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Search Results: 1 - 10 of 347753 matches for " Paulo Sávio Peixoto Maia "
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Forma e unidade como condi es de uma ciência pura: a influência do neokantismo de Marburgo no “primeiro” Hans Kelsen
Paulo Sávio Peixoto Maia
Sequência : Estudos Juridicos e Politicos , 2010,
Abstract: Um dos tra os mais marcantes da longa trajetória intelectual de Hans Kelsen foi a busca pela constru o de um conhecimento jurídico puro, isento de qualquer considera o a respeito do conteúdo do direito. A compreens o desse leitmotiv depende do exame da primeira fase metodológica de Kelsen, aquela em que o neokantismo de Marburgo aparecia como sua principal referência. é ent o que surge, em Kelsen, a redu o da normatividade à pertinência a um sistema lógico dotado de unidade e coerência. Só assim o conhecimento jurídico poderia ser considerado válido, científico; um argumento que se fará muito presente no restante da atividade intelectual de Kelsen. Dessa forma, entender esse “primeiro” Kelsen, aquele Kelsen neokantiano, acaba por ser uma pré-condi o para uma compreens o mais completa da obra do jurista de Viena.Abstract: One of the most leading features of Hans Kelsen’s long intellectual trajectory was the persecution for the construction of a pure juridical knowledge; free from any kind of consideration in what concern its content. The comprehension of this leitmotiv depends on the exam of the Kelsen’s first methodological phase, the one that the neo-kantism was his main reference. Insomuch appears Kelsen’s reduction of the normativity in the pertinence to a logical system endowed with unity, coherence. Only in this way the juridical knowledge may be considered as valid and proper to the science; an argument that will be very present in the rest of Kelsen’s intellectual activity. Thereby understanding this “first” Kelsen, the neo-kantian one, results to be a precondition to a more complete comprehension of the work of the Vienna’s jurist.
Aspectos clínico-patológicos e laboratoriais do envenenamento crotálico experimental em bovinos
Gra?a, Flávio A.S.;Peixoto, Paulo V.;Coelho, Cleide D.;Caldas, Saulo A.;Tokarnia, Carlos Hubinger;
Pesquisa Veterinária Brasileira , 2008, DOI: 10.1590/S0100-736X2008000600001
Abstract: crotalus poisoning was experimentally reproduced by subcutaneous inoculation of crotalus durissus terrificus (south american rattlesnake) venom into 10 clinically healthy mixed bred 12 to 36-month-old cattle, weighing 125 to 449 kg. two animals were used as controls. the animal that received a dose of 0.03mg/kg body weight died 7h40min after inoculation. a 0.015mg/kg dose provoked death in 4 out of 7 young oxen. two animals given 0.0075mg/kg became slightly sick and recovered. onset of symptoms occurred from 1h30min to 13h45min after inoculation. the clinical course varied from 5h25min to 45h for animals that died, and from 33h15min to 17 days for animals that recovered. the main nervous signs observed were diminished response to external stimuli, hypotonic reflexes, dragging of the hooves, apathy, difficulties in moving around obstacles, ocular globe paralysis, lateral and sternal decubitus, and tongue paralysis. adipsia and sometimes petechiae in the conjunctival and vaginal mucosa were observed. a slight to moderate increase in bleeding time was noted in 6 animals, and a moderate increase in partial thromboplastin time was found in 7 others. moderate leukocytosis with neutrophilia, relative lymphopenia, eosinopenia, and monocytosis was found. there was a significant increase in creatine kinase serum levels of a ten-fold order. no significant alterations were revealed by urinalysis. necropsy revealed minimal edema at the inoculation site, few petechiae and equimoses in the epicardium, omentum, biliary vesicle and bladder mucosa of some animals. histopathological examination revealed necrosis (hyalinization) of groups or isolated myocytes in different muscles examined, both near and far from the inoculation site, in all animals. the diagnosis of crotalus poisoning and its differentiation from diseases causing paralysis and muscular necrosis in cattle in brazil are discussed.
Aspectos clínico-patológicos e laboratoriais do envenenamento experimental por Bothrops alternatus em bovinos
Caldas, Saulo A.;Tokarnia, Carlos H.;Fran?a, Ticiana N.;Brito, Marilene F.;Gra?a, Flávio A.S.;Coelho, Cleide D.;Peixoto, Paulo V.;
Pesquisa Veterinária Brasileira , 2008, DOI: 10.1590/S0100-736X2008000600008
Abstract: the aim of this study was to determine the clinical-pathological alterations and laboratory findings in cattle inoculated with bothrops alternatus venom, with the intention of providing information for the establishment of diagnosis and differential diagnosis procedures, as well as to elucidate some obscurities observed in the pertinent literature. the lyophilized venom was diluted in 1 ml of physiologic solution. it was administered to 5 bovines by the subcutaneous route at doses of 0.0625, 0.125 and 0.25mg/kg body weight, and to 2 bovines by the intramuscular route at doses of 0.25 e 0.45mg/kg. six bovines died and the only animal that survived, who had subcutaneously received the venom at a dose of 0.0625mg/kg, recovered. the first clinical signs were observed from 25min to 5h30min after the inoculation. the clinical evolution time varied from 7 hours 18 minutes to 92 hours. regardless of the dose, the clinical picture was characterized by swelling (hemorrhage/hematoma) at the site of inoculation, increase in bleeding time and capillary refill time, paleness of mucous membranes and apathy. the laboratory exams revealed progressive normocytic normochromic anemia, thrombocytopenia, reduction in fibrinogen and total plasma proteins, decreased hematocrit and hemoglobin, and slight increase in creatine kinase and lactate dehydrogenase. when subjected to necropsy, the animals that received the venom through the subcutaneous route showed large hematomas and hemorrhagic areas in the subcutaneous tissue, extending from the site of inoculation. the animals in which inoculation was performed intramuscularly exhibited, in addition, intramuscular hemorrhage. the left endocardium showed extensive hemorrhagic lesions, and petechiae were found on the serosae of rumen, omasum, abomasum and gall bladder. the colon, rectum and perirenal areas were surrounded by clotted blood in three animals. besides hemorrhage, the histological examination revealed hemorrhage and coagulative muscl
Envenenamento experimental por Bothropoides jararaca e Bothrops jararacussu em ovinos: aspectos clínico-patológicos e laboratoriais
Arag?o, Ana Paula;Tokarnia, Carlos H.;Gra?a, Flávio A.S.;Fran?a, Ticiana N.;Coelho, Cleide D.;Caldas, Saulo A.;Peixoto, Paulo V.;
Pesquisa Veterinária Brasileira , 2010, DOI: 10.1590/S0100-736X2010000900003
Abstract: the purpose of this study was to establish the clinic-pathological and laboratory changes in sheep inoculated with bothropoides jararaca and bothrops jararacussu venom to provide subsidies for the differential diagnosis of snake bites. the liofilized venoms were diluted in 1 ml saline and administrated subcutaneously to four sheep. three of the animals died, and the one that received 0.5mg/kg (b. jararaca venom) recovered. first symptoms were observed from 7 minutes to 1 hour after inoculation, and the clinical course varied from 7 hours and 9 minutes to 21 hours and 59 minutes. the symptoms, independent of the dosage, were swelling of the inoculation site, increased bleeding time and capillary filling, tachycardia, dyspnea, pale mucous membranes and diminished reaction to external stimuli. laboratory tests revealed pronounced normocytic and normochromic anemia, trombocytopenia, slight reduction of fibrogen and total plasmatic protein, in two animals diminished hematocrit, besides pronounced increase of creatinaquinase and lactic dehydrogenase. at necropsy, the main findings at the inoculation site and adjacent tissues were extensive hemorrhages in the sheep inoculated with jararaca venom, and predominantly edema in the two animals inoculated with jararacussu venom. in two sheep which received jararacussu venom, acute pulmonary edema was observed. hemorrhage and edema as the main histopathological changes, besides necrosis of muscle fibers and vessels at the inoculation site and adjacent tissue was observed. the renal tubular necrosis was attributed to shock. the volume increase at the inoculation site and surroundings was mainly due to hemorrhage (b. jararaca) or edema (b. jararacussu).
Parametros genéticos de características reprodutivas de touros e vacas Gir leiteiro
Santana Júnior, Mário Luiz;Lopes, Paulo Sávio;Verneque, Rui da Silva;Pereira, Rodrigo Junqueira;Lagrotta, Marcos Rodrigues;Peixoto, Maria Gabriela Campolina Diniz;
Revista Brasileira de Zootecnia , 2010, DOI: 10.1590/S1516-35982010000800013
Abstract: this work aimed to estimate genetic parameters for age at first calving, scrotal circumference, and seminal traits, and to evaluate genetic trend for age at first calving for dairy gyr breed animals by analyzing data of 7,055 females and 97 males from several brazilian herds. covariance components were estimated by using the restricted maximum likelihood method under animal model in univariate analyses. the model for seminal traits included the company-year-season of semen collection fixed effects, age at the collection as a covariate, linear and quadratic effects. for scrotal circumference, it was included year of birth, age class at measurement, and insemination company fixed effects. for age at first calving, it was included herd-year-season of birth fixed effects and animal and residual random effects. the heritabilities for scrotal circumference and age at first calving were, respectively, 0.37 and 0.22. the genetic trend of age at first calving was significant, with estimated value of -0.018 month/year and it shows that genetic progress in this trait practically did not occur over the studied years. the genetic correlations from bivariate analyses among scrotal circumference with volume, concentration, vigor, motility, major, minor, and total defects, number of doses, total number of feasible spermatozoid and age at first calving were 0.33, 0.22, 0.91, 0.86, -0.07, -0.03, -0.04, 0.30, 0.23 and -0.37, respectively. these results suggest improvements in reproductive efficiency of females when they are used in herds with bulls with greater scrotal circumference.
Association between insulin-like growth factor I (IGF-I) microsatellite polymorphisms and important economic traits in pigs
Faria, Danielle Assis de;Peixoto, Jane de Oliveira;Lopes, Paulo Sávio;Paiva, Samuel Rezende;Silva, Priscila Vendramini;Guimar?es, Simone Eliza Facioni;
Revista Brasileira de Zootecnia , 2009, DOI: 10.1590/S1516-35982009000200007
Abstract: this study investigated the association between igf-i microsatellite marker in an f2 population (n=459) generated by mating of native boars to brazilian commercial sows with performance, carcass cut, and meat quality traits. association analyses were carried out using a statistical model that included genotype, sex, and group as fixed effects and sire as random effect. the igf-i genotypes were significantly associated with different quantitative traits and these results corroborate with previous qtl analyses obtained for this chromosome region in swine. additive and dominance effects, as well as a genotype-sex interaction, were estimated and discussed in the text. according to the results obtained, this marker is suitable for qtl search in the genotyped population.
Association between leptin gene single nucleotide polymorphisms and carcass traits in pigs
Peixoto, Jane de Oliveira;Faria, Danielle Assis de;Silva, Priscila Vendramini;Fonseca, Isabela;Lopes, Paulo Sávio;Guimar?es, Simone Eliza Facioni;
Revista Brasileira de Zootecnia , 2009, DOI: 10.1590/S1516-35982009000200008
Abstract: it was investigated the association between leptin gene single nucleotide polymorphisms (snps) t2411c and t3266g with carcass traits in f2 pigs obtained by crossing native brazilian piau with commercial sows composed of landrace, large white and pietrain breeds. association analyses were performed using a statistical model that included genotype, sex, and batch as fixed effects, sire and error as random effects. the t2411c snp was associated with skinless and fatless boston shoulder weight (bsw), backfat thickness at last rib, 6.5 cm from the midline (p2), skinless and fatless picnic shoulder weight, and sirloin weight (slw). the t3266g mutation was associated with slaughter age, bacon weight, bsw, midline backfat thickness between last and last but one lumbar vertebra, midline backfat thickness at last rib, p2 and rib weight. phenotypic associations were also performed by combining genotypes for both snps. associations with p2, carcass yield, total boston shoulder weight, and slw were observed. the results obtained demonstrate that the snps analyzed have potential to be explored as markers for carcass composition in pigs.
Relationship between the Porcine Stress Syndrome gene and carcass and performance traits in F2 pigs resulting from divergent crosses
Band, Guilherme de Oliveira;Guimar?es, Simone Eliza Facioni;Lopes, Paulo Sávio;Peixoto, Jane de Oliveira;Faria, Danielle Assis;Pires, Aldrin Vieira;Figueiredo, Frederico de Castro;Nascimento, Carlos Souza do;Gomide, Lúcio Alberto de Miranda;
Genetics and Molecular Biology , 2005, DOI: 10.1590/S1415-47572005000100016
Abstract: the pss genotypes of 596 f2 pigs produced by initial mating of brazilian native boars commercial sows and were characterized by pcr-rflp and their carcass and performance traits were evaluated. among the 596 animals analyzed, 493 (82.72%) were characterized as nn and 103 (17.28%) as nn. with respect to carcass traits, nn animals presented higher (p < 0.05) right half carcass weight, left half carcass weight, loin depth and loin eye area, and lower shoulder backfat thickness, backfat thickness between last and next to last but one lumbar vertebrae and backfat thickness after last rib at 6.5 cm from the midline compared to nn animals. nn animals also showed (p < 0.05) higher values for most of the cut yields, indicating higher cutting yields for animals carrying the n allele and lower values for bacon depth, confirming lower fat deposition in carcass. in addition, nn animals presented (p < 0.05) lower values for the performance trait weight at 105 days of age. these results indicate that animals carrying the pss gene generate leaner carcasses, higher cut yields, and that the effects of the gene can be observed even in divergent crosses.
Uso da itera??o nos dados para resolu??o de equa??es de modelo misto
Lopes, Paulo Sávio;
Revista Brasileira de Zootecnia , 2000, DOI: 10.1590/S1516-35982000000200017
Abstract: breeding values were predicted by iterating on data using reduced animal model. body weight at 35 days of age from two lines of meat-type chickens was measured in two generations and data file was consisted on 1044 parents (base population), 829 progeny parents and 9039 progeny non-parents. the number of iterative rounds and processing time for mixed model equations solutions via iterating on data were evaluated using seven convergence criteria (101 to 10-5). a total of six rounds of iteration and 9 s of time and 158 rounds and 5 min and 38 s were required to reach the solutions for 101 and 10-5 convergence criteria, respectively. the correlation between predicted breeding values were perfect (r=1,00) and there were no significant differences between estimated genetic trends using 10-1 to 10-5 as a convergence criteria. based on these results, it was concluded that iterating on data could be efficiently used for animal genetic evaluation in microcomputer without great computational requirements.
Uso da itera o nos dados para resolu o de equa es de modelo misto
Lopes Paulo Sávio
Revista Brasileira de Zootecnia , 2000,
Abstract: Valores genéticos foram preditos usando-se a itera o nos dados em um modelo animal reduzido. O peso corporal, aos 35 dias de idade, de duas linhas de aves de corte foi medido em duas gera es, cujo arquivo de dados consistia de 1044 pais (popula o-base), 829 progênies-pais e 9039 progênies-n o-pais. O número de itera es e o tempo de processamento, para obten o das solu es das equa es de modelo misto via itera o nos dados, foram avaliados por sete critérios de convergência (101 a 10-5 ). Seis itera es foram necessárias, com 9 s de tempo, e 158 itera es, com 5 min e 38 s, para se obterem as solu es para os critérios de convergência de 101 e 10-5, respectivamente. As correla es entre os valores genéticos preditos foram perfeitas (r=1,00), e n o houve diferen as entre as tendências genéticas estimadas pelos critérios de convergência de 10-1 a 10-5. Com base nestes resultados, conclui-se que a itera o nos dados pode ser eficientemente usada em microcomputadores, na avalia o genética animal, sem grande demanda de tempo e memória computacional.
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