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Search Results: 1 - 10 of 121013 matches for " Patrick O'Beirne "
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Information and Data Quality in Spreadsheets
Patrick O'Beirne
Computer Science , 2008,
Abstract: The quality of the data in spreadsheets is less discussed than the structural integrity of the formulas. Yet it is an area of great interest to the owners and users of the spreadsheet. This paper provides an overview of Information Quality (IQ) and Data Quality (DQ) with specific reference to how data is sourced, structured, and presented in spreadsheets.
Spreadsheet Refactoring
Patrick O'Beirne
Computer Science , 2010,
Abstract: Refactoring is a change made to the internal structure of software to make it easier to understand and cheaper to modify without changing its observable behaviour. A database refactoring is a small change to the database schema which improves its design without changing its semantics. This paper presents example 'spreadsheet refactorings', derived from the above and taking into account the unique characteristics of spreadsheet formulas and VBA code. The techniques are constrained by the tightly coupled data and code in spreadsheets.
Facing the Facts
Patrick O'Beirne
Computer Science , 2008,
Abstract: Human error research on overconfidence supports the benefits of early visibility of defects and disciplined development. If risk to the enterprise is to be reduced, individuals need to become aware of the reality of the quality of their work. Several cycles of inspection and defect removal are inevitable. Software Quality Management measurements of defect density and removal efficiency are applicable. Research of actual spreadsheet error rates shows data consistent with other software depending on the extent to which the work product was reviewed before inspection. The paper argues that the payback for an investment in early review time is justified by the saving in project delay and expensive errors in use. 'If debugging is the process of removing bugs, then programming must be the process of putting them in' - Anon.
Checks and Controls in Spreadsheets
Patrick O'Beirne
Computer Science , 2009,
Abstract: Spreadsheets that are informally created are harder to test than they should be. Simple cross-foot checks or being easily readable are modest but attainable goals for every spreadsheet developer. This paper lists some tips on building self-checking into a spreadsheet in order to provide more confidence to the reader that a spreadsheet is robust.
Excel 2013 Spreadsheet Inquire
Patrick O'Beirne
Computer Science , 2014,
Abstract: Excel 2013 (version 15) includes an add-in "Inquire" for auditing spreadsheets. We describe the evolution of such tools in the third-party marketplace and assess the usefulness of Microsoft's own add-in in this context. We compare in detail the features of Inquire with similar products and make suggestions for how it could be enhanced. We offer a free helper add-in that in our opinion corrects one major shortcoming of Inquire.
Generation of functional CD8+ T Cells by human dendritic cells expressing glypican-3 epitopes
James O'Beirne, Farzin Farzaneh, Phillip M Harrison
Journal of Experimental & Clinical Cancer Research , 2010, DOI: 10.1186/1756-9966-29-48
Abstract: Dendritic cells (DC) were derived from adherent PBMC cultured at 37°C for 7 days in X-Vivo, 1% autologous plasma, and 800 u/ml GM-CSF plus 500 u/ml IL-4. Immature DC were transfected with 20 μg of in vitro synthesised GPC-3 mRNA by electroporation using the Easy-ject plus system (Equibio, UK) (300 V, 150 μF and 4 ms pulse time), or pulsed with peptide, and subsequently matured with lipopolysaccharide (LPS). Six predicted GPC-3 peptide epitopes were synthesized using standard f-moc technology and tested for their binding affinity to HLA-A2.1 molecules using the cell line T2.DC transfected with GPC-3 mRNA but not control DC demonstrated strong intracellular staining for GPC-3 and in vitro generated interferon-gamma expressing T cells from autologous PBMC harvested from normal subjects. One peptide, GPC-3522-530 FLAELAYDL, fulfilled our criteria as a naturally processed, HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope: i) it showed high affinity binding to HLA-A2, in T2 cell binding assay; ii) it was generated by the MHC class I processing pathway in DC transfected with GPC-3 mRNA, and iii) HLA-A2 positive DC loaded with the peptide stimulated proliferation in autologous T cells and generated CTL that lysed HLA-A2 and GPC-3 positive target cells.These findings demonstrate that electroporation of GPC-3 mRNA is an efficient method to load human monocyte-derived DC with antigen because in vitro they generated GPC-3-reactive T cells that were functional, as shown by interferon-gamma production. Furthermore, this study identified a novel naturally processed, HLA-A2-restricted CTL epitope, GPC-3522-530 FLAELAYDL, which can be used to monitor HLA-A2-restricted CTL responses in patients with HCC. Further studies are required to investigate whether anti-GPC-3 immunotherapy has a role in the treatment of GPC-3 dependent tumours, such as HCC.Increasing evidence suggests that immune responses play an important role in the control of cancer and manipulation of the immune sys
“Fashioning The L Word."
Rebecca Beirne
Nebula , 2006,
The Value of Positive Pressure Ventilations for Clients in Acute Respiratory Distress as a Result of Cardiac and Pulmonary Issues  [PDF]
Patrick O’Connell
Open Journal of Respiratory Diseases (OJRD) , 2015, DOI: 10.4236/ojrd.2015.52005
Abstract: Objective: Research was conducted to examine benefits to using non-invasive ventilation (NIV) or continuous positive airway pressure (CPAP) early in the treatment of respiratory distress caused by pulmonary edema, chronic obstructive pulmonary disease (COPD) and asthma. Limitations to successful NIV and CPAP therapy were evaluated to determine how prolonged initiation of treatment may lead to hypoxemia (decreased oxygen in the blood) and hypercapnia (increased carbon dioxide in the blood) resulting in poor outcomes. Method: Reviews of literature from nursing and allied health data bases (CINAHL and ProQuest) with terms pulmonary edema, positive pressure device and non-invasive ventilation from 2010 to 2014 were used. Studies were conducted in the hospital and prehospital settings. Results: The literature search located 7 articles from CINAHL and 25 articles from ProQuest. A total of 6 of these articles were analyzed. Additional sources of data were obtained from Ignatavicius and Workman (2013) Medical-Surgical Nursing Patient-Centered Collaborative Care 7th edition and American Journal of Nursing (02/2013) Volume 113: 2. Conclusion: All of the articles concluded that early initiation of continuous positive airway pressure ventilations in the short-term was beneficial; however, late initiation of therapy required additional interventions. The studies indicated that early use of positive airway pressure in acute respiratory distress improved breath rate, heart rate and blood pressure. The use of positive airway pressure for respiratory distress may decrease the need for endotracheal intubation.
Transtympanic Electrocochleography for the Diagnosis of Ménière's Disease
Jeremy Hornibrook,Catherine Kalin,Emily Lin,Greg A. O'Beirne,John Gourley
International Journal of Otolaryngology , 2012, DOI: 10.1155/2012/852714
Abstract: This paper evaluated the diagnostic power of electrocochleography (ECochG) in detecting Ménière's disease (MD) as compared with two subjective assessment methods, including the clinical guidelines provided by the American Academy of Otolaryngology—Head and Neck Surgery Committee on Hearing Equilibrium and the Gibson score. A retrospective study of 250 suspected MD cases was conducted. The agreement between the three assessment methods was found to be relatively high, with a total reliability being higher than 70%. Participants who tested “positive” with ECochG exhibited a higher occurrence rate of asymmetric hearing threshold as well as the four MD symptoms, namely, vertigo, hearing loss, tinnitus, and aural fullness. The “positive” ECochG group also showed a high correlation between the ECochG measures in response to stimuli at adjacent frequency ranges, suggesting that the interfrequency ECochG correspondence may be sensitive to the presence of endolymphatic hydrops and thus may serve as a useful diagnostic marker for MD.
Neurogenic diabetes insipidus presenting in a patient with subacute liver failure: a case report
Manu Shankar Hari, Anthony K Parsons, Andy K Burroughs, Steve Shaw, James O'Beirne, Banwari Agarwal
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-232
Abstract: A 25-year-old man presented with subacute liver failure. While awaiting a liver transplant, the patient developed cerebral edema, which resulted in neurogenic diabetes insipidus secondary to cerebral edema. The patient died before the liver transplantation could be carried out.Neurogenic diabetes insipidus is well recognized in the neurosurgical population as a consequence of cerebral edema and increased intracranial pressure, both of which occur commonly in patients with subacute liver failure.Cerebral edema occurs in patients presenting with fulminant liver failure, resulting in increased intracranial pressure (ICP). The incidence and severity of cerebral edema increases as the onset of liver failure becomes rapid. It occurs in up to 80% of patients with acute and hyperacute fulminant liver failure but less frequently (20%) in those with subacute fulminant liver failure. There is a significant association between the presence of cerebral edema and the development of central diabetes insipidus in patients with traumatic brain injury [1] and in postoperative neurosurgical patients. We present a case of neurogenic diabetes insipidus that developed during the course of subacute fulminant liver failure.A 25-year-old Nigerian man was admitted to our hospital's intensive care unit (ICU), after emergency tracheal intubation and ventilation for worsening encephalopathy and a deteriorating Glasgow Coma Scale score. The working diagnosis was seronegative hepatitis leading to subacute fulminant liver failure and grade three hepatic encephalopathy.His admission to our hospital was preceded by an admission to a local hospital with a ten day history of painless jaundice and malaise, progressing to three days of nausea and vomiting. The patient had no history of encephalopathy or coagulopathy. Liver function tests on admission were abnormal (bilirubin, 381 μmol/L, alanine transferase [ALT], 684 U/L), but an ultrasound scan showed a normal liver. Autoimmune and viral screen result
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