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Search Results: 1 - 10 of 144796 matches for " Parvin F. Peddi "
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Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy
Parvin F. Peddi,Matthew J. Ellis,Cynthia Ma
International Journal of Breast Cancer , 2012, DOI: 10.1155/2012/217185
Abstract: Triple negative breast cancer is an aggressive form of breast cancer with limited treatment options and is without proven targeted therapy. Understanding the molecular basis of triple negative breast cancer is crucial for effective new drug development. Recent genomewide gene expression and DNA sequencing studies indicate that this cancer type is composed of a molecularly heterogeneous group of diseases that carry multiple somatic mutations and genomic structural changes. These findings have implications for therapeutic target identification and the design of future clinical trials for this aggressive group of breast cancer. 1. Introduction Triple negative breast cancer (TNBC) is defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER-2 Overexpression. It accounts for 15–20% of all breast cancer cases [1, 2], but occurs at a higher frequency in young premenopausal women with African Ancestry (AA) [3]. High body mass index (BMI) and high parity, instead of low parity in other types of breast cancer, have been associated with increased risk for TNBC [4–6]. TNBC is associated with an overall poor prognosis as exemplified by a higher rate of early recurrence and distant metastasis to brain and lungs compared to other breast cancer subtypes [7, 8]. The unfavorable clinical outcome is partly explained by its aggressive pathologic features including a higher histology grade and mitotic index [9]. Chemotherapy is the only systemic therapy currently available for TNBC and is curative in a subset of patients with chemotherapy-sensitive disease. A higher rate of pathologic complete response (pCR) to standard chemotherapy has been observed in patients with TNBC compared to ER+ disease. A pCR rate of 22% in TNBC versus 11% in ER+ disease was reported in a study of over 1?000 patients treated with neoadjuvant anthracycline and taxane-based chemotherapy regimens [10]. The excellent outcome associated with the pCR, however, is in contrast to the high risk of recurrence and cancer-related deaths in those with residue disease. Although alternative agents such as platinum compounds have demonstrated promising activity, up to 70–80% of patients have residual cancer following neoadjuvant cisplatin [11]. In the metastatic setting, TNBC is typically associated with an initially higher response rate, but in a shorter time to progression following treatment with existing chemotherapy agents, resulting a shorter overall survival compared to ER+ breast cancer in multiple studies [12]. The underlying molecular mechanism for this paradox is yet to be
The Rate of Decline and Trend Line Analysis of Groundwater underneath Dhaka and Gazipur City  [PDF]
Mithila Parvin
Journal of Water Resource and Protection (JWARP) , 2019, DOI: 10.4236/jwarp.2019.113020
Abstract: Groundwater is reported to account for 87% of all drinking water resources in Dhaka which has suffered a decline of up to 75 m in some specific location. Over-extraction of groundwater is an extensive social problem in Dhaka and Gazipur city which needs to be investigating thoroughly. This study presents the diagnosis of groundwater depletion pattern and the yearly rate of decline over the last three decades for Dhaka and Gazipur metropolitan area. Groundwater data were collected from the relevant institutions in order to analyse the trend line and the rate of decline of groundwater levels for more than 30 years period to understand the long-time variability. Ten individual stations datasets for GWL have been analyzed for Dhaka and Gazipur within a selected reference time period (1980-2012). The highest depleted GWL were found in the Mirpur station which is now 68 m below ground. To find out the time span when the depletion rate is highest, the rate of decline of all datasets has been computed which shows that 1998-2005 is the consecutive eight years time span with the fastest depletion rate. On the other hand, the annual trend-line analysis shows rapid depletion pattern after the year 2000.
Phacolytic Glaucoma in Fuch′s Heterochromic Uveitis
Peddi Anita,Chandra Sekhar G
Indian Journal of Ophthalmology , 2005,
Relationship Between Maternal Nutritional-Social Status and Pregnancy Outcomes
F. Borazjani,K.A. Ahmadi,Parvin Shahri
Pakistan Journal of Nutrition , 2011,
Abstract: The aims of present study were to determine effect of maternal dietary intake and also socio-economical status on outcomes of pregnancy. A cross sectional study in Pune city Maharashtra state (India) was carried out among 156 singleton healthy pregnant women. Directly interview method was accomplished of the pregnant women who were visiting for their monthly check up. During each interview, information was sought concerning the demography background of pregnant women and 24 h diet recall and also food frequency questionnaire. Regression result showed the maternal fish, saturated oil and milk intake significant and positively contributed to birth biometrical parameters. While, unsaturated oil intakes was negatively associated. Moreover, birth size was influenced by maternal income-educational status. Subsequently, polynomial linearity test approved existence of increasing tendency among the variable. The study indicates that maternal dietary consumption can be considered as a reliable predictor of fetal growth. Similarly, educational status has an effect on fetal growth and pregnancy outcome.
Phase stability and physical properties of hypothetical V4SiC3
F. Parvin,M. M. Hossain,A. K. M. A. Islam
Physics , 2011,
Abstract: We study the phase stability, mechanical, electronic, optical properties and Vicker's hardness of the newly predicted layered compound V4SiC3 using the first-principles method. This hypothetical compound is found to possess higher bulk modulus as well as higher hardness than those of a similar V4AlC3. The Mulliken bond population analysis indicates that the substitution of Al atom with the Si atom increases the Vicker's hardness of this compound. The electronic band structure shows that the conductivity is metallic and the main contribution comes from V 3d states. The partial density of states (PDOS) shows that the hybridization peak of V 3d and C 2s lies lower in energy than that of V 3d and Si 3p states which suggests that the V 3d - C 2s bond is stronger than the V 3d - Si 3p bond. The results are consistent with our bond analysis. Further we have discussed the origin of the features that appear in the optical properties. V4SiC3 is seen as a promising dielectric material showing a much better candidate material as a coating to avoid solar heating than those of V4AlC3, {\alpha}-Nb4SiC3 and Ti4AlN3 compounds. Keywords: MAX phase V4SiC3; Phase stability; Electronic properties; Optical properties; Vicker's hardness. PACS: 61.66.Fn, 62.20.-x, 62.20.Dc, 71.15Mb, 78.20.Ci
A Classifier Ensemble of Binary Classifier Ensembles
Hamid Parvin,Sajad Parvin
International Journal of Electronics Communication and Computer Technology , 2011,
Abstract: This paper proposes an innovative combinational algorithm to improve the performance in multiclass classification domains. Because the more accurate classifier the better performance of classification, the researchers in computer communities have been tended to improve the accuracies of classifiers. Although a better performance for classifier is defined the more accurate classifier, but turning to the best classifier is not always the best option to obtain the best quality in classification. It means to reach the best classification there is another alternative to use many inaccurate or weak classifiers each of them is specialized for a sub-space in the problem space and using their consensus vote as the final classifier. So this paper proposes a heuristic classifier ensemble to improve the performance of classification learning. It is specially deal with multiclass problems which their aim is to learn the boundaries of each class from many other classes. Based on the concept of multiclass problems classifiers are divided into two different categories: pairwise classifiers and multiclass classifiers. The aim of a pairwise classifier is to separate one class from another one. Because of pairwise classifiers just train for discrimination between two classes, decision boundaries of them are simpler and more effective than those of multiclass classifiers.The main idea behind the proposed method is to focus classifier in the erroneous spaces of problem and use of pairwise classification concept instead of multiclass classification concept. Indeed although usage of pairwise classification concept instead of multiclass classification concept is not new, we propose a new pairwise classifier ensemble with a very lower order. In this paper, first the most confused classes are determined and then some ensembles of classifiers are created. The classifiers of each of these ensembles jointly work using majority weighting votes. The results of these ensembles are combined to decide the final vote in a weighted manner. Finally the outputs of these ensembles are heuristically aggregated. The proposed framework is evaluated on a very large scale Persian digit handwritten dataset and the experimental results show the effectiveness of the algorithm.
Impact of Irrigation on Food Security in Bangladesh for the Past Three Decades  [PDF]
M. Wakilur RAHMAN, Lovely PARVIN
Journal of Water Resource and Protection (JWARP) , 2009, DOI: 10.4236/jwarp.2009.13027
Abstract: Bangladesh has made impressive progress in agriculture sector in the last three decades and has almost be-come self-sufficient in food grain production. This is a tremendous achievement owing to its small territory and huge population and this was achieved through agricultural mechanization and modernization. Irrigation is one of the leading inputs has direct influence to increase yield, food grains production and plays vital role for ensuring food security in Bangladesh. The present study examined the growth of irrigated area and its impact on food grain production during last three decades. Time series data were used for the study. Differ-ent statistical methods such as mean, percentage, linear and exponential growth model were applied for get-ting meaningful findings. Various technologies have been used for irrigating crops which have contributed to rapid expansion of irrigated area. The conventional irrigation methods (Low Lift Pump, Dhone, Swing Bas-ket, Treadle Pump etc.) were replaced by modern methods (i.e Deep Tube Well and Shallow Tube Well). In addition, surface water irrigation also sharply declined, losing its importance due to lack of new surface irri-gation project and the ineffectiveness of earlier project. Groundwater covered 77 percent of total irrigated area and major (62%) extractions occurred through Shallow Tube Wells (STWs). The rapid expansion of ground water irrigation in respect to STWs irrigation was due to government’s withdrawal on restrictions on tube well setting rule, encouraging private sector and the cost effectiveness of Chinese engine which have been affordable to the small and medium farmers. Irrigated area thus, increased by about three times and cropping intensity also increased from 154 to 176 percent. Boro rice, an irrigated crop, consumed 73 percent of the total crop irrigation and contributed to a greater extent in total rice production in Bangladesh. Boro rice alone contributed to 55 percent of total food grain and was also highest (3.44 MT per hectare) compared to aus rice (1.66 MT per hectare) and aman rice (1.99 MT per hectare) per unit production. Consequently, the cultivated area of boro rice increased by 1168 to 4068 thousand hectares. The higher productivity of boro rice has almost helped the nation to meet her food requirements (about 24 Million MT). Boro rice production was highly correlated (r = .978) with irrigated area. Expansion of one hectare of irrigated area added 3.22 MT of boro rice in Bangladesh. Finally, the study suggested for expansion of irrigated areas (ground water and surface water),
Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats  [PDF]
Parvin Babaei, Bahram Soltani Tehrani
Journal of Behavioral and Brain Science (JBBS) , 2013, DOI: 10.4236/jbbs.2013.31015

In this study, the potential for recovery mediated by co-treatment of brain-derived neurotrophic factor (BDNF) and adipose tissue derived stem cells (ASCs) on functional recovery after Ibotenic acid (Ibo) lesion of the nucleus basalis magnocellularis (NBM) was examined. Ibotenic acid was injected bilaterally into the NBM of experimental rats, then the animals received treatments as follows: ASCs (500 × 103), BDNF (5 ug/ul) and a combination of BDNF and ASCs. Two months after the treatment, cognitive recovery was assessed by the Morris water-maze. These results showed that ASCs transplantation may have therapeutic value in disease and conditions that result in memory loss, and co-treatment with BDNF doesn’t offer more efficacious cognitive function.

Effect of Different Parameters on Removal and Quality of Soybean Lecithin
Parvin Eshratabadi
Research Journal of Biological Sciences , 2012,
Abstract: With regard to study the effective factors on removal and quality of lecithin extracted from soybean oil and the residual amount of phosphatids in degummed oil, this study was arranged. Crude oil recovered from soybean which had been processed by conventional solvent extraction and reached to a phosphorus content of 454 ppm, was used for this purpose. Treatment were carried out under different concentrations of phosphoric acid (0, 0.05, 0.1, 0.2, 0.5, 2) and different percents of water ( 0.5, 1, 2, 5, 3, 4) at different temperatures (25, 50, 60, 75, 90 C) and with different stirring times (5,10, 20, 40, 60 min). The highest phosphatid recovery was obtained with 3% (v v 1) water at 75 C with stirring time of 20 min. Phosphoric acid adding decreased the phosphatid residue in degummed oil but the quality of lecithin was reduced. However addition of phosphoric acid lower than 0.05% (v v 1) at 60 C resulted the same recovery efficiency without important effect on quality of lecithin.
Investigation of the prevalence of aggression against women by husbands in among the persons who are dependent to opium substance who were referred to an addiction clinic of the Medical University of Rafsanjan during the year 2004
Aghamohammadhasani Parvin
Annals of General Psychiatry , 2006, DOI: 10.1186/1744-859x-5-s1-s167
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