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ANTICANCER AND CYTOTOXIC POTENTIAL OF TRITICUM AESTIVUM EXTRACT ON HELA CELL LINE
Patel Janki B.,Patel Piyush M.
International Research Journal of Pharmacy , 2013,
Abstract: The objective of the study was to analyze the anticancer property of the leaves of Triticum aestivum on HeLa cells. The Indian medicinal plant Triticum aestivum that is used in traditional medicine for cancer and non cancerous diseases was collected. The crude methanolic extract was prepared by using standard protocols. The antiproliferative effect the methanolic extract was evaluated in vitro by employing MTT assay. The potency of each plant extract concentration was calculated in terms of percent decrease in viable HeLa cells as compared to the control value. The extract showed dose dependent antitumor activity. The MTT assay showed an anti proliferative activity (IC50) at 156 μg/ml of crude extract.
EVALUATION OF ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT OF SEEDS OF PHYLA NODIFLORA LINN.
Patel Janki B,Shah Kinjal H,Patel Rashmika C
International Research Journal of Pharmacy , 2011,
Abstract: ‘Jalapippali’ described in classical texts of Ayurveda is botanically identified as Phyla nodiflora Linn. (Syn. Lippia nodiflora Rich). In present study methanolic extract of seeds of Phyla nodiflora Linn. was screened for in-vitro antibacterial activity against gram positive and gram negative bacteria by cup- plate method. The methanolic extract of the seeds significantly inhibit the growth of bacteria as compared to the standard bactericide (streptomycin). The study reveals that the methanolic fraction of seeds of Phyla nodiflora Linn possesses significant antibacterial activity.
FORMULATION, DEVELOPMENT AND EVALUATION OF DOXOPHYLLINE SUSTAINED RELEASE MATRIX TABLET
Pandya Hima V,Patel Akshay R,Bodiwala Janki B
International Research Journal of Pharmacy , 2011,
Abstract: The study was done with an objective to achieve a potential sustained and controlled release oral drug delivery system of a antiasthmatic drug, doxophylline which having shorter half life. Hydroxypropyl methyl cellulose was used for gel forming agent. Differential scanning calorimeter (DSC) study show that drug and other excipints are compatible with each other. The tablets were evaluated for physical characteristic like hardness, weight variation, fraibilty, and thickness. It was found that drug release rate increased with the amount of osmogent because of the increased water uptake and hence increased driving force for drug release. Accelerated stability study was also performed for three months indicated that optimized formulation was stable. Use of HPMC as the total matrix material significantly influenced the release rate of the drug. Addition of different diluents like magnesium stearate and microcrystalline cellulose were used for improving flow ability and compressibility. Based on dissolution studies all the formulations showed sustained release of drugs from the formulations.
PREPARATION AND EVALUATION OF COLON SPECIFIC IBUPROFEN TABLETS
Patel Krunal M,Karna Nabin,Biswal Biswajit,Patel Janki
International Research Journal of Pharmacy , 2011,
Abstract: The aim of the present study was done to evaluate drug release at the colon specific region by developing the formula which can deliver the drug at the colonic region of the GIT. For this particular study the pelletization process was adopted and the pellets which were formed were compressed into the tablets and the tablets which were formed were coated with Eudragit L100. The in vitro dissolution studies were carried out and test like hardness, friability and weight variation were carried out. In brief the formulation that was develop was the pH dependent one the widely used method for the developing the colon specific drug delivery.
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
Huizar Isham,Malur Anagha,Patel Janki,McPeek Matthew
Respiratory Research , 2013, DOI: 10.1186/1465-9921-14-7
Abstract: Background Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products of manufacture or the environment, have been associated with granulomatous disease. This paper utilizes a previously described carbon nanoparticle granuloma model to address the issue of whether peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear transcription factor and negative regulator of inflammatory cytokines might play a role in granulomatous lung disease. PPARγ is constitutively expressed in alveolar macrophages from healthy individuals but is depressed in alveolar macrophages of patients with sarcoidosis, a prototypical granulomatous disease. Our previous study of macrophage-specific PPARγ KO mice had revealed an intrinsically inflammatory pulmonary environment with an elevated pro-inflammatory cytokines profile as compared to wild-type mice. Based on such observations we hypothesized that PPARγ expression would be repressed in alveolar macrophages from animals bearing granulomas induced by MWCNT instillation. Methods Wild-type C57Bl/6 and macrophage-specific PPARγ KO mice received oropharyngeal instillations of multiwall carbon nanotubes (MWCNT) (100 μg). Bronchoalveolar lavage (BAL) cells, BAL fluids, and lung tissues were obtained 60 days post-instillation for analysis of granuloma histology and pro-inflammatory cytokines (osteopontin, CCL2, and interferon gamma [IFN-γ] mRNA and protein expression. Results In wild-type mice, alveolar macrophage PPARγ expression and activity were significantly reduced in granuloma-bearing animals 60 days after MWCNT instillation. In macrophage-specific PPARγ KO mice, granuloma formation was more extensive than in wild-type at 60 days after MWCNT instillation. PPARγ KO mice also demonstrated elevated pro-inflammatory cytokine expression in lung tissue, laser-microdissected lung granulomas, and BAL cells/fluids, at 60 days post MWCNT exposure. Conclusions Overall, data indicate that PPARγ deficiency promotes inflammation and granuloma formation, suggesting that PPARγ functions as a negative regulator of chronic granulomatous inflammation.
Comparative Study of Intranasal Midazolam and Intravenous Benzodiazepines in Control of Seizures in Children
Janki Panchal,Khyati Kakkad,Prashant Kariya,Prakash Patel
National Journal of Medical Research , 2013,
Abstract: Background: Seizures are very common in pediatric patients. As duration of seizures impacts morbidity and mortality to child s life, control of seizures should be achieved as early as possible, preferably at home. Rectal diazepam and intranasal midazolam are available methods for control of seizures and can be learnt by parents. Methods: We assessed safety and efficacy of intranasal midazolam for control of seizures and also compared its effect with other benzodiazepines given by intravenous route. Results: Among 84 patients, success rate of treatment with Midazolam (intranasal) was 45.5% and success rate with Benzodiazepines (intravenous) was 90%. The difference is statistically significant. In present study, average time recorded to give drug after arrival at hospital in IN Midazolam group was 0.379 min, where as it was 1.598 min in IV Benzodiazepine group. Average time for cessation of seizures after giving drug was 3.001 min in IN Midazolam group, where as it was 1.009 min in IV Benzodiazepine group. Conclusion: Intra-venous route for control of seizures is most effective compare to Inta-nasal Midazolam. However intranasal Midazolam can be use full when IV access is not available at home or during transport of patient to health care centre. [Natl J of Med Res 2013; 3(1.000): 30-33]
Induction of Defense-Related Enzymes in Banana Plants: Effect of Live and Dead Pathogenic Strain of Fusarium oxysporum f. sp. cubense
Janki N. Thakker,Samiksha Patel,Pinakin C. Dhandhukia
ISRN Biotechnology , 2013, DOI: 10.5402/2013/601303
Abstract:
Induction of Defense-Related Enzymes in Banana Plants: Effect of Live and Dead Pathogenic Strain of Fusarium oxysporum f. sp. cubense
Janki N. Thakker,Samiksha Patel,Pinakin C. Dhandhukia
ISRN Biotechnology , 2013, DOI: 10.5402/2013/601303
Abstract: The aim of the present study was to scrutinize the response of banana (Grand Naine variety) plants when interacting with dead or live pathogen, Fusarium oxysporum f.sp. cubense, a causative agent of Panama disease. Response of plants was evaluated in terms of induction of defense-related marker enzyme activity, namely, peroxidase (POX), polyphenol oxidase (PPO), -1,3 glucanase, chitinase, and phenolics. Plant's interaction with live pathogen resulted in early induction of defense to restrain penetration as well as antimicrobial productions. However, pathogen overcame the defense of plant and caused disease. Interaction with dead pathogen resulted in escalating defense response in plants. Later on plants inoculated with dead pathogen showed resistance to even forced inoculation of live pathogen. Results obtained in the present study suggest that dead pathogen was able to mount defense response in plants and provide resistance to Panama disease upon subsequent exposure. Therefore, preparation from dead pathogen could be a potential candidate as a biocontrol agent or plant vaccine to combat Panama disease. 1. Introduction Musa acuminata (Banana) is one of the most important fruit crops of world as well as of India. Banana could be considered poor man’s apple, and it is the cheapest among all other fruits in the country. Fusarium wilt caused by Fusarium oxysporum f.sp. cubense (Foc) is the most destructive disease of banana [1]. The pathogen is soil-borne and remains viable up to several years and cause 20%–80% loss of banana. Several disease management strategies can be used such as crop rotation, burning infected plants or plant parts, and application of carbendazim [2]. Methods mentioned have limited success, and the application of synthetic fungicides may result in undesirable effects on the environment. An alternative to above strategies for managing fusarium wilt is the use of biological control. Biocontrol agent can be a beneficial organism (live or dead) or its part such as cell wall, protein, and oligosaccharides [3]. While using live organisms as a biocontrol agent, appropriate conditions for maintaining it should be strictly followed. Nevertheless, if part of the organism such as cell wall, protein, oligosaccharide, or attenuated/killed organism is used then strict conditions are not required. Plants, humans, and animals give instantaneous response to the pathogen or its part. Animals and humans produce antibodies against pathogen or vaccine, similarly plants response to pathogen attack by producing PR-proteins, defense-related enzymes [4],
Spectroscopic Investigation and Characterizations of PAM/PEO Blends Films  [PDF]
Gaurang Patel, Mundan B. Sureshkumar, Purvi Patel
Soft (Soft) , 2015, DOI: 10.4236/soft.2015.42002
Abstract: Polymer blends have been obtained in the form of dimensionally stable and free standing films and their properties were characterized by different techniques. FTIR analysis and Raman spectroscopic analysis cleared the hydrogen bonding intermolecular interaction between –CONH2 groups in Poly Acrylamide (PAM) and C-O-C and –CH2OH group in Poly Ethylene Oxide (PEO). From Differential Scanning Calorimeter (DSC) the study shows that crystallinity is increasing with PEO wt%. From polymer interaction parameter we also show that the polymer blend is miscible. Thermal stability of films is investigated by Thermo Gravimetric Analysis (TGA) and derivative Thermo Gravimetric Analysis (DrTG). From UV-Vis absorption spectra, absorption band edge, direct/ indirect band gap and optical activation energy have been calculated.
Efficacy And Safety Of Systemic Antifungal Agents In Chronic Dermatophytosis -An Open Trial
Nirmala S,Shanker B,Sentamilselvi G,Janki C
Indian Journal of Dermatology , 2000,
Abstract: Forty patients comprising of 20 males and 20 females suffering from dermatophytosis for more than one year and who were not on any topical or systemic medication 3 months prior to the institution of therapy, were divided into 4 groups, each comprising of 5 males and 5 females, were given oral griseofulvin 250 mg twice daily for 8 weeks for group A, oral ketoconzole 200mg daily for group B, oral fluconazole 150 mg twice weekly for group C and oral itraconazole and fluconazole were most effective drugs. Griseofulvin and itraconazole were found less effective. All the four drugs did not give rise to any side effect.
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