oalib

OALib Journal期刊

ISSN: 2333-9721

费用:99美元

投稿

时间不限

2017 ( 54 )

2016 ( 72 )

2015 ( 1280 )

2014 ( 1829 )

自定义范围…

匹配条件: “Paul Manash” ,找到相关结果约23465条。
列表显示的所有文章,均可免费获取
第1页/共23465条
每页显示
Tyrosine kinase – Role and significance in Cancer
Paul Manash K.,Mukhopadhyay Anup K.
International Journal of Medical Sciences , 2004,
Abstract: Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli. Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer. Though their activity is tightly regulated in normal cells, they may acquire transforming functions due to mutation(s), overexpression and autocrine paracrine stimulation, leading to malignancy. Constitutive oncogenic activation in cancer cells can be blocked by selective tyrosine kinase inhibitors and thus considered as a promising approach for innovative genome based therapeutics. The modes of oncogenic activation and the different approaches for tyrosine kinase inhibition, like small molecule inhibitors, monoclonal antibodies, heat shock proteins, immunoconjugates, antisense and peptide drugs are reviewed in light of the important molecules. As angiogenesis is a major event in cancer growth and proliferation, tyrosine kinase inhibitors as a target for anti-angiogenesis can be aptly applied as a new mode of cancer therapy. The review concludes with a discussion on the application of modern techniques and knowledge of the kinome as means to gear up the tyrosine kinase drug discovery process.
BACTERIAL DNA GYRASE IS NOT THE TARGET OF QUINOLINE-BASED ANTI-TUBERCULOSIS COMPOUNDS
Verma Rahul,Tripathy Rajan K.,Paul Manash,Nayyar Amit
International Research Journal of Pharmacy , 2013,
Abstract: Few quinoline-based synthetic compounds (2, 8 Dicyclopentyl-4-methyl quinoline and 2, 8 Dicyclohexyl-4-methyl quinoline), the synthesis of which have been already shown by our medicinal chemistry group, were found to be potent inhibitor of mycobacterial growth. Based on the results of cell culture-based cell killing assays using DNA gyrase positive E. coli strains, we presumed that bacterial DNA gyrase might be a probable target of quinolines. The resemblance of the basic skeletal structural moiety of quinolone and quinoline inspired us to hypothesize that these quinolines might inhibit DNA gyrase. While the non-gyrase inhibitors like ethambutol and isoniazid did not inhibit the growth of these strains. The genesis of the notion of using E. coli DNA gyrase as an alternative to DNA gyrase from the pathogenic Mycobacterium, stems from the fact that E. coli DNA gyrase is found to be about eighty times more sensitive to the action of quinolones than the Mycobacterium DNA gyrase. Therefore, we had used E. coli DNA gyrase as a model enzyme for studying the action of some synthetic quinoline compounds synthesized by us. In the present work, we have used cell killing assay, gel electrophoresis assay (for DNA supercoiling) and UV spectroscopy-based coupled assay (for ATP hydrolysis) for characterizing the activity of DNA gyrase. Quinolones exhibited low IC50 values as compared to the studied quinolines on DNA gyrase positive E. coli strains We found that although quinolones are the potent inhibitors of supercoiling activity of E. coli DNA gyrase, quinolines are not. We further found that ATPase activity of E. coli DNA gyrase (Non-specific inhibitor) was inhibited to a very minor extent in the presence of very high concentration of these synthetic quinolines. DNA gyrase is not the primary target of these synthetic quinolines (2, 8 Dicyclopentyl-4-methyl quinoline and 2, 8 Dicyclohexyl-4-methyl quinoline).
Involutive Spacetime Distributions and p-Brane Dynamics
Manash Mukherjee
Physics , 1997,
Abstract: We propose a precise definition of multidimensional fluids generated by self-gravitating extended objects such as strings and membranes: a p-dimensional perfect fluid is a smooth involutive p-dimensional distribution on a spacetime, each integral manifold of which is a timelike, connected, immersed submanifold of dimension, p -- representing the history of a (p-1)-dimensional extended object. This geometric formulation of perfect fluids of higher dimensions naturally leads to the associated stress-energy tensor. Furthermore, the laws of temporal evolution and symmetries of such systems are derived, in general, from the Einstein field equations and the integrability conditions. We also present a matter model based on a 2-dimensional involutive distribution, and it is shown that the stress-energy tensor for self-gravitating strings gives rise to a non-trivial spherically symmetric spacetime with a naked singularity.
Spacetime Foliations and p-Brane Dynamics
Manash Mukherjee
Physics , 1998,
Abstract: This paper has been withdrawn by the author. Proofs of two propositions need more details.
Logarithmic corrections to finite size spectrum of SU(N) symmetric quantum chains
Kingshuk Majumdar,Manash Mukherjee
Physics , 2002, DOI: 10.1088/0305-4470/35/38/101
Abstract: We consider SU(N) symmetric one dimensional quantum chains at finite temperature. For such systems the correlation lengths, ground state energy, and excited state energies are investigated in the framework of conformal field theory. The possibility of different types of excited states are discussed. Logarithmic corrections to the ground state energy and different types of excited states in the presence of a marginal opeartor, are calculated. Known results for SU(2) and SU(4) symmetric systems follow from our general formula.
Irrational Numbers of Constant Type --- A New Characterization
Manash Mukherjee,Gunther Karner
Physics , 1997,
Abstract: We obtain a new characterization for irrational numbers of constant type -- defined as irrationals with bounded partial quotients in their continued fraction expansion. The result is essential in the formulation of stability criteria for orbits of quantum twist maps in a class of dynamical systems.
Domain Wall Spacetimes and Particle Motion
Richard Gass,Manash Mukherjee
Physics , 1999, DOI: 10.1103/PhysRevD.60.065011
Abstract: We present a mathematical framework for generating thick domain wall solutions to the coupled Einstein-scalar field equations which are (locally) plane symmetric. This approach leads naturally to two broad classes of wall-like solutions. The two classes include all previously known thick domain walls. Although one of these classes is static and the other dynamic, the corresponding Einstein-scalar equations share the same mathematical structure independent of the assumption of any reflection symmetry. We also exhibit a class of thick static domain wall spacetimes with different asymptotic vacua. Our analyses of particle motion in such spacetimes raises the interesting possibility that static domain walls will possess a unique experimental signature.
Primitive Central Idempotents of the Group Algebra
Robin Endelman,Manash Mukherjee
Mathematics , 2008,
Abstract: An approach to representations of finite groups is presented without recourse to character theory. Considering the group algebra C[G] as an algebra of linear maps on C[G] (by left multiplication), we derive the primitive central idempotents as a simultaneous eigenbasis of the centre, Z(C[G]). We apply this framework to obtain the irreducible representations of a class of finite meta-abelian groups. In particular, we give a general construction of the isomorphism between simple blocks of C[G] and the corresponding matrix algebra where G can be any finite group.
A COMPARATIVE STUDY OF TRANSVAGINAL SONOHYSTERO-SALPINGOGRAPHY (TV-SH) AND HYSTERO-SALPINGOGRAPHY (HSG) FOR ASSESSMENT OF TUBAL PATENCY IN INFERTILITY PATIENTS
Nirmala Jaget Lakkawar,Manash Bora,Thirupurasundari Rangaswamy
Acta Medica Medianae , 2011,
Abstract: There has been a significant increase in cases of infertility and sterility in the last decade. Approximately, 10-15% of couples in reproductive age are affected by the inability to conceive and bear a child. Amongst all causes, anatomical defect linked to the fallopian pathological conditions contributes considerably to female infertility. The evaluation of tubal patency is traditionally considered fundamental in the study of cases of infertility and it represents one third of the total cost in the management of infertility. Tubal patency is routinely assessed by hysterosalpingograpgy (HSG) and/or laparoscopy. However, other techniques are nowadays being investigated to obtain high efficacy, with low cost and risk, and also can be used as office procedures at an outpatient infertility clinic. Transvaginal sonohysterosalpingography (Tv-Sh) is one of such promising procedure which can be simultaneously performed in place of HSG at the time of conventional ultrasonogram in the initial workup of infertile patients. It also provides additional information regarding intracavitary and intramyomentrial components of submucous myomas as well as information about adnexae. The present study encompasses the comparative diagnostic accuracy of Tv-Sh and HSG in evaluating uterine cavity and tubal patency in women of reproductive age group. The compatibility between Tv-Sh and HSG was found to be 87% and efficacy in diagnosis of hydrosalpinx by both procedures was the same. There was also no significant difference in the diagnosis of congenital malformations of uterus or intracavity adhesions. The study concludes that Tv-Sh can be used as a “first choice” screening procedure without any risk of ionizing radiation.
Effect of HF Concentration on Physical and Electronic Properties of Electrochemically Formed Nanoporous Silicon
Pushpendra Kumar,Peter Lemmens,Manash Ghosh,Frank Ludwig,Meinhard Schilling
Journal of Nanomaterials , 2009, DOI: 10.1155/2009/728957
Abstract: The most common fabrication technique of porous silicon (PS) is electrochemical etching of a crystalline silicon wafer in a hydrofluoric (HF) acid-based solution. The electrochemical process allows for precise control of the properties of PS such as thickness of the porous layer, porosity, and average pore diameter. The effect of HF concentration in the used electrolyte on physical and electronic properties of PS was studied by visual color observation, measuring nitrogen sorption isotherm, field emission type scanning electron microscopy, Raman spectroscopy, and photoluminescence spectroscopy. It was found that with decrease in HF concentration, the pore diameter increased. The PS sample with large pore diameter, that is, smaller nanocrystalline size of Si between the pores, was found to lead to a pronounced photoluminescence peak. The systematic rise of photoluminescence peak with increase of pore diameter and porosity of PS was attributed to quantum confinement. The changes in nanocrystalline porous silicon were also clearly observed by an asymmetric broadening and shift of the optical silicon phonons in Raman spectra. The change in electronic properties of PS with pore diameter suggests possibilities of use of PS material as a template for fundamental physics as well as an optical material for technological applications.
第1页/共23465条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.