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Search Results: 1 - 10 of 646 matches for " Pauline Louche "
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Dendritic Cells Crosspresent Antigens from Live B16 Cells More Efficiently than from Apoptotic Cells and Protect from Melanoma in a Therapeutic Model
Diana Matheoud,Camille Baey,Lene Vimeux,Andy Tempez,Michael Valente,Pauline Louche,Agnès Le Bon,Anne Hosmalin,Vincent Feuillet
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019104
Abstract: Dendritic cells (DC) are able to elicit anti-tumoral CD8+ T cell responses by cross-presenting exogenous antigens in association with major histocompatibility complex (MHC) class I molecules. Therefore they are crucial actors in cell-based cancer immunotherapy. Although apoptotic cells are usually considered to be the best source of antigens, live cells are also able to provide antigens for cross-presentation by DC. We have recently shown that prophylactic immunotherapy by DC after capture of antigens from live B16 melanoma cells induced strong CD8+ T-cell responses and protection against a lethal tumor challenge in vivo in C57Bl/6 mice. Here, we showed that DC cross-presenting antigens from live B16 cells can also inhibit melanoma lung dissemination in a therapeutic protocol in mice. DC were first incubated with live tumor cells for antigen uptake and processing, then purified and irradiated for safety prior to injection. This treatment induced stronger tumor-specific CD8+ T-cell responses than treatment by DC cross-presenting antigens from apoptotic cells. Apoptotic B16 cells induced more IL-10 secretion by DC than live B16 cells. They underwent strong native antigen degradation and led to the expression of fewer MHC class I/epitope complexes on the surface of DC than live cells. Therefore, the possibility to use live cells as sources of tumor antigens must be taken into account to improve the efficiency of cancer immunotherapy.
Unconfused Ultraconservative Multiclass Algorithms
Ugo Louche,Liva Ralaivola
Computer Science , 2014,
Abstract: We tackle the problem of learning linear classifiers from noisy datasets in a multiclass setting. The two-class version of this problem was studied a few years ago by, e.g. Bylander (1994) and Blum et al. (1996): in these contributions, the proposed approaches to fight the noise revolve around a Perceptron learning scheme fed with peculiar examples computed through a weighted average of points from the noisy training set. We propose to build upon these approaches and we introduce a new algorithm called UMA (for Unconfused Multiclass additive Algorithm) which may be seen as a generalization to the multiclass setting of the previous approaches. In order to characterize the noise we use the confusion matrix as a multiclass extension of the classification noise studied in the aforementioned literature. Theoretically well-founded, UMA furthermore displays very good empirical noise robustness, as evidenced by numerical simulations conducted on both synthetic and real data. Keywords: Multiclass classification, Perceptron, Noisy labels, Confusion Matrix
From Cutting Planes Algorithms to Compression Schemes and Active Learning
Liva Ralaivola,Ugo Louche
Computer Science , 2015,
Abstract: Cutting-plane methods are well-studied localization(and optimization) algorithms. We show that they provide a natural framework to perform machinelearning ---and not just to solve optimization problems posed by machinelearning--- in addition to their intended optimization use. In particular, theyallow one to learn sparse classifiers and provide good compression schemes.Moreover, we show that very little effort is required to turn them intoeffective active learning methods. This last property provides a generic way todesign a whole family of active learning algorithms from existing passivemethods. We present numerical simulations testifying of the relevance ofcutting-plane methods for passive and active learning tasks.
Unconfused ultraconservative multiclass algorithms
Ugo Louche,Liva Ralaivola
Computer Science , 2015, DOI: 10.1007/s10994-015-5490-3
Abstract: We tackle the problem of learning linear classifiers from noisy datasets in a multiclass setting. The two-class version of this problem was studied a few years ago where the proposed approaches to combat the noise revolve around a Per-ceptron learning scheme fed with peculiar examples computed through a weighted average of points from the noisy training set. We propose to build upon these approaches and we introduce a new algorithm called UMA (for Unconfused Multiclass additive Algorithm) which may be seen as a generalization to the multiclass setting of the previous approaches. In order to characterize the noise we use the confusion matrix as a multiclass extension of the classification noise studied in the aforemen-tioned literature. Theoretically well-founded, UMA furthermore displays very good empirical noise robustness, as evidenced by numerical simulations conducted on both synthetic and real data.
Usefulness of Natural Starters in Food Industry: The Example of Cheeses and Bread  [PDF]
Demarigny Yann, Gerber Pauline
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.517181
Abstract: Natural starters have been extensively used for many centuries to make many different fermented food products from different raw materials: Milk, meat, roots, vegetables, etc. The industrialisation of food production at the end of the 19th century necessitated the use of regular selected starters to standardize the organoleptic characteristics of the final product. As a consequence, during the 20th century, there was a decline in the use of natural starters in Western countries except in the production of local cheeses or sourdough breads. The beginning of this new millennium has witnessed a deep change in consumer demand, in pursuit of quality, safety and pleasure. In this context, natural starters could, in the future, play an important role in the development of fermented products. However, food producers and researchers have first to cope with fundamental problems in the understanding of these complex ecosystems. The dynamic evolution of the microbial population inside the natural starter (its resilience, its genetic and physiological aptitudes) and the consequences on the product are still partially unknown. This document reviews a broad range of articles concerning the use of natural starters with a specific focus on cheeses and breads, and discusses the major stakes for local food production and the consumption of typical products.
Guardians and Targets: A Routine Activity Approach to Terrorism in Southeast Asia  [PDF]
Camille Laurence Pauline Bigot
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.512011
Abstract:
Since 9/11, terrorism has been an important subject of study within the political and social fields, having often been examined critically. However, empirical frameworks have been lacking within the study of terrorism. This paper aims to counter reductionist views of terrorism and provide a holistic analysis under the arch of a criminological ontological framework. This study tests the relevance of routine activity theory to terrorism, taking the specific case study of terrorism within Southeast Asia. Working with Interpol, terror attacks, and counter-terrorism operations were quantified to mathematically model Routine Activity Theory where I aimed to find predictive terror patterns. Using a time-series analysis of terrorist attacks and counter-terrorism operations, Deterrence Theory, Randomness Theory in targeting and Contagion theory will be tested. A comparative framework will be established between religious attacks and politically related ones. My research aims to disprove any discursive assumptions of terrorism through a quantitative empirical focus. Furthermore, it aims to find patterns within terrorism to learn how to better combat it.
Deployment of Soft Skills for Effective Customer Service in the 21st Century Library  [PDF]
Adeniran Pauline Oghenekaro
Journal of Computer and Communications (JCC) , 2018, DOI: 10.4236/jcc.2018.63003
Abstract: The advent of information communication technology in the information environment has brought dramatic changes in the way information is being handled and managed today. This wind of change engineered by ICT has also changed the information seeking behavior of users making them to place more demands on libraries. There is a need for libraries to strive to be effective in their services to customers in order to remain relevant in the information age. The paper considered the deployment of soft skills expressed in terms of staff appearance, approachability, effective communication, positive attitude, ability to cope in difficult situation, and so on, for more effective customer services in the 21st century library. The paper concluded that, effective customer service in libraries is imperative in the 21st century library as it will make library users feel important, improves learning, increases patronage, and promotes library and university image. The outcome of this paper will help the management of libraries irrespective of the type to be more effective in the services they render to their clients. This will ultimately increase patronage and clients retention.
The Hydrodynamism of the Coastal Aquifer System Belonging to the Southern Border of the Rharb Basin (Morocco)
Lahcen Zouhri,Brahim Ben Kabbour,Christian Gorini,Barbara Louche
Journal of Applied Sciences , 2005,
Abstract: The present study examines the hydrodynamism of the southern border of the Rharb basin. The groundwater system is characterized by two piezometric families marked by stable and unstable groundwater behaviours. The analysis and the interpretation of the piezometric levels are concentrated on the most informative piezometers. Between 1988 and 1998, the study reveals a variability in the piezometric levels according to different sectors of the coastal zone. The piezometric levels vary globally from +1.6 to +5.88 m in the northern sector (Ns), +0.5 to +4.5 m in the central sector (Cs) and +1.9 to +25.73 m in the southern sectors (Ss). The lateral repartition of the transmissivity values is materialized by a heterogeneous distribution (1,5.10-1 to 2,8.10-3 m2s-1 in the coastal part with an average is about 5.10-2 to 4,9.10-3 m2s-1). The causes of piezometric level variations are related firstly to the combination of deductions and pumping effects to supply in drinking water, towns and the industrial sector. They are also related to the geometry of the aquifer, that displays an important role in the knowledge of these variations and the aquifer functioning.
LA TEORíA DE LOS MERCADOS DE CAPITALES EFICIENTES. UN EXAMEN CRíTICO
Hyme,Pauline;
Cuadernos de Economía , 2003,
Abstract: e. fama published an article in 1970 about " the theory of efficient capital markets" which had -and still has- a strong impact on finance. this article shows that fama′s theory has little to do with efficiency as understood by economists. all that fama really did was give a new name to a theory which had been around for more than a century, according to which the stock exchange is an " equitative game" or a martingale, as shown by samuelson, conditioned by supposing expectations′ homogeneity. what fama said about efficiency can only be explained by ideological reasoning, since it was proposed as part of the " new classics" anti-keynesian offensive launched during the 1970s.
‘Children and fools, they say, cannot lie’: un dicton tourné en plaisanterie dans Misogonus d’Anthony Rudd ‘Children and fools, they say, cannot lie’: a Proverb Turned Upside Down in Anthony Rudd’s Misogonus
Pauline Blanc
Revue LISA / LISA e-journal , 2009, DOI: 10.4000/lisa.395
Abstract: In the play entitled Misogonus that is attributed to Anthony Rudd by one of its editors, Lester E. Barber, the Vice-character, Cacurgus, stands out as a virtuoso performer even though he merely demonstrates a moral lesson. The double-dealing servant of two masters, Cacurgus goes out of his way to prove the ill-founded premises of the saying “Children and fools, they say, cannot lie”. He deceives both of his masters, but remains loyal to his audience for whom he performs a highly entertaining play. The two aspects of his role are shown to be quite distinct as he intervenes on the outside and inside of two separate plots in which the twists and turns of a devious mind are displayed as being a series of disagreeable tricks played upon a group of malleable, credulous victims.
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