rs1751031 in MRP4 coding genes. Upon a stratified analysis a measurable gene-environment interaction was noticed between rs689466 and smoking habits, with individuals ever-smokers carriers of rs689466 GG homozygous genotype having a nearly 6-fold increased susceptibility for CRC onset (95%CI: 1.49–22.42, P = 0.011). Furthermore, the multifactor dimensionality reduction (MDR) analysis identified an overall four-factor best gene-gene interactive model, including the rs1426945, rs6439448, rs1751051 and rs1751031 polymorphisms. This model had the highest cross-validation consistency (10/10, P<0.0001) and an accuracy of 0.6957 and was further associated with a 5-fold increased risk for CRC development (95%CI: 3.89–7.02, P<0.0001). In conclusion, specific low penetrance genes in the pro-carcinogenic PGE2 pathway appear to modulate the genetic susceptibility for CRC development. A clearer understanding on CRC etiology through the identification of biomarkers of colorectal carcinogenesis might allow a better definition of risk models that are more likely to benefit from targeted preventive strategies to reduce CRC burden.
Conflitos de interesse: reflex?es ao regime do pós-emprego público
Nunes,Pedro;
Economia Global e Gest?o , 2010,
Abstract: the legal regime applicable to the post-public employment situations states that the individuals who have held political positions, elected or appointed, cannot exercise, for a period of three years, from the end of their appointments or election, futures position that could possibly collide with the regime of incompatibilities, in particular, which may cause a conflict of interest . this article intends to make a synopsis and also make some reflections about the state of the art in such systems.
Reforma do emprego público: breves considera??es às grandes reformas em curso em Portugal
Nunes,Pedro;
Tékhne - Revista de Estudos Politécnicos , 2009,
Abstract: the present article analyzes the subjects of the public administration reform and the models that had served to it, in synthesised format. it is appreciated, also, the cause of the reform with the particular state of the public employment. with supranational arguments and more concrete reasons for portugal, we display the reform stimulated for the xvii constitutional government, since 2005. we think that is the biggest reform, some time practiced in the portuguese public administration. in the article we do appreciations to the aspects of the public employment, to its regimen, careers and wages, recruitment and selection, in brief considerations.
Conflitos de interesse: reflex es ao regime do pós-emprego público Conflicts of interest: reflections ON the post-public employment regime
Pedro Nunes
Economia Global e Gest?o , 2010,
Abstract: No regime jurídico aplicável às situa es de pós-cessa o de fun es (post-public employment) dos cargos políticos e altos cargos públicos refere-se que os titulares de órg os de soberania e titulares de cargos políticos n o podem exercer, pelo período de três anos, contado da data de cessa o das respectivas fun es, cargos futuros que possam, eventualmente, colidir com o regime de incompatibilidades e, em particular, que possam provocar um conflito de interesse . O presente artigo pretende fazer um resumo e, além disso, integrar reflex es éticas com o estado da arte dessas mesmas situa es. The legal regime applicable to the post-public employment situations states that the individuals who have held political positions, elected or appointed, cannot exercise, for a period of three years, from the end of their appointments or election, futures position that could possibly collide with the regime of incompatibilities, in particular, which may cause a conflict of interest . This article intends to make a synopsis and also make some reflections about the state of the art in such systems.
Participa o das mulheres na política autárquica em Portugal nos últimos 25 anos (1982 a 2005): especial relevo para as mulheres eleitas apuradas para a presidência dos órg os
Pedro Nunes
Revista Enfoques : Ciencia Política y Administración Pública , 2008,
Abstract: The debate around the women`s participation in politics continues to be a very present subject. This article has the intention to select, in quantitative terms, that kind of participation, particularly in the case of the autarchic local administration in Portugal, through the last 25 years. It does not intend, thus, to study the best or worse feminine performance in the respective elections and/or the exercise of the mandate. The analysis involves the 308 local governments and the 4.261 parish’s existing in Portugal. It covers almost the totality of the elected officers in the period analysed which covers the elections of 1982, 1989, 1993, 1997, 2001 and 2005,with a total of 276.068 elected men and women, where a total of 24.905 were women.
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