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Search Results: 1 - 10 of 214200 matches for " Patricio Herrera L "
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Pediatría y Medicina basada en evidencias
Patricio Herrera L.
Revista chilena de pediatría , 2000,
Abstract:
Hipótesis explícita y su importancia en investigación clínica: Una evidencia empírica Relevance of the hypothesis in clinical research
Patricio Herrera L
Revista médica de Chile , 2003,
Abstract:
?Existen bases para el uso de la proteína C reactiva en la detección de infecciones bacterianas en ni?os?: A review
Herrera L,Patricio; Duffau T,Gaston;
Revista médica de Chile , 2005, DOI: 10.4067/S0034-98872005000500005
Abstract: although c-reactive protein (crp) was described more than 70 years ago and it still is commonly used in practice, studies exploring its usefulness persist while some propose its replacement by other inflammatory acute-phase-mediators. the aim of this clinical review is to answer the question if crp measurement warrant clinical decisions for febrile children because it discriminates between bacterial from non bacterial etiologies. we made a systematic search by means of medline, scielo and lilacs with the following mesh terms: "c-reactive protein", "bacterial", "infection", "children", "diagnosis" or "detection", besides the haynes selector for articles on diagnosis, between 1950 and 2004. selection data extraction and critical appraisal were independently made by the two authors, following standard criteria. we selected 7 primary articles, 3 clinical reviews and two randomized clinical trials. there was no disagreement between reviewers. only one of the clinical reviews followed standard guidelines; two reviews concluded that no isolated crp values would warrant to make decisions on starting or withholding antimicrobial therapy in febrile children. all primary articles showed methodological flaws in basic validity criteria. both randomized clinical trials showed that crp results did not change either doctor's decisions about antimicrobial prescriptions nor the studied patients' prognosis. we did not find evidences that could warrant the use of crp for the defined problem in pediatrics. main problems affecting validity of studies on crp as diagnostic resource are the lack of laboratory methods uniformity -including the gold standard make up- the heterogeneity of cut off points, clinical spectrum inappropriateness of study groups as well as the resulting diversity of the fixed indexes values. moreover, no validation of this test in children population has been made so far
Educación de postitulo en pediatría Postgraduate pediatric training
Marcos Emilfork S,Patricio Herrera L
Revista chilena de pediatría , 1997,
Abstract:
Contribución al estudio de pruebas diagnosticas: sobre sus índices fijos y valores predictivos Predictive values of diagnostic tests: potential distortions
Patricio Herrera L,Rosanna Lagos Z
Revista chilena de pediatría , 1995,
Abstract:
Pruebas diagnosticas: algunos aspectos cuantitativos para su desarrollo e interpreta Sensitivity and specificity of diagnostic tests
Patricio Herrera L,Gastón Duffau T
Revista chilena de pediatría , 1995,
Abstract:
Errores metodológicos aún en revistas de corriente principal Methodological errors even in mainstream journals
Patricio Herrera L,Gastón Duffau T
Revista médica de Chile , 2001,
Abstract:
Existen bases para el uso de la proteína C reactiva en la detección de infecciones bacterianas en ni os?: A review Usefulness of C-reactive protein for the diagnosis of bacterial infections in children
Patricio Herrera L,Gaston Duffau T
Revista médica de Chile , 2005,
Abstract: Although C-Reactive protein (CRP) was described more than 70 years ago and it still is commonly used in practice, studies exploring its usefulness persist while some propose its replacement by other inflammatory acute-phase-mediators. The aim of this clinical review is to answer the question if CRP measurement warrant clinical decisions for febrile children because it discriminates between bacterial from non bacterial etiologies. We made a systematic search by means of MEDLINE, SciELO and LILACS with the following MESH terms: "C-reactive protein", "bacterial", "infection", "children", "diagnosis" or "detection", besides the Haynes selector for articles on diagnosis, between 1950 and 2004. Selection data extraction and critical appraisal were independently made by the two authors, following standard criteria. We selected 7 primary articles, 3 clinical reviews and two randomized clinical trials. There was no disagreement between reviewers. Only one of the clinical reviews followed standard guidelines; two reviews concluded that no isolated CRP values would warrant to make decisions on starting or withholding antimicrobial therapy in febrile children. All primary articles showed methodological flaws in basic validity criteria. Both randomized clinical trials showed that CRP results did not change either doctor's decisions about antimicrobial prescriptions nor the studied patients' prognosis. We did not find evidences that could warrant the use of CRP for the defined problem in Pediatrics. Main problems affecting validity of studies on CRP as diagnostic resource are the lack of laboratory methods uniformity -including the gold standard make up- the heterogeneity of cut off points, clinical spectrum inappropriateness of study groups as well as the resulting diversity of the fixed indexes values. Moreover, no validation of this test in children population has been made so far
Importancia de las probabilidades preprueba en el uso de pruebas diagnósticas Diagnostic tests: importance of pre-test probabilities
Patricio Herrera L,Gastón Duffau T,Rosanna Lagos Z
Revista chilena de pediatría , 1997,
Abstract:
On small sample studies
Patricio Herrera
Medwave , 2011,
Abstract:
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