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Search Results: 1 - 10 of 30784 matches for " Paula Paulo "
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Self-Assembled Dextrin Nanogel as Curcumin Delivery System  [PDF]
Catarina Gon?alves, Paula Pereira, Peter Schellenberg, Paulo J. Coutinho, Francisco M. Gama
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32024
Abstract: Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this study, we show that self-assembled nanogels obtained from hydrophobically modified dextrin are effective curcumin nanocarriers. The stability and loading efficiency of curcumin-loaded nanogel depends on the nanogel/curcumin ratio. Higher stability of the formulation is achieved in water than in PBS buffer, as evaluated by dynamic light scattering and fluorescence measurements. The in vitro release profile, using sink conditions, indicates that dextrin nanogel may perform as a suitable carrier for the controlled release of curcumin. Biological activity of curcumin-loaded nanogel in HeLa cell cultures was assessed using the MTS assay.
Contribui??o para o conhecimento ecodendrométrico de matas ripárias da regi?o Centro-Oeste brasileira
Heringer, Ezechias Paulo;Paula, José Elias de;
Acta Botanica Brasilica , 1989, DOI: 10.1590/S0102-33061989000200004
Abstract: this study is a contribution to the dendrometrical and ecological knowledge of gallery forests of the brazilian mid-west region. its objective is to add biological information to the practice of sustained ecological handling. among other parameters, the volume, basal areas and number of trees/ha are considered. a total of 1,416 trees was found in 3,525 hectares corresponding to 402 units per hectare and 282,672 m3 of wood.
Pilocarpus spp.: a survey of its chemical constituents and biological activities
Santos, Ana Paula;Moreno, Paulo Roberto Hrihorowitsch;
Revista Brasileira de Ciências Farmacêuticas , 2004, DOI: 10.1590/S1516-93322004000200002
Abstract: pilocarpus species have been exploited as the only source of the imidazole alkaloid pilocarpine (used in glaucoma treatment), since its isolation up to the present. almost all pilocarpusspecies are native from brazil. because of the medicinal importance of pilocarpine, several of them are in the path of extinction. other secondary metabolites, such as coumarins, flavonoids and terpenes, were described for pilocarpusspecies. in this review the secondary metabolites, other than pilocarpine, isolated from pilocarpusspecies and their biological activities were compiled. although the variety of structures and the importance of the biological activities described in literature for pilocarpusspecies this is an unexploited field of research in natural products and pharmacology.
Rastreamento Pré-natal de Anormalidades Cardíacas: Papel da Ultra?sonografia Obstétrica de Rotina
Bacaltchuk, Tzvi;Antunes, Paula;Zielinsky, Paulo;
Revista Brasileira de Ginecologia e Obstetrícia , 2001, DOI: 10.1590/S0100-72032001000900002
Abstract: purpose: to evaluate the role of routine obstetrical ultrasound scan in suspecting the presence of fetal congenital heart diseases and severe arrhythmias, as well as the factors involved in its accuracy. methods: the sample was made up of 77 neonates and infants hospitalized at the institute of cardiology of rio grande do sul from may to october of 2000, with confirmed postnatal diagnosis of structural heart disease or severe arrhythmia, whose mothers had been submitted to at least one obstetrical ultrasound scan after 18 weeks of gestation. after informed consent, a customized standard questionnaire was used. categorical variables were compared using c2 test or fisher's exact test and a logistic regression model was used to determine independent variables possibly involved in the prenatal suspicion of cardiac abnormalities. results: in 19 patients (24.6%), obstetrical ultrasound was able to rise prenatal suspicion of structural or rhythm abnormalities. considering only congenital heart diseases, this prevalence was 19.2% (14/73). in 73.7% of these cases, the cardiac disorder was accessible by the four-chamber view alone. arrhythmias during obstetrical scan were observed in 26.3 of the babies with prenatal suspicion of a heart abnormality, while only 3.4% of the patients without prenatal suspicion showed a rhythm alteration (p=0.009). significant differences between the groups with and without prenatal suspicion of cardiac abnormalities were observed in relation to parity (p=0.029), delivery by cesarean section (p=0.006), need for intensive care (p=0.046) and school education level of the father (p=0.014). at multivariate analysis, only the presence of a rhythm alteration during ultrasound scan was shown to be an independent variable associated with prenatal suspicion of cardiac abnormalities. conclusions: routine obstetrical ultrasound has been underused in prenatal screening of congenital heart diseases. adequate training and making obstetricians and the populatio
Rastreamento Pré-natal de Anormalidades Cardíacas: Papel da Ultra?sonografia Obstétrica de Rotina
Bacaltchuk Tzvi,Antunes Paula,Zielinsky Paulo
Revista Brasileira de Ginecologia e Obstetrícia , 2001,
Abstract: Objetivo: avaliar o papel da ultra-sonografia obstétrica de rotina no rastreamento pré-natal de cardiopatias congênitas ou arritmias graves e os fatores envolvidos na sua acurácia. Métodos: a amostra foi constituída de 77 neonatos ou lactentes internados no Instituto de Cardiologia do Rio Grande do Sul no período de maio a outubro de 2000, com diagnóstico pós-natal confirmado de cardiopatia estrutural ou arritmia grave, que tinham sido submetidos, durante a vida fetal, a pelo menos uma ultra-sonografia obstétrica após a 18a semana de gesta o. Após consentimento informado, um questionário padronizado foi aplicado. As variáveis categóricas (tipo de cardiopatia e a acessibilidade ecográfica para o diagnóstico, altera o do ritmo cardíaco, número de gesta es, paridade, abortamentos prévios, estado civil das gestantes, tipo de parto, área de interna o hospitalar, sexo, tipo de servi o onde foi realizado o pré-natal, indica o da ultra-sonografia obstétrica, número de ultra-sonografias realizadas, tipo de servi o onde foi realizada a ultra-sonografia obstétrica, local onde foi realizada a ultra-sonografia obstétrica, renda familiar, escolaridade materna e escolaridade paterna) foram comparadas pelo teste do chi2 ou pelo teste exato de Fisher e um modelo de regress o logística foi utilizado para determinar variáveis independentes eventualmente envolvidas na suspeita pré-natal de cardiopatia. Resultados: em 19 pacientes (24,7%), a ultra-sonografia obstétrica foi capaz de levantar suspeita de anormalidades estruturais ou de arritmias. Ao serem consideradas apenas as cardiopatias congênitas, esta taxa foi de 19,2% (14/73). Em 73,7% dos pacientes com suspeita de anormalidades cardíacas durante a ultra-sonografia obstétrica, as cardiopatias suspeitadas eram acessíveis ao corte de 4 camaras isolado. Observou-se que 26,3% das crian as com suspeita pré-natal de cardiopatia apresentaram arritmias durante o estudo ecográfico, ao passo que apenas 3,4% dos pacientes sem suspeita pré-natal apresentaram altera es do ritmo (p=0,009). Constituíram fatores comparativos significantes entre o grupo com suspeita pré-natal e o sem suspeita a paridade (p=0,029), o parto cesáreo (p=0,006), a interna o em unidade de tratamento intensivo (p=0,046) e a escolaridade paterna (p=0,014). à análise multivariada, apenas a presen a de altera o do ritmo cardíaco durante a ultra-sonografia obstétrica mostrou-se como variável independente associada à suspeita pré-natal de anormalidade cardíaca. Conclus es: a ultra-sonografia obstétrica de rotina ainda tem sido subutilizada no rastreamento
Immunological Intolerance and Tolerance by Antigenic Co-Stimulation  [PDF]
Alexandre Paulo Machado, Gabriel de Paula Albuquerque, Letícia Souza Santana, Olga Fischman Gompertz
Open Journal of Immunology (OJI) , 2017, DOI: 10.4236/oji.2017.74006
The plasticity and dynamism in the immune responses to both self and environmental stimulation promote the maintenance and adaptation of a system that tends to harmoniously survive and evolve. Fluctuating antigenic forces coexist within the immune system and oscillate between order and chaos to the equilibrium. Thus, when mounting a response to internal or environmental antigens, the main host responses can be divided into two immunological categories. The first, a well-adapted mechanism of complex multi-cellular organisms classically known as tolerance, promotes persistent immunological responses. In the second, opposite way, the modulation of inflammatory immune responses occurs, which we call “intolerance”. Tolerance and intolerance can be mediated by humoral molecules, such as inflammatory compounds, complement, and antibodies, and by different cell types, such as sentinel cells, antigen-presenting cells, and cells that orchestrate the immune response. Tolerogenesis is important in vertebrates because it predisposes species to adapt to self and environmental negative-selective forces. This process depends, in large part, on antigenic co-stimulation (AgCS), which operates as a multi-integrated network formed by all immune and non-immune cells of the body that establishes tolerant immunoregulatory interactions from cells to cells and from cells to the environment. Antigenic distribution, quantity, nature, route of administration, and antigenic convergence on co-stimulatory pathways, and concurrent infections, and the presence of microorganisms (commensals and pathogens) in more than one site are important factors for activating AgCS. To conclude, the AgCS route is a natural immune response generated by heterogeneous APC profile with centralized regulation that promote the counterbalance between intolerant e tolerant status, which can have several applications in the medical and biological fields.
How Growth Ability of Multidrug-Resistant Escherichia coli Is Affected by Abiotic Stress Factors  [PDF]
Lucinda Janete Bessa, Vania Filipa Dias, ?ngelo Mendes, Paula Martins-Costa, Helena Ramos, Paulo Martins da Costa
Open Journal of Preventive Medicine (OJPM) , 2014, DOI: 10.4236/ojpm.2014.45031

The ability of multidrug-resistant Escherichia coli to adapt and grow in a wide range of different environmental conditions may be crucial to the global spread of antimicrobial resistance. The aim of this study was to evaluate the survival ability of 54 multidrug-resistant E. coli strains, isolated from three different biotopes (clinical setting, gull intestine, river water) when subjected to variations in pH (from 3 to 11) and salinity (from 0.5% to 6% of NaCl) and to nutrient deprivation. The growth of each isolate as well as of a reference strain was assessed during 168 h in every varying condition. Slight variations in the growth ability under some abiotic stress factors were recorded among the isolates from the different biotopes. Multidrug-resistant isolates from gull feces were found to be the more tolerant to environmental abiotic changes, while isolates from river water were the less tolerant. In addition, it was notorious that the carriage of antimicrobial resistance has a clear fitness cost in comparison with the susceptible (reference) strain, highlighting the necessity of reducing the selective pressure exerted by antibiotics. This study underlines the ecological hardness of multidrug-resistant E. coli isolates with a consequent ability to reach and colonize new host and environments.

A Deviation from the Bipolar-Tetrapolar Mating Paradigm in an Early Diverged Basidiomycete
Marco A. Coelho,José Paulo Sampaio,Paula Gon?alves
PLOS Genetics , 2010, DOI: 10.1371/journal.pgen.1001052
Abstract: In fungi, sexual identity is determined by specialized genomic regions called MAT loci which are the equivalent to sex chromosomes in some animals and plants. Usually, only two sexes or mating types exist, which are determined by two alternate sets of genes (or alleles) at the MAT locus (bipolar system). However, in the phylum Basidiomycota, a unique tetrapolar system emerged in which four different mating types are generated per meiosis. This occurs because two functionally distinct molecular recognition systems, each encoded by one MAT region, constrain the selection of sexual partners. Heterozygosity at both MAT regions is a pre-requisite for mating in both bipolar and tetrapolar basidiomycetes. Tetrapolar mating behaviour results from the absence of genetic linkage between the two regions bringing forth up to thousands of mating types. The subphylum Pucciniomycotina, an early diverged lineage of basidiomycetes encompassing important plant pathogens such as the rusts and saprobes like Rhodosporidium and Sporidiobolus, has been so far poorly explored concerning the content and organization of MAT loci. Here we show that the red yeast Sporidiobolus salmonicolor has a mating system unlike any previously described because occasional disruptions of the genetic cohesion of the bipolar MAT locus originate new mating types. We confirmed that mating is normally bipolar and that heterozygosity at both MAT regions is required for mating. However, a laboratory cross showed that meiotic recombination may occur within the bipolar MAT locus, explaining tetrapolar features like increased allele number and evolution rates of some MAT genes. This pseudo-bipolar system deviates from the classical bipolar–tetrapolar paradigm and, to our knowledge, has never been observed before. We propose a model for MAT evolution in the Basidiomycota in which the pseudo-bipolar system may represent a hitherto unforeseen gradual form of transition from an ancestral tetrapolar system to bipolarity.
Itinerários terapêuticos: trajetórias entrecruzadas na busca por cuidados
Pinho, Paula Andréa;Pereira, Pedro Paulo Gomes;
Interface - Comunica??o, Saúde, Educa??o , 2012, DOI: 10.1590/S1414-32832012005000026
Abstract: the general purpose of this paper is to present the therapeutic itineraries of hiv-positive people. these courses, consisting of unusual blends and compositions, reveal the complex ways in fighting hiv/aids taken by people who undergo therapies trying to restore or preserve health. admitting the existence of numerous available treatments, we analyze the itineraries of therapies known as being of the "religious type" in their relation to the biomedical model. ethnography revealed that the interlocutors do not separate the religious and the biomedical therapy on different levels. what stood out was the simultaneous interaction of the two solutions employed for the same purpose: health. it was possible to observe a therapeutic continuum, i.e., the options are not isolated; rather, they appear as consecutive parts that flow without clearly demarcated boundaries.
Repair of bone cavities in dog's mandible filled with inorganic bovine bone and bioactive glass associated with platelet rich plasma
Bassi, Ana Paula Farnezi;Carvalho, Paulo Sérgio Perri de;
Brazilian Dental Journal , 2011, DOI: 10.1590/S0103-64402011000100002
Abstract: the aim of this study was to evaluate the effect of platelet rich plasma (prp) associated to bovine inorganic bone (bio-oss?; geistlich) or bioactive glass (bio-gran?; orthovita, implant innovations) on bone healing. bone cavities were prepared in both sides of the mandible of 4 adult male dogs. the cavities were divided into 4 groups according to the filling material as follows: control, prp, prp/bio-oss, prp/bio-gran. the animals were sacrificed after 120 days and histological and histomorphometrical analysis was performed. the control group showed 80.6% of bone formation in the longitudinal sections at 6 mm depth and 83.7% at 13 mm depth. the transverse sections displayed 74.2% at both 6 and 13 mm depths. the prp group showed 21.1% of bone formation in the longitudinal sections at 6 mm depth, and 23.1% at 13 mm depth. the transverse sections presented 28.98% of bone formation at 6 mm depth and 41.2% at 13 mm depth. the prp/bio-gran group showed 25.1% of bone formation in the longitudinal sections at 6 mm depth and 30.4% at 13 mm depth. in the transverse sections, the bone formation was 43.0% at 6 mm depth and 39.7% at 13 mm depth. the prp/bio-oss group showed 35.5% of bone formation in the longitudinal sections at 6 mm depth and 42% at 13 mm depth. in the transversal sections, the bone formation was 26.8% and 31.2% at the depths of 6 and 13 mm, respectively. prp alone or associated with bovine inorganic bone or bioglass had no significant effect in bone healing.
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