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Search Results: 1 - 10 of 129 matches for " Parekh Hejal "
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ADVANCEMENTS IN CONTROLLED RELEASE GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW
Makwana Ami,Sameja Krunal,Parekh Hejal,Pandya Yogi
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: Oral delivery of the drug is by far the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in the formulations but has a drawback of non-site specificity and short gastric resident time. In order to overcome the drawbacks of conventional oral drug delivery systems, several technical advancements have led to the development of gastro retentive drug delivery system that could revolutionize method of medication and provide a number of therapeutic benefits. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastroretentive approaches designed and developed until now, i.e. floating drug delivery system(FDDS), bio- or mucoadhesive system, expandable, unfoldable system, high density system, raft forming system, super porous hydrogel system and magnetic systems. Among these systems, FDDS have been most commonly used. Finally, advantages, disadvantages, evaluation, marketed preparation and future potential of gastro retentive drug delivery systems were covered.
The Crisis and Emancipation of the Modern Corporate Executive: How the Bhagavad Gita Reinforces Edward Freeman’s Stakeholder Theory
Shreyans Parekh
Michigan Journal of Business , 2008,
Abstract: Business leaders are looking towards corporate social responsibility as a critical means to satisfying their stakeholders, while facilitating their firm’s long-term sustainability. As part of this holistic trend, more managers are looking towards the Bhagavad-Gita for lessons on leadership and character development in place of the classic Sun Tzu’s Art of War. Companies that currently lack strong CSR initiatives must follow suit in developing socially responsible products and projects due to the tremendous value that such actions can unlock for stakeholders. The Gita requests leaders to be the sattvic frame of reference for ethics and morality that the corporate world has lacked for many years. Important implications of CSR are the cooperation of corporations and NGOs with like-minded social objectives, and the creation of new firms and careers dedicated towards the research and development of socially responsible projects. With the greening effect sweeping across the United States, CSR will be a crucial moving force in the corporate world, and business executives must acknowledge that social value can be an amplifying force for corporate value.
Debate on industry influence on OH organizations/T.K. Joshi′s tantrums!
Parekh Ramnik
Indian Journal of Occupational and Environmental Medicine , 2008,
Abstract:
Isolated tuberculous epididymitis
Parekh D
Journal of Postgraduate Medicine , 2005,
Abstract:
Case Series of Methylene Blue Injections for the Treatment of Zygapophysial and Sacroiliac Joint Pain: Results of 5 Cases  [PDF]
Jay Parekh,Maxim Eckmann,Somayaji Ramamurthy
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.36066
Abstract: Introduction: Shealy is credited with the use of fluoroscopy guided radiofrequency ablation (RFA) for denervation of the lumbar zygapophysial (L-Z) joint in the mid-1970’s. Peng and colleagues described the use of methylene blue (MB) injection for discogenic pain; MB may work through direct neurotoxicity or inhibition of nitric oxide synthesis. We present a retrospective case series of five patients with L-Z or SI joint pain where MB used as an alternative to RFA. Materials and Methods: This is a retrospective case series of five patients who received MB for the chemical neurolysis of either medial or/and lateral branch’s for zygapophysial or SI joint pain. All of the MB blocks were done under fluoroscopic guidance and performed in the same manner as diagnostic medial and lateral branch blocks but with care to consider the medication as neurotoxic in relation to spinal nerves. On average 1cc of 0.05% final concentration MB was injected per nerve or sacral foraminal level. Results: Four of the five patients had significant lasting pain relief. Discussion: Chemical neurolysis has potential to achieve technical success in these refractory cases of spine pain possibly due to spread over a broader area; for this same reason the procedure should be performed carefully under fluoroscopic guidance.
Case Series of Methylene Blue Injections for the Treatment of Zygapophysial and Sacroiliac Joint Pain: Results of 5 Cases  [PDF]
Jay Parekh, Maxim Eckmann, Somayaji Ramamurthy
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.36066
Abstract:

Introduction: Shealy is credited with the use of fluoroscopy guided radiofrequency ablation (RFA) for denervation of the lumbar zygapophysial (L-Z) joint in the mid-1970’s. Peng and colleagues described the use of methylene blue (MB) injection for discogenic pain; MB may work through direct neurotoxicity or inhibition of nitric oxide synthesis. We present a retrospective case series of five patients with L-Z or SI joint pain where MB used as an alternative to RFA. Materials and Methods: This is a retrospective case series of five patients who received MB for the chemical neurolysis of either medial or/and lateral branch’s for zygapophysial or SI joint pain. All of the MB blocks were done under fluoroscopic guidance and performed in the same manner as diagnostic medial and lateral branch blocks but with care to consider the medication as neurotoxic in relation to spinal nerves. On average 1cc of 0.05% final concentration MB was injected per nerve or sacral foraminal level. Results: Four of the five patients had significant lasting pain relief. Discussion: Chemical neurolysis has potential to achieve technical success in these refractory cases of spine pain possibly due to spread over a broader area; for this same reason the procedure should be performed carefully under fluoroscopic guidance.

Prevalence of Overweight and Obesity in Adolescents of Urban AND Rural Area of Surat, Gujarat
Alok Parekh,Malay Parekh,Divyeshkumar Vadasmiya
National Journal of Medical Research , 2012,
Abstract: Background: The present study in prevalence of overweight and obesity among urban & rural adolescents in Surat (Gujarat, India). Methods: The data were derived from cross-sectional sampling of children, 176 in rural and 213 in urban, aged 14–16 years doing study in government schools in year of 2009. Age, gender and body mass index (BMI) were used to define overweight and obesity. Result: The prevalence of obesity increased significantly from 12.8% in rural to 14.6% in urban (p<0.01), whereas underweight decreased from 13.6% to 4.6% (p<0.001). There was a significantly higher risk of being overweight and obese in urban than rural, after adjusting for age, gender. Urban Males had significantly higher increase in prevalence and risk of being overweight and obese. Conclusion: This study showed an increasing in prevalence of overweight and obesity in urban adolescents especially with male gender, calling for an urgent need for immediate and targeted preventive measures. [National J of Med Res 2012; 2(3.000): 325-329]
In vitro antibacterial activity of the crude methanol extract of Woodfordia fruticosa Kurz. flower (Lythraceae)
Parekh, Jigna;Chanda, Sumitra;
Brazilian Journal of Microbiology , 2007, DOI: 10.1590/S1517-83822007000200004
Abstract: the antibacterial activity of the crude methanol extract of woodfordia fruticosa kurz. flower was evaluated at two different concentrations by the agar well diffusion method. the methanol extract of the flower exhibited antibacterial activity at varied levels except against bacillus subtilis and micrococcus flavus. the methanol extract was most active against pseudomonas pseudoalcaligenes. the extract was more active against gram-negative bacteria as compared to gram-positive. the inhibitory effect of the extract was compared with standard antibiotics, amoxicillin and ciprofloxacin.
In vitro antimicrobial activity of Trapa natans L. fruit rind extracted in different solvents
J Parekh, S Chanda
African Journal of Biotechnology , 2007,
Abstract: Trapa natans L. fruit rind was extracted in different solvents with increasing polarity; 1,4-dioxan, chloroform, acetone, imethylformamide, ethanol and water. The extractive yield ranged from 0.62 –12.62%. The antibacterial activity of all the extracts was determined by agar disc diffusion method. Maximum antibacterial activity was observed against Gram negative bacteria. The resistant Gram negative strains were C. fruendii, E. aerogenes, E. coli, P. vulgaris, P. aeruginosa and S. typhimurium. Amongst Gram positive bacteria, M. flavus was the most susceptible bacteria and B. subtilis was most resistant. The moulds showed better antifungal activity than yeast. A. niger was the most resistant fungal strain. The best antimicrobial activity was with 1,4-dioxan extract and the least activity was with petroleum ether extract. The inhibitory effects of the extracts were comparable with the standard antimicrobics used. This work has highlighted the antimicrobial effects of fruit rind of Trapa natans L. on some of the medically important pathogens.
In-vitro antimicrobial activities of extracts of Launaea procumbens roxb. (Labiateae), Vitis vinifera l. (Vitaceae) and Cyperus rotundus l. (Cyperaceae
J Parekh, S Chanda
African Journal of Biomedical Research , 2006,
Abstract: The aqueous and ethanolic extracts of Launaea procumbens Roxb. (Labiateae), Vitis vinifera L. (Vitaceae) and Cyperus rotundus L. (Cyperaceae) were evaluated for antimicrobial activity against clinically important bacteria viz. Alcaligenes faecalis ATCC8750, Bacillus cereus ATCC11778, Bacillus subtilis ATCC6633, Enterobacter aerogenes ATCC13048, Escherichia coli ATCC25922, Klebsiella pneumoniae NCIM2719, Proteus mirabilis NCIM224, Proteus vulgaris NCTC8313, Pseudomonas aeruginosa ATCC27853, Pseudomonas pseudoalcaligenes ATCC17440, Salmonella typhimurium ATCC23564, Staphylococcus aureus ATCC25923, Staphylococcus epidermidis ATCC12228, Staphylococcus subfava NCIM2704 and Candida tropicalis ATCC4563. The in vitro antimicrobial activity was performed by agar disc diffusion and agar well diffusion method. The ethanolic extracts of all the plants were active against all the investigated bacterial strains while all the aqueous extracts were inactive except for Vitis vinifera L. S. typhimurium was the most resistant bacterial strain against all the extracts (Afr. J. Biomed. Res. 9:89 – 93, May 2006)
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