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Search Results: 1 - 10 of 226846 matches for " Patel R "
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Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity  [PDF]
Ketan S. Patel, Jiten C. Patel, Hitesh R. Dholariya, Vishal K. Patel, Kanuprasad D. Patel
Open Journal of Metal (OJMetal) , 2012, DOI: 10.4236/ojmetal.2012.23008
Abstract: Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.
Patel R
Indian Journal of Ophthalmology , 1954,
MCI Regulations on Graduate Medical Education, 2012- Are we ready for paradigm shift?
Varsha Patel,Pankaj R Patel
NHL Journal of Medical Sciences , 2012,
Abstract: Medical college equips medical students with the scientific background and technical skills they need for practice. But it is equally important for the new graduates to both understand and commit to high personal and professional values. Globally, there is an increasing concern among society about doctors‘ adequacy of the scientific education, clinical skills, interactions with patients and commitment to improving healthcare and providing leadership. India is no exception with frequent hue and cry expressed about proficiency of our doctors. Obviously a need has been felt since long for overhauling our medical education to make it more relevant to the role of future graduates as ―Good Doctors‖.
Mechanisms of potentiation of Angiotensin II-induced contractile response of isolated rat aorta by hydrogen peroxide and tert-butyryl hydroperoxide
Patel R,Patel P,Patel M,Patel N
Indian Journal of Pharmacology , 2009,
Abstract: Objective: To study the mechanism involved in hydrogen peroxide (H 2 O 2 ) or tert-butyl hydroperoxide (t-BHP)-induced potentiation of the Ang II-mediated contraction of isolated rat thoracic aorta. Materials and Methods: Thoracic aorta was isolated from the Sprauge dawley rats (300-320 gm), cut spirally and response to Ang II (5 ′ 10 -8 M) was taken in the absence and presence of H 2 O 2 (10 -6 M) and t-BHP (10 -5 M). To explore the probable mechanism of H 2 O 2 and t-BHP-induced potentiation of Ang II-mediated contractile response, different blockers such as losartan (AT 1 receptor blocker; 1 μM), catalase (H 2 O 2 scavenger; 500 U/ml), lercanidipine (L-type calcium channel blocker; 1 μM), geinistein (tyrosine kinase inhibitor; 100 μM), and indomethacin (cyclo-oxygenase inhibitor; 10 μM) were used. Results: In spiral preparation of rat thoracic aorta, H 2 O 2 (10 -6 M) and t-BHP (10 -5 M) did not produce the contraction as such. However, when they are added simultaneously with Ang II (5 ′ 10 -8 M), they potentiated the contractile response of the Ang II. Catalase (500 U/ml) partially antagonized the Ang-II-induced contraction, as well as antagonized the potentiation induced by H 2 O 2 . Losartan (1 μM) and lercanidipine (1 μM) antagonized the Ang II-induced contractile response without affecting H 2 O 2 (10 -6 M)-mediated potentiation. Geinistein (100 μM) antagonized H 2 O 2 (10 -6 M)-mediated potentiation, but it slightly decreased the Ang II response. Losartan (1 μM) and lercanidipine (1 μM) and Geinistein (100 μM) antagonized the Ang II-induced contractile response but not t-BHP-mediated potentiation. Indomethacin antagonized t-BHP-mediated potentiation without affecting much of Ang II response. Conclusion: From the above-mentioned results, we can reasonably conclude that H 2 O 2 and t-BHP potentiated the contraction induced by the Ang II. H 2 O 2 -induced potentiation of Ang II response may be mediated through tyrosine kinase activation and t-BHP through the activation of cyclo-oxygenase enzyme.
Novel Therapeutic Options for the Treatment of Nonvalvular Atrial Fibrillation  [PDF]
Rupal Patel Mansukhani, Lucio R. Volino
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.511116
Abstract: Objective: To review the literature for the emerging oral anticoagulants, dabigatran, rivaroxaban, and apixaban currently available in the United States. Data Source: A literature review was performed in MEDLINE (1947–July 2014) using the keywords atrial fibrillation AND dabigatran OR rivaroxaban OR apixaban. The references identified from the literature review were then evaluated. All of the literature retrieved from MEDLINE that was published as an original clinical trial was included in this review. Other pertinent articles published related to the original clinical trials were also considered. The references included in this review were limited to studies conducted in humans and written in the English language. Conclusion: The new oral anticoagulant agents have demonstrated benefit over warfarin. The pharmacologic profiles of the newer agents are predictable, with rapid onsets of action. The newer agents are also more convenient for patients since they do not require regular INR monitoring. Although there are many advantages to the newer agents, a patient evaluation must be considered prior to initiating them.
Gentamicin Renal Excretion in Rats: Probing Strategies to Mitigate Drug-Induced Nephrotoxicity  [PDF]
Aruna Dontabhaktuni, David R. Taft, Mayankbhai Patel
Pharmacology & Pharmacy (PP) , 2016, DOI: 10.4236/pp.2016.71007
Abstract: The renal excretion of gentamicin, an aminoglycoside antibiotic, was studied in the isolated perfused rat kidney (IPRK) model. Dose-linearity experiments were carried out at four doses (400, 800, 1600, 3200 μg), targeting initial perfusate levels of 5, 10, 20 and 40 μg/ml. Additionally, gentamicin was co-perfused with sodium bicarbonate (0.25 mM) and/or cimetidine (2 mM) to evaluate the effect of urinary alkalization and secretory inhibition on gentamicin excretion and kidney accumulation. Gentamicin displayed net reabsorption in the IPRK, consistent with extensive luminal uptake. Kinetic analysis indicated that luminal transport of gentamicin (kidney ? urine) is the rate-determining step for gentamicin urinary excretion. Clearance and cumulative excretion decreased with increased gentamicin dose. Gentamicin kidney accumulation, estimated by mass balance, ranged from ~20% - 30%. Urinary alkalization significantly increased gentamicin excretion, with no effect on kidney accumulation. Conversely, cimetidine co-administration did not affect gentamicin clearance in the IPRK, but kidney accumulation was significantly reduced. When both sodium bicarbonate and cimetidine were administered together, gentamicin kidney accumulation decreased ~80% with corresponding increases in clearance and excretion ratio (XR) compared to gentamicin alone. A main strategy to reduce the incidence of nephrotoxicity with gentamicin therapy (up to ~25%) involves reducing kidney accumulation of the compound. The results of this research suggest that the combination of urinary alkalization and inhibition of basolateral secretion (blood → kidney) may be a viable approach to mitigate aminoglycoside toxicity, and warrants further investigation.
Ophthalmia nodosa - (a case report)
Patel R,Shanbhag R
Indian Journal of Ophthalmology , 1973,
Regeneration of stevia plant through callus culture
Patel R,Shah R
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: Stevia rebaudiana Bertoni that conventionally propagated by seed or by cuttings or clump division which has a limitation of quality and quantity seed material. In present study, callus culture technique was tried to achieve rapid plant multiplication for quality seed material. Callus induction and multiplication medium was standardized from nodal as well as leaf sagments. It is possible to maintain callus on Murashige and Skoog medium supplemented with 6-benzyl amino purine and naphthalene acetic acid. Maximum callus induction was obtained on Murashige and Skoog medium incorporated with 6-benzyl amino purine (2.0-3.0 mg/l) and naphthalene acetic acid (2.0 mg/l) treatments. However, Murashige and Skoog medium containing 2.0 mg/l 6-benzyl amino purine+2.0 mg/l naphthalene acetic acid was found to be the best for callus induction. Higher regeneration frequency was noticed with Murashige and Skoog medium supplemented with 2.0 mg/l 6-benzyl amino purine+0.2 mg/l naphthalene acetic acid. Regenerated plants were rooted better on Murashige and Skoog strength supplemented with 0.1 mg/l indole-3-butyric acid. The rooted plantlets were hardened successfully in tera care medium with 63 per cent survival rate. The developed protocol can be utilized for mass production of true to type planting material on large scale independent of season, i.e. external environmental conditions.
Novel Interecting Blends Based on Amino Terminited Oligoimides by Using Michael Addition Reaction-II
Rita R. Patel,Mukesh C. Patel
Journal of Chemistry , 2012, DOI: 10.1155/2012/687540
Abstract: New amino terminated oligoimides (AOIs) were prepared by the Michael addition reaction of various bismaleimide (1), namely, 1-(4-((4-((2, 5-dioxocyclopent-3 enylamino) methyl) cyclohexyl) methyl) cyclohexyl)-1, 6-dihydropyridine-2, 5-dione with excess of various diamines (2a-c). These AOIs were characterized by elemental analysis, FT-IR spectral studies and number average molecular weight estimated by non-aqueous conductometric titrations. AOIs were then treated with acrylol chloride and resultant acryl terminated oligoimides (AcOIs) samples were also characterized thermogravimetrically. Each of these AcOI was then combined with the N-phenyl maleimide (PM) in THF solvent. The resultant suspensions were then heated in the presence of azobisisobutyronitrile (AIBN) as an initiator. The AcOI and PM polymerized through double bond simultaneously and form interacting blends, which were analyzed thermogravimetrically. The glass fiber reinforced composites were fabricated by using the suspensions of the AcOI and PM. The composites of Interacting blends were analyzed for their mechanical, chemical and electrical properties.
A Facile Synthesis and Studies of Some New Chalcones and Their Derivatives Based on Heterocyclic Ring
A. Solankee,K. Patel,R. Patel
Journal of Chemistry , 2012, DOI: 10.1155/2012/638452
Abstract: Chalcones (6a-f) have been prepared by the condensation of ketone (5) and different aromatic and heterocyclic aldehydes. These chalcones (6a-f) on treatment with guanidine hydrochloride and phenyl hydrazine hydrochloride in presence of alkali give aminopyrimidines (7a-f) and phenylpyrazolines (8a-f) respectively. All the newly synthesized compounds have been characterized on the basis of IR, 1HNMR spectral data as well as physical data. Antibacterial activity (minimum inhibitory concentration MIC) against Gram-positive S. aureus MTCC 96 and S. pyogeneus MTCC 442 and Gram-negative P. aeruginosa MTCC 1688 and E. coli MTCC 443 bacteria, as well as antifungal acivities (MIC) against C. albicans MTCC 227, A. niger MTCC 282 and A. clavatus MTCC 1323 were determined by broth dilution method.
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