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Search Results: 1 - 10 of 9796 matches for " Patrick Chames "
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Therapeutic Antibodies for the Treatment of Pancreatic Cancer
Patrick Chames,Brigitte Kerfelec,Daniel Baty
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.103
State of the Art in Tumor Antigen and Biomarker Discovery
Klervi Even-Desrumeaux,Daniel Baty,Patrick Chames
Cancers , 2011, DOI: 10.3390/cancers3022554
Abstract: Our knowledge of tumor immunology has resulted in multiple approaches for the treatment of cancer. However, a gap between research of new tumors markers and development of immunotherapy has been established and very few markers exist that can be used for treatment. The challenge is now to discover new targets for active and passive immunotherapy. This review aims at describing recent advances in biomarkers and tumor antigen discovery in terms of antigen nature and localization, and is highlighting the most recent approaches used for their discovery including “omics” technology.
Dan a escolar: uma possibilidade na Educa o Física
Chames Maria Stalliviere Gariba,Ana Franzoni
Movimento , 2007,
Abstract: El presente articulo relata las reflexiones con respecto a la danza, su actuación en la sociedad y su comprensión asociada al proceso educacional; destaca informaciones primordiales que deben ser abordadas y discutidas con el profesor de Educación Física, dirigidas hacia el proceso de comprensión corporal a través de la danza, como posibilidad de establecer múltiples relaciones con otras áreas del conocimiento. Hace referencia con énfasis a los enfrentamientos, así como a las barreras a seren quebradas, para que la danza este cada vez mas incluida en el ambiente escolar. Estas discusiones se refiren al compromiso que debe tener, el educador, en busca de una práctica pedagógica direccionada a la formación de ciudadanos, críticos, autónomos y concientes de sus actos, para una transformación social.
Tissue-specific cytokine release from human extra-placental membranes stimulated by lipopolysaccharide in a two-compartment tissue culture system
Natalie W Thiex, Mark C Chames, Rita K Loch-Caruso
Reproductive Biology and Endocrinology , 2009, DOI: 10.1186/1477-7827-7-117
Abstract: Gestational membranes were collected from healthy non-laboring caesarean deliveries at term. Full-thickness membranes from each placenta were cut into pieces, mounted on Transwell frames, and placed in culture wells to create a two-compartment culture with the gestational membranes serving as the barrier between compartments. The LPS (100 ng/ml) was added to the amniotic, choriodecidual or both chambers of the culture, and cytokines were assayed in the medium of the amniotic and choriodecidual chambers after 8 h of LPS exposure. Cytokine concentrations were analyzed by two-way analysis of variance for effects of treatment and side specificity of cytokine release from the membranes.LPS exposure on the choriodecidual side of the membranes significantly increased TNF-alpha, IL-6, IL-10 and IL-8 in the choriodecidual compartment, whereas TNF-alpha was the only cytokine observed to increase in the amniotic compartment. When LPS treatment was to the amniotic side of the membranes, there were significant increases in TNF-alpha and IL-6 in the amniotic compartment as well as increased concentrations of TNF-alpha, IL-6 and IL-8 in the choriodecidual compartment; however, there were no statistically significant differences for IL-10 in either compartment. No statistically significant differences were observed for IL-1beta, TGF-beta or IL-4 concentrations in response to LPS, regardless of the exposure modality.The amnion and choriodecidua exhibited distinct patterns of response to LPS with evidence of inflammatory signaling across the layers of the gestational membranes. These results suggest a complicated network of signaling within the gestational membranes, in which cytokine- and tissue-specific responses to inflammatory stimulation may have important implications for maintaining pregnancy in the challenge of microbial invasion of the uterine compartment.Although cytokines were initially described as immune cell messengers, cytokine expression occurs in non-immune cells, in
Ego Depletion and the Humean Theory of Motivation  [PDF]
Patrick Fleming
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.43042

By what capacities do human beings engage in intentional action? Humeans about motivation claim that the source of all action is desire. Volitionalists claim that action has two distinct sources, one in the will and one in desire. Recent work suggests that volitionalism has some empirical support. Roy F. Baumeister and colleagues have argued for a phenomenon called “ego depletion”. They argue that some aspect of the self exerts volition in a number of different contexts. The main evidence for this claim is that experimental subjects who engage in acts of self-regulation are less likely to engage in similar actions on later tests. The evidence calls for a reformulation of the Humean theory, not a rejection of it. And the reformulation is one that still has interest for metaethics. Many philosophers are interested in the Humean theory of motivation because they believe that it has implications for the correct theory of normative practical reasons. Here I argue that if the Humean theory of motivation was ever a threat to the objectivity of morality, it still is.

Letter to Editor  [PDF]
Patrick Velte
Open Journal of Business and Management (OJBM) , 2014, DOI: 10.4236/ojbm.2014.21001
Abstract: Letter to Editor
Rain Attenuation Effects on 2.6 GHz WiMAX Networks Deployment in Ghana  [PDF]
Patrick Fiati
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33009
Abstract: WiMAX communication systems operating at 2.6 G frequencies are used for broadband multimedia and internet based services. At these frequencies, the signal will be affected by various propagation impairments such as rain attenuation, cloud attenuation, tropospheric scintillation, ionospheric scintillation, water vapour attenuation, and rain and ice depolarization. Among all the pro-pagation impairments, rain attenuation is the most important and critical parameter. In this research, rain attenuation is calculated at KNUST, Kumasi using ITU-R rain attenuation model. The preliminary results of the work will be used to calculate the attenuation experimentally and comparison can be made, which helps to develop a new rain attenuation model at 2.6 G bands. Rain attenuation is an important aspect of signal propagation above 2.6 GHz frequency. The attenuation time series generation from point rain rate measurement is crucial due to unavailability of actual signal measurements. In this research, a simple and realistic approach has been demonstrated for better estimation of rain attenuation using WiMAX-band signal propagation data and ground rain rate measurements in Ghana. The ITU-R model of rain attenuation has been modified by incorporating an effective slant path model. The effective slant path has been estimated and modeled in terms of a power-law relationship of rain rate data of 2007-2008. The methodology has been validated with the measured data of 2014. Comparison with ITU-R and GMET clearly demonstrates the improved predictability of the proposed model at the present tropical location.
Association between Cardiovascular Disease Risk Factor Knowledge and Lifestyle  [PDF]
Patrick Mullie, Peter Clarys
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.210140
Abstract: Objective: To relate cardiovascular risk factor knowledge to lifestyle. Methods: In this cross-sectional study, food consumption and lifestyle characteristics were recorded using mailed questionnaires. The dietary pattern was described using the Mediterranean Diet Score (MDS). An open ended questionnaire without predefined choices or answers was used to capture cardiovascular knowledge. Results: Lack of physical activity, smoking and eating too much fat were the 3 most cited potential cardiovascular risk factors, while being overweight, eating too much salt and a low consumption of fruits and vegetables were the least cited risk factors. Age, Body Mass Index, physical activity, smoking, income and dietary habits were not consistently associated with knowledge of risk factors. A low socioeconomic position as measured by the indicator education was associated with a lower knowledge of established and modifiable cardiovascular risk factors. Conclusions: Risk factor knowledge, an essential step in prevention of CVD, is not systematically associated with a healthier lifestyle. The findings of this study confirm that there is a gap between risk factor knowledge and lifestyle.
Site Specific Uncertainty in Regional Haze RuleHaze Indexes  [PDF]
Patrick A. Ryan
Atmospheric and Climate Sciences (ACS) , 2012, DOI: 10.4236/acs.2012.21001
Abstract: In 1999, the US Environmental Protection Agency (EPA) published the regional haze rule (RHR). The RHR default implementation plan calls for each class I area 20% worst baseline (2000-2004) visibility to improve linearly in time to natural conditions in 2064 and in calendar year 2018, each class I area 20% worst visibility is to comply with the 2018 visibility that falls on the linear improvement glide path from baseline (2000-2004) to natural (2064) conditions. This study shows that accurately assessing compliance depends on assessing the uncertainty in baseline, natural and 2018 visibility estimates. This study identifies ±3 dV and ±4 dV of uncertainty in 20% worst natural and baseline visibility estimates. The percent uncertainty in calculated 2018 glide path visibility values ranges from 10% - 45%.
Leaf Wand for Measuring Chlorophyll Fluorescence on Cylindrical Leaves and Its Application on Juncus roemerianus (Black Needlerush)  [PDF]
Patrick D. Biber
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.31007
Abstract: Chlorophyll fluorescence is a well established technique to rapidly and non-invasively determine photosynthesis parameters in plant leaves. It can be used in both laboratory and field settings, and frequently dark-adaptation of a leaf sample is called for. In the field, this can be accomplished on flat leaves using standard leaf clips supplied by instrument manufacturers. However, not all plant leaves are flat, many are cylindrical or otherwise three-dimensional in shape. The standard leaf clip does not close fully on three-dimensional leaves, therefore, does not allow the sample to be properly dark adapted in the field. A new leaf “wand” was developed that can be slipped over an entire cylindrical leaf or culm of rushes and sedges for both light- and dark-adapted measurements. This new leaf wand is compared to the standard leaf clip (DLC-8) using a Walz mini-PAM on Juncus roemerianus(Black needlerush). Results indicate that dark-adapted yield measurements are not significantly different between leaf clips, while light-adapted yields are higher with the leaf wand. The potential sources of difference in the optical path of the excitation light and fluorescence return are discussed and compared between leaf clips. Construction of specialized leaf wands should be considered for any leaves are not flat and therefore that do not fit the standard leaf clip for complete dark-adaptation under field conditions.
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