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Search Results: 1 - 10 of 10033 matches for " Patrick Keane "
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The general motor programmer: its specialization for speech perception & movement  [PDF]
Anne Maria Keane
World Journal of Neuroscience (WJNS) , 2012, DOI: 10.4236/wjns.2012.23024
Abstract: A common neural mechanism—the General Motor Programmer—is proposed by Keane (1999) to underlie both the perception of speech and the initiation of hand movement. A proposal to investigate the specific aspect of cognitive functioning this mechanism is specialized for, namely the timing or place of articulation, is outlined.
Outcome of Glansectomy and Skin Grafting in the Management of Penile Cancer
Hugh F. O'Kane,Ajay Pahuja,K. J. Ho,Ali Thwaini,Thaigarajan Nambirajan,Patrick Keane
Advances in Urology , 2011, DOI: 10.1155/2011/240824
Abstract: Purpose. To report outcome data for patients with penile cancer treated surgically with glansectomy and skin grafting. Materials and Methods. We retrospectively reviewed data on all patients undergoing surgical management of penile cancer by a single surgeon between 1998 and 2008. Outcomes in patients who underwent glansectomy and skin grafting were analysed. Results. Between 1998 and 2008 a total of 25 patients with a mean age 60 (39–83) underwent glansectomy and skin grafting. Six patients had carcinoma in situ (CIS); the stage in the remaining patients ranged from T1G1 to T3G3. Mean followup for patients was 28 months (range 6–66). Disease specific survival was 92% with 2 patients who had positive nodes at lymph node dissection developing groin recurrence. One patient developed a local recurrence requiring a partial penectomy. Conclusions. Penile preserving surgery with glansectomy and skin grafting is a successful technique with minimal complications for local control of penile carcinoma arising on the glans. Careful followup to exclude local recurrence is required. 1. Introduction Penile cancer is an uncommon malignancy in the industrialized world, particularly in Europe and in the USA with an incidence of less than 1 per 100?000 of the male adult population. In contrast to this, the incidence in some parts of the developing world is as high as 19 per 100?000 per year [1]. More than 95% of penile cancers are primary squamous cell carcinomas with other uncommon histological types including melanoma, sarcoma, and basal cell carcinomas. Historically, the surgical management of the primary lesion in penile carcinoma has meant either partial or radical penectomy. Oncologically, radical surgical excision has stood the test of time, with excellent local control. These operations are however often mutilating and associated with urinary and sexual dysfunction as well as significant psychological morbidity [2]. In an attempt to reduce the negative impact of radical surgery and retain functional penile length, a variety of therapeutic strategies have been developed particularly for the management of more distal lower-grade cancers. The obvious risk is always that there will be compromise of local oncological control. Oncological outcomes of “penile preserving” surgical techniques should always, if possible, be measured against the gold standard of radical excision. Randomised trials are next to impossible in such an uncommon disease and although widely practiced and results are encouraging, only a small number of centres have published their outcome data on
Disease Development Caused by Ascochyta rabiei on Chickpea Detached-Leaves in Petri Dishes  [PDF]
Nunung Harijati, Philip J. Keane
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.310165
Abstract: A study using detached-leaves aimed to improve selection method. The improving method was done by scoring both disease symptom and lesion size. The research was begun by selecting agar concentration and dose of conidia that could distinguish response of very susceptible or resistant chickpea genotype. The result was used to determine disease severity (DS) and disease incident (DI) of eight genotypes that were previously tested in the field. Results of the tested agar concentration and dose of conidia showed that 1.5% and 2% agar were good to determine susceptible or resistant genotype; while 1 × 105 or 5 × 104 conidia dose was suitable for inoculation. The formula of DS (no. of leaflets in category × category value/Total no. of leaflets ×10) × 100, and DI (no. leaflets with pycnidial lesions + no. leaflets with necrotic lesions)/Total no. of leaflets × 100 successfully measured genotype response. The lesions development on detached leaves of the susceptible cultivar (Lasseter) began as circular, pale-colored areas, extending to the area covered by the drop of inoculum, then became light brown and finally dark brown. However, the response of resistant line (FLIP508) was restricted in area (and often confined to a tiny speck) surrounded by chlorosis or drying of the tissue.
Partial differential equations versus cellular automata for modelling combat
Therese Keane
Mathematics , 2009,
Abstract: We reproduce apparently complex cellular automaton behaviour with simple partial differential equations as developed in (Keane 09). Our PDE model easily explains behaviour observed in selected scenarios of the cellular automaton wargame ISAAC without resorting to anthropomorphisation of autonomous 'agents'. The insinuation that agents have a reasoning and planning ability is replaced with a deterministic numerical approximation which encapsulates basic motivational factors and demonstrates a variety of spatial behaviours approximating the mean behaviour of the ISAAC scenarios. All scenarios presented here highlight the dangers associated with attributing intelligent reasoning to behaviour shown, when this can be explained quite simply through the effects of the terms in our equations. A continuum of forces is able to behave in a manner similar to a collection of individual autonomous agents, and shows decentralised self-organisation and adaptation of tactics to suit a variety of combat situations.
Deconstructing analogy
Mark Keane
Computer Science , 2013,
Abstract: Analogy has been shown to be important in many key cognitive abilities, including learning, problem solving, creativity and language change. For cognitive models of analogy, the fundamental computational question is how its inherent complexity (its NP-hardness) is solved by the human cognitive system. Indeed, different models of analogical processing can be categorized by the simplification strategies they adopt to make this computational problem more tractable. In this paper, I deconstruct several of these models in terms of the simplification-strategies they use; a deconstruction that provides some interesting perspectives on the relative differences between them. Later, I consider whether any of these computational simplifications reflect the actual strategies used by people and sketch a new cognitive model that tries to present a closer fit to the psychological evidence.
Correlation of selected molecular markers in chemosensitivity prediction  [PDF]
David King, Thomas Keane, Wei Hu
Journal of Biomedical Science and Engineering (JBiSE) , 2009, DOI: 10.4236/jbise.2009.27073
Abstract: Finding effective cancer treatment is a challenge, because the sensitivity of the cancer stems from both intrinsic cellular properties and acquired resistances from prior treatment. Previous research has revealed individual protein markers that are significant to chemosensitivity prediction. Our goal is to find correlated protein markers which are collectively significant to chemosensitivity prediction to complement the individual markers already reported. In order to do this, we used the D’ correlation measurement to study the feature selection correlations for chemosensitivity prediction of 118 anticancer agents with putatively known mechanisms of action. Three data-sets on the NCI-60 were utilized in this study: two protein datasets, one previously studied for chemosensitivity prediction and another novel to this topic, and one DNA copy number dataset. To validate our approach, we identified the protein markers that were strongly correlated by our analysis with the individual protein markers found in previous studies. Our feature analysis discovered highly correlated protein marker pairs, based on which we found individual protein markers with medical significance. While some of the markers uncovered were consistent with those previously reported, others were original to this work. Using these marker pairs we were able to further correlate the cellular functions associated with them. As an exploratory analysis, we discovered feature selection correlation patterns between and within different drug mechanisms of action for each of our datasets. In conclusion, the highly correlated protein marker pairs as well as their functions found by our feature analysis are validated by previous studies, and are shown to be medically significant, demonstrating D’ as an effective measurement of correlation in the context of feature selection for the first time.
Retinal vein occlusion and macular edema – critical evaluation of the clinical value of ranibizumab
Keane PA, Sadda SR
Clinical Ophthalmology , 2011, DOI: http://dx.doi.org/10.2147/OPTH.S13774
Abstract: inal vein occlusion and macular edema – critical evaluation of the clinical value of ranibizumab Review (6604) Total Article Views Authors: Keane PA, Sadda SR Published Date June 2011 Volume 2011:5 Pages 771 - 781 DOI: http://dx.doi.org/10.2147/OPTH.S13774 Pearse A Keane1, Srinivas R Sadda2 1NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; 2Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA Abstract: Retinal vein occlusions (RVOs) constitute the second most common cause of retinal vascular disease after diabetic retinopathy, with a prevalence of between 1% and 2% in persons older than 40 years of age. Despite the existence of numerous potential therapeutic options, none is entirely satisfactory, and many patients with RVO suffer irreversible visual loss. Fortunately however, the recent introduction of antivascular endothelial growth factor (VEGF) agents, such as ranibizumab (Lucentis , Genentech, South San Francisco, CA) and bevacizumab (Avastin , Genentech), offers a potentially new treatment approach for clinicians managing this disorder. The results of the BRAVO and CRUISE trials have provided the first definitive evidence for the efficacy and safety of ranibizumab in the treatment of RVO. As a result, ranibizumab has recently been approved by the US Food and Drug Administration for the treatment of RVO-associated macular edema. In this review, we provide a critical evaluation of clinical trial data for the safety and efficacy of ranibizumab, and address unresolved issues in the management of this disorder.
Die joodse volk en die kerk: nog 'n beskouing van die Probleem
Marie Henry Keane
Koers : Bulletin for Christian Scholarship , 1989, DOI: 10.4102/koers.v54i2.822
Abstract: The Jewish nation and church: Another view of the problem. This article takes a look at the "Jewish problem" using Roman 9-11 as the point of departure . The apostle Paul is convinced that God has not rejected Israel. The Jews s till have a decisive role to p la y in the divine action in history . The problem o f the Jewish -Christian relationship is as old as Christianity itself. On this article the writer does not attempt to offer solutions b u t reminds the church that the people o f God will be incomplete until Jews and Christian s alike are united .
The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
Keane Michael,Strieter Robert
Respiratory Research , 2002,
Abstract: The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates that diffuse lung disease results from an imbalance between the pro-inflammatory and anti-inflammatory mechanisms, with a persistent imbalance that favors pro-inflammatory mediators dictating the development of chronic diffuse lung disease. This review focuses on the mediators that influence this imbalance.
Partnership on Reducing Mercury in Artisanal and Small-Scale Gold Mining (ASGM)
Bernaudat L.,Keane S.
E3S Web of Conferences , 2013, DOI: 10.1051/e3sconf/20130136003
Abstract: The Artisanal and Small Scale Gold Mining Partnership area is an initiative to reduce global mercury pollution through coordinated voluntary actions. This partnership area, co-led by Natural Resources Defense Council and the United Nations Industrial Development Organization, gathers the major actors in the sector, including governments, academia and civil society. The ASGM sector remains the largest demand sector for mercury globally (best global estimates put mercury use by the sector in the range of 1400 tonne/year in 2011). Virtually all of the mercury introduced in the process is released to the environment. This sector involves an estimated 10-20 million miners, and the numbers are likely increasing as the rising price of gold attracts additional poverty-driven miners. Serious long-term environmental health hazards exist for populations associated with or living downstream/wind from mining operations, often including indigenous peoples. The objective of the ASGM Partnership area is to minimize and where possible eliminate mercury uses and releases in artisanal and small scale gold mining. The presentation will outline the key challenges associated with the ASGM sector and summarize the activities under the Partnership to address those challenges.
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