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Search Results: 1 - 10 of 659 matches for " Paraneoplastic Syndromes "
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Cutaneous manifestations of internal malignancies in a tertiary health care hospital of a developing country
Ortega-Loayza, Alex G;Ramos, Willy;Gutierrez, Ericson L;Paz, Patricia Chavez de;Bobbio, Lucia;Galarza, Carlos;
Anais Brasileiros de Dermatologia , 2010, DOI: 10.1590/S0365-05962010000500026
Abstract: in a public hospital in lima, peru, 24 patients with 16 types of paraneoplastic dermatoses were identified by data collection. the most frequent dermatosis was dermatomyositis (four patients). the other dermatoses were malignant acanthosis nigricans, palmoplantar keratoderma, bullous dermatoses, lymphomatoid papulosis, edematous scarring vasculitic panniculitis, norwegian scabies, primary systemic amyloidosis, necrolytic migratory erythema, infective dermatitis, pancreatic panniculitis, generalized pruritus, lesser-trelat syndrome, and acquired ichthyosis. most of these paraneoplastic dermatoses were diagnosed before (45.8%) or at the time of (38.5%) the diagnosis of the underlying malignancy. the most frequent underlying malignancies were lymphoma, adenocarcinomas of the upper digestive tract, and malignant neoplasms of the pancreas. the average age of the patients was 47.0 ± 16.9 years and the length of the disease since diagnosis was 13.7 months. the mortality rate was 75%. paraneoplastic dermatoses are rare dermatologic entities that are difficult to diagnose. surveillance is also hampered when patients do not have easy access to health care centers due to financial and geographical issues. however, when identified, they might facilitate the early diagnosis of an associated tumor and contribute to increase the surveillance of patients.
Síndromes reumáticos paraneoplásicos
González Naranjo,Luis Alonso;
Iatreia , 2011,
Abstract: a wide variety of rheumatic manifestations has been associated with malignancies. they may result from direct invasion of bone, joints or soft tissue by the tumor, and may also occur by distant effects of the tumor mediated by humoral factors (paraneoplastic syndromes). among the paraneoplastic rheumatic syndromes, hyperthrophic ostearthropaty, carcinomatous polyarthritis, dermatomyositis and vasculitis are the most frequently diagnosed. paraneoplastic syndromes may precede the tumor, by no longer than two years, appear simultaneously with it or follow its diagnosis. the clinical course usually is parallel to that of the tumor. therefore, cure of the underlying malignancy often, although not invariably, results in regression of the paraneoplastic syndrome. in this article a review is presented on paraneoplastic rheumatic syndromes.
Caso para diagnóstico
Albuquerque, Vanessa Martins Ferreira de;Cardoso, Alberto Eduardo Cox;Melo, Maria José de Medeiros Barros;Souza, Paulo Fernando de;
Anais Brasileiros de Dermatologia , 2008, DOI: 10.1590/S0365-05962008000200013
Abstract: a case of erythema gyratum repens is described in a 40-year-old man with a generalized, bizarre, figurated and pruritic erythema with fine scaling borders. laboratorial exams and radiography of the thorax were normal in the first visit. a tomographic study of the thorax showed a lobulated pulmonary nodule and the immunohistochemistry on the biopsy of an inguinal lymph node confirmed the lung cancer as the primary site of the neoplasia.
Síndrome de Guillain-Barré crónico y neoplasia gástrica: ?causalidad o casualidad?
Ibá?ez Frías,J.; Teresa Romero,G. de; Casado Vicente,V.;
Medifam , 2001, DOI: 10.4321/S1131-57682001000400007
Abstract: paraneoplastic syndromes are not a direct consequence of neither the primary tumour nor its metastasis. the clinical course of these syndromes sometimes correlates to the malignancy underneath itself, what may suggest an ascertain paraneoplastic etiology. however, some other times both the paraneoplastic syndrome and the tumour follow independent courses. in any of these situations it is essential to consider their potential existence for they may suppose the first sign of a malignant process. this will contribute to their early detection in a curable stage and their use as clinical tumour markers of early recurrences in treated patients
Acute onset paraneoplastic cerebellar degeneration in a patient with small cell lung cancer
Bhatia R,Prabhakar S,Lal V,Khurana D
Neurology India , 2003,
Abstract: A patient with small cell lung cancer presented with a rare presentation of an acute onset pancerebellar dysfunction. His clinical condition markedly improved following the surgical removal of the tumor and chemo- and radiotherapy.
Síndromes paraneoplásicos neurológicos: para entender la respuesta inmune y los anticuerpos paraneoplásicos
González Trujillo,Fernando; Medina,Yimy F; Penagos González,Pedro José; Zubieta Vega,Camilo; Melo Gómez,Gonzalo;
Acta Neurológica Colombiana , 2011,
Abstract: paraneoplastic disorders of the central nervous system (cns) define the compromise of central nervous system diffuse or focally and it is due to an immune response of humoral type or cellular type without either metastasis or direct extension of the tumor. its incidence is low. the pathogenesis of paraneoplastic syndromes of the cns result from immune responses to intracellular antigens mediated mainly by t cells and responses mainly by antibodies to antigens expressed by tumors on cell membranes. the non paraneoplastic neurologic syndromes and syndromes without a subjacent cns tumor are two important entities for differential diagnosis, in which there is mediation by antibodies against synaptic proteins and surface cellular proteins. these share similar clinical characteristics with paraneoplastic disorders of cns. they affect children and young adult and are susceptible to immunotherapy depending on the immunologic mechanism involved. paraneoplastic disorders of the central nervous system may precede the tumor presentation. the onconeural antibodies facilitate limit a differential spectrum and lead to an early diagnosis and treatment. the objective of this review article is sought to the paraneoplastic disorders of the central nervous system characteristics and the immunologic mechanisms that identify them, to define the antibodies best studied and present a diagnostic and a treatment plans.
Un hombre con poliartritis, orejas inflamadas, esplenomegalia y diaforesis nocturna
Restrepo,Mauricio;
Acta Medica Colombiana , 2007,
Abstract: this a clinical case of a patient with chronic polyarthritis of the hands and feet, who also reported red eyes and recurrent painful inflamation of the ears, as well as a cervical mass, splenomegaly and diaphoresis during the night. the diagnosis of polycondritis was made associated to hematological neoplasia of the leukemia/lymphoma type, recurrent associated to chronic lymphoids. at the end, there is a list of some rheumatic manifestations of neoplastic disorders and special emphasis is placed on relapsing polychondritis as a possible para-neoplastic manifestation, highlighting that there are very few associations reported in the national and international literature between relapsing polychondritis and malignant lymphoma.
Papilomatose cutanea florida e acantose nigricante maligna reveladoras de neoplasia gástrica
Brinca, Ana;Cardoso, José Carlos;Brites, Maria Manuel;Tellechea, óscar;Figueiredo, Américo;
Anais Brasileiros de Dermatologia , 2011, DOI: 10.1590/S0365-05962011000300025
Abstract: this paper reports the case of a 57-year-old, previously healthy male with no systemic symptoms who over a short period of time developed multiple wart-like lesions on his trunk, limbs and face, typical lesions of acanthosis nigricans in the major body folds and tripe palms. diagnostic tests revealed a metastatic gastric adenocarcinoma. despite the implementation of therapy, which had a transient effect on the tumor and skin lesions, the patient died in 14 months. the association of these three paraneoplastic dermatoses (florid cutaneous papillomatosis, acanthosis nigricans maligna and tripe palms) in the same patient, apparently with a common pathogenic mechanism, is noteworthy
Dermatologia comparativa: paquidermatoglifia adquirida associada a carcinoma gástrico avan?ado
Ribas, Jonas;Peixoto, Lucíola de Fátima Albuquerque de Almeida;Almeida, Maíra Fernandes de;Lima, Walquíria de Castro;
Anais Brasileiros de Dermatologia , 2007, DOI: 10.1590/S0365-05962007000600014
Abstract: we report the case of a 67-year-old man suffering from acquired pachydermatoglyphia associated with advanced gastric carcinoma. this is a paraneoplasic syndrome with skin manifestations that may be compared to the wrinkled surface of the bovine stomach.
Síndrome de Sweet e policondrite recidivante reveladores de síndrome mielodisplásica
Diamantino, Filipa da Encarna??o Roque;Raimundo, Pedro Manuel Oliveira da Cunha;Fidalgo, Ana Isabel Pina Clemente;
Anais Brasileiros de Dermatologia , 2011, DOI: 10.1590/S0365-05962011000700045
Abstract: the emergence of certain skin conditions belonging to the group of mucocutaneous paraneoplastic syndromes may indicate the future appearance of a previously unknown malignancy. sweet's syndrome and relapsing polychondritis are included in this group. sweet's syndrome and relapsing polychondritis are very rarely found together in the same patient. this dual occurrence is more commonly found in cancer patients with associated hematological malignancies. we report the case of a 79year-old male with sweet's syndrome and relapsing polychondritis, who was subsequently diagnosed with a myelodysplastic syndrome
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