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Search Results: 1 - 10 of 23610 matches for " Paul Fasutin Seke Etet "
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Sedative and Anticonvulsant Properties of the Decoction of Balanites aegyptiaca (Balanitaceae)
Elisabeth Ngo Bum,Neteydji Sidiki,Taiwe,Paul Fasutin Seke Etet,Frededic Maidawa,Silvere Vincent Rakotonirina,Alice Rakotonirina
Journal of Animal and Veterinary Advances , 2012,
Abstract: The decoction of Balanites aegyptiaca, a plant used in traditional medicine in Africa for many diseases, possesses anticonvulsant and sedative activity in mice. This decoction protected mice against strychnine- and pentylenetetrazol-induced seizures. But Balanites aegyptiaca decoction had no effect against picrotoxin-induced seizures. In the other side, the decoction of Balanites aegyptiaca potentiated sleep-induced by diazepam. The total sleep time of the control group was multiply by 4 in the presence of the decoction at a dose of 1000 mg /kg (from 12 to 59 min). With these effects, the decoction of Balanites aegyptiaca L. seem to posses sedative and anticonvulsant properties that might explain its use as a traditional medicine for epilepsy in Africa.
Actigraphy in Human African Trypanosomiasis as a Tool for Objective Clinical Evaluation and Monitoring: A Pilot Study
Alfred K. Njamnshi ,Paul F. Seke Etet,Stephen Perrig,Alphonse Acho,Julius Y. Funsah,Dieudonné Mumba,Jean-Jacques Muyembe,Krister Kristensson,Marina Bentivoglio
PLOS Neglected Tropical Diseases , 2012, DOI: 10.1371/journal.pntd.0001525
Abstract: Background Human African trypanosomiasis (HAT) or sleeping sickness leads to a complex neuropsychiatric syndrome with characteristic sleep alterations. Current division into a first, hemolymphatic stage and second, meningoencephalitic stage is primarily based on the detection of white blood cells and/or trypanosomes in the cerebrospinal fluid. The validity of this criterion is, however, debated, and novel laboratory biomarkers are under study. Objective clinical HAT evaluation and monitoring is therefore needed. Polysomnography has effectively documented sleep-wake disturbances during HAT, but could be difficult to apply as routine technology in field work. The non-invasive, cost-effective technique of actigraphy has been widely validated as a tool for the ambulatory evaluation of sleep disturbances. In this pilot study, actigraphy was applied to the clinical assessment of HAT patients. Methods/Principal Findings Actigraphy was recorded in patients infected by Trypanosoma brucei gambiense, and age- and sex-matched control subjects. Simultaneous nocturnal polysomnography was also performed in the patients. Nine patients, including one child, were analyzed at admission and two of them also during specific treatment. Parameters, analyzed with user-friendly software, included sleep time evaluated from rest-activity signals, rest-activity rhythm waveform and characteristics. The findings showed sleep-wake alterations of various degrees of severity, which in some patients did not parallel white blood cell counts in the cerebrospinal fluid. Actigraphic recording also showed improvement of the analyzed parameters after treatment initiation. Nocturnal polysomnography showed alterations of sleep time closely corresponding to those derived from actigraphy. Conclusions/Significance The data indicate that actigraphy can be an interesting tool for HAT evaluation, providing valuable clinical information through simple technology, well suited also for long-term follow-up. Actigraphy could therefore objectively contribute to the clinical assessment of HAT patients. This method could be incorporated into a clinical scoring system adapted to HAT to be used in the evaluation of novel treatments and laboratory biomarkers.
Evaluation of Diabetic Rats Behavior after Treatment by Artemisia herba-alba Relative to Insulin  [PDF]
Yahia M. Bushara, Abdelhay Mohammed Ali, Mohammed A. Ali Omer, John Gergis Gouda, Paul F. Seke Tet, Mohamed F. Mohamed
Journal of Diabetes Mellitus (JDM) , 2017, DOI: 10.4236/jdm.2017.71001
Abstract: The aim of the study was to evaluate the behavioral signs of diabetic rats after treatment by Artemisia herba-alba (AHA) and insulin. Method: Based on the induction of diabetes in wistar rats by intraperitoneal (I/P) injection of 60 mg/kg streptozotocin (STZ), then treated by AHA as 20 mg (I/P) and insulin subcutaneously (S/C). The samples of rats were: 1) Diabetic control, 2) Injected with insulin, 3) Injected with AHA, 4) Non diabetic rats, which were fostered for 21 day; then weighted and the behavioral tests were conducted. Results: The board hole tests (BHT) showed that: the induced diabetes reduced the cognition of the rats in view of Latency of the First Head Dipping (LFHD) in seconds, number of head dipping (NHD) and duration of head dipping (DHD) by 49.3%, while it’s improved in AHA and insulin treated rats by 52% and 69% in average respectively. The exploratory activity reduced in diabetic rats by 36%, while AHA and Insulin treated rats increased by 53% and 72% respectively. The rearing test showed an increase of anxiety among diabetic in form of duration of rearing, number of rearing and time spend in center by 51.7% in average respectively, while the anxiety reduced after treatment by AHA and insulin by 39% and 47.3% in average respectively. Also the diabetes increased the depression state by 106%, while the treatment by AHA and insulin reduced the depression state by 77% and 88% respectively. And VPT showed that: motor impairment occurred in diabetic cases and improved after AHA and insulin treatment.
ética e técnica? Dialogando com Marx, Spengler, Jünger, Heidegger e Jonas
Brüseke, Franz Josef;
Ambiente & Sociedade , 2005, DOI: 10.1590/S1414-753X2005000200003
Abstract: the nineteenth century took technology as a central element of historical progress, but the perspective occurred to change during the first decades of the twentieth century. the criticism of technology formulated between the two world wars period in the stream of culture criticism, emblematically in spengler's work, does not confront ethics and technology. by that time of interludium bellicum (1918-1939), there was a comprehension of technology rid of any metaphysical and artistic dimension on the one hand, and, on the other hand, technology was recharged with a redeemer, utopian or heroic promise, despite totally absorbed by a materialistic conception of the world, conceived as a battle ground (ernst jünger). martin heidegger elaborated, at the end of the thirties and middle forties, in a getaway move from the intellectual scene, the basis for a repercussive philosophy of technology. one of his pupils, hans jonas, originally tries, but not rid of mistakes, to show us an ethics meant to be valid for a technological civilization. according to jonas, the human situation and the context of any ethical purpose would be, nowadays, fundamentally changed; a traditional ethics is not up to the mark. the modern technology introduced new objects and processes with unknown consequences for the human society, in a way that would require an adaptation of ethics (and consequently of human action) to technological challenges. the "neighbor ethics" would be valid, though, in the "neighborhood"; but the future of humanity in its global habitat would claim an "ethics of responsibility".
Romantismo, mística e escatologia política
Brüseke, Franz Josef;
Lua Nova: Revista de Cultura e Política , 2004, DOI: 10.1590/S0102-64452004000200003
Abstract: philosophical, political or esthetic visions which have contested central paradigms of modernity are traditionally seen as external to modernity itself. this text talks about what modernizing ideology denounces as an antimodern irrationalism which, however, has followed this modernity since its beginning and receives from it, paradoxically, accelerating impulses. presenting romanticism, mystique and eschatology as companions of technical modernity also means to understand them as historical phenomena which have not handed over the imaginary alternatives to the machine myth, the one constructed by a modernity that wants to forget the dimensions of being and human existence which overflow the factual and the world exposed to manipulation.
Risco e contingência
Brüseke, Franz Josef;
Revista Brasileira de Ciências Sociais , 2007, DOI: 10.1590/S0102-69092007000100006
Abstract: references to the society of risk have become common and frequently tend to express more the spirit of uncertainty and insecurity of times than some properly defined sociological theory. the article briefly recalls the contribution of beck and luhmann, among others, to the sociology of risk and then moves towards the interpretation of risk as some aspect of the contingency of the modern society. contingency awareness, though present in the occidental thinking since aristotle, gained some accelerating impulse with descartes? methodical doubting, before dramatically imposing itself with the implosion of the grand metaphysical systems. making references to tomas de aquino and richard rorty, the article proposes reintegrating its essence to its accidental meaning. in rescuing the paradoxical structure of contingency it can then come to a better understanding of the standards of possibility for technical modernity.
A modernidade técnica
Brüseke, Franz Josef;
Revista Brasileira de Ciências Sociais , 2002, DOI: 10.1590/S0102-69092002000200009
Abstract: the fact that modernity, as a historical event, emerges with modern science and technique, shows all its virulence today. it is even possible to say that this modernity is so embedded in "technique" that it can be named and characterized as a "technical modernity." this article proposes that such a concept can be used to reveal the essence and to discuss the emergency of this modernity in order to evoke, on one hand, its processual and historical event and, on the other hand, its highly unstable and unpredictable degree. giving its contingent character, the technique contributes to a deprivation of a rationality of ends predominance, something characteristic of the historical phase in which the capitalism appeared within a contingent rationality. this rationality reveals the being scientifically and technically but without revealing an end to be reached that could give direction or even identify its limits. with no direction or limits, the technical modernity is developed rationally, lacking protection against irrational oscillations that progressively punish its route. the article presents the german national-socialism, the russian communism and the american democracy as three ideal types of the technical modernity. a comparative glance in the direction of this modernizing triad of the xxth century shows the indifference for values for the technical modernity at the same time that promotes the understanding of the contingent and irrational phenomena generated in this process.
A descoberta da contingência pela teoria social
Brüseke, Franz Josef;
Sociedade e Estado , 2002, DOI: 10.1590/S0102-69922002000200004
Abstract: historically, the contingency is thought by aristotle, for the first time, in his text peri hermeneias where the philosopher introduces the concept endechómenon, translated later as contingency. the discovery of the contingency reflects a new spirit in the works of weber, parsons and luhmann as in the western philosophy in husserl, heidegger, camus, sartre and other, that notice the dramatic tension of the relationships and contingent phenomena. in spite of the long tradition of the conscience of the contingency in the western thought, it is the coming of the "postmodernity", relatively late, that brings its meaning to the light of day. authors as lyotard, maffesoli and bauman explore the discovery of the contingency in the field of the social theory and they show that the world is necessarily as it is but, also, it could be different. our hypothesis is that the highly contingent character of the modern technique, as long as it penetrates the contemporary society more and more it affects decisively the man and its way of living in the world; in this way the problem of the contingency wins sociological relevance.
A técnica moderna e o retorno do sagrado
Brüseke, Franz Josef;
Tempo Social , 1999, DOI: 10.1590/S0103-20701999000100012
Abstract: the return to the sacred points to a problem beyound the sociological horizon, if thought in a fundamental way. if so, why not reading one of the classical works concerning this topic, the theologist rudolf otto ? why not trying to decipher the late texts from heidegger and its frequent allusions to the sacred as a clue to the renegated gods? it is curious that the cognitive programme of modern sciences guide us to some results which seems to confront a strange, paradoxal and antinomical world, with its inovating contribution to this change. these features were presented by otto. and what does it have to do with technique, modern society and sociology ? this is the topic of the textthe modern society and the return to the sacred .
A modernidade técnica
Brüseke Franz Josef
Revista Brasileira de Ciências Sociais , 2002,
Abstract: O fato de que a modernidade, como época histórica, nasce com a ciência e técnica moderna, mostra hoje toda sua virulência. Podemos até dizer que essa modernidade é t o penetrada pela "técnica" que ela pode ser denominada e caracterizada como "modernidade técnica". Propomos este conceito para evidenciar sua essência e falamos sobre a emergência desta modernidade para evocar, por um lado, seu advento processual e histórico e, por outro, seu alto grau de instabilidade e imprevisibilidade. A técnica contribui, em fun o de seu caráter contingente, para uma destitui o da predominancia da racionalidade de fins, t o característica da fase histórica na qual surgiu o capitalismo, por uma racionalidade contingente. Essa racionalidade desoculta científica e tecnicamente o Ser, sem dispor de um fim que daria dire o ou identificaria limites. Sem dire o e limites a modernidade técnica desenvolve-se racionalmente, sem que haja uma prote o contra oscila es irracionalizantes que castigam cada vez mais seu percurso. Apresentamos o nacional-socialismo alem o, o comunismo russo e a democracia americana como três tipos ideais da modernidade técnica. Um olhar comparativo na dire o da tríade modernizante do século XX demonstra tanto a indiferen a valorativa da modernidade técnica, quanto nos faz compreender melhor os fen menos contingentes e irracionais gerados no seu bojo.
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