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OALib Journal期刊

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Managing human bites
Patil Pradnya,Panchabhai Tanmay,Galwankar Sagar
Journal of Emergencies, Trauma and Shock , 2009,
Abstract: Human bites are frequently overlooked in making a diagnosis in the emergency room. They are particularly notorious due to the polymicrobial nature of human saliva inoculated in the wound and the risk they pose for transmission of infectious diseases. Early treatment, appropriate prophylaxis and surgical evaluation are the key to achieving desired treatment outcomes. Through this article, we have tried to summarize the diagnostic features, complications as well as the recommended treatment alternatives for human bites based on the current available evidence.
Preparation and characterization of mucoadhesive microcapsules of salbutamol sulfate
Patil Pradnya,Raghavendra Rao N,Hiremath Doddayya
Asian Journal of Pharmaceutics , 2010,
Abstract: Salbutamol sulfate microcapsules with a coat consisting of sodium alginate and mucoadhesive polymer such as sodium carboxy methyl cellulose (NaCMC), methyl cellulose (MC), carbopol-934, and hydroxy propyl methyl cellulose (HPMC) were prepared by ionotropic gelation technique and were evaluated for morphological characters, drug content, loading efficiency, drug-polymer interactions, swelling ratio, mucoadhesive properties, and in vitro release. The resulting microcapsules were discrete, spherical, and free-flowing, and microencapsulation efficiency was 51.28-96.70%. The microcapsules prepared with alginate alone (A4) have exhibited good mucoadhesive property in the in vitro washoff test. The swelling ratio of microcapsules was enhanced with increased alginate concentration. Salbutamol sulfate release from these mucoadhesive microcapsules was slow and extended over a period of 8 h and depends upon the concentration of the alginate. The drug release from alginate-HPMC/carbopol microcapsules followed diffusion-controlled first-order kinetics. The release rate of alginate-HPMC microcapsules (A4H) was higher than other formulations and comparable with commercially available controlled-release capsules. Microcapsules with alginate alone (A4) followed diffusion mechanism. In conclusion, alginate-HPMC/carbopol mucoadhesive microcapsules could be promising vehicle for oral controlled release of salbutamol sulfate.
SPHERICAL AGGLOMERATION – DIRECT TABLETTING TECHNIQUE
Patil Pradnya B.,Gupta V.R.M.,Udupi R.H.,K. Srikanth
International Research Journal of Pharmacy , 2011,
Abstract: Direct tabletting technique is the modern and the most efficient process used in tablet manufacturing and has been successfully employed for various poorly soluble and poorly compressible drugs. Spherical agglomeration is particle engineering technique which involves the transformation of fine crystals into spherical shape particles which enhances the powder properties such as particle size, shape, flow properties, solubility and bioavailability of pharmaceutical drug substances. This technique can also be applied to sustain the drug release from solid dosage forms. The present article is on the detailed comprehensive review about advantages and disadvantages, mechanism, different manufacturing methods of spherical agglomerates and characterization of spherical agglomerates.
APPLICATION OF SPHERICAL AGGLOMERATION TECHNIQUE TO IMPROVE MICROMERITIC PROPERTIES AND DISSOLUTION CHARACTERISTICS OF NABUMETONE
Pradnya Patil,V R M Gupta,R.H Udupi,B Sree Giri Prasad
International Research Journal of Pharmacy , 2012,
Abstract: The present work is aimed to enhance the solubility and dissolution rate of Nabumetone, 4-(6-methoxy-2-naphalenyl)-2-butanone water insoluble anti-inflammatory drug by spherical agglomeration technique using a solvent change method consisting of acetone, water and dichloromethane as solvent, non solvent and bridging liquid respectively. The hydrophilic polymers like poly vinyl pyrrolidone K-30 (PVP) and sodium alginate were used in the agglomeration process. Infrared (I.R) spectroscopic studies, Differential scanning calorimetery (DSC) and Scanning electron microscopy (SEM) were used for characterization of pure drug and its agglomerates. The I.R spectroscopy revealed that there is no chemical interaction between drug and polymers, also indicated that no chemical changes in the crystallized agglomerates .The agglomerates exhibited significantly improved solubility, dissolution rate and micromeritic properties (angle of repose, Carr’s index, bulk density, tapped density. Hausner’s ratio) compared with pure drug Nabumetone. The aqueous solubility and dissolution rate of the drug from spherical agglomerates was significantly (p < 0.05) increased (nearly two times). SEM studies revealed that the agglomerates possess a good spherical shape. The study revealed that Micromeritic Properties, Solubility and Invitro drug release rate is increased with increase in PVP concentration from 0.25% to 1% as compared to sodium alginate.
Establishment of a Tongue Squamous Cell Carcinoma Cell Line from Indian Gutka Chewer
Tejas T. Patil,Pradnya K. Kowtal,Abhijeet Nikam,Madan S. Barkume,Asawari Patil,Shubhada V. Kane,Aarti S. Juvekar,Manoj B. Mahimkar,Jyoti J. Kayal
Journal of Oral Oncology , 2014, DOI: 10.1155/2014/286013
Abstract: CD cell line has been established from a poorly differentiated squamous cell carcinoma of tongue. This is a first ever cell line established from an Indian gutka chewer. Cell line was characterized for morphology, ultrastructure, doubling time, expression of epithelial markers, DNA content, karyotyping, STR markers, p53 mutations, HPV status, and tumorigenicity in SCID mice with all-trans-retinoic acid and cisplatin. The epithelial phenotype of the cell line was confirmed with surface markers and ultrastructure. The cell line is hyperploid with chromosomal alterations like gain of chromosomes 8q and 11q. CD cell line shows a unique pattern on STR genotyping and carries a missense mutation R273C in TP53. It does not show genomic integration of HPV. The cells are nontumorigenic to SCID mice and show growth inhibition upon treatment with cisplatin, and all-trans-retinoic acid. This cell line may be useful as an in vitro tool to understand the molecular changes associated with oral cancers. 1. Introduction Cancer of oral cavity is the third most common cancer in India (http://globocan.iarc.fr/Pages/online.aspx). The important risk factors identified so far are tobacco use and alcohol consumption, which seem to have a synergistic effect. Statistics for head and neck squamous cell cancers (HNSCCs) throughout the world show these cancers to be prevalent in areas where consumption of tobacco and alcohol is high [1]. The process of oral carcinogenesis is multifactorial with interplay of various environmental factors. Though treatment modalities have shown an advancement, the survival rates of oral cancer patients have not improved markedly over the past few decades [2]. Tumor derived cell lines form a useful resource as model systems with reflections of the original tumors [3]. Therefore, development of cell lines from tumor tissues will aid in understanding the events associated with development of cancer. Moreover, cell lines are required to study the effects of various known and novel drug formulations and help in studying future treatment strategies. In spite of these advantages, there are very few cell lines developed from Indian oral cancer patients [4–6]. We have established an oral cancer cell line CD from a young gutka chewer. Gutka is a dry mixture of areca nut, catechu, and slaked lime with tobacco. Due to its easy availability and low cost, it has become popular chewing substitute in young Indian tobacco habitués. Use of gutka has been strongly implicated in increased incidence of oral submucous fibrosis, a precancerous lesion, which has a high rate
Green Synthesis of Gold Nanoparticles Using Glycerol as a Reducing Agent  [PDF]
Pradnya Nalawade, Tulsi Mukherjee, Sudhir Kapoor
Advances in Nanoparticles (ANP) , 2013, DOI: 10.4236/anp.2013.22014
Abstract: We report one pot synthesis of uniform and stable polyvinyl pyrolidone (PVP) protected gold nanoparticles (Au NPs) using environmental friendly, glycerol as reducing agent. The effect of the presence of a capping agent (PVP) and the concentration of reactants (glycerol, tetra chloroauric acid, and NaOH) on the size and homogeneity of the Au NPs formed were investigated. Highly stable and well-distributed Au NPs were obtained at higher concentration of NaOH in the presence of PVP with a clear dependence of the size and the concentration of glycerol, NaOH and the presence of capping agent, whereas, large heterogeneous Au NPs were obtained in absence of PVP. The particle morphology, size and crystallinity were characterized using UV-Vis spectroscopy, transmission electron microscopy and X-ray diffraction techniques. The catalytic performance of as synthesized Au NPs for the reduction of o-nitro aniline was investigated in aqueous solution. The pseudo-first-order rate constants were also calculated for the catalytic reaction.

Fermentative Production of Mycelial Chitosan from Zygomycetes: Media Optimization and Physico-Chemical Characterization  [PDF]
Pradnya N. Vaingankar, Archana R. Juvekar
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.512108
Abstract: The present study focused on production of mycelial chitosan from fungal mycelium by submerged fermentation with ecologically more balanced process. Different fungal strains were screened and Absidia butleri NCIM 977 was found to produce the highest mycelial chitosan. The one-factor-at-a-time method was adopted to investigate the effect of batch time, environmental factors (i.e. initial pH and temperature) and medium components (i.e. carbon and nitrogen) on the yield of mycelial chitosan. Among these variables, the optimal condition to increase in yield of mycelial chitosan was found to be batch time (72 h), pH (5.5), temperature (30°C), carbon source (glucose) and nitrogen source (tryptone and yeast extract). Subsequently, a three-level Box– Behnken factorial design was employed combining with response surface methodology (RSM) to maximise yield of mycelial chitosan by determining optimal concentrations and investigating the interactive effects of the most significant media components (i.e. carbon and nitrogen sources). The optimum value of parameters obtained through RSM was glucose (1.58%), tryptone (1.61%) and yeast extract (1.11%). There was an increase in mycelial chitosan yield after media optimization by one-factor-at-a-time and statistical analysis from 683 mg/L to 1 g/L. Mycelial chitosan was characterized for total glucosamine content (80.68%), degree of deacetylation (DD) (79.89%), molecular weight (8.07 × 104 Da) and, viscosity (73.22 ml/g). The results of this study demonstrated that fungi are promising alternative sources of chitosan with high DD and high purity.
IMPACT OF SHORT TERM TRAINING OF ANULOM VILOM PRANAYAM ON BLOOD PRESSURE AND PULSE RATE IN HEALTHY VOLUNTEERS
Dandekar Pradnya Deepak
International Journal of Research in Ayurveda and Pharmacy , 2013, DOI: 10.7897/2277-4343.04234
Abstract: In present scenario, Yoga is becoming most popular science due to its positive effect on health. To achieve preventive, curative and rehabilitative aspects of health, Yoga draws the attention of large group of people. Prana (energy) and Ayam (to expand or control) form the word Pranayam. Pranayam is a technique to control or expand the energy in body. Practice of Pranayam has been known to modulate cardiac autonomic status with an improvement in cardio-respiratory functions. Keeping this in view, the present study designed to determine whether Anulom- Vilom Pranayam followed by Shawasan has immediate effect on pulse rate, systolic and diastolic blood pressure. Thirty normal healthy subjects aged between 17-20 years, volunteered for this study. All the selected physiological parameters were measured before and after performing ‘Anulom – Vilom Pranayama’ followed by Shawasan for four weeks. Experimental group showed a significant decline in Systolic Blood Pressure (p<0.021). On other hand there was no significant change in Diastolic Blood Pressure and pulse rate, though it showed slight decrease. Our study indicates that, short-term training of ‘Anulom- Vilom Pranayam ‘shows significant decrease in Systolic Blood Pressure. Control of breathing process to make it deep and prolong by doing alternate nostril breathing with slow and rhythmic manner brings about balance in autonomous nervous system. In addition, practice of Anulom- Vilom pranayama for short-term duration could get better parasympathetic control over the heart.
A Recent Survey on Incremental Temporal Association Rule Mining
Pradnya A. Shirsath,,Prof. Vijay Kumar Verma
International Journal of Innovative Technology and Exploring Engineering , 2013,
Abstract: One of the most challenging areas in data mining is Association rule mining. Several algorithms have been developed to solve this problem. These algorithms work efficiently with static datasets. But if new records are added time to time to the datasets means if the datasets are incremental in nature, scenario of association rules may changed. Some of the new itemsets may become frequent, while some previously derived frequent set may become infrequent. Due to updated dataset some rules that are already derived may dropped and some new rules may arrive up. For the up to-date rules over the updated dataset, if the association mining technique redo the rule generation process for the whole dataset, based on the frequent itemsets, simply by discarding the earlier computed results, it will inefficient. It is mostly due to the multiple scanning over the older dataset. Recently, temporal data mining has become a core technical data processing technique to deal with changing data. Actually, temporal databases are continually appended or updated so that the discovered rules need to be updated. In this paper we represent the survey of various methods for incremental as well as temporal association rule mining.
APPLICATION OF PROTEASE FROM BACILLUS CEREUS MCM B-326 AS A BATING AGENT IN LEATHER PROCESSING
Vasudeo Zambare, Smita Nilegaonkar* and Pradnya Kanekar
The IIOAB Journal , 2010,
Abstract: Laboratory scale experiments were carried out to test the efficiency of the extracellular protease from Bacillus cereus MCM B-326; cattle dung and commercial bate powder (ComBate) as bating agents on delimed buffalo hide. Protease treated pelt was free from scud and pigments, clean and fine grain, white, smooth and silkier with loosen fat. Histological sections of bated pelts showed greater opening up of collagen fibers with Bacillus protease. The studies indicated potential importance of Bacillus protease as effective bating agent in leather processing.
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