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Search Results: 1 - 10 of 7653 matches for " Park KyoungHo "
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On Interpolation Functions of the Generalized Twisted -Euler Polynomials
Park KyoungHo
Journal of Inequalities and Applications , 2009,
Abstract: The aim of this paper is to construct -adic twisted two-variable Euler-( , )- -functions, which interpolate generalized twisted ( , )-Euler polynomials at negative integers. In this paper, we treat twisted ( , )-Euler numbers and polynomials associated with -adic invariant integral on . We will construct two-variable twisted ( , )-Euler-zeta function and two-variable ( , )- -function in Complex -plane.
Identities of Symmetry for Euler Polynomials Arising from Quotients of Fermionic Integrals Invariant under
Kim DaeSan,Park KyoungHo
Journal of Inequalities and Applications , 2010,
Abstract: We derive eight basic identities of symmetry in three variables related to Euler polynomials and alternating power sums. These and most of their corollaries are new, since there have been results only about identities of symmetry in two variables. These abundances of symmetries shed new light even on the existing identities so as to yield some further interesting ones. The derivations of identities are based on the -adic integral expression of the generating function for the Euler polynomials and the quotient of integrals that can be expressed as the exponential generating function for the alternating power sums.
On Some Arithmetical Properties of the Genocchi Numbers and Polynomials
Park KyoungHo,Kim Young-Hee
Advances in Difference Equations , 2008,
Abstract: We investigate the properties of the Genocchi functions and the Genocchi polynomials. We obtain the Fourier transform on the Genocchi function. We have the generating function of -Genocchi polynomials. We define the Cangul-Ozden-Simsek's type twisted -Genocchi polynomials and numbers. We also have the generalized twisted -Genocchi numbers attached to the Dirichlet's character . Finally, we define zeta functions related to -Genocchi polynomials and have the generating function of the generalized -Genocchi numbers attached to .
Magnetically Separable and Recyclable Fe3O4-Supported Ag Nanocatalysts for Reduction of Nitro Compounds and Selective Hydration of Nitriles to Amides in Water
Hyunje Woo,Kyoungho Lee,Sungkyun Park,Kang Hyun Park
Molecules , 2014, DOI: 10.3390/molecules19010699
Abstract: As hybrid nanostructures have become more important in many fields of chemistry, Ag nanoparticles (NPs) are being increasingly immobilized onto Fe 3O 4 microspheres in situ. Structural characterization reveals that the Ag NPs are uniformly immobilized in the Fe 3O 4 microsphere-based supports. Moreover, Ag NPs are more stable in the hybrid structure than in the naked state and show high catalytic activity for the reduction of nitro compounds and hydration of nitriles to amides in water. The Fe 3O 4 microspheres were recycled several times using an external magnet.
On the Identities of Symmetry for the -Euler Polynomials of Higher Order
Kim Taekyun,Park KyoungHo,Hwang Kyung-won
Advances in Difference Equations , 2009,
Abstract: The main purpose of this paper is to investigate several further interesting properties of symmetry for the multivariate -adic fermionic integral on . From these symmetries, we can derive some recurrence identities for the -Euler polynomials of higher order, which are closely related to the Frobenius-Euler polynomials of higher order. By using our identities of symmetry for the -Euler polynomials of higher order, we can obtain many identities related to the Frobenius-Euler polynomials of higher order.
Mild Hypothermia Attenuates Intercellular Adhesion Molecule-1 Induction via Activation of Extracellular Signal-Regulated Kinase-1/2 in a Focal Cerebral Ischemia Model
Jung Sook Choi,Jaechan Park,Kyoungho Suk,Cheil Moon,Yong-Ki Park,Hyung Soo Han
Stroke Research and Treatment , 2011, DOI: 10.4061/2011/846716
Abstract: Intercellular adhesion molecule-1 (ICAM-1) in cerebral vascular endothelium induced by ischemic insult triggers leukocyte infiltration and inflammatory reaction. We investigated the mechanism of hypothermic suppression of ICAM-1 in a model of focal cerebral ischemia. Rats underwent 2 hours of middle cerebral artery occlusion and were kept at 37°C or 33°C during occlusion and rewarmed to normal temperature immediately after reperfusion. Under hypothermic condition, robust activation of extracellular signal-regulated kinase-1/2 (ERK1/2) was observed in vascular endothelium of ischemic brain. Hypothermic suppression of ICAM-1 was reversed by ERK1/2 inhibition. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) in ischemic vessel was attenuated by hypothermia. STAT3 inhibitor suppressed ICAM-1 production induced by stroke. ERK1/2 inhibition enhanced phosphorylation and DNA binding activity of STAT3 in hypothermic condition. In this study, we demonstrated that hypothermic suppression of ICAM-1 induction is mediated by enhanced ERK1/2 activation and subsequent attenuation of STAT3 action. 1. Introduction Intercellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin superfamily and the principal ligand for leukocyte function-associated antigen-1 (LFA-1), a member of the integrin superfamily. ICAM-1/LFA-1 adhesion system assists leukocyte movement into the tissue. LFA-1-positive leukocytes are induced to adhere to ICAM-1-positive endothelial surface [1, 2], and then to pass through the basement membrane into the tissue [3, 4]. Many animal and human studies indicate that ICAM-1 is implicated in the pathogenesis of ischemic cardiovascular and cerebrovascular disorders [5–8]. Especially during reperfusion period of stroke, infiltrated leukocytes contribute to the secondary injury by producing toxic substances that damage the brain cells and disrupt the blood-brain barrier [9, 10]. Since ICAM-1 is an important factor of leukocyte infiltration and reperfusion injury in stroke, intervention of ICAM-1 induction has been a promising therapeutic strategy against stroke. The remarkable benefit of mild hypothermia in brain ischemia has long been recognized and remains one of the most powerful neuroprotective strategies in cerebral ischemia both experimentally and clinically [11]. Many studies indicate that inflammatory response contributes significantly to the secondary injury after ischemia [12, 13], and protection by mild hypothermia is associated with anti-inflammatory processes [14–16]. Even though there is considerable
Time-dependent effects of hypothermia on microglial activation and migration
Jung-Wan Seo, Jong-Heon Kim, Jae-Hong Kim, Minchul Seo, Hyung Soo Han, Jaechan Park, Kyoungho Suk
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-164
Abstract: Microglial cells in culture were subjected to mild (33?°C) or moderate (29?°C) hypothermic conditions before, during, or after lipopolysaccharide (LPS) or hypoxic stimulation, and the production of nitric oxide (NO), proinflammatory cytokines, reactive oxygen species, and neurotoxicity was evaluated. Effects of hypothermia on microglial migration were also determined in in vitro as well as in vivo settings.Early-, co-, and delayed-hypothermic treatments inhibited microglial production of inflammatory mediators to varying degrees: early treatment was the most efficient, and delayed treatment showed time-dependent effects. Delayed hypothermia also suppressed the mRNA levels of proinflammatory cytokines and iNOS, and attenuated microglial neurotoxicity in microglia-neuron co-cultures. Furthermore, delayed hypothermia reduced microglial migration in the Boyden chamber assay and wound healing assay. In a stab injury model, delayed local hypothermia reduced migration of microglia toward the injury site in the rat brain.Taken together, our results indicate that delayed hypothermia is sufficient to attenuate microglial activation and migration, and provide the basis of determining the optimal time window for therapeutic hypothermia. Delayed hypothermia may be neuroprotective by inhibiting microglia-mediated neuroinflammation, indicating the therapeutic potential of post-injury hypothermia for patients with brain damages exhibiting some of the inflammatory components.
Grassmann manifold Bosonization of QCD in Two Dimensions
KyoungHo Han,H. J. Shin
Mathematics , 1997, DOI: 10.1063/1.532081
Abstract: Two dimensional QCD is bosonized to be an integrably deformed Wess-Zumino-Witten model under proper limit. Fermions are identified having indices of the Grassmann manifold. Conditions for integrability are analyzed and their physical meanings are discussed. We also address the nature of the exactly solvable part of the theory and find the infinitely many conserved quantities.
Inhibitors of Microglial Neurotoxicity: Focus on Natural Products
Dong Kug Choi,Sushruta Koppula,Kyoungho Suk
Molecules , 2011, DOI: 10.3390/molecules16021021
Abstract: Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. Recently, much attention has been paid to therapeutic strategies aimed at inhibiting neurotoxic microglial activation. Pharmacological inhibitors of microglial activation are emerging as a result of such endeavors. In this review, natural products-based inhibitors of microglial activation will be reviewed. Potential neuroprotective activity of these compounds will also be discussed. Future works should focus on the discovery of novel drug targets that specifically mediate microglial neurotoxicity rather than neuroprotection. Development of new drugs based on these targets may require a better understanding of microglial biology and neuroinflammation at the molecular, cellular, and systems levels.
Composite Skyrme Model with Vector Mesons
Kwanghoon Hahm,KyoungHo Han,H. J. Shin
Physics , 1997, DOI: 10.1103/PhysRevD.56.1812
Abstract: We study the composite Skyrme model, proposed by Cheung and G\"{u}rsey, introducing vector mesons in a chiral Lagrangian. We calculate the static properties of baryons and compare with results obtained from models without vector mesons.
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