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Search Results: 1 - 10 of 48626 matches for " Patrícia; Santos-Neto "
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Apresenta??o incomum de vasculite associada à infec??o por vírus C da hepatite
Santos-Neto, Leopoldo Luiz dos;Andrade, Elvis Henrique Santos;Watanabe-Silva, Carlos Hirokatsu;Yamakawa, Patrícia Eiko;
Revista Brasileira de Reumatologia , 2007, DOI: 10.1590/S0482-50042007000600011
Abstract: vasculitis is a pleomorfic inflammatory syndrome that involves mainly the wall of blood vessels. the hepatitis c virus infection may be associated to extra-hepatic manifestations, including autoimmune diseases. two forms of vasculitis have been associated to hepatitis c virus, namely: mixed cryoglobulinemia and polyarteritis nodosa. the diagnosis and the therapeutic management of these conditions are clinical challenges. there are few data available in the literature about the antiviral treatment efficacy in patients with hepatitis c virus and autoimmune diseases. we describe an unusual patient displaying vasculitis of small vessels and with hepatitis c virus infection.
The Use of Herbal Medicine in Alzheimer's Disease—A Systematic Review
Leopoldo Luiz dos Santos-Neto,Maria Alice de Vilhena Toledo,Patrícia Medeiros-Souza,Gustavo Almeida de Souza
Evidence-Based Complementary and Alternative Medicine , 2006, DOI: 10.1093/ecam/nel071
Abstract: The treatments of choice in Alzheimer's disease (AD) are cholinesterase inhibitors and NMDA-receptor antagonists, although doubts remain about the therapeutic effectiveness of these drugs. Herbal medicine products have been used in the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD) but with various responses. The objective of this article was to review evidences from controlled studies in order to determine whether herbs can be useful in the treatment of cognitive disorders in the elderly. Randomized controlled studies assessing AD in individuals older than 65 years were identified through searches of MEDLINE, LILACS, Cochrane Library, dissertation Abstract (USA), ADEAR (Alzheimer's Disease Clinical Trials Database), National Research Register, Current Controlled trials, Centerwatch Trials Database and PsychINFO Journal Articles. The search combined the terms Alzheimer disease, dementia, cognition disorders, Herbal, Phytotherapy. The crossover results were evaluated by the Jadad's measurement scale. The systematic review identified two herbs and herbal formulations with therapeutic effects for the treatment of AD: Melissa officinalis, Salvia officinalis and Yi-Gan San and BDW (Ba Wei Di Huang Wan). Ginkgo biloba was identified in a meta-analysis study. All five herbs are useful for cognitive impairment of AD. M. officinalis and Yi-Gan San are also useful in agitation, for they have sedative effects. These herbs and formulations have demonstrated good therapeutic effectiveness but these results need to be compared with those of traditional drugs. Further large multicenter studies should be conducted in order to test the cost-effectiveness of these herbs for AD and the impact in the control of cognitive deterioration.
Diagnosis and control of polypharmacy in the elderly
Medeiros-Souza,Patrícia; Santos-Neto,Leopoldo Luiz dos; Kusano,Liana Tieko Evangelista; Pereira,Maurício Gomes;
Revista de Saúde Pública , 2007, DOI: 10.1590/S0034-89102006005000050
Abstract: the article had the purpose of commenting on studies on polypharmacy in the elderly, focusing on diagnosis and control. polypharmacy is defined as the use of a number of medications at the same time and the use of additional drugs to correct drug adverse effects. the fact that the elderly take more medications for the treatment of several diseases makes them more susceptible to the occurrence of adverse reactions. prophylactic actions such as balanced prescriptions are vital to reduce the incidence of these reactions and prevent longer hospital stay, increased costs and aggravation of the elderly health condition.
Retorno ao trabalho de pacientes adultos submetidos a transplante de fígado
PAROLIN, M?nica Beatriz;COELHO, Júlio Cézar Uili;COSTA, Patrícia Burda;PIMENTEL, Silvania Klug;SANTOS-NETO, Lauro Estefano dos;VAYEGO, Stela Adami;
Arquivos de Gastroenterologia , 2001, DOI: 10.1590/S0004-28032001000300006
Abstract: background ? orthotopic liver transplantation is an established therapy for patients with end-stage liver disease. in the last years more attention has been given for the improvement of the quality of life after liver transplantation, and the return to important life pursuits, such as employment, are important goals of this type of therapy. aim - to assess the work's return rate in liver transplant recipients and the reasons for inability after liver transplant. patients and methods - forty-one adults (age 3 18 years) who underwent liver transplantation at our institution, between september 1991 and june 1999, with a post-transplant survival 3 9 months, good graft function and a regular clinical follow-up were enrolled for the study. a questionnaire that measured aspects of inactivity before and after liver transplantation had been applied. results - thirty-one of 41 patients were unable to work due end-stage liver disease before liver transplantation. return to work was observed in 28 of 41 patients (68%) in a mean time of 5,9 months after the surgical procedure. eleven of 28 active patients after liver transplant (39%) contribute significantly to family income. the reasons for inactivity after liver transplantation were: early retirement (n = 5), unemployment (n = 4), and physical disability (n = 4). conclusion - successful liver transplantation not only improves the survival rate but allows patients to return to social function and workforce.
Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
Porto, Carlos Eduardo Dobrovolskni;Maia, Patrícia Penido;Freitas, Daniela Fernanda de;Araújo, Rafhaella Carolina Cedro;Siqueira, Maria Elisa Pereira Bastos de;Martins, Isarita;Santos-Neto, álvaro José dos;
Química Nova , 2012, DOI: 10.1590/S0100-40422012000100014
Abstract: a method using liquid phase microextraction for simultaneous detection of citalopram (cit), paroxetine (par) and fluoxetine (flu), using venlafaxine as internal standard, in plasma by high performance liquid chromatography with fluorescence detection was developed. the linearity was evaluated between 5.0 and 500 ng ml-1 (r > 0.99) and the limit of quantification was 2.0, 3.0 and 5.0 ng ml-1 for cit, par and flu, respectively. therefore, it can be applied to therapeutic drug monitoring, pharmacokinetics or bioavailability studies and its advantages are that it necessary relatively inexpensive equipment and sample preparation techniques.
Mallochianamyia, nome novo para Gayomyia Malloch (Diptera, Chamaemyiidae)
Santos-Neto, Luiz Gonzaga dos;
Revista Brasileira de Zoologia , 1996, DOI: 10.1590/S0101-81751996000100008
Abstract: a brief bibliography of gayomyia banks, 19i3 (neuroptera, hemerobiidae) and of gayomyia malloch, 1933 is presented.
DNA damage levels in systemic lupus erythematosus patients with low disease activity: An evaluation by comet assay  [PDF]
Thaís Muniz Montalv?o, Ana Luisa Miranda-Vilela, Mariana Matos Roll, Cesar Koppe Grisolia, Leopoldo Santos-Neto
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.327121
Abstract: Oxidative stress has been implicated in the inflammatory process of Systemic Lupus Erythematosus (SLE), particularly by the formation of anti-DNA autoantibodies, which can lead to DNA damage. The aim of this study was to investigate, through comet assay, whether the level of DNA damage in SLE patients is different from that of healthy subjects. Twenty-five adult SLE patients with SLEDAI up to ten, and 25 healthy subjects were paired according to age, gender and Body Mass Index (BMI). Other anthropometric variables were also assessed. Comet assay was assessed as the marker of oxidative stress described as DNA Damage (DD) percentage. Waist Circumference (WC), Hip Circumference (HC) and BMI were also performed. Exclusion criteria for patients and controls comprised smoking and other chronic disorders. Level of damage index was remarkably higher in SLE patients than in controls, and no significant differences between the groups were found for age, BMI, WC and HC. No stratification concerning gender was performed, since there were just two males per group. No correlation was observed between BMI and DD (%). DD increased in SLE, which reflects the oxidant/antioxidant imbalance in these patients. These findings support an association between oxidative stress and SLE. This stronger correlation observed in patients with low disease activity may be useful in elucidating the mechanisms of disease pathogenesis.
Aspectos ecológicos de Anopheles cruzii e Culex ribeirensis (Diptera, Culicidae) da Mata Atlantica de Morretes, Paraná, Brasil
Santos-Neto, Luiz Gonzaga dos;Lozovei, Ana Leuch;
Revista Brasileira de Entomologia , 2008, DOI: 10.1590/S0085-56262008000100018
Abstract: a study of adult mosquitoes was performed from april 1995 to march 1996 in the atlantic forest near to morretes city, paraná, brazil. the research was carried out by using two cdc-m light traps installed in different vertical stratification levels. mosquitoes were collected monthly throughout the year from 6 p.m. to 6 a.m., with total work hours of 144. a number of 1,408 specimens of mosquitoes was obtained (409 at canopy level and 999 near the ground), belonging to 10 genera and 31 species. anopheles cruzii and culex ribeirensis were predominant and are the main subjects of the present study. difference was not observed between the traps for anopheles cruzii. however, the higher number of culex ribeirensis was collected in cdc-m/ground. according to time intervals, anopheles cruzii showed peaks in the early hours of the night, and decreased progressively until dawn, without a secondary peak. as for the monthly distribution, anopheles cruzii was more frequent in april and may 1995 and march 1996. correlations between specimens and temperature or rainfall were not significant. the flight activity of culex ribeirensis was more intense from 10 p.m. until 4 a.m., but significant peaks were not observed. the monthly distribution of culex ribeirensis showed peaks in december and january. significant correlation of this culicine was found for temperature and rainfall. first records for paraná state: ochlerotatus rhyacophilus, culex misionensis, culex pedroi, culex ribeirensis and culex zeteki.
New concepts in accommodation and presbyopia
Santos-Neto, Edson dos;Alves, Milton Ruiz;
Revista Brasileira de Oftalmologia , 2011, DOI: 10.1590/S0034-72802011000500008
Abstract: the authors conducted a review of classical and conflicting theories of accommodation and presbyopia. they make a critical comparison with the findings of magnetic resonance imaging (mri) that have been developed in recent decades. based on these studies, formulates a new approach on the subject, shifting the focus of the discussion of the lens to the posterior pole of the eye.
Tracking User Attention in Collaborative Tagging Communities
Elizeu Santos-Neto,Matei Ripeanu,Adriana Iamnitchi
Computer Science , 2007,
Abstract: Collaborative tagging has recently attracted the attention of both industry and academia due to the popularity of content-sharing systems such as CiteULike, del.icio.us, and Flickr. These systems give users the opportunity to add data items and to attach their own metadata (or tags) to stored data. The result is an effective content management tool for individual users. Recent studies, however, suggest that, as tagging communities grow, the added content and the metadata become harder to manage due to an ease in content diversity. Thus, mechanisms that cope with increase of diversity are fundamental to improve the scalability and usability of collaborative tagging systems. This paper analyzes whether usage patterns can be harnessed to improve navigability in a growing knowledge space. To this end, it presents a characterization of two collaborative tagging communities that target scientific literature: CiteULike and Bibsonomy. We explore three main directions: First, we analyze the tagging activity distribution across the user population. Second, we define new metrics for similarity in user interest and use these metrics to uncover the structure of the tagging communities we study. The structure we uncover suggests a clear segmentation of interests into a large number of individuals with unique preferences and a core set of users with interspersed interests. Finally, we offer preliminary results that demonstrate that the interest-based structure of the tagging community can be used to facilitate content usage as communities scale.
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