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Search Results: 1 - 10 of 37454 matches for " Paula Rodríguez-Otero "
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MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations
Edurne San José-Enériz, José Román-Gómez, Antonio Jiménez-Velasco, Leire Garate, Vanesa Martin, Lucia Cordeu, Amaia Vilas-Zornoza, Paula Rodríguez-Otero, María José Calasanz, Felipe Prósper, Xabier Agirre
Molecular Cancer , 2009, DOI: 10.1186/1476-4598-8-69
Abstract: The development of Imatinib Mesylate (IM), the first specific inhibitor of BCR-ABL1, has had a major impact in patients with Chronic Myeloid Leukemia (CML) [1]. Treatment with IM induces a complete hematological and cytogenetic response in more than 90 and 80% of newly diagnosed patients with chronic phase CML respectively, [2] which has established IM as the standard therapy for CML. Despite the clinical success obtained with the use of IM, primary resistance to IM and molecular evidence of persistent disease has been observed in 20-25% of IM treated patients [1]. Different mechanisms of resistance have been described, including the presence of point mutations in the tyrosine kinase domain of BCR-ABL1, amplification and overexpression of BCR-ABL1, overexpression of efflux transporters (such as ABCB1, also known as MDR1 or p-glycoprotein, and ABCG2) and underexpression of uptake transporters (such as SLC22A1, also known as hOCT1) [1]. However, it is currently impossible to predict whether a patient will develop resistance to IM. The existence of second generation TK inhibitors, which are effective in patients with IM resistance, makes identification of predictors of resistance to IM an important goal in CML.MicroRNAs (miRNAs) are non-coding, single-stranded RNAs of 21-25 nucleotides that have recently been implicated in the regulation of a number of biological processes such as development, differentiation, apoptosis, proliferation and hematopoiesis. They regulate gene expression by promoting degradation of the mRNA or repressing its translation [3]. In addition, miRNAs have been implicated in the development of human cancers, either as tumor suppressors or as oncogenes. Aberrant miRNA expression has recently been described for a variety of solid tumors (lung, breast or colorectal cancer among others) and hematological malignancies (chronic lymphocytic leukemia, B-cell lymphomas, acute promyelocytic leukemias, acute lymphocytic leukemia and CML). In CML, abnormal ex
Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia
Amaia Vilas–Zornoza,Xabier Agirre,Vanesa Martín-Palanco,José Ignacio Martín-Subero,Edurne San José-Eneriz,Leire Garate,Sara álvarez,Estíbaliz Miranda,Paula Rodríguez-Otero,José Rifón,Antonio Torres,María José Calasanz,Juan Cruz Cigudosa,José Román-Gómez,Felipe Prósper
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017012
Abstract: Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diagnosis (n = 48). We found that 154 genes were methylated in more than 10% of ALL samples. Interestingly, the expression of 13 genes implicated in the TP53 pathway was downregulated by hypermethylation. Direct or indirect activation of TP53 pathway with 5-aza-2′-deoxycitidine, Curcumin or Nutlin-3 induced an increase in apoptosis of ALL cells. The results obtained with the initial group of 48 patients was validated retrospectively in a second cohort of 200 newly diagnosed ALL patients. Methylation of at least 1 of the 13 genes implicated in the TP53 pathway was observed in 78% of the patients, which significantly correlated with a higher relapse (p = 0.001) and mortality (p<0.001) rate being an independent prognostic factor for disease-free survival (DFS) (p = 0.006) and overall survival (OS) (p = 0.005) in the multivariate analysis. All these findings indicate that TP53 pathway is altered by epigenetic mechanisms in the majority of ALL patients and correlates with prognosis. Treatments with compounds that may reverse the epigenetic abnormalities or activate directly the p53 pathway represent a new therapeutic alternative for patients with ALL.
Endocarditis por Stenotrophomonas maltophilia: presentación de un caso y revisión de la literatura
López Rodríguez,R.; Lado Lado,F. L.; Rodríguez López,I.; Gamallo Theodosio,R.; Lorenzo Zú?iga,V.; Rodríguez-Otero,L.;
Anales de Medicina Interna , 2003, DOI: 10.4321/S0212-71992003000600010
Abstract: we report a case of a 65 year-old woman with late endocarditis of prosthetic aortic valve and paravalvular abscess by stenotrophomonas maltophilia, which had an acute presentation for the memtionated abscess broken, with fever, bacteremia and congestive heart failure secondary to severity aortic regurgitation. it′s a rare cause of endocarditis with only 22 cases descripted in medical literature, the most of them in parenteral drug addict and as complication of cardiac valve replacement. the literature is reviewed and relate the epidemiology, clinical and prognosis characteristics of this disease, the same as his treatment and prevention.
Expansion of T Cells in an Immunocompetent Patient with Acute Toxoplasmosis
R. García-Mu oz,P. Rodríguez-Otero,A. Galar,J. Merino,J. J. Beunza,J. A. Páramo,R. Lecumberri
Advances in Hematology , 2009, DOI: 10.1155/2009/173439
Abstract: CD57
Las cefaleas psicógenas de la infancia
Otero Rodríguez,Juan;
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2002, DOI: 10.4321/S0211-57352002000200003
Abstract: thorough bibliographic review about the tension type headache in childhood. it's described its clinic expression, differential diagnosis, epidemiology and the biopsychosocial and developmental-psychodinamic explanatory models.
Alexitimia, una revisión.
Juan Otero Rodríguez
Revista de la Asociación Espa?ola de Neuropsiquiatría , 1999,
Abstract: Se realiza una revisión del concepto de alexitimia: los antecedentes, la aparición y el desarrollo del constructo, las críticas más importantes, el estado actual del tema y la propuesta de distinción entre alexitimia primaria y secundaria.
Las cefaleas psicógenas de la infancia.
Juan Otero Rodríguez
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2002,
Abstract: Revisión bibliográfica exhaustiva de los dolores de cabeza tensionales de la infancia. Se describe su expresión clínica, el diagnóstico diferencial, la epidemiología y los enfoques explicativos biopsicosocial y evolutivopsicodinámico.
Estrategias de lo traumático y la "memoria airada" en Un muro de silencio
Rodríguez Marino,Paula;
Signo y Pensamiento , 2006,
Abstract: this aim of this article is to inquire into the forms and possibilities trough which the traces of the traumatic are insculped in the postdictatorial cinematographic narratives. we analyze the discursive strategies used in the film a wall of silence (un muro de silencio) (1993) by lita stantic as an exponent of a "politic of remembrance" which uses what we call "irate memory". this notion implies a subjective form of the collective memory about traumatic events which will be a characteristic of the argentine cinema made by women.
Flashblack MTV: sem retorno à música negra na família da MTV
Paula Rodríguez Marino
Revista Latina de Comunicación Social , 2001,
Abstract: Analiza-se a constru es dos conceitos de juventud, família e "música negra" (black music) no programa Flashblack do canal MTV Brasil, a partir das reflex es e categorias utilizadas pela pesquisadora brasileira Ida Lúcia Machado e pelo pesquisador argentino Eliseo Verón. Desta forma, é possível estudar o corpus estabelecendo um paralelo entre os movimentos e angula es de camara e a proxêmica, e também, precissar as modalidades do apresentador em fun o de outros aspectos do comportamento verbais e n o verbais.
Characterization of admitted patients with cervicofacial inflammatory process in the Maxilo facial surgery service. Caracterización de pacientes ingresados con procesos inflamatorios cérvico-faciales en el servicio de cirugia maxilofacial.
Sahily Espino Otero,Julio Romero Rodríguez
MediSur , 2006,
Abstract: Fundament: Cervico-facial inflammatory processes constituyen an important health problem and not to treat them since its onset could cause associated complications that could be fatal for the health of the patient. Objective: To characterize the patients with inflammatory processes who were admitted at the Maxillo-Facial service in Cienfuegos province. Method: Descriptive study that included all the patients admitted because of cervico-inflammatory processes from January 2001 to December 2003 in Cienfuegos. The variables under study were: Age, sex, data related with the disease under study, signs and symptoms on admission, applied treatment, complications, follow up and hospital stay. Results: The odontogenous processes are the most frequent and within these those caused by caries. The widespread of the process to other regions, fever, malaise and trismus were the predominant symptoms. The main cause of admission was the inadequate treatment in the initial period of the disease. Fundamento: Los procesos inflamatorios cérvico-faciales constituyen un importante problema de salud, no tratarlos correctamente desde sus inicios provocaría complicaciones asociadas que pueden resultar fatales para la vida de los pacientes. Objetivo: Caracterizar los pacientes con procesos inflamatorios que ingresaron en el Servicio de Cirugía Máxilo-Facial en la provincia de Cienfuegos. Método: Estudio descriptivo que incluyó todos los pacientes ingresados por procesos inflamatorios cérvico-faciales desde enero del 2001 al 31 de diciembre del 2003 en Cienfuegos. Se estudiaron las variables: edad y sexo, datos relacionados con la afección objeto de estudio, signos y síntomas al ingreso, tratamiento aplicado, complicaciones, evolución y la estadía hospitalaria. Resultados: Los grupos etáreos jóvenes predominaron en ambos sexos. Los procesos de origen odontógeno son los más frecuentes y dentro de éstos los causados por caries. La extensión de los procesos a otras regiones, la fiebre, toma del estado general y el trismo fueron los signos que predominaron . El factor fundamental que motivó el ingreso de los pacientes fue el tratamiento inadecuado en los períodos iniciales de los procesos.
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