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Search Results: 1 - 10 of 211614 matches for " Paul G. Waddell "
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Alexandra M. Z. Slawin,Paul G. Waddell,J. Derek Woollins
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810006471
Abstract: The title compound, [PdCl2(C8H11O2P)2], has a comparable structure to those of related palladium dichloride complexes containing trimethyl phosphinite and methyl diphenyl phosphinite. The Pd atom is located on a crystallographic twofold rotation axis: thus, there is just one half-molecule in the asymmetric unit. The structure is isomorphous with the platinum analogue cis-[PtCl2{P(OMe)2Ph}2].
(Disulfur dinitrido)triphenylantimony(V)
Alexandra M. Z. Slawin,Paul G. Waddell,J. Derek Woollins
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810009487
Abstract: The title compound, [Sb(C6H5)3(N2S2)], contains a molecular entity that is very similar to that of the known polymorph of Sb(S2N2)Ph3 [Kunkel et al. (1997). Z. Naturforsch. Teil B, 52, 193–198], differing only in the orientation of the phenyl rings. The bond order in the SNSN unit is S—N=S=N, consisting of one long S—N bond, an intermediate length N=S bond and a short S=N bond.
Alexandra M. Z. Slawin,Paul G. Waddell,J. Derek Woollins
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809042226
Abstract: The title compound, [PtCl2(C9H21O3P)2], was obtained from a solution of PtCl2(COD) (COD = 1,5-cyclooctadiene) and triisopropylphosphite in dichloromethane. The complex features a Pt(II) atom coordinated by two Cl and two P atoms, yielding a slightly distorted cis square-planar geometry.
cis-Dichloridobis(trimethoxyphosphine)palladium(II) at 125 K
Alexandra M. Z. Slawin,Paul G. Waddell,J. Derek Woollins
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809041919
Abstract: The title compound, [PdCl2(C3H9O3P)2], which is isotypic with its platinum analogue, adopts a slightly distorted cis square-planar geometry for the Pd centre.
Alexandra M. Z. Slawin,Paul G. Waddell,J. Derek Woollins
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810012055
Abstract: The title compound, [Pd2Cl4(C8H11O2P)2], is binuclear and disposed about a crystallographic centre of symmetry with a Pd...Pd distance of 3.4662 (17) . It has a similar geometry to that observed in the triphenylphosphite and triphenylphosphine analogues. The Pd—P bond length is ca 0.04 shorter than those in mononuclear PdCl2(P(OMe)2Ph)2, possibly due to the lower trans-influence of the bridging Cl compared to a single-bonded Cl atom.
trans-Dibromidobis(triphenylphosphane)platinum(II) chloroform monosolvate
Alexandra M. Z. Slawin,Paul G. Waddell,J. Derek Woollins
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811016849
Abstract: Both the platininum complex and the solvent molecule of the title compound, [PtBr2(C18H15P)2]·CHCl3, are located on a twofold rotation axis. The CH unit and the Cl atoms of the CHCl3 molecule are disordered over two equally occupied positions. The complex shows a trans square-planar geometry about the Pt atom.
Hui-Chang Chang,Jacqueline M. Cole,Tze-Chia Lin,Paul G. Waddell
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811015662
Abstract: The title binuclear Cu(II) complex, [Cu2(CH3CO2)4(C5H4Cl2N2)2], is disposed about a crystallographic inversion center, located at the mid-point of the Cu—Cu connecting line. The Cu...Cu distance is 2.6600 (6) and each metal atom exhibits a Jahn–Teller-distorted octahedral geometry.
Evolution of a Pathogen: A Comparative Genomics Analysis Identifies a Genetic Pathway to Pathogenesis in Acinetobacter
Jason W. Sahl, John D. Gillece, James M. Schupp, Victor G. Waddell, Elizabeth M. Driebe, David M. Engelthaler, Paul Keim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054287
Abstract: Acinetobacter baumannii is an emergent and global nosocomial pathogen. In addition to A. baumannii, other Acinetobacter species, especially those in the Acinetobacter calcoaceticus-baumannii (Acb) complex, have also been associated with serious human infection. Although mechanisms of attachment, persistence on abiotic surfaces, and pathogenesis in A. baumannii have been identified, the genetic mechanisms that explain the emergence of A. baumannii as the most widespread and virulent Acinetobacter species are not fully understood. Recent whole genome sequencing has provided insight into the phylogenetic structure of the genus Acinetobacter. However, a global comparison of genomic features between Acinetobacter spp. has not been described in the literature. In this study, 136 Acinetobacter genomes, including 67 sequenced in this study, were compared to identify the acquisition and loss of genes in the expansion of the Acinetobacter genus. A whole genome phylogeny confirmed that A. baumannii is a monophyletic clade and that the larger Acb complex is also a well-supported monophyletic group. The whole genome phylogeny provided the framework for a global genomic comparison based on a blast score ratio (BSR) analysis. The BSR analysis demonstrated that specific genes have been both lost and acquired in the evolution of A. baumannii. In addition, several genes associated with A. baumannii pathogenesis were found to be more conserved in the Acb complex, and especially in A. baumannii, than in other Acinetobacter genomes; until recently, a global analysis of the distribution and conservation of virulence factors across the genus was not possible. The results demonstrate that the acquisition of specific virulence factors has likely contributed to the widespread persistence and virulence of A. baumannii. The identification of novel features associated with transcriptional regulation and acquired by clades in the Acb complex presents targets for better understanding the evolution of pathogenesis and virulence in the expansion of the genus.
Quantification of global transcription patterns in prokaryotes using spotted microarrays
Ben Sidders, Mike Withers, Sharon L Kendall, Joanna Bacon, Simon J Waddell, Jason Hinds, Paul Golby, Farahnaz Movahedzadeh, Robert A Cox, Rosangela Frita, Annemieke MC ten Bokum, Lorenz Wernisch, Neil G Stoker
Genome Biology , 2007, DOI: 10.1186/gb-2007-8-12-r265
Abstract: The biological landscape has been transformed by the sequencing of genomes, and more recently by global gene expression analyses using microarrays [1,2]. Microarrays contain DNA probes representing all coding sequences in a genome, which are either synthesized in situ or are spotted onto a modified glass surface [3]. Comparison of mRNA from two conditions by competitive hybridization to these probes is used to identify differentially expressed genes [1]. In the case of spotted microarrays, these are performed either with labeled cDNA prepared from separate mRNA preparations co-hybridized to the same array, or as is increasingly the case, by employing genomic DNA (gDNA) as a standard reference [4]. In the latter case, each cDNA preparation is hybridized separately alongside a gDNA reference and differential expression is determined using a ratio of ratios. The use of gDNA corrects for most spatial and spot-dependent biases inherent with microarrays, and also allows direct comparison between multiple datasets [4]. These are sometimes called type 2 experiments, with RNA:RNA hybridizations being type 1 [5]. Traditionally, microarray experiments focus almost exclusively on changes in gene expression, and in the case of a type 1 experiment this is the only possible interpretation.Focusing on changes in expression has helped to direct us toward genes that warrant further investigation; however, it has been shown in recent meta-analyses that up-regulated genes may bear little correlation to other measures of biological importance [6-8]. One reason for this lack of correlation is that, in a traditional microarray experiment, absolute levels of mRNA are not considered; thus, no difference is reported between a gene where expression increases from 20 to 100 copies and one where it increases from 20,000 to 100,000 copies, yet the biological inference may be very different. Furthermore, all genes whose level of expression does not alter significantly between conditions are compl
Evolutionary History of LINE-1 in the Major Clades of Placental Mammals
Paul D. Waters, Gauthier Dobigny, Peter J. Waddell, Terence J. Robinson
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000158
Abstract: Background LINE-1 constitutes an important component of mammalian genomes. It has a dynamic evolutionary history characterized by the rise, fall and replacement of subfamilies. Most data concerning LINE-1 biology and evolution are derived from the human and mouse genomes and are often assumed to hold for all placentals. Methodology To examine LINE-1 relationships, sequences from the 3′ region of the reverse transcriptase from 21 species (representing 13 orders across Afrotheria, Xenarthra, Supraprimates and Laurasiatheria) were obtained from whole genome sequence assemblies, or by PCR with degenerate primers. These sequences were aligned and analysed. Principal Findings Our analysis reflects accepted placental relationships suggesting mostly lineage-specific LINE-1 families. The data provide clear support for several clades including Glires, Supraprimates, Laurasiatheria, Boreoeutheria, Xenarthra and Afrotheria. Within the afrotherian LINE-1 (AfroLINE) clade, our tree supports Paenungulata, Afroinsectivora and Afroinsectiphillia. Xenarthran LINE-1 (XenaLINE) falls sister to AfroLINE, providing some support for the Atlantogenata (Xenarthra+Afrotheria) hypothesis. Significance LINEs and SINEs make up approximately half of all placental genomes, so understanding their dynamics is an essential aspect of comparative genomics. Importantly, a tree of LINE-1 offers a different view of the root, as long edges (branches) such as that to marsupials are shortened and/or broken up. Additionally, a robust phylogeny of diverse LINE-1 is essential in testing that site-specific LINE-1 insertions, often regarded as homoplasy-free phylogenetic markers, are indeed unique and not convergent.
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