OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Pawar Atmaram” ,找到相关结果约399条。
Crystallo-co-agglomeration: A novel particle engineering technique
Paradkar Anant,Pawar Atmaram,Jadhav Namdeo
Asian Journal of Pharmaceutics , 2010,
Abstract: Crystallo-co-agglomeration (CCA) is a novel particle engineering/design technique developed by Kadam et al, to overcome the limitations of spherical crystallization (SC). Basically, it′s single step process used for size enlargement of single, two or more, small dose or large dose drugs, in combination with or without diluent. The process of CCA involves simultaneous crystallization and agglomeration of drug/s with/without excipients/s from good solvent and/or bridging liquid by addition of a non-solvent. Till date CCA has been applied for spherical agglomeration of talc, bromhexine hydrochloride-talc, ibuprofen-talc, ibuprofen-paracetamol, and naproxen-starch. The spherical agglomerates obtained by CCA can be used as intact beads (encapsulated spansules) or directly compressible tablet intermediates having satisfactory micromeritic (flowability), mechanical (friability, crushing), compressional (compressibility, compactibility), and drug release properties. Modified drug release from agglomerates and compacts thereof can be achieved using suitable polymer composition in the process design. Thus, it can be concluded that, CCA is a simple and cost effective process, which can be tailor-made for particle design of all majority of drugs and combinations thereof.
Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study
Ashwin J. Mali,Atmaram P. Pawar,Ravindra N. Purohit
Journal of Pharmaceutics , 2014, DOI: 10.1155/2014/795371
Abstract: The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs. 1. Introduction Corticosteroids have been found to be very effective for the control of mortality rate and approved as a maintenance therapy in asthmatic patients [1, 2]. Budesonide, a corticosteroid used in the first line therapy for coronary obstructive pulmonary disease (COPD), is available in the market as a conventional dry powder inhale (DPI). The optimum dose for budesonide is ranging between 200?μg and 800?μg. This is a potent nonhalogenated corticosteroid having maximum glucocorticoids receptor activity. The hepatic first pass metabolism of budesonide is approximately 90% which is the main reason for its low oral bioavailability of 6–11% having half-life 2-3?h [3]. The high doses of corticosteroids produce serious side effects upon long-term administration. There is need for controlled release budesonide DPI which could be administered through pulmonary route. Such a formulation could reduce the systemic side effects by achieving high local concentration in the lung and improve the patient compliance [4]. Pulmonary drug delivery system is explored as one of the alternative drug delivery systems due to higher surface area (100–140?m2), high permeation of lung, avoidance of hepatic first pass metabolism, and noninvasive route for drug administration [5, 6]. It was found to be the most efficient route for treatment of asthma, chronic obstructive pulmonary disease, and cystic fibrosis and now it is being explored for systemic administration of various categories of drug [7]. Drugs used for cancer, diabetes, and migraine could be efficiently administered by this route. Furthermore peptides, proteins, and genes can be administered through this route as these are stable in the dry form [8]. Conventionally dry powder inhalers (DPIs) are prepared by micronization methods which are often blends of fine drug
Obstructive sleep apnea: Screenings in primary, secondary and tertiary care settings  [PDF]
Atmaram Yarlagadda, Jayaprada Kasaraneni, Anita H. Clayton
Health (Health) , 2013, DOI: 10.4236/health.2013.58A2009

Insomnia is a major health problem affecting millions of people around the globe, particularly in the developed world, substantially impacting on individual work performance and raising disability costs. Insomnias can be broadly divided into primary and secondary types. Primary insomnias can further be divided into parasomnias and dyssomnias. Diagnostic approaches to insomnias can be challenging, thereby complicating the treatment process. Obstructive sleep apnea (OSA) falls under the category of primary insomnias and is a good example of frequently missed diagnoses. The goal of this paper is to document the development of a self-reporting sleep apnea scale based on graded percentage scores to correlate with primary, secondary and tertiary risks. Scores falling under fifty percent represent primary prevention risks of OSA and suggest possible interventions. A score of fifty percent highlights three core symptoms on the scale as described in detail below to represent early detection of OSA or secondary prevention. Finally, scores exceeding fifty percent will include associated risks of comorbidities as well as other factors contributing to OSA, or tertiary prevention, with separate scores assigned to individual risk factors. Analysis of final scores on the proposed scale would therefore, in our opinion help achieve the goal of grading the risk of OSA from a multidisciplinary preventive care aspect.

Osseous Metaplasia Leading to Traction Retinal Detachment in the Nonphthisical Eye of Young Boy with Cytomegalovirus Retinitis  [PDF]
Gurunadh Atmaram Vemulakonda, Joshua A. Sonnen
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.32019

Title: Osseous Metaplasia Leading to Traction Retinal Detachment in the nonphthisical eye of Young Boy with Cytomegalovirus Retinitis. Purpose: To report a case of intraocular bone formation in an 11-year-old boy with a history cytomegalovirus (CMV) retinitis secondary to immunosuppression following Bone Marrow Transplantation due to hyper Immunoglobulin G (IgG) syndrome. Methods: An 11-year-old male presented with decreased vision in his better seeing eye. Clinical examination and Bscan ultrasound discovered a tractional retinal detachment with a large subretinal lesion. The patient was taken for surgical intervention. Results: The subretinal lesion was removed during surgery, and histopathologic evaluation revealed mature lamellar bone. Conclusion: This case shows that mature intraocular bone can be associated with tractional retinal detachment in a nonphthisical eye.

Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: NSS programme have expanded both qualitatively and qualitatively over the years. Areview committee was set up by the Government of India in August, 1984. One of the important recommendations of the committee was that the programme of NSS had great potential and, therefore, should continue and expand. The committee also recommended a 10 percent rate of growth of coverage of students under NSS in each year. This recommendation of the committee has been accepted by the government and by the end of IX Plan, the target of covering 20.00 lakh students under the programme is to be achieve Recently, the scheme has been extended to form an open unit, involving exNSS volunteers, and persons having an aptitude for social work.
K-Means Graph Database Clustering and Matching for Fingerprint Recognition  [PDF]
Vaishali Pawar, Mukesh Zaveri
Intelligent Information Management (IIM) , 2015, DOI: 10.4236/iim.2015.74019
Abstract: The graph can contain huge amount of data. It is heavily used for pattern recognition and matching tasks like symbol recognition, information retrieval, data mining etc. In all these applications, the objects or underlying data are represented in the form of graph and graph based matching is performed. The conventional algorithms of graph matching have higher complexity. This is because the most of the applications have large number of sub graphs and the matching of these sub graphs becomes computationally expensive. In this paper, we propose a graph based novel algorithm for fingerprint recognition. In our work we perform graph based clustering which reduces the computational complexity heavily. In our algorithm, we exploit structural features of the fingerprint for K-means clustering of the database. The proposed algorithm is evaluated using realtime fingerprint database and the simulation results show that our algorithm outperforms the existing algorithm for the same task.
Phytochemical and physiological changes in Ashwagandha (Withania somnifera Dunal) under soil moisture stress
Shah, Sonal;Saravanan, Raju;Gajbhiye, Narendra Atmaram;
Brazilian Journal of Plant Physiology , 2010, DOI: 10.1590/S1677-04202010000400005
Abstract: ashwagandha, commonly known as the indian ginseng (withania somnifera) is an ingredient in many herbal preparations used for healing various ailments. it is cultivated in semi-arid regions of india as rain-fed crop. the response of this crop (cv. ja-134) to progressive soil moisture deficit on growth, physiology and content of phytochemicals was studied. at the end of treatment period, soil water potential (ψw) decreased to -10.93, -1.15 mpa at 30 cm depth, predawn leaf water potentials were reduced to -0.62 and -0.51 mpa in the severe and moderate stress. leaf area was reduced by 27.4% and 34.4% in moderate and severe water stress treatment compared to control. chlorophyll content was reduced by 60% in the severe water stress. changes in the steroidal alkaloids and lactones that are the major medicinal active principles derived from root extracts of this plant species was also analyzed. a reduction of 52.6% in net photosynthesis was noticed under severe stress. at the end of the treatment period, moderate and severe stress treatments had 0.751 and 0.714 mg g-1 12-deoxywithastramonolide (12-dws) content in the roots respectively. the content of 12-dws and withanolide were at 77% and 93% of the control in the moderate and severe stress, respectively, while yield of these compounds were at 65% and 78% of control in mild and severe stress. thus, preferential partitioning of biomass in roots leads to higher root yield in moderate stress. higher root yield partially offset the loss of bioactive compounds under soil moisture stress.
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Caste is an important element of the Indian political process. It is legitimate. Caste has been inequality creating in Indian society. Therefore its influence on power shaping & Policy Making process. In this sense caste element has got sphere of influence in political process. Relationship between Caste & politics has been more eminent. Caste has been influencing on politics & politics has been influenced by caste. Limitation of Dominant caste at national level: dominant caste has been demanding for representation on national level. But their demands were not accepted by forward castes. The forward caste has been controlling National level power. Dominant caste has been controlling the state level power.Hinduvat Framework has Successes but Caste Framework has Failure. ST'S Community is not related to Caste Politics. Caste framework is Failure to inclusion of all backward Caste. Caste framework had not successful to decided Social & Economic Public Policy. Because of this caste framework is empty so it has no capacity to competing with other frameworks. It has own Sense of Political Efficacy but on national level it made no impact.
T.S. Eliot's Theory / Process Of Impersonality In Literature
Shivaji Pawar
Golden Research Thoughts , 2012, DOI: 10.9780/22315063
Abstract: In his essay, “ Tradition and the individual Talent”, Eliot announces his famous theory of impersonality as well as defines ' tradition' afresh. For Eliot 'tradition' is not the dead past but the ever-present tradition, which influences every writer of the present. He defines 'historical sense' as that sense of writer which makes him fully conscious, not only of his own age but also of the great writers of the past. The more he matures in his writing the more does he feel the influence of tradition, that is , the past masters on his works. In this awareness of tradition which directs or guides his writing lies his recognition of tradition as a more valuable institution, than he, the individual writer. The individual writer modifies the tradition as much as he is informed by it
Extended Fuzzy Hyperline Segment Neural Network for Handwritten Character Recognition
Dipti Pawar
Lecture Notes in Engineering and Computer Science , 2012,

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