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Advances in novel parentral drug delivery systems
Patel Rakesh,Patel Kaushal
Asian Journal of Pharmaceutics , 2010,
Abstract: The parenteral administration route is the most effective and common form of delivery for active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. Drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in terms of compliance, but also to improve the quality of the therapy. Such reduction in frequency of drug dosing is achieved by the use of specific formulation technologies that guarantee the release of the active drug substance in a slow and predictable manner. The development of new injectable drug delivery system has received considerable attention over the past few years. A number of technological advances have been made in the area of parenteral drug delivery leading to the development of sophisticated systems that allow drug targeting and the sustained or controlled release of parenteral medicines.
EXPLICIT SOLUTION OF BURGERS’ AND GENERALIZED BURGERS’ EQUATION USING HOMOTOPY PERTURBATION METHOD
Miral Bhagat,P. H. Bhathawala,Kaushal Patel
International Journal of Advances in Engineering and Technology , 2013,
Abstract: In recent years, many more of the numerical methods were used to solve a wide range of mathematical, physical and engineering problems, linear and nonlinear. In this article, Homotopy Perturbation Method (HPM) is employed to approximate the solution of the Burgers’ equation which is a one-dimensional non-linear differential equation in fluid dynamics. The explicit solution of the Burgers’ equation was obtained and compared with the exact solutions. We take the cases where the exact solution was not available for viscosity smaller than 0.01, we apply the HPM structure for obtaining the explicit solution. The results reveal that the HPM is very effective, convenient and quite accurate to partial differential equation.
METHOD DEVELOPMENT, VALIDATION AND STABILITY STUDY FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND INDAPAMIDE BY REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY IN PURE AND MARKETED FORMULATION.
Patel Amit R,,Chandrul Kaushal Kishor
International Journal of Pharmaceutical and Biological Research , 2011,
Abstract: An approach of forced degradation study was successfully applied for the development of a stability-indicating assay method for simultaneous determination of telmisartan and indapamide in a formulation in the presence of its degradation products. The method showed adequate separation of Telmisartan and indapamide from theirassociated main impurities and degradation products. Separation was achieved on an Amazone C18, 5 microm, 150 x 4.6 mm the mobile phase (Buffer: acetonitrile: methanol) (45+25+30) KH2PO4 & Triethaylamine Ph 3.0 with ortho phosphoric acid buffer flow rate of 1 mL/min and UV detection at 285 nm. Comprehensive stress testing of telmisartan and indapamide Rt= 4.7 min, 10.7 min was according to the International Conference on Harmonization (ICH) guideline Q1A (R2). The drug was subjected to acid hydrolysis, base hydrolysis, to apply stress conditions. There were no other coeluting, interfering peaks from excipients, impurities. The method was validated in terms of linearity, precision, accuracy, specificity, robustness, and solution stability. The linearity of the proposed method was investigated in the range of 6-22.5 microg/mL (r2 = 0.999) for telmisartan and 11.2-42microg/mL (r2 = 0.9997) for indapamide.
System Dynamic Modelling And Analysis Of A Single Stage Single Product Kanban Production System
KAUSHAL K.PATEL,S.J.THANKI
International Journal of Innovative Research in Science, Engineering and Technology , 2013,
Abstract: ystem dynamic (SD) provides a useful interpretation of business contexts, analysing how policies and decisions affect the structure of companies and the dynamics of the available resources. For this reason, it has successfully applied to many problems related to industrial management and operation research. Due to its ability to model and simulate the complex system for understanding the system behaviour over time horizon, it can be applied to Kanban production system to meet the customer demand in right quantity and time. This article presents the application of system dynamics approach in KANBAN production system. SD models for single stage single product kanban system is developed and simulated over different time horizon to study the behaviour of kanban production system. Simulation results are discussed later.
The effect of starch paste and sodium starch glycolate on the compaction behavior of wet granulated acetaminophen formulations.
Sarsvatkumar Patel,Aditya Mohan Kaushal,Arvind Kumar Bansal
Journal of Excipients and Food Chemicals , 2011,
Abstract: The effect, of varying the proportion of binder starch paste (SP) and the disintegrant sodium starch glycolate (SSG), on the compaction behavior of wet granulated acetaminophen (ACM) formulations using a fully instrumented rotary tablet press, was studied. Wet granulation formulations were prepared using ACM, SP as binder (equal to 2.5%, 5% or 10% starch concentration), SSG as disintegrant (0%, 4%, 8%, or 12 % w/w), microcrystalline cellulose (MCC) and magnesium stearate (MS) (1.5 % w/w). Upper and lower punch force displacement data during in-die compaction was captured using a fully instrumented rotary tablet press at 13.8 rpm at 96 ± 8, 163 ± 13, 235 ±12 MPa compaction pressures. Elastic energy [EE] and tablet tensile strength was determined as a function of starch and SSG concentration and compaction pressure. At a given compaction pressure, increasing the proportion of SSG resulted in higher values of elastic energy (0.28 to0.76 Nm with increase in SSG from 0% to 12% at 5% starch and 235 ±12 MPa compaction pressures). The negative effect of SSG on the overall compressibility of granules was due to its high elastic energy anddecrease in interparticulate bonding. When examining the elastic energy at increasing SP levels, a decrease in elastic energy was evident (0.60, 0.50 and 0.31 Nm for 2.5%, 5% and 10% starch at 4% SSG and 235 ±12 MPa compaction pressures respectively). At a given composition, an increase in compaction pressure led to an increase in elastic energy (0.15, 0.33 and 0.50 Nm at 4% SSG and 5% starch for 96 ± 8, 163 ± 13, 235 ±12 MPa compaction pressures, respectively). When changing SSG and binder (SP) concentration levels tensile strength was indirectly proportional to elastic energy during compaction. Negative influence of SSG on elastic energy indicated by increased EE and decreased tensile strength and positive influence of SP was evident onlower elastic energy and higher tensile strength of tablets.
Rupture of the Left External Iliac Artery and Right Groin Pseudoaneurysm Formation following Angioplasty in a Patient with Neurofibromatosis Type 1 and Undiagnosed Bilateral Phaeochromocytoma
Brett Doleman,Sushila Kaushal,Asha Patel,James Kirk,John Quarmby
Case Reports in Radiology , 2013, DOI: 10.1155/2013/526421
Abstract: Neurofibromatosis type 1 (NF1) is a genetic condition, which affects 1 in every 3000 births. Patients with NF1 are at increased risk of a variety of vascular abnormalities. This report presents the case of a 60-year-old male with NF1 who suffered a left external iliac rupture and a right pseudoaneurysm following angioplasty. In addition, these were further complicated by previously undiagnosed, bilateral phaeochromocytomas. The inherent weakness in vessel wall architecture found in NF1 coupled with the hypertension evident during and after the procedure contributed to haemorrhage and pseudoaneurysm formation. Caution must be taken in such patients when considering vascular intervention. 1. Introduction Neurofibromatosis type 1 (Von Recklinghausen disease) is caused by a mutation in the gene responsible for the production of neurofibromin 1, which is involved in cell signalling. Phenotypic characteristics include formation of neurofibromas, learning difficulties and epilepsy. Neurofibromatosis type 1 (NF1) has an incidence of 1 in 3000 live births, with affected individuals having a 2.7 times increased risk of malignancy compared with the general population??[1]. Although less commonly described, NF1 patients also have an increased risk of vascular lesions, though the actual incidence remains unknown [2]. This increase in vascular lesions results in a higher risk of mortality from vascular disease in younger adults??[3]. The types of vascular lesions are varied and include aneurysms, stenosis, and arteriovenous malformations. Vascular intervention for patients with NF1 is effective and durable over the longer term, although patient survival at 10 years after intervention remains lower than that of the general population??[4]. In addition to an increase in vascular lesions, patients with NF1 have an increased risk of endocrine tumours such as phaeochromocytoma??[5]. Typical symptoms include episodic headaches, sweating, anxiety, and palpitations. Diagnosis is typically made by measuring urinary metanephrines and imaging using computerised tomography (CT) or iodine-131 metaiodobenzylguanidine (I-131 MIBG) scintigraphy. 2. Case Presentation A 60-year-old male with a background of NF1 (diagnosed around 30 years previously) was referred by his general practitioner with a history of intermittent left lower limb claudication at 100–200 yards. Magnetic resonance angiography (MRA) revealed mild atheromatous disease of both lower limbs, with a 6.5?cm occlusion of the left external iliac artery attributed as being the likely cause of his symptoms (Figure 1). He was
Impact of malathion on some haematological parameters of Channa punctatus (Bloch)
Kaushal DUBE,kaushal DUBE
International Journal of Biomedical and Advance Research , 2012, DOI: 10.7439/ijbar.v3i9.711
Abstract: Malathion is an organophosphorous insecticide widely used in agricultural and non agricultural purposes in India, creates a serious threat to the environment as well as target and non target organisms. The present investigation was undertaken to study the effect of malathion on some haematological parameters of Channa punctatus. Channa punctatus was treated with malathion and LC50 value for 96 hours was calculated following probit analysis methods. Channa punctatus was exposed to sublethal concentration of malathion (0.8 ppm). The study revealed a declining trend of RBC, Haemoglobin and increasing trend of WBC indicated toxic effect of malathion on Channa punctatus.
Radiation Beam Characterization and Dosimetry of Theratron Equinox-80 Telecobalt Machine Using BEAMnrc Monte Carlo Simulation Code  [PDF]
Narayan Prasad Patel, Rahul Shukla, Nagappan Balasubramanian, Rajeev Atri, Anil Kumar Dhull, Hanuman Prasad Yadav, Vivek Kaushal
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2016, DOI: 10.4236/ijmpcero.2016.54030
Abstract: The BEAMnrc code was used for the simulation of the Theratron Equinox-80 telecobalt machine. The phase space of radiation beam was generated at treatment distance of 80 cm for various field sizes. The phase spaces in air were analyzed by BEAMdp data processing program. The electron energy fluence with respect to photon energy was 0.09% and 0.34% for field size of 05 × 05 and 35 × 35 cm2 respectively and it was maximum at the central axis which gradually decreases beyond this. The profiles for photon fluence were in symmetry for all the fields. The full width at half maximum of profiles in photon energy fluence shows good agreement with the field size. The photon energy fluence was flat till the field size of 27 cm2, after which it decreases gradually till the edge in larger field sizes. The air-kerma output factor from the simulation was in good agreement with measured value. We analyzed the dose data scored in the voxels in a large water phantom by simulation using dosxyznrc code. The percentage depth dose for all field sizes was in good agreement with the BJR supplement 25 and the data supplied by the manufacturer of machine. Significant deviation of about 20% in isodose line near the edge of the profile was observed for 35 × 35 cm2 field size. The penumbra widths of all field sizes were comparable except for 35 × 35 cm2, which has a penumbra width of 4.1 cm at 10 cm depth. The significant under dose near the edge as compared to central axis for larger field sizes may be the indication for its careful use in treatment.
Use of patch testing for identifying allergen causing chronic urticaria
Verma Kaushal
Indian Journal of Dermatology, Venereology and Leprology , 2008,
Abstract:
Type I hypersensitivity to Parthenium hysterophorus in patients with parthenium dermatitis
Verma Kaushal
Indian Journal of Dermatology, Venereology and Leprology , 2007,
Abstract:
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