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Search Results: 1 - 10 of 4318 matches for " Patel Prashant "
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Adenoid cystic carcinoma of breast and the importance of differentiation from collagenous spherulosis by FNAC
Pandya Amrish,Shah Pinal,Patel R,Patel Prashant
Journal of Cytology , 2010,
Abstract: We are presenting a case of adenoid cystic carcinoma (ACC) of breast in a 66-year-old woman having lump in left breast, admitted to surgical ward of our institute. A diagnosis of ACC of breast was made and subsequently confirmed histopathologically and on immunohistochemistry.
Analysis of Gastrointestinal Malignancy: A Five Years Study
Patel Mandakini M, Gamit Bhavna, Patel Prashant R
National Journal of Community Medicine , 2012,
Abstract: With addition of western life style GI malignancy is increasing in developing country. Recent studies have indicated increasing incidence. Our study was five year analysis of Gastrointestinal Malignancies diagnosed in the Department of Pathology, Government Medical Collage Surat. This study includes 244 cases of gastrointestinal tract malignancies. Incidence of gastrointestinal malignancy was gradually increased from 2006 to 2010. Most common age group affected was 41-50 years (64 cases, 26.22%) followed by age group of 51-60 year (58 cases, 23.77%). Most common malignancy came across was esophageal carcinoma (38.93%) followed by colorectal carcinoma(32.79%) and carcinoma of stomach(16.80%). Microscopically, adenocarcinoma was the commonest malignancy (45.90%), followed by Squamous cell carcinoma (33.60%).
In Silico mutagenesis and Docking studies of active site residues suggest altered substrate specificity and possible physiological role of Cinnamoyl CoA Reductase 1 (Ll-CCRH1)
Prashant Sonawane,Krunal Patel,Rishi Kishore Vishwakarma,Somesh Singh
Bioinformation , 2013,
Abstract: Cinnamoyl CoA reductase (CCR) carries out the first committed step in monolignol biosynthesis and acts as a first regulatory point in lignin formation. CCR shows multiple substrate specificity towards various cinnamoyl CoA esters. Here, in silico mutagenesis studies of active site residues of Ll-CCRH1 were carried out. Homology modeling based modeled 3D structure of Ll-CCRH1 was used as template for in silico mutant preparations. Docking simulations of Ll-CCRH1 mutants with CoA esters by AutoDock Vina tools showed altered substrate specificity as compared to wild type. The study evidences that conformational changes, and change in geometry or architecture of active site pocket occurred following mutations. The altered substrate specificity for active site mutants suggests the possible physiological role of CCR either in lignin formation or in defense system in plants.
Histopathological Study of 100 Cases of Vasculartumours
Kapuriya Dharmesh P,Patel Prashant,Shah Amrish N
National Journal of Medical Research , 2012,
Abstract: Introduction: Vascular tumors show a broad variety of morphological appearances and cilinical behavior, the lesions are ranging from benign hemangiomas to intermediate lesion, which are locally aggressive, to highly malignant angiosarcoma. There is also the grey zone between true neoplasia and hamartoma, which makes difficulty in histopathological assessment. It is also important to decide the degree of malignancy as it can strongly influence the choice of treatment and prognosis. Methodology: Hundred cases of vascular tumors received at the department of pathology, medical college and SSG hospital, Baroda have been studied with a view to carrying out a histopathological analysis. Results: mploying modified Enzinger’s classification (2001) the break up of 100 cases was as follows : 37 – capillary hemangiomas, 26 – granuloma pyogenicum, 15 – cavernous hemangiomas, 07 – lymphangiomas, 04 – masson’s hemangiomas (papillary endothelial hyperplasia), 03 – epithelioid hemangiomas, 03 – lymphangiomas circumscriptum, 01 – cystic hygroma, 01 – spindle cell hemangioendothelioma, 01 – epithelioid hemangioendothelioma, 01 – glomus tumor, 01 – angiosarcoma. Majority of vascular tumors were benign, more common in children and young adults, most common sites were head and neck, which required only local surgical excision. Conclusion: Malignant and intermediate tumors formed as extremely small proportion of vascular tumors, which should be treated aggressively and closely followed up. [National J of Med Res 2012; 2(2.000): 152-155]
Comparative Study of Intranasal Midazolam and Intravenous Benzodiazepines in Control of Seizures in Children
Janki Panchal,Khyati Kakkad,Prashant Kariya,Prakash Patel
National Journal of Medical Research , 2013,
Abstract: Background: Seizures are very common in pediatric patients. As duration of seizures impacts morbidity and mortality to child s life, control of seizures should be achieved as early as possible, preferably at home. Rectal diazepam and intranasal midazolam are available methods for control of seizures and can be learnt by parents. Methods: We assessed safety and efficacy of intranasal midazolam for control of seizures and also compared its effect with other benzodiazepines given by intravenous route. Results: Among 84 patients, success rate of treatment with Midazolam (intranasal) was 45.5% and success rate with Benzodiazepines (intravenous) was 90%. The difference is statistically significant. In present study, average time recorded to give drug after arrival at hospital in IN Midazolam group was 0.379 min, where as it was 1.598 min in IV Benzodiazepine group. Average time for cessation of seizures after giving drug was 3.001 min in IN Midazolam group, where as it was 1.009 min in IV Benzodiazepine group. Conclusion: Intra-venous route for control of seizures is most effective compare to Inta-nasal Midazolam. However intranasal Midazolam can be use full when IV access is not available at home or during transport of patient to health care centre. [Natl J of Med Res 2013; 3(1.000): 30-33]
Correlation of Hormonal Receptor and Her-2/neu Expression in Breast Cancer: A Study at Tertiary Care Hospital in South Gujarat
Vasudha M Bhagat,Bharti M Jha,Prashant R Patel
National Journal of Medical Research , 2012,
Abstract: Introduction: Breast cancer is the most common cancer in women and leading cause of cancer death in women. In India its incidence is rapidly rising. Present study was aimed to study pattern of expression of Hormone receptor and Her-2/neu in invasive breast carcinoma and to correlate ER PR status and Her-2/neu expression with various Clinicopathological aspects. Method: The present study was carried out in the Department of Pathology, Government Medical Collage, Surat, from the period of January 2011 to December 2011. Routine H&E staining for histological diagnosis and IHC analysis for ER, PR and Her-2/neu was carried out in all cases. Result: This study includes total 58 cases of breast malignancies. 94.82% cases of invasive duct carcinoma. The age of patients ranged from 35 to 73 years of age. Majority of tumors are grade 2 (43.10%) followed by grade 3 (29.31%). ER, PR and Her-2/neu expression was seen in 48.27%, 37.93% and 27.58% respectively. Triple negative cases comprised of 25.86% in our study. Significant correlation was observed between hormonal receptor status and Her-2/neu expression. Conclusion: Our study of ER, PR and Her-2/neu in breast carcinoma by IHC method indicates higher rates of positive expression correlated with various clinicopathological aspects. Higher number of grade 1 tumor showed ER, PR positivity as compared to grade 3 tumors. Inverse relationship was observed between Her-2/neu expression and ER, PR receptor status. Her-2/neu expression was increased with size and high grade of tumor. Her-2/neu expression did not show any significant correlation with age. [National J of Med Res 2012; 2(3.000): 295-298]
A Clinico-Pathological Study of 22 Cases of Pemphigus
Prashant R Patel,Dharmesh P Kapuriya,S G Chiplonkar
National Journal of Medical Research , 2012,
Abstract: Introduction: Blistering diseases are alarming skin conditions where blister formation occurs in various ways and cannot be differentiated clinically. For confirmation of diagnosis routine histological examination of early lesions is very much helpful. Pemphigus is one of autoimmune blistering disorder involving skin and mucosal surfaces. Tzanck smear may be used as a rapid diagnostic tool. Material and Method: A clinico-palhological study of 22 cases of pemphigus over a span of two year at the Department of Pathology, Medical College Baroda and S.S.G. Hospital has been carried out to know incidence of pemphigus. Result: Pemphigus vulgaris constituted the single largest group of 18 cases followed by pemphigus foliaceus (2 cases) and pemphigus erythmatosus (2 cases). Majority of the cases were seen in the age group of 21-60 years, with a slight female predominance. The youngest patient was 20 years while the eldest was aged 73 years. Flaccid bullae were present in 100% cases. Tzank smear found to successful in 75% cases of pemphigus vulgaris. However, it is difficult to take Tzank smear in some patients as patients were presented with predominantly crusted lesions. Conclusion: Most of the patients have pemphigus vulgaris. Tzank smear is proved very useful tool for rapid diagnosis of pemphigus. [National J of Med Res 2012; 2(3.000): 269-271]
Object Oriented Testing Techniques: Survey and Challenges
Prashant
International Journal of Computer Technology and Applications , 2012,
Abstract: Object-oriented programs involve many unique features that are not present in their conventional counterparts. Examples are message passing, synchronization, dynamic binding, object instantiation, persistence, encapsulation, inheritance, and polymorphism. Testing for such program is, therefore, more difficult than that for conventional programs. Object-orientation has rapidly become accepted as the preferred paradigm for large-scale system design. In this paper we have discussed about how testing is being carried out in the Object Oriented environment. To accommodate this, several new techniques have been proposed like fault-based techniques, Scenario based, Surface structure testing, and Deep structural testing
Historical Background as an Essential Ingredient for the Understanding of New Developments in Quantum Mechanics
Prashant
Physics , 2005,
Abstract: Paper is taken out with immediate effect.
Evolving Quantum Circuits using Genetic Algorithms
Prashant
Physics , 2005,
Abstract: The article is taken out.
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