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Search Results: 1 - 10 of 231909 matches for " Paunovi? Vladimir R. "
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Neurodevelopmental correlates in schizophrenia
Ivkovi? Maja,Damjanovi? Aleksandar,PaunoviVladimir R.
Srpski Arhiv za Celokupno Lekarstvo , 2003, DOI: 10.2298/sarh0308294i
Abstract: Contemporary aetiopathogenetic considerations, based on neuro-imaging genetic and developmental neurobiology studies, suggest neurodevelopmental origin of schizophrenia. Several lines of evidence including structural abnormalities on in vivo brain imaging, the excess of prenatal and obstetric complications and the association of congenital and minor physical anomalies with schizophrenia, strongly indicate the neurodevelopmental pathogenesis of schizophrenia. On the other hand, controversial concept of psychotic continuum suggests schizophrenia and depression sharing the same genetic contribution to the pathogenesis. If this would be the case, depression could also be considered as neuro developmental disorder. The aims of the study were to investigate the association between: a) pregnancy and birth complications (PBC), and b) minor physical anomalies (MPA) and schizophrenia or depression. Experimental groups consisted of 60 schizophrenic, 28 major depression patients and 30 healthy controls. All patients were diagnosed according to DSM-IV. Schizophrenic group was divided with regard to PANSS score into positive (n=32) and negative form (n=28) subgroups. PBC information were gathered from maternal recall while MPA were examined by using Waldrop scale for adults. The results showed that negative and positive schizophrenic subgroups had significantly more PBC than depressive group (p<0,05), as well than controls (p<0,001; p<0,05; respectively). There was no significant trend for more PBC in negative than in positive subgroup. All schizophrenic patients had higher rates of MPA than depressives (p<0,05). This trend for more MPA was not significant in comparison with healthy controls. These findings suggest that schizophrenia, especially its negative forms, could be considered as a member of the spectrum of neuro developmental disorders, which does not seem to be the case with depression. PBC and MPA could also be valuable in evaluation of risks for schizophrenia and possible predictive indicators of its development.
Neuropsychological profile of patients with bipolar depression in remission
Toti?-Poznanovi? Sanja,Marinkovi? Dragan,Pavlovi? Dragan,PaunoviVladimir R.
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0508543t
Abstract: Aim. To determine if the patients with bipolar affective disorder, after the depressive phase, would exhibit cognitive impairment in remission. Methods. Twenty three euthymic patients with bipolar disorder were matched, on a case-by-case basis, to twenty-one healthy subjects in the control group, for the presence of the symptoms of depression. The patients and the control group were tested with a battery of neuropsychological tests. Results. Impairments were found in the patients compared with the control group in tests of verbal learning and memory and in tests of executive function. Verbal learning and memory, as well as executive functions, did not correlate either with the clinical indices of patients, or with the demographic and baseline clinical measures of depression. Conclusion. Impaired verbal learning and memory and executive functions may represent a trait rather than the state variables in bipolar disorder.
Carbamazepine for acute psychosis with eeg abnormalities
Ivkovi? Maja,Damjanovi? Aleksandar,Marinkovi? Dragan,PaunoviVladimir R.
Vojnosanitetski Pregled , 2004, DOI: 10.2298/vsp0404399i
Abstract: Aim. To investigate the efficacy of carbamazepine as adjuvant drug therapy in acute paranoid psychosis with associated EEG abnormalities, compared to sole antipsychotic treatment. Methods. Eleven medication-naive patients diagnosed with acute paranoid psychosis with associated EEG abnormalities were divided into two treatment groups: sole fluphenazine group, with flexible dosing of 5-10 mg/day (n=6), and carbamazepine group (n=5) with the addition of carbamazepine (600 mg/day) to fluphenazine treatment. Clinical Global Impression (CGI), Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), and EEG were assessed on the baseline and after 6 weeks of treatment. Paired and two-tailed t-tests were used for statistical significance. Results. All the patients showed significant improvement of mental state after 6 weeks of treatment with no significant differences in CGI, BPRS, and total SANS scores in relation to the therapy with carbamazepine. Nevertheless, after 6 weeks of the treatment, EEG findings were significantly better in carbamazepine group, in relation to the findings from the onset of the treatment, as well as in comparison to sole fluphenazine group. Conclusion. Although carbamazepine stabilized abnormal brain electrical activities it seemed that the associated EEG abnormalities were not significant for acute psychosis observed. These preliminary results suggested that there was no convincing evidence that carbamazepine was efficient as the augmentation of antipsychotic treatment for patients with both acute paranoid psychosis and EEG abnormalities.
Panic disorder: Psychobiological aspects of personality dimensions
Dragani?-Gaji? Saveta,Le?i?-To?evski Du?ica,PaunoviVladimir R.,Cveji? Vesna
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0504129d
Abstract: Attempts to understand the underlying mechanisms of association between psychological factors and panic disorder have been mostly based on psychodynamic description. Evidence of the importance of serotonergic (5-HT) system in panic disorder (PD), however, has substanti ally increased in recent years. OBJECTIVE The objective of our study was to determine whether there was a specific personality profile of panic disorder patients and how it was related to possible neurobiological mechanisms underlying personality dimensions. PATIENTS AND METHODS Sample consisted of 14 inpatients with ICD-X diagnosis of panic disorder and 34 healthy control subjects. Personality dimensions were assessed by Minnesota Multiphasic Personality Inventory (MMPI-201) and Tridimensional Personality Questionnaire (TPQ). To assess central 5-HT function, platelet monoamine-oxidase (MAO) activity was measured. RESULTS In panic disorder group, higher scores of histrionic, depressive and hypochondriac subscales and significant increase of harm avoidance (HA) scale as well as low MAO activity were found. Negative correlation was established between MAO activity and psychopathic deviance MMPI scale. CONCLUSION The obtained results might indicate a specific personality profile of patients with panic disorder, which is characterized by high neuroticism, fearfulness, inhibition, shyness and apprehensive worry. Low MAO activity and high HA scores possibly indicate underlying hyperserotonergic state. The observed correlation between personality traits and MAO activity provide additional support for the hypothesized functional relationship between underlying central monoaminergic activity and temperament traits associated with anxiety, depression and impulsivity.
Psychosomatic concept of hyperthyroidism - Graves type: Behavioral and biochemical characteristics
Dragani?-Gaji? Saveta,Le?i?-To?evski Du?ica,?vraki? Dragan,PaunoviVladimir R.
Medicinski Pregled , 2008, DOI: 10.2298/mpns0808383d
Abstract: Introduction. In this study we test the hypothesis that specific behavioral and biochemical vulnerabilities characterize individuals with hyperthyroidism - Graves type, one of the classically cited 'psychosomatic disorders'. Material and methods. The sample included 24 subjects with Graves disease and 34 controls. All participants were evaluated for personality and temperament characteristics and for platelet MAO activity. A smaller group of panic disorder patients was tested with the same set of measures to ensure a validity of the study, especially regarding results on personality tests. RESULTS. Individuals with hyperthyroidism had lower platelet MAO activity and higher scores on histrionic (Hy), depressive (D) and hypochondriac (H) subscale on the MMPI-201 than normal controls. Their TPQ temperament scores were characterized by high Harm Avoidance, whereas other temperament traits were average. Platelet MAO activity was inversely correlated with the MMPI-201 psychopatic deviance scale (Pd) and positively correlated with the TPQ Reward Dependence scale. CONCLUSIONS. Our results provide support for the psychosomatic concept of Graves' disease. Personality features, temperament traits, and platelet MAO activity of hyperthyroid individuals are different from those in normal controls and correspond to those observed in anxiety disorders. We propose that the observed behavioral and biochemical similaritites between hyperthyroid and anxiety disorder patients represent an equicausality phenomenon, where the same underlying heritable factors, such as variable central monoaminergic activity coupled with temperament-related susceptibility to stress, facilitate phenotypic manifestation of a number of psychosomatic and psychiatric disorders - including Graves disease. The observed correlations between personality traits and MAO activity provide support for the hypothesized functional relationship between the underlying central monoaminergic activity and temperament traits associated with anxiety, depression, and impulsivity.
Differentiated thyroid cancer: Growth factors, oncogenes and environmental influences
Paunovi? Ivan R.
Archive of Oncology , 2003, DOI: 10.2298/aoo0303171p
Abstract: The present data of growth factors, oncogenes, tumor-suppressor-genes and environmental factors can be summarized in thus: thyrotropin, growth factors and other hormones do increase thyrocyte growth and specific mutations of growth factor receptors (thyrotropin receptor [TSH-R], alpha subunit of hetero-trimeric transducer protein [GSP]) cause autonomously functioning thyroid tissue and differentiated thyroid carcinoma. In the thyroid, as in other organs, genes that are found to be differentially expressed between normal thyroid tissue and thyroid carcinomas can be used as targets for molecular-based diagnosis and therapy. Deregulation of tumor suppressor gene p53, however, parallels dedifferentiation of papillary and follicular thyroid cancer but has been found in few cases only. Iodide inhibiting thyrocyte growth will have to be investigated more intensively after sodium-iodide-symporter (NIS) has been cloned, and studies may now be available that could lead to form of conservative treatment in especially dedifferentiated thyroid cancer.
Exposure Inhibition Therapy as a Treatment for Chronic Posttraumatic Stress Disorder: A Controlled Pilot Study  [PDF]
Nenad Paunovi
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.26093
Abstract: Exposure inhibition therapy as a treatment for chronic posttraumatic stress disorder (PTSD) is evaluated in a randomized treatment outcome pilot study. The exposure inhibition therapy is based on crucial parts of the behavioral-cognitive inhibition theory (Paunovi?, 2010). In this treatment primary incompatible respondent memories are utilized in order to 1) directly counter numbing and depressive symptoms, 2) incorporate the primary trauma memory into primary incompatible memories, and 3) inhibit primary respondent trauma memories. Twenty-nine crime victims with chronic PTSD were randomized to a group that received exposure inhibition therapy immediately (N = 14), or a wait-list control group (N = 15) that waited for 2.5 months and then received the treatment. The group that first received treatment improved significantly on PTSD symptoms, (CAPS, IES-R, PCL) depression (BDI), anxiety (BAI), posttraumatic cognitions of self, others and guilt (PTCI), and coping self-efficacy (CES) compared to the wait-list control group. The treatment efficacy was high for PTSD symptoms, depressive and anxiety symptoms, as well as on most cognitive measures. When the wait-list control group received treatment similar results were observed. Results were maintained at a 3-months follow-up in the treatment group, and on some measures improvement continued. Three empirically derived cut-off criteria (44, 39 27) were used for the CAPS, and one cut-off level for the BDI (10), in order to assess the clinical significance of the results. The majority of clients no longer fulfilled PTSD as a result of the treatment regardless of the level of cut-off criteria, and similar results were observed on the BDI. In conclusion, exposure inhibition therapy was an effective treatment for chronic PTSD in this study. A proposal is made to compare exposure inhibition therapy with the state-of-the-art therapy for chronic PTSD, i.e. exposure therapy. Several hypotheses are presented; e.g. that exposure inhibition therapy may be more effective for some symptoms, and involving less emotional pain in the therapeutic process.
Positional installation of contrast cystography: A new approach in the diagnosis of vesicoureteral reflux
Paunovi? Milan,Pavi?evi? Polina,Radlovi? Vladimir,Vukadinovi? Vojkan
Srpski Arhiv za Celokupno Lekarstvo , 2008, DOI: 10.2298/sarh0812617p
Abstract: INTRODUCTION Positional installation of contrast cystography (PIC cystography) represents a new method to identify vesicoureteral reflux (VUR) that is unrevealed by standard diagnostic procedures. It is performed by radiological examination of the vesicoureteral junction during cystoscopic installation of the contrast medium at the ureteral orifice. OBJECTIVE We studied the significance of PIC cystography to demonstrate VUR that failed to be revealed by standard voiding cystourethrography (MCUG), as well as the degree of the correlation of such a finding with endoscopic appearance and the position of the ureteral orifice (UO). METHOD The aim of the paper was to analyze a sample of 5 children (4 girls and 1 boy), aged 6-15 years (mean 9.8 years) with recurrent febrile urotract infections, complicated with scarring changes of the renal parenchyma and normal findings on MCUG. The grade of VUR demonstrated by PIC cystography was classified using the standard hydrodistensional scale. RESULTS All 5 patients had VUR, disclosed by PIC cystography, of whom in 4 it was unilateral and in one bilateral. Of 5 patients, 4 had VUR grade I and one grade II. All the children with VUR detected by PIC cystography also had evident cystoscopic abnormalities in the position and/or configuration of the ureteral orifice at the same side, while at the side with normal finding on PIC cystography, the endoscopic finding was also within normal limits. CONCLUSION PIC cystography is the method of choice in the confirmation of VUR as the cause of recurrent urotract infection and its complications in children with a normal finding on standard MCUG. In all our patients with VUR verified by PIC cystography, at the same side we also revealed endoscopic changes in the position and/or configuration of UO.
Microstructure evolution and phase transition in La/Mn doped barium titanate ceramics
Vesna Paunovi,Vojislav Miti?,Vladimir Pavlovi?,Miroslav Miljkovi?
Processing and Application of Ceramics , 2010,
Abstract: La/Mn codoped BaTiO3 with different La2O3 content, ranging from 0.1 to 5.0 at% La, was investigated regarding their microstructural and dielectric characteristics. The content of 0.05 at% Mn was constant in all investigated samples. The samples were sintered at 1320°C and 1350°C for two hours. Microstructural studies were done using SEM and EDS analysis. The fine-grained microstructure was obtained even for low content of La. The appearance of secondary abnormal grains with serrated features along grain boundaries was observed in 1.0 at% La-BaTiO3 sintered at 1350°C. Nearly flat permittivity-temperature response was obtained in specimens with 2.0 and 5.0 at% La. Using the modified Curie-Weiss law a critical exponent γ and C’were calculated. The obtained values of γ pointed out the diffuse phase transformation in heavily doped BaTiO3 and great departure from the Curie-Weiss law for low doped ceramics.
Characteristics of thyroid carcinoma in Graves' disease, chronic lymphocitic thyroiditis and nodular goiter
Filipovi? Aleksandar B.,Paunovi? Ivan R.
Acta Chirurgica Iugoslavica , 2003, DOI: 10.2298/aci0303135f
Abstract: The biology of thyroid cancer represents a spectrum of behavior ranging from well - differentiated lesions with an excellent prognosis to anaplastic carcinoma, wich is almost fatal. For this reason, it is important that clinicians have methods at their disposal to asses the characteristics of patient's thyroid malignancy. In this work we discuss the behavior of differentiated thyroid cancer in associated diseases of thyroid as : Graves’ disease, chronic lymphocitic thyroiditis - Hashimoto and nodular goiter. This is retrospectively reviewing of 50 patients treated for differentiated thyroid carcinoma at Department of surgery, Clinical Centre of Montenegro in Podgorica from 1998 until 2003. We evaluated occurrence, as well as the role of this diseases in patients with thyroid cancer.We found a more favorable course of thyroid cancer in the presence of chronic lymphocitic thyroiditis and nodular goiter, a contrary Graves’ disease. In associated diseases of thyroid, a significantly greater proportion of patients with thyroid cancer, have modular goiter.
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