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Search Results: 1 - 10 of 9899 matches for " Patrick Haffner "
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Efficient Multiclass Implementations of L1-Regularized Maximum Entropy
Patrick Haffner,Steven Phillips,Rob Schapire
Computer Science , 2005,
Abstract: This paper discusses the application of L1-regularized maximum entropy modeling or SL1-Max [9] to multiclass categorization problems. A new modification to the SL1-Max fast sequential learning algorithm is proposed to handle conditional distributions. Furthermore, unlike most previous studies, the present research goes beyond a single type of conditional distribution. It describes and compares a variety of modeling assumptions about the class distribution (independent or exclusive) and various types of joint or conditional distributions. It results in a new methodology for combining binary regularized classifiers to achieve multiclass categorization. In this context, Maximum Entropy can be considered as a generic and efficient regularized classification tool that matches or outperforms the state-of-the art represented by AdaBoost and SVMs.
Terrestrial mammal fauna and threatened species in France
Fran?ois De Beaufort,Hervé Maurin,Patrick Haffner
Hystrix : the Italian Journal of Mammalogy , 1996, DOI: 10.4404/hystrix-8.1-2-4089
Abstract: With the passing of time, the terrestrial mammal fauna changed considerably in France: definitive extinctions, temporary disappearances, natural reapparitions, introductions and reintroductions. 21 species are considered as threatened (endangered and vulnerab1e) and two have completely disappeared. However, more precise data are needed for a few of them.
Accelerated Parallel Optimization Methods for Large Scale Machine Learning
Haipeng Luo,Patrick Haffner,Jean-Francois Paiement
Computer Science , 2014,
Abstract: The growing amount of high dimensional data in different machine learning applications requires more efficient and scalable optimization algorithms. In this work, we consider combining two techniques, parallelism and Nesterov's acceleration, to design faster algorithms for L1-regularized loss. We first simplify BOOM, a variant of gradient descent, and study it in a unified framework, which allows us to not only propose a refined measurement of sparsity to improve BOOM, but also show that BOOM is provably slower than FISTA. Moving on to parallel coordinate descent methods, we then propose an efficient accelerated version of Shotgun, improving the convergence rate from $O(1/t)$ to $O(1/t^2)$. Our algorithm enjoys a concise form and analysis compared to previous work, and also allows one to study several connected work in a unified way.
The Distribution of Warm Ionized Medium in Galaxies
L. M. Haffner
Physics , 2010,
Abstract: Ionized nebulae have been targets of interest since the introduction of the telescope centuries ago. These isolated, "classical" H II regions gave us some of the earliest insight into the copious feedback energy that stars inject into the interstellar medium. Their unique spectra contain information about the quality and quantity of the ionizing field as well as the temperature, density, and metallicity of these discrete locations in the Galaxy. With increasing sensitivity across many spectral domains, we now know that ionized gas is not localized to massive star regions in many star-forming galaxies. In particular, recent observational studies allow a thorough comparison of the physical conditions and distribution of the well-studied classical H II regions to the more widespread warm, diffuse gas. By more realistically evolving a dynamic interstellar medium, models are beginning to reproduce the observed emission measure variations and provide a natural solution to the propagation of ionizing flux from a predominantly neutral galactic disk to the distant halo.
The Wisconsin H-Alpha Mapper Northern Sky Survey
L. M. Haffner
Physics , 2000,
Abstract: The Wisconsin H-Alpha Mapper (WHAM) has completed a survey in Balmer Alpha of the entire Northern sky above declination -30 deg. This survey provides the first calibrated, velocity-resolved map of the H-Alpha emission from the Galaxy. With one-degree spatial resolution, 12 km s^{-1} velocity resolution, and sensitivity to features as faint as 0.1 R (EM ~ 0.2 cm^{-6} pc), this survey provides the deepest maps of the ionized content of the Galaxy to date. In addition to probing the detailed kinematic structure of the Warm Ionized Medium and the vertical structure of the ionized content in spiral arms, initial results include the discovery of several faint, extended (d > 1\deg) H II regions and the first map of the ionized component of an intermediate velocity cloud.
Patient-specific instruments as a standard procedure in total knee arthroplasty: Logistics and postoperative radiological results in 70 patients  [PDF]
Dominik Drnek, Nicolas Haffner, Armin Sadjed, Peter Ritschl
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.31014
Abstract:


Serous Purpose: There is limited information in the literature surrounding the use of patient-specific instrumentation (PSI) by a large number of surgeons. This prospective observational study was therefore designed to evaluate the logistics of using PSI for total knee arthroplasty (TKA) in a multi-surgeon environment, as well as its accuracy in positioning components. Methods: Of 73 patients enrolled in this study, 3 were excluded after the surgeon decided intraoperatively to switch to conventional instrumentation. Results: Mean operative time was 77.6 minutes. The component size had to be changed in 19 patients and bone cuts corrected in 12. In 65 of the 70 cases (92.9%), mechanical alignment was within the optimal range from 3° varus to 3° valgus, with the remaining 5 cases considered outliers (7.1%). Mean overall mechanical alignment was 0.3° varus (standard deviation, ±2°). There was a distinct variance with regard to the position of the tibial component in the sagittal plane. Conclusions: PSI can be effectively incorporated in larger, multisurgeon practices. Although high accuracy was observed for overall mechanical alignment and component positioning in the frontal and sagittal planes, further attention must be paid to the tibial slope. We highly recommend the use of the extramedullary alignment rod to the proper position of the tibial block, as well as double-checking the slope before performing bone cuts.


Non-small cell lung carcinoma in an adolescent manifested by acute paraplegia due to spinal metastases: a case report
Ulrike Ackert, Dieter Haffner, Carl Classen
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-486
Abstract: We report on a 16-year-old Caucasian German boy with non-small cell lung carcinoma (squamous cell non-small cell lung carcinoma) stage IV, T4N2M1, without epidermal growth factor receptor overexpression and/or mutation or k-ras mutation. He presented with paraplegia due to spinal metastases of the bronchial carcinoma. No familial predisposition or toxin exposure was identified. Treatment following adult protocols consisted of surgical intervention for spinal metastases, first-line cisplatinum and gemcitabine, irradiation and second-line docetaxel. After a transient response our patient experienced disease progression and died about 10 months later.Response and survival in our 16-year-old patient were similar to adult patients with stage IV non-small cell lung carcinoma.Lung cancer is the leading cause of cancer-related mortality in adults in many countries, especially in smokers [1,2]. There are small cell and non-small cell lung cancers (NSCLC). NSCLC are subdivided into adenocarcinomas (about 50%), squamous cell (about 20%), large cell (about 10%), and otherwise not defined carcinomas [1]. The TNM staging system is closely associated with prognosis. Metastatic disease, defined as stage IV, accounting for 10% to 20% of cases, has a median survival time of nine months and a five-year survival of about 1% [2]. The peak age for NSCLC is 50 years to 60 years [2]. Recently, several molecular characteristics of NSCLC, including p53 mutations, epidermal growth factor receptor (EGFR) mutations with subsequent dysregulation of the ras/raf kinase pathway and k-ras mutations, have been defined [3], leading to some targeted therapy approaches. Their benefit is still not quite clear [4,5].The therapy options--surgery, chemotherapy, irradiation and targeted therapy--are usually applied according to the TMN staging and the molecular signature [3-5]. Tumors should be resected primarily whenever possible [6]. Unresectable tumors imply a palliative condition. Combination first-line
The Psychoanalytic Defence Mechanisms in the Context of Chronic Kidney Disease and Living Kidney Organ Donation Occuring in Children and their Parents
D. Horstmann,E.-M. Haffner
Transplantationsmedizin , 2011,
Abstract: This review deals with the psychoanalytic defence mechanisms, an important aspect of kidney transplantation from parents to their child. The different modes of defence, appearing in this process will be discussed. There is evidence that the psychodynamic defence behaviour of physically disabled persons and people with chronic diseases is significantly enhanced. Children and adolescents with chronic or end-stage renal failure or kidney transplantation and their parents have to deal with problems like adherence, infections, rejection and – most important – graft survival next to the conscious and unconscious coping. Unconscious behaviour of defence exerts a decisive influence on coping even in intra-family relationships. To which extent and in which specific form do these defence mechanisms occur in infant and adolescent patients and their families, coping with end stage renal diseases or living kidney donation? This question will be discussed exemplarily.
Growth after Solid-organ Transplantation
D.-C. Fischer,D. Haffner
Transplantationsmedizin , 2011,
Abstract: One of the ultimate goals of solid organ transplantation in children is to attain a normal adult height. Many children with organ failure present with severe growth retardation already at time of transplantation. This is due to the metabolic/hormonal consequences of organ dysfunction, malnutrition, infections, and markedly influenced by the primary disease. Despite excellent organ function catch-up growth in children after solid-organ transplantation remains often incomplete. Of note, remarkably similar factors impact on growth in pediatric kidney, liver, heart, and lung recipients. Beside genetic factors, age and degree of growth failure at time of transplantation, malnutrition, treatment with corticosteroids and graft function have to be mentioned as factors significantly influencing post transplant growth. During the last 10 years great efforts have been made to improve pre-transplant growth by providing adequate nutrition and/or growth hormone therapy. New immunosuppressive protocols allow to minimize or even to avoid exposure to corticosteroids in the majority of patients. Thus, attaining a normal adult height is within reach for children requiring solid-organ transplantation.
Optimal control of entangling operations for trapped ion quantum computing
V. Nebendahl,H. Haffner,C. F. Roos
Physics , 2008, DOI: 10.1103/PhysRevA.79.012312
Abstract: Optimal control techniques are applied for the decomposition of unitary quantum operations into a sequence of single-qubit gates and entangling operations. To this end, we modify a gradient-ascent algorithm developed for systems of coupled nuclear spins in molecules to make it suitable for trapped ion quantum computing. We decompose unitary operations into entangling gates that are based on a nonlinear collective spin operator and complemented by global spinflip and local light shift gates. Among others, we provide explicit decompositions of controlled-NOT and Toffoli gates, and a simple quantum error correction protocol.
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