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Search Results: 1 - 10 of 465553 matches for " Patel Satish A "
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HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD FOR ESTIMATION OF PANTOPRAZOLE IN INJECTION
Patel Satish A
International Research Journal of Pharmacy , 2011,
Abstract: A simple and sensitive high performance thin layer chromatography (HPTLC) method has been developed for the quantitative estimation of pantoprazole in its single component injection formulation (40 mg). Pantoprazole chromatographed on silica gel 60 F254 TLC plate using toluene: ethyl acetate: methanol: acetic acid (7:2:1:0.1 v/v/v/v) as mobile phase. Pantoprazole showed Rf value 0.40 + 0.005 and scanned at 290 nm using a camag TLC scanner 3. The method was validated in terms of linearity (50 – 800 ng/spot), precision (intra-day variation, 1.28 to 2.40% and inter-day variation, 2.40 to 3.62%), accuracy (98.16 to 100.5%) and specificity. The limit of detection and limit of quantification for pantoprazole were found to be 8.45 ng/spot and 25.60 ng/spot, respectively. The developed method was successfully used for the assay of pantoprazole injection formulation. The method was found to be simple, sensitive, specific, accurate and precise and can be used for the routine quality control testing of pantoprazole in injection dosage form.
DEVELOPMENT AND VALIDATION OF VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF AMOXYCILLIN TRIHYDRATE IN PHARMACEUTICAL DOSAGE FORM
Patel Satish A,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: A simple, sensitive, accurate, precise and economical visible spectrophotometric method was developed and validated for the estimation of amoxycillin trihydrate in tablets. The method is based on the reaction of amoxycillin trihydrate with ninhydrin reagent in methanol giving blue color chromogen, which shows maximum absorbance at 578 nm against reagent blank. The chromogen obeyed Beer’s law in the concentration range of 10-80 μg/ml for amoxycillin trihydrate. The results of the analysis have been validated statistically and by recovery studies.
VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CEFADROXIL IN TABLET DOSAGE FORM
Patel Satish A,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: A simple, sensitive, accurate, precise and economical visible spectrophotometric method was developed and validated for the estimation of cefadroxil in tablets. The method is based on the reaction of cefadroxil with ninhydrin reagent in methanol giving blue color chromogen, which shows maximum absorbance at 578 nm against reagent blank. The chromogen obeyed Beer’s law in the concentration range of 5-50 μg/ml for cefadroxil. The results of the analysis have been validated statistically and by recovery studies.
VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CARVEDILOL IN TABLETS
Patel Satish A,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: Three simple, sensitive, precise and economical UV- spectrophotometric methods have been developed for the determination of Carvedilol in tablet formulation. Method A is simple UV spectrophotometric method and is based on determination of carvedilol in 0.1 N HCl at 241.2 nm. Linearity was obtained in the concentration range of 1 – 12 μg/ml. Method B is first order derivative spectrophotometric method and involved estimation of carvedilol in 0.1 N HCl usingt the first- order derivative technique at 251 nm as maxima and 290.8 nm as minima. Calibration curve was prepared by plotting the absorbance difference between maxima and minima versus concentration. Linearity was obtained in the concentration range of 2- 20 μg/ml. Method C is area under curve (AUC) method. The method involved calculation of integrated value of absorbance with respect to the wavelength between two selected wavelength 246 nm and 228.6 nm, respectively. Linearity was obtained in the concentration range of 2- 20 μg/ml. These methods were successfully applied to pharmaceutical formulations because no interferences from tablet excipients were found. The suitability of these methods for the quantitative determination of cavedilol was proved by validation. The proposed methods were found to be simple, sensitive, accurate, precise, rapid and economical for the routine quality control application in pharmaceutical formulations.
DEVELOPMENT AND VALIDATION OF DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND OFLOXACIN IN TABLET DOSAGE FORM
Patel Satish A,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: The present manuscript describe simple, sensitive, rapid, accurate, precise and economic dual wavelength spectrophotometric method was developed for the simultaneous determination of cefixime trihydrate (CEFI) and ofloxacin (OFLO) in combined tablet dosage form. The utility of dual wavelength data processing program is its ability to calculate unknown concentration of components of interest in a mixture containing an interfering component. The principle for dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest”. The method was based on determination of ofloxacin at 350 nm using its absorptivity value and cefixime at 264 nm after deduction of absorbance due to ofloxacin. The two drugs follow Beer-Lanbert’s law over the concentration range of 2-14 μg/ml. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.
SPECTROPHOTOMETRIC DETERMINATION OF CEPHALEXIN USING NINHYDRIN REAGENT IN TABLET DOSAGE FORM
Patel Satish A,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: A simple, sensitive, accurate, precise and economical visible spectrophotometric method was developed and validated for the estimation of cephalexin in tablets. The method is based on the reaction of cephalexin with ninhydrin reagent in methanol giving blue color chromogen, which shows maximum absorbance at 576 nm against reagent blank. The chromogen obeyed Beer’s law in the concentration range of 5-60 μg/ml for cephalexin. The results of the analysis have been validated statistically and by recovery studies.
SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND LINEZOLID IN TABLET DOSAGE FORM
Patel Satish A,Patel Jinalben V
International Research Journal of Pharmacy , 2013,
Abstract: The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Cefixime Trihydrate and Linezolid in bulk and tablet dosage form. The method is based on the simultaneous equations for analysis of both the drugs using 0.05 M Potassium phosphate buffer pH 7.2 as solvent. Cefixime Trihydrate has absorbance maxima at 287.20 nm and Linezolid has absorbance maxima at 250.60 nm in 0.05 M Potassium phosphate buffer pH 7.2. The linearity was obtained in the concentration range of 2-22 μg/ml and 2-18 μg/ml for Cefixime Trihydrate and Linezolid, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 100.2 ± 0.56 and 101.23 ± 0.63 for Cefixime Trihydrate and Linezolid, respectively. The method was successfully applied to tablet dosage form. The suitability of this method for the quantitative determination of Cefixime Trihydrate and Linezolid was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of Cefixime Trihydrate and Linezolid in combination. The results of analysis have been validated statistically and by recovery studies.
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DIAZEPAM AND PROPRANOLOL HYDROCHLORIDE IN COMBINED DOSAGE FORM
Patel Satish A,Patel Paresh U,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of diazepam and propranolol hydrochloride in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in 0.05M methanolic sulphuric acid and the determinations were made at 248 nm (ZCP of propranolol hydrochloride) for diazepam and 242 nm (ZCP of diazepam) for propranolol hydrochloride. The linearity was obtained in the concentration range of 2.5-30 μg/ml for both diazepam and propranolol hydrochloride. The mean recovery was 99.77 ± 1.39 and 100.6 ± 1.18 % for diazepam and propranolol hydrochloride, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of diazepam and propranolol hydrochloride in pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF MONTELUKAST SODIUM AND BAMBUTEROL HYDROCHLORIDE IN TABLETS
Patel Satish A,Patel Dhara J,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of montelukast sodium and bambuterol hydrochloride in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in chloroform and the determinations were made at 241 nm (ZCP of bambuterol hydrochloride) for montelukast sodium and 258.4 nm (ZCP of montelukast sodium) for bambuterol hydrochloride. The linearity was obtained in the concentration range of 10-60 μg/ml for montelukast sodium and 10-80 μg/ml for bambuterol hydrochloride. The mean recovery was 100.1 ± 1.25 and 99.70 ± 1.38 for montelukast sodium and bambuterol hydrochloride, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of montelukast sodium and bambuterol hydrochloride in pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF CEFIXIME TRIHYDRATE AND OFLOXACIN IN TABLETS
Patel Satish A,Patel Paresh U,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of cefixime trihydrate and ofloxacin in combined tablet dosage form. Absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. Cefixime trihydrate and ofloxacin show an isoabsorptive point at 280.2 nm in methanol. The second wavelength used is 291.4 nm, which is the λ-max of cefixime trihydrate in methanol. The linearity was obtained in the concentration range of 2-14 μg/ml for both cefixime trihydrate and ofloxacin. The concentrations of the drugs were determined by using ratio of absorbances at isoabsorptive point and at the λ-max of cefixime trihydrate. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.
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