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Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity  [PDF]
Ketan S. Patel, Jiten C. Patel, Hitesh R. Dholariya, Vishal K. Patel, Kanuprasad D. Patel
Open Journal of Metal (OJMetal) , 2012, DOI: 10.4236/ojmetal.2012.23008
Abstract: Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.
Future implications: Compliance and failure with antiretroviral treatment
Patel Atul,Patel K
Journal of Postgraduate Medicine , 2006,
Abstract: HIV management is currently in an era of effective, potent antiretroviral therapy. Modern drug discovery and development have transformed HIV-1 disease into a treatable, chronic infectious disease. Complete suppression of viral replication is critical for long-term durability of antiretroviral therapy. Partial suppression, even at very low levels, is likely to lead to virologic failure and ultimately to the appearance of drug resistance. The relationship between adherence and resistance to HIV antiretroviral therapy is more complex than to state ′non-adherence increases the risk of drug resistance.′ In many patients who fail to respond to initial therapy, the primary reason for failure is their inability to take the prescribed drug regimen or nonadherence.
New Approach for the Determination of Tricyclic Antidepressant Amitriptyline Using β-Cyclodextrin-PEG System via Spectrophotomerty  [PDF]
Pankaj Soni, Santosh K. Sar, Rajmani Patel
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2012, DOI: 10.4236/jasmi.2012.22019
Abstract: A new and simple procedure for the spectrophotometric determination of the tricyclic antidepressant drug amitriptyline is proposed. The method is based on enhancement of sensitivity of the [AMIYTP]+ β-cyclodextrin and PEG molecules involved in formation of molecules inclusion complex, in presence of polyethylene glycol (PEG) medium. The mole ratio of [AMIYTP]+ β-cyclodextrin and PEG molecules in inclusion complex were determined by the curve fitting method. The value of molar absorptivity of {[AMIYTP: (β CD)] PEG} complex in term of the drug lies in rage of (2.20 - 2.23) × 104 L·mole–1·cm–1 at absorption maximum 242 nm. The slope, intercept and correlation co-efficient were found to be 14.21, 0.0046, and 0.998, respectively. The effect of analytical variables on the determination of the drug and composition of the ion associated complex are discussed in the paper. This method is applicable in the determina-tion of amitriptyline in the pharmaceutical preparations.
Estimation of duloxetine hydrochloride in pharmaceutical formulations by RP-HPLC method
Patel Sejal,Patel N,Patel K,Patel P
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Simple, specific, accurate and precise method, namely, reverse phase high performance liquid chromatography was developed for estimation of duloxetine HCl in pharmaceutical formulations. For the high performance liquid chromatography method, Phenomenox C-18, 5 μm column consisting of 250x4.6 mm i.d. in isocratic mode, with mobile phase containing 0.01M 5.5 pH phosphate buffer: acetonitrile (60:40 v/v) and final pH adjust to 5.5±0.02 with phosphoric acid was used. The flow rate was 1.2 ml/min and effluent was monitored at 231 nm. The retention time was 5.61 min. The method was validated in terms of linearity, accuracy and precision. The linearity curve was found to be linear over 0.25-4 μg/ml. The limit of detection and limit of quantification were found to be 0.10 and 0.25 μg/ml respectively. The proposed method was successfully used to determine the drug content of marketed formulations.
IMPLEMENTATION OF ON-BOARD WEIGHING SYSTEM FOR TRAILER APPLICATION
VIJAY K. PATEL,,BHAVESHKUMAR P. PATEL,,RAVI K. PATEL
International Journal of Engineering Science and Technology , 2011,
Abstract: Now days, fast growth of the manufacturing industry is possible by rapid development and advancement in material handling equipment for their accurate and productive operations. There are different industrial sectors like timber, waste, aggregate, general trucking, mining; construction etc. uses the trailer for material handling. Some of the common problems are faced by such above applications likeunder loading, over loading, loading time loss, traffic fines, pay load over legal limits etc. The above problem can be eliminated by designing and implementing of on board weighing system.
New agents for the treatment of hepatitis C virus – focus on telaprevir
Thompson AJ, Patel K
Virus Adaptation and Treatment , 2012, DOI: http://dx.doi.org/10.2147/VAAT.S12707
Abstract: gents for the treatment of hepatitis C virus – focus on telaprevir Review (1102) Total Article Views Authors: Thompson AJ, Patel K Published Date November 2012 Volume 2012:4 Pages 75 - 84 DOI: http://dx.doi.org/10.2147/VAAT.S12707 Received: 21 May 2012 Accepted: 06 July 2012 Published: 01 November 2012 AJ Thompson,1–3 K Patel3 1Department of Gastroenterology, St Vincent's Hospital, University of Melbourne, 2Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia; 3Duke Clinical Research Institute and Department of Gastroenterology, Duke University Medical Center, Durham, NC, USA Abstract: Antiviral therapy for hepatitis C virus (HCV) is rapidly evolving with the advent of direct-acting antiviral agents. Telaprevir is a first-generation linear ketoamide inhibitor of HCV NS3 protease. Approved in 2011 as standard-of-care for the treatment of patients chronically infected with HCV genotype 1, telaprevir represents a major therapeutic advance. Used in combination with PEGylated interferon-alfa and ribavirin, telaprevir-based regimens cured > 75% of treatment-na ve patients in the Phase III registration studies. Telaprevir is also effective for patients who have previously failed interferon-based therapy. Telaprevir presents a number of new challenges for clinicians, including a more demanding dosing schedule, telaprevir-specific adverse events, potential for drug–drug interactions, and selection of drug-resistant HCV variants.
EXPERIMENTAL ANALYSIS ON SURFACE ROUGHNESS OF CNC END MILLING PROCESS USING TAGUCHI DESIGN METHOD
PATEL K. P.
International Journal of Engineering Science and Technology , 2012,
Abstract: Here, we study about, influence of various machining parameters like tool speed, tool feed, depth of cut and tool diameter. In the present study, experiments are conducted on AL 6351 –T6 material with four factors and five levels and try to find out optimum surface roughness by using taguchi method. This paper attempts to introduce how Taguchi parameter design could be used in identifying the significant processing parameters and optimizing the surface roughness of end-milling operations. In this study, it was observed that, the order of significance of the main variables is as A1 > B4 > C4 > D1(tool feed (A), tool speed (B), tool diameter(C), depth of cut (D)).
Medicinal plants in G.G.V. Campus, Bilaspur, Chhattisgarh in central India
D.K. PATEL
International Journal of Medicinal and Aromatic Plants , 2012,
Abstract: Herbal medicines used for treatment of various diseases are of significant value throughout the world. Among the plant diversity some of them have great potential to treat many diseases which are referred as medicinal plants. The main aim of the present study is to focus on the diversity of medicinal plants for further utility and conservation. Current research is a useful account on medicinal plants flora in Central University Guru Ghasidas Vishwavidyalaya, Bilaspur Campus. A survey on medicinal plant diversity was made during August 2009 to December 2010 in G. G. V., Campus, Bilaspur (Chhatisgarh). After field survey, observed medicinal plants were listed followed by botanical name, family, habit, part used, uses and propagation with the help of available literature. Total of 157 medicinal plants species belonging to 58 families were recorded, which indicate the heterogeneous floristic composition in the University campus. Maximum species diversity was recorded under the family Fabaceae. Over the recorded medicinal plants 70.06 % plants are propagated by their seeds. Herbaceous medicinal plants showed their maximum presence in the Campus.
Further report of our experiences with scleral flap transposition (Russian operation), trabeculectomy and iridencleisis in glaucoma surgery
Patel Chhotubhai,Bavishi K
Indian Journal of Ophthalmology , 1982,
Abstract:
Immunotherapy of condyloma acuminatawrm dinitrochlrobenzene
Shah K,Patel Raksha
Indian Journal of Dermatology, Venereology and Leprology , 1990,
Abstract: In a control study of 75 male patients of coudyloma acuminata Dinitrochlorobenzene. (DNCB) was used as immuno therapeutic agent. The DNCB was not found to be superior in curing the warts when compared with control groups. No serious side effects and toxic were observed with DNCB.
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