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Liposomal Iron for Iron Deficiency Anemia in Women of Reproductive Age: Review of Current Evidence  [PDF]
Parag Biniwale, Bhaskar Pal, Tripura Sundari, Gorakh Mandrupkar, Nikhil Datar, Amandeep Singh Khurana, Amit Qamra, Salman Motlekar, Rishi Jain
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.811100
Abstract: Iron deficiency anemia is the most frequent nutritional deficiency disorder. Conventionally administered oral iron is associated with gastrointestinal intolerance that affects the outcomes and compliance. Liposomal iron is associated with increased absorption without causing significant adverse effects. In this review, we have discussed the technology of liposomal iron preparation, mechanisms of its absorption and clinical evidence on its utility in iron deficiency states in pregnant and non-pregnant women. Based on the available evidence, we compared liposomal iron to conventional oral iron. Encapsulation of micronized iron in liposomes is associated with lesser exposure to gastric contents, lesser interaction with food contents, no exposure to different digestive juices, targeted delivery of iron and allows lower doses to be administered in lieu of direct absorption without need for protein carriers. The available evidence suggests that liposomal iron significantly increases hemoglobin, ferritin levels in pregnant women as well as in women with iron deficiency.
Heme Iron Polypeptide in Iron Deficiency Anemia of Pregnancy: Current Evidence  [PDF]
Bhaskar Pal, Hemant Deshpande, Tripura Sundari, Parag Biniwale, Kamlesh Shah, Sugandh Goel, Amandeep Singh Khurana, Amit Qamra, Salman Motlekar, Hanmant Barkate
Open Journal of Obstetrics and Gynecology (OJOG) , 2017, DOI: 10.4236/ojog.2017.74044
Abstract: Iron deficiency is the most common nutritional deficiency leading to anemia in pregnancy. Conventionally, non-heme form of iron salts has been the mainstay of treatment. However, patient compliance is an important concern with existing oral iron therapy due to gastrointestinal side effects. Heme iron, a better bioavailable and tolerable form of iron can be suitable form of iron for supplementation in pregnancy. Evidence suggests its utility in pregnancy for treatment of iron deficiency anemia with benefits extending to postpartum period. Effective transfer across placenta to fetus further supports its utility in pregnancy. This review discusses in details the absorption kinetics along with clinical evidence on efficacy, safety, and tolerability of heme-iron supplementation in iron deficiency anemia of pregnancy.
Tuberculous osteomyelitis of the bone flap following craniotomy for a glioma.
Biniwale S,Rajshekhar V
Neurology India , 2000,
Transient and Permanent Fault Injection in VHDL Description of Digital Circuits  [PDF]
Parag K. Lala
Circuits and Systems (CS) , 2012, DOI: 10.4236/cs.2012.32026
Abstract: The ability to evaluate the testability of digital circuits before they are actually implemented is critical for designing highly reliable systems. This feature enables designers to verify the fault detection capability of online as well as offline testable digital circuits for both permanent and transient faults, during the design stage of the circuits. This paper presents a technique for transient and permanent fault injection at the VHDL level description of both combinational and sequential digital circuits. Access to all VHDL blocks a system is straight forward using a specially designed single fault injection block. This capability of inserting transient and permanent faults should help in evaluating the testability of a digital system before it is actually implemented.
Multistep-ahead River Flow Prediction using LS-SVR at Daily Scale  [PDF]
Parag P. Bhagwat, Rajib Maity
Journal of Water Resource and Protection (JWARP) , 2012, DOI: 10.4236/jwarp.2012.47062
Abstract: In this study, potential of Least Square-Support Vector Regression (LS-SVR) approach is utilized to model the daily variation of river flow. Inherent complexity, unavailability of reasonably long data set and heterogeneous catchment response are the couple of issues that hinder the generalization of relationship between previous and forthcoming river flow magnitudes. The problem complexity may get enhanced with the influence of upstream dam releases. These issues are investigated by exploiting the capability of LS-SVR–an approach that considers Structural Risk Minimization (SRM) against the Empirical Risk Minimization (ERM)–used by other learning approaches, such as, Artificial Neural Network (ANN). This study is conducted in upper Narmada river basin in India having Bargi dam in its catchment, constructed in 1989. The river gauging station–Sandia is located few hundred kilometer downstream of Bargi dam. The model development is carried out with pre-construction flow regime and its performance is checked for both pre- and post-construction of the dam for any perceivable difference. It is found that the performances are similar for both the flow regimes, which indicates that the releases from the dam at daily scale for this gauging site may be ignored. In order to investigate the temporal horizon over which the prediction performance may be relied upon, a multistep-ahead prediction is carried out and the model performance is found to be reasonably good up to 5-day-ahead predictions though the performance is decreasing with the increase in lead-time. Skills of both LS-SVR and ANN are reported and it is found that the former performs better than the latter for all the lead-times in general, and shorter lead times in particular.
Introductory Editorial (Palliative Care: Research and Treatment)
Parag Bharadwaj
Palliative Care: Research and Treatment , 2012,
An Opportunity Missed is an Opportunity Lost
Parag Bharadwaj
Palliative Care: Research and Treatment , 2012,
Congenital sialoblastoma of the accessory parotid gland
P Parag
South African Journal of Radiology , 2012,
Abstract: Sialoblastomas are rare, locally aggressive, perinatal or congenital salivary gland tumours that mostly originate in the parotid gland. Significant variability in histological range and clinical course exists. This report is of a case of congenital sialoblastoma of the accessory parotid gland.
A Novel Approach for Simulation of Transmission Line Compensation
Parag Nijhawan
International Journal of Engineering and Technology , 2010,
Abstract: This paper presents an efficient method based on bus power injection for transmission line compensation. In this method, the load flow solution is first obtained using specified generations and loads. The terminal buses connecting the line to be compensated and the compensation level are identified. The differences of the line flows before and after compensation are injected in or out of the two terminal buses. The proposed method has been successfully used tosimulate compensation of transmission line by a series capacitor and then by SSSC.
An Opportunity Missed is an Opportunity Lost
Parag Bharadwaj
Palliative Care: Research and Treatment , 2009,
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