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Search Results: 1 - 10 of 335604 matches for " Paula; Moyano S "
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Influencia de componentes de la matriz extracelular en la agresividad y potencial invasor del cáncer cérvicouterino: ?Qué hay de nuevo?
Segura H,Paula; Moyano S,Leonor;
Revista chilena de obstetricia y ginecología , 2011, DOI: 10.4067/S0717-75262011000500012
Abstract: squamous cell carcinoma of the cervix (scc) is a pathology that has high incidence and mortality. so far, research has been focused in the study of its association with papilloma virus. however, knowledge about extracellular matrix (ecm) has given a new perspective for the study of factors that induce or perpetuate neoplasms. in epithelial neoplasms like scc, the tumoral stroma exhibits a dynamic composition of cellular elements, highlighting the presence of alpha actin of smooth muscle positive myofibroblasts (asma+) and cd34+ fibrocytes. ecm has an essential role, because it not only provides the appropriate conditions for tumor's development, but also affects stromal cell population phenotype, where a loss of cd34+ fibrocytes associated with a gain of αsma+ myofibroblasts could be a sensitive indicator of stromal invasion, even in early stages. tgf-βι does it in the same way, as its presence is a reflection of the synthesis of αsma+. a new element is versican, a proteoglycan whose v0 and v1 isoforms expression is also observed in neoplastic tissues of ovary, breast and brain tumors, among others. it plays an important role in the phenomena of cellular adhesion, proliferation, migration and assembly of the ecm. therefore, the analysis of the stroma adjacent to epithelial injuries of the cervix can complement the knowledge about the biological conducts of these, constituting a powerful diagnostic tool, as a complement to the elements used nowadays.
Influencia de componentes de la matriz extracelular en la agresividad y potencial invasor del cáncer cérvicouterino: Qué hay de nuevo?
Paula Segura H,Leonor Moyano S
Revista Chilena de Obstetricia y Ginecología , 2011,
Abstract: El cáncer cérvico uterino (CCU) es una patología de alta incidencia y mortalidad. La investigación hasta ahora se ha enfocado en estudiar su asociación con virus papiloma. Sin embargo, el estudio de la matriz extracelular (MEC) ha dado una nueva perspectiva para el estudio de factores inductores o perpetuadores de las neoplasias. En las neoplasias epiteliales como CCU el estroma tumoral presenta una composición dinámica de elementos celulares, destacando la presencia de miofibroblastos positivos a alfa actina de músculo liso (aSMA+) y fibrocitos CD34+. La MEC tiene un papel fundamental, ya que no sólo otorga las condiciones apropiadas para el desarrollo del tumor, sino que además condiciona el fenotipo de la población celular del estroma, donde la pérdida de fibrocitos CD34+ asociada a una ganancia de miofibroblastos αSMA+ podría ser un indicador muy sensible de invasión estromal, incluso en estadios iniciales. De la misma forma lo hace TGF-βΙ, ya que su presencia es un reflejo de la síntesis de αSMA. Un nuevo elemento es versicán, un proteoglicano cuyas isoformas V0 y V1 se expresan también en tejidos neoplásicos de tumores ováricos, mama y cerebro, entre otros. Desempe a un papel muy importante en los fenómenos de adhesión celular, proliferación, migración y ensamblaje a la MEC. Por lo tanto, el análisis del estroma adyacente a las lesiones epiteliales del cuello uterino puede complementar el conocimiento sobre la conducta biológica de éstas, constituyendo una poderosa herramienta diagnóstica, de forma complementaria a los elementos utilizados hasta ahora. Squamous cell carcinoma of the cervix (SCC) is a pathology that has high incidence and mortality. So far, research has been focused in the study of its association with papilloma virus. However, knowledge about extracellular matrix (ECM) has given a new perspective for the study of factors that induce or perpetuate neoplasms. In epithelial neoplasms like SCC, the tumoral stroma exhibits a dynamic composition of cellular elements, highlighting the presence of alpha actin of smooth muscle positive myofibroblasts (aSMA+) and CD34+ fibrocytes. ECM has an essential role, because it not only provides the appropriate conditions for tumor's development, but also affects stromal cell population phenotype, where a loss of CD34+ fibrocytes associated with a gain of αSMA+ myofibroblasts could be a sensitive indicator of stromal invasion, even in early stages. TGF-βΙ does it in the same way, as its presence is a reflection of the synthesis of αSMA+. A new element is versican, a proteoglycan whose V0 and V1 isofo
Detección de marcadores de malignidad en nódulos tiroideos por transcripción reversa y reacción en cadena de la polimerasa (RT-PCR)
Pineda B,Pedro; Rojas G,Paula; Liberman G,Claudio; Moyano S,Leonor; Goecke S,Irmgadt;
Revista médica de Chile , 2003, DOI: 10.4067/S0034-98872003000900001
Abstract: nodular thyroid disease is a very common disorder with a low frequency of malignancy. the most accurate diagnostic test is fine needle aspiration biopsy (fnab) of nodules with cytological analysis of the sample. however, this procedure has some limitations in the diagnosis of follicular and papillary thyroid carcinoma. aim: to detect mrna from specific malignancy markers in thyroid nodules and to evaluate their potential correlation with cytological and pathological diagnosis. patients and methods: in 20 patients with thyroid nodules fnab was performed prior to surgery. the main part of the fnab sample was used to perform classical cytology. in the remaining of the sample were detected muc-1, cd26, galectin-3 and tsh receptor mrnas by rt-pcr technique. results: eight patients had positive cytology for papillary cancer; which was confirmed by pathology. nine had suspicious or non conclusive cytological findings and 3 were negative for neoplastic cells; all 12 were pathologically benign. we detected tsh receptor and galectin-3 mrna in almost all benign and malignant nodules. muc-1 was present in 5/8 papillary carcinoma (62.5%), and 1/12 benign nodules (8.3%). cd26 was detected in 7/8 papillary carcinomas but also in 8/12 benign nodules. conclusions: rt-pcr can be performed in very small samples of thyroid tissue to detect several mrna markers. muc-1 can be a potentially useful marker of malignancy in thyroid nodules. it can be detected by rt-pcr as a complementary technique in the diagnostic evaluation of thyroid nodules
Detección de marcadores de malignidad en nódulos tiroideos por transcripción reversa y reacción en cadena de la polimerasa (RT-PCR) Detection of malignancy markers in thyroid nodules by reverse transcriptase polymerase chain reaction (RT-PCR)
Pedro Pineda B,Paula Rojas G,Claudio Liberman G,Leonor Moyano S
Revista médica de Chile , 2003,
Abstract: Nodular thyroid disease is a very common disorder with a low frequency of malignancy. The most accurate diagnostic test is fine needle aspiration biopsy (FNAB) of nodules with cytological analysis of the sample. However, this procedure has some limitations in the diagnosis of follicular and papillary thyroid carcinoma. Aim: To detect mRNA from specific malignancy markers in thyroid nodules and to evaluate their potential correlation with cytological and pathological diagnosis. Patients and methods: In 20 patients with thyroid nodules FNAB was performed prior to surgery. The main part of the FNAB sample was used to perform classical cytology. In the remaining of the sample were detected MUC-1, CD26, galectin-3 and TSH receptor mRNAs by RT-PCR technique. Results: Eight patients had positive cytology for papillary cancer; which was confirmed by pathology. Nine had suspicious or non conclusive cytological findings and 3 were negative for neoplastic cells; all 12 were pathologically benign. We detected TSH receptor and galectin-3 mRNA in almost all benign and malignant nodules. MUC-1 was present in 5/8 papillary carcinoma (62.5%), and 1/12 benign nodules (8.3%). CD26 was detected in 7/8 papillary carcinomas but also in 8/12 benign nodules. Conclusions: RT-PCR can be performed in very small samples of thyroid tissue to detect several mRNA markers. MUC-1 can be a potentially useful marker of malignancy in thyroid nodules. It can be detected by RT-PCR as a complementary technique in the diagnostic evaluation of thyroid nodules
Relación entre el feedback emocional, feedback cognitivo-verbal y percepción emocional en la variante frontal de demencia frontotemporal resultados preliminares
Calodolce,Florencia; Politis,Daniel; Moyano,Paula;
Anuario de investigaciones , 2008,
Abstract: several studies found dissociations, both between social cognition tests among themselves, and between these and those evaluating executive functions, which supports the idea that emotional feedback, emotional perception and verbal-cognitive feedback are independent cognitive domains. nevertheless in present literature there is a controversy respect to that dissosciation. with the objective to study the relation between these processes a group of 15 subjects with frontal variant of frontotemporal dementia (dftvf), was evaluated with a neuropsycological battery and in addition using: wisconsin card sorting test (wcst), iowa gamblig task (igt) and the reading the mind in eyes test (lmo). there was found: an inverse correlation between igt and wcst, a direct correlation between lmo and wcst and a lack of correlation between igt and lmo. these results support the hypothesis that the studied cognitive domains are dissociated (bechara,a., damasio, a.r. y lough, s.).
Trastorno generalizado del desarrollo no especificado: Una reflexión sobre este diagnóstico Pervasive developmental disorder not otherwise specified: A reflection on the diagnosis
Angélica Sandoval,Andrea Moyano,Paula Barrera
Revista Chilena de Neuro-Psiquiatría , 2012,
Abstract:
Violencia de género sobre inmigrantes en Espa a. Un análisis psicosocial
Pilar Monta?és,Manuel Moyano
Pensamiento Psicológico , 2006,
Abstract: En este artículo se analiza la violencia de género perpetrada sobre mujeres inmigrantes en Espa a desde un marco psicosocial. Se persiguen fundamentalmente tres objetivos globales. Primero, revisar algunos de los datos estadísticos más significativos de los que disponemos en nuestro país. Segundo, describir los factores psicológicos y sociales relacionados con el problema, la especial vulnerabilidad de este colectivo, así como las barreras a las que sistemáticamente tiene que enfrentarse. Y, tercero, ofrecer una visión de la prostitución como un ejemplo evidente de violencia de género, del que son víctimas un importante número de mujeres inmigrantes. Finalmente, se discuten las aportaciones más importantes realizadas desde las ciencias sociales y del comportamiento en general, y de la Psicología en particular, proponiendo posibles iniciativas investigadoras para el futuro
Melting of Lennard-Jones rare gas clusters doped with a single impurity atom
Nicolás Quesada,Gloria E. Moyano
Physics , 2010, DOI: 10.1103/PhysRevB.82.054104
Abstract: Single impurity effect on the melting process of magic number Lennard-Jones, rare gas, clusters of up to 309 atoms is studied on the basis of Parallel Tempering Monte Carlo simulations in the canonical ensemble. A decrease on the melting temperature range is prevalent, although such effect is dependent on the size of the impurity atom relative to the cluster size. Additionally, the difference between the atomic sizes of the impurity and the main component of the cluster should be considered. We demonstrate that solid-solid transitions due to migrations of the impurity become apparent and are clearly differentiated from the melting up to cluster sizes of 147 atoms.
Evolving learning rules and emergence of cooperation in spatial Prisoner's Dilemma
Luis G. Moyano,Angel Sánchez
Quantitative Biology , 2008,
Abstract: In the evolutionary Prisoner's Dilemma (PD) game, agents play with each other and update their strategies in every generation according to some microscopic dynamical rule. In its spatial version, agents do not play with every other but, instead, interact only with their neighbors, thus mimicking the existing of a social or contact network that defines who interacts with whom. In this work, we explore evolutionary, spatial PD systems consisting of two types of agents, each with a certain update (reproduction, learning) rule. We investigate two different scenarios: in the first case, update rules remain fixed for the entire evolution of the system; in the second case, agents update both strategy and update rule in every generation. We show that in a well-mixed population the evolutionary outcome is always full defection. We subsequently focus on two-strategy competition with nearest-neighbor interactions on the contact network and synchronized update of strategies. Our results show that, for an important range of the parameters of the game, the final state of the system is largely different from that arising from the usual setup of a single, fixed dynamical rule. Furthermore, the results are also very different if update rules are fixed or evolve with the strategies. In these respect, we have studied representative update rules, finding that some of them may become extinct while others prevail. We describe the new and rich variety of final outcomes that arise from this co-evolutionary dynamics. We include examples of other neighborhoods and asynchronous updating that confirm the robustness of our conclusions. Our results pave the way to an evolutionary rationale for modelling social interactions through game theory with a preferred set of update rules.
Acumulación de compuestos nitrogenados en relación al problema de baya blanda en uva de mesa
Ruiz S.,Rafael; Moyano A.,Stella; Navia P.,Tania;
Agricultura Técnica , 2004, DOI: 10.4067/S0365-28072004000400012
Abstract: with the objective of evaluating a probable association between n metabolic disorders and the problem known as "soft berry" at the beginning of 2002 rachis and berries of bunches from a vineyard, vitis vinifera l. cv. thompson seedless, of the vi region, chile (34o15? s. lat, 72o25? w. long) with the presence of "soft", "intermediate", and "firm" berries were collected the results indicated that soft or intermediate berries had higher levels of n in the pulp and skin, and higher arginine and putrescine levels in berries and rachis. evaluations of the fruit indicated that soft berries showed less firmness, less than 190 g-strength mm-1, less weight and less soluble solids (obrix). the results indicated some similarity with factors that have been associated to the disorder known as "bunch stem necrosis" or "waterberry".
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