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The Computational and Qualitative Analysis of Failures in the Studies on the Vulnerability of Guyed Towers Modelación computacional y análisis cualitativo de fallas en el estudio de la vulnerabilidad de torres atirantadas de telecomunicaciones
Vivian Elena Parnás,Patricia Martín Rodríguez
Revista Cubana de Ingeniería , 2011, DOI: 10.1234/rci.v2i1.37
Abstract: Guyed masts are a specialized type of structure commonly used in the broadcasting industry to support equipment at substantial heights. Surprisingly, the failure rate of this structural typology with respect to others of similar complexity is high. Therefore, this study searches for the reason behind the failure of telecommunication towers under extreme wind action, which does so by making a comparison between qualitative analysis and the physical –mathematic computational models of the failed towers. The results of the physical- mathematic models are obtained by means of a non – lineal geometric analysis of the structures. Results are then discussed after which are used to outline the importance of both studies as a means of validating results Las torres atirantadas son estructuras comúnmente empleadas en el área de las telecomunicaciones que soportan antenas a grandes alturas. El índice de fallo de esta tipología estructural con respecto a otras de similar complejidad es elevado. En este trabajo se expone el análisis de torres de telecomunicaciones falladas bajo la acción de vientos extremos a partir de la comparación entre el análisis cualitativo y la modelación físico-matemática de la torre fallada. Los resultados de la modelación físico-matemática se obtienen por medio del análisis no lineal geométrico de la estructura. Ambos estudios, por su importancia y necesidad, son empleados como vía para validar los resultados.
IDENTIFICACIóN DE DELECIONES EN AFECTADOS DE DISTROFIA MUSCULAR DE DUCHENNE Y BECKER (DMD/DMB) Y DIAGNóSTICO DE PORTADORAS POR METODOLOGíAS MOLECULARES
Patricia Hernández Rodríguez,Carlos Martín Restrepo
Universitas Scientiarum , 2002,
Abstract: Se dise ó un ensayo de PCR múltiplex (6-plex) que amplifica simultáneamente 6 exones del gen de la distrofina, estos exones son los que presentan mayor frecuencia de mutación. La proporción de deleciones observada en este estudio mediante el sistema 6-plex correspondió al31,25%, además el60% del total de las deleciones involucró los exones 44 al 52. Con el fin de identificar mujeres portadoras de DMD y DMB se utilizó el cálculo de dosis génica, a través de esta metodología fueron identificadas 7 mujeres como portadoras y 15 como no portadoras de deleción para los exones analizados, en este estudio no se encontró ninguna mujer como portadora de duplicación. Con la utilización de polimorfismos dinucleotídicos (CA)n localizados en el interior del gen fue posible establecer inforrnación sobre el cromosoma X que posiblemente está afectado en el 63% de las mujeresanalizadas.
Melatonin: Bone Metabolism in Oral Cavity
Fanny López-Martínez,Patricia N. Olivares Ponce,Miriam Guerra Rodríguez,Ricardo Martínez Pedraza
International Journal of Dentistry , 2012, DOI: 10.1155/2012/628406
Abstract: Throughout life, bone tissue undergoes a continuous process of resorption and formation. Melatonin, with its antioxidant properties and its ability to detoxify free radicals, as suggested by Conconi et al. (2000) may interfere in the osteoclast function and thereby inhibit bone resorption, as suggested by Schroeder et al. (1981). Inhibition of bone resorption may be enhanced by a reaction of indoleamine in osteoclastogenesis. That it has been observed melatonin, at pharmacological doses, decrease bone mass resorption by suppressing through down regulation of the RANK-L, as suggested by Penarrocha Diago et al. (2005) and Steflik et al. (1994). These data point an osteogenic effect towards that may be of melatonin of clinical importance, as it could be used as a therapeutic agent in situations in which would be advantageous bone formation, such as in the treatment of fractures or osteoporosis or their use as, a bioactive surface on implant as suggested by Lissoni et al. (1991). 1. Introduction The bone tissue is a variety of connective tissues that are essentially a mineralized extracellular matrix and specialized cells: osteoblasts, osteocytes, and osteoclasts. The organic component, or osteoid matrix produced by osteoblasts, is constituted by 90% of type I collagen fibers, which represents the major structural protein of bone matrix. The remaining 10% is made up of a series of non-collagenous proteins that modulate smaller mineralization and binding of cells to the matrix, and among them (see Table 1). Table 1: Osteoid matrix proteins. The inorganic phase consists of small crystals of a mineral alkaline character, hydroxyapatite [Ca10(PO4)6(OH)2]. These crystals are embedded among the collagen fibers to form a fabric that meets the appropriate characteristics of rigidity, flexibility, and endurance [1–3]. Osteoblasts derived embryologically multipotent progenitor cells from bone marrow stroma. These cells originate from osteoblasts, as well as fibroblasts, chondrocytes, adipocytes, and muscle cells, some of which are phenotypic characteristics similar to those of osteoblast. These cells are metabolically active secretory proteins expressed as osteocalcin and osteopontin, osteonectin and other proteoglycans and soluble markers factors (BMPs, TGF-β, IGF I and II, IL-1 and PDGF). The expression of these products by osteoblasts bone occurs during embryogenesis, and during maintenance (remodeling), and repair. The signals that direct osteoid mineralization have not yet been identified. It is likely that the accumulation of proteins in a calcium will be the
Stratified Cox Regression Analysis of Survival under CIMAvax®EGF Vaccine  [PDF]
Carmen Viada Gonzalez, Jean-Fran?ois Dupuy, Martha Fors López, Patricia Lorenzo Luaces, Camilo Rodríguez Rodríguez, Gisela González Marinello, Elia Neninger Vinagera, Beatriz García Verdecia, Bárbara Wilkinson Brito, Liana Martínez Pérez, Mayelin Troche de la Concepción, Tania Crombet-Ramos
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48A002
Abstract:

Background: The Center of Molecular Immunology (CIM) is a center in Cuba devoted to the research, development and manufacturing of biotechnological products. CIMAvax?EGF is a vaccine for the treatment of non-small cell lung cancer patients (NSCL). Purpose: The aim of this work is to evaluate the effects of some potential prognostic factors on the overall survival of patients treated with CIMAvax?EGF vaccine, based on data collected in a phase II and a phase III clinical trials. Methods: The stratified Cox regression model is used to evaluate the effects of these prognostic factors, based on separate analysis for each trial, and on the combined data from both trials. Results: Patients with Performance status 0 or 1, with IV stage of tumor and male under 60 years obtain more benefit in terms of overall survival if they receive CIMAvax?EGF. Conclusions: Vaccinated group has a better performance if patients have a performance status 0 or 1, stage IV and age under 60 years. These prognostic factors influence overall survival in a positive way for those patients that received CIMAvax?EGF.

Defense mechanisms in cardiovascular disease patients with and without panic disorder
Ríos Martínez, Blanca Patricia;Chávez León, Enrique;Rangel Rodríguez, Gabriela Alejandra;Pedraza Moctezuma, Luis Guillermo;
Salud mental , 2010,
Abstract: introduction throughout the investigation of psychosocial factors in cardiovascular diseases, type a personality, anger, hostility, anxiety, and depression have been proved to participate in this kind of sufferings. cardiac patients exposed more frequently to life stressing events than patients who do not suffer a cardiac disease might lack adaptive coping defense mechanisms to protect them or use maladaptive defense mechanisms that facilitate the pathogenic effects of anxiety. few studies have been done in mexico related to psychological defense mechanisms; none of them was related to medically ill patients. in the present study, the use of defense mechanisms by cardiac patients with panic disorder (panic attack) was compared to the use of defense mechanisms by patients that present similar cardiovascular pathologies but without mental disorders. material and method the present investigation was made as a comparative and explanatory study with a nonexperimental design. the sample was constituted by two groups: one of 33 cardiac patients diagnosed with panic attack and another group, used as control, of 30 cardiac outpatients without psychiatric disorder; all attended the instituto nacional de cardiología ignacio chávez (mexico city). the 63 cardiac patients were evaluated using the structured interview for the diagnosis of axis i, hamilton's anxiety scale, hopkins's 90 symptom checklist and the defensive styles questionnaire, self-report instrument whose reliability and validity has been established for mexican patients with panic disorder. the statistical analysis was made through chi-square test, student's t test, pearson correlation and a gradual multiple regression analysis. results within the group of cardiac patients with panic attack, 72.73% were female patients and 27.27% male, with an average age of 38.52 ± 14.18 years and 5.73 ± 2.75 years of schooling. the group of cardiac patients used as control was formed by 30 subjects also in its majority female (56
Defense mechanisms in cardiovascular disease patients with and without panic disorder
Blanca Patricia Ríos Martínez,Enrique Chávez León,Gabriela Alejandra Rangel Rodríguez,Luis Guillermo Pedraza Moctezuma
Salud mental , 2010,
Abstract: Introducción Gracias a la investigación de los factores psicosociales de las enfermedades cardiovasculares, se ha demostrado la participación de la conducta tipo A, enojo, hostilidad, aislamiento social, estrés, ansiedad y depresión en este tipo de padecimientos. La depresión asociada con frecuencia al infarto agudo del miocardio incrementa el riesgo de morir; los niveles altos de angustia se asocian al aumento en el riesgo de enfermedad coronaria y muerte súbita. Los pacientes cardiópatas expuestos a sucesos estresantes de la vida con más frecuencia que los pacientes que no padecen cardiopatía pueden carecer de mecanismos de defensa y afrontamiento adaptativos que los protejan o bien usan mecanismos de defensa desadaptativos que facilitan los efectos patogénicos de la ansiedad. En México se han realizado pocos estudios respecto a los mecanismos psicológicos de defensa y no hay estudios acerca del tema en pacientes médicamente enfermos. Conocer la forma en que el sujeto afronta su enfermedad permitiría una intervención psicoterapéutica oportuna en los pacientes médicos con el objetivo de mejorar su adaptación psicosocial y quizás su supervivencia. Por lo anterior, el objetivo del presente estudio es comparar el uso de los mecanismos de defensa de los pacientes cardiópatas con trastorno de angustia (crisis de angustia) con el de pacientes con patología cardiovascular similar pero sin trastornos mentales.
Dietas desequilibradas en ni?os preescolares: estudio en un jardín integral de la provincia de Buenos Aires, Argentina
Rodríguez,Patricia N; Zeni,Susana N; Suárez,Cristina E; Ferreira Monteiro,Andres G; Pita Martín de Portela,María Luz; Friedman,Silvia M; Lifshitz,Fima;
Archivos Latinoamericanos de Nutrición , 2002,
Abstract: imbalance diets: study in children age 2 to 5 years attending a day-care center in the province of buenos aires, argentina. the purpose of this study was to investigate the impact of low fat diets in children aged 2 to 5. eighty two children (40 females and 42 males) attending a school cafeteria (province of buenos aires, argentina), in a cross sectional study, were evaluated. body weight (w), height (h) and body composition (bc) by bioimpedance were recorded. the anthropometric raw data were processed as z-score of the weight-for-age (wez) and of the height-for-age (haz). serum insulin-like growth factor 1 (igf-1) and zinc/haemoglobin ratio (zn/hb) were also measured. results showed that 73,2% of the children were adequate (a) according wez, 13,4% were lean (l) and 13,4% overweight (o). 8,5% presented simultaneously impairment in wez and haz. body fat percentage and energy metabolism were higher in o than in l and a (p<0,05). serum igf-1?s children -aged 4 to 5 years- with haz deficit were low than adequate haz ones. no statistical differences in zn/hb ratio between a, l and o were found. this cross sectional study suggests metabolic disorders in young children attending school cafeterias. these conclusions will allow to design balanced diets in order to optimize the resources, promote optimal growth and development and prevent adult diseases through dietary practices in childhood.
Aplicaciones de las lectinas
Hernández Díaz,Patricia; Martín González,Odalys; Rodríguez de Pablos Vélez,Yoryelín; Ganem Báez,Félix A;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 1999,
Abstract: lectins are an interesting group of proteins of nonimmune origin that have the common property of binding in a specific and reversible way to carbohydrates, whether they are free or part of more complex structures. they have at least 2 binding sites that allow them to bind first to a specific sugar and then to a glycosylated molecule. they have interesting properties that turn this type of proteins into very valuable tools for biological laboratories, since they may be used in several investigations including the study of membrane structure, the detection of malignant transformations, the purification of glycoconjugates and the cytogenetic studies. they are also utilized in histochemical and enzymatic assays and in blood typing
Estudio de la fitohemaglutinina proveniente del frijol colorado (Phaseolus Vulgaris)
Hernández Díaz,Patricia; Martín González,Odalys; Rodríguez de Pablos Vélez,Yoryelín; Ganen Báez,Félix A;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 1999,
Abstract: raw preparations of phytohemagglutinin (pha) were obtained from red bean (phaseolus vulgaris) by 2 methods: aqueous extraction and acid extraction. better results were obtained with the acid methods as regards the protein concentration and its purity. hydroxyapatite chromatography was used to separate the isoforms forming the phytohemagglutinin. 5 protein fractions were obtained and functionally evaluated together with the raw preparations through their erythroagglutinating and leukoagglutinating properties. as the ionic force of the medium increased it was observed that the fractions obtained presented a relative decrease of the leukoagglutinating activity as well as a relative rise of the crythroagglutinating activity. the raw preparations and the fractions were electrophoretically evaluated and bands very similar to that of the pha used as a pattern were obtained
Estudio de la fitohemaglutinina proveniente del frijol colorado (Phaseolus Vulgaris) Study of phytohemagglutinin from red bean (Phaseolus vulgaris)
Patricia Hernández Díaz,Odalys Martín González,Yoryelín Rodríguez de Pablos Vélez,Félix A Ganen Báez
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 1999,
Abstract: Se obtuvieron preparaciones crudas de fitohemaglutinina (PHA) a partir de frijol colorado (Phaseolus vulgaris) por 2 métodos: extracción acuosa y extracción ácida. Por el método ácido se obtuvieron mejores resultados en cuanto a concentración de proteínas y pureza de la misma. Se empleó la cromatografía en hidroxiapatita para separar las isoformas que forman la PHA y se obtuvieron 5 fraccciones proteicas que se evaluaron funcionalmente junto con las preparaciones crudas, a través de sus propiedades eritroaglutinantes y leucoaglutinantes. A medida que se aumentó la fuerza iónica del medio se observó que las fracciones obtenidas presentaban una disminución relativa de la actividad leucoaglutinante, así como un incremento relativo de la actividad eritroaglutinante. Las preparaciones crudas y las fracciones se evaluaron electroforéticamente y se obtuvieron bandas muy similares a la de la PHA patrón utilizada Raw preparations of phytohemagglutinin (PHA) were obtained from red bean (Phaseolus vulgaris) by 2 methods: aqueous extraction and acid extraction. Better results were obtained with the acid methods as regards the protein concentration and its purity. Hydroxyapatite chromatography was used to separate the isoforms forming the phytohemagglutinin. 5 protein fractions were obtained and functionally evaluated together with the raw preparations through their erythroagglutinating and leukoagglutinating properties. As the ionic force of the medium increased it was observed that the fractions obtained presented a relative decrease of the leukoagglutinating activity as well as a relative rise of the crythroagglutinating activity. The raw preparations and the fractions were electrophoretically evaluated and bands very similar to that of the PHA used as a pattern were obtained
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