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Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation
Pradeep Patil , Vandana Patil , Anant Paradkar
Acta Pharmaceutica , 2007, DOI: 10.2478/v10007-007-0009-5
Abstract: The objective of the present work was to formulate a self-emulsifying drug delivery system (SEDDS) for simvastatin, which is widely used in the treatment of hypercholesterolemia and dyslipidemia as an adjunct to diet. Simvastatin SEDDS were formulated using a 1:1 (V/V) mixture of diesters of caprylic/capric acids and polyglycolyzed glycerides with varying concentrations of polyoxy castor oil and C8/C10 mono-/diglycerides. The developed SEDDS were evaluated for turbidimetry, droplet size analysis, drug content and in vitro diffusion profiles. In vivo performance of the optimized formulation was evaluated in rats using pharmacodynamic marker parameters like plasma total cholesterol (CH), triglycerides (TG) and high-density lipoprotein (HDL-CH) for 21 days. SEDDS containing 9.1% (m/m) simvastatin and 23.0% (m/m) of each excipient showed minimum mean droplet size (124 nm) and optimal drug diffusion. This test formulation showed significant reduction in plasma CH and TG (around 5-fold and 4-fold, respectively), while HDL-CH concentration was markedly higher (2-fold) compared a reference simvastatin suspension formulation after oral administration for 21 days of study. Test formulation has shown enhanced pharmacodynamic performance compared to reference formulation in rats. The study illustrated the potential of simvastatin SEDDS for oral administration and its biopharmaceutic performance.
Crystallo-co-agglomeration: A novel particle engineering technique
Paradkar Anant,Pawar Atmaram,Jadhav Namdeo
Asian Journal of Pharmaceutics , 2010,
Abstract: Crystallo-co-agglomeration (CCA) is a novel particle engineering/design technique developed by Kadam et al, to overcome the limitations of spherical crystallization (SC). Basically, it′s single step process used for size enlargement of single, two or more, small dose or large dose drugs, in combination with or without diluent. The process of CCA involves simultaneous crystallization and agglomeration of drug/s with/without excipients/s from good solvent and/or bridging liquid by addition of a non-solvent. Till date CCA has been applied for spherical agglomeration of talc, bromhexine hydrochloride-talc, ibuprofen-talc, ibuprofen-paracetamol, and naproxen-starch. The spherical agglomerates obtained by CCA can be used as intact beads (encapsulated spansules) or directly compressible tablet intermediates having satisfactory micromeritic (flowability), mechanical (friability, crushing), compressional (compressibility, compactibility), and drug release properties. Modified drug release from agglomerates and compacts thereof can be achieved using suitable polymer composition in the process design. Thus, it can be concluded that, CCA is a simple and cost effective process, which can be tailor-made for particle design of all majority of drugs and combinations thereof.
Rectal gel application of Withania somnifera root extract expounds anti-inflammatory and muco-restorative activity in TNBS-induced Inflammatory Bowel Disease
Pankaj Pawar, Suhit Gilda, Siddhesh Sharma, Suresh Jagtap, Anant Paradkar, Kakasaheb Mahadik, Prabhakar Ranjekar, Abhay Harsulkar
BMC Complementary and Alternative Medicine , 2011, DOI: 10.1186/1472-6882-11-34
Abstract: The study included (i) preparation of gel formulation from aqueous Withania somnifera root extract (WSRE), (ii) biochemical assays to determine its performance potential, (iii) testing of formulation efficacy in TNBS-induced IBD rat model, and (iv) histo-patholgical studies to assess its healing and muco-regenerative effect in IBD-induced rats. For this purpose, concentration dependant antioxidant activity of the extracts were evaluated using biochemical assays like (a) inhibition of lipid peroxidation, (b) NO scavenging, (c) H2O2 scavenging, and (d) ferric reducing power assay.The extract, at 500 μg/ml, the highest concentration tested, showed 95.6% inhibition of lipid peroxidation, 14.8% NO scavenging, 81.79% H2O2 scavenging and a reducing capacity of 0.80. The results were comparable with standard antioxidants, ascorbic acid and curcumin. WSRE treatment positively scored on histopathological parameters like necrosis, edema, neutrophil infiltration. The post treatment intestinal features showed restoration at par with the healthy intestine. In view of these results, gel formulation containing an aqueous extract of W. somnifera, prepared for rectal application was tested for its anti-inflammatory activity in TNBS-induced rat models for IBD. Commercially available anti-inflammatory drug Mesalamine was used as the standard in this assay.Dose of the rectal gel applied at 1000 mg of WSRE per kg rat weight showed significant muco-restorative efficacy in the IBD-induced rats, validated by histo-pathological studies.Withania somnifera (Dunal), also known as Ashwagandha, is an important member of family Solanaceae, utilized as a medicine for more than 2500 years in Indian medicinal classic "Ayurveda" [1]. Roots of this plant are considered most active for therapeutic purposes by virtue of significant accumulation of active constituents, withanolides [2]. Several withanolides with cyclooxygenase inhibitory and lipid peroxidation inhibitory activity were isolated from leaves
Mental health services in rural India: challenges and prospects  [PDF]
Anant Kumar
Health (Health) , 2011, DOI: 10.4236/health.2011.312126
Abstract: Mental health services in India are neglected area which needs immediate attention from the government, policymakers, and civil society organizations. Despite, National Mental Health Programme since 1982 and National Rural Health Mission, there has been a very little effort so far to provide mental health services in rural areas. With increase in population, changing life-style, unemployment, lack of social support and increasing insecurity, it is predicted that there would be a substantial increase in the number of people suffering from mental illness in rural areas. Considering the mental health needs of the rural community and the treatment gap, the paper is an attempt to remind and advocate for rural mental health services and suggest a model to reduce the treatment gap.
Should Health Professionals Allow Reporters Inside Hospitals and Clinics at Times of Natural Disasters?
Anant Bhan
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020177
Abstract:
Almost periodic motion in complete space
Anant Kumar
International Journal of Mathematics and Mathematical Sciences , 1986, DOI: 10.1155/s0161171286000789
Abstract: It is interesting that in a complete space an almost periodic motion is periodic if the null set is closed and if is not closed then every point of its trajectory is a limit point.
A REVIEW ON PLANT RECOGNITION AND CLASSIFICATION TECHNIQUES USING LEAF IMAGES
Anant Bhardwaj
International Journal of Engineering Trends and Technology , 2013,
Abstract: Automatic digital plant classification and retrieval can be achieved by extracting features from its leaves. There are various opportunities to improve plant species identification due to omputerization through the designing of a convenient automatic plant recognition system. Many different approaches consist of some major parts. First, images of leaf are acquired with digital camera or scanners. Then the user can selects the base point of the leaf and a few reference points on the leaf blades or done this automatically. Then several morphological features are extracted. These features are used as inputs to the classifier system for discrimination as probabilistic neural network. The network was trained with leaves from different plant species. Then the recognition accuracy of the proposed method has been tested. The method works only for the plants with broad flat leaves which are more or less two dimensional in nature. This paper presented various effective algorithms used for plant classification using leaf images and review the main computational, morphological and image processing methods that have been used in recent years and we conclude with a discussion of ongoing work and outstanding problems in the area
Should health professionals allow reporters inside hospitals and clinics at times of natural disasters?
Bhan Anant
PLOS Medicine , 2005,
Abstract:
Tackling polyauthoritis giftosa
Bhan Anant
Indian Journal of Dermatology, Venereology and Leprology , 2010,
Abstract:
Substance abuse among medical professionals: A way of coping with job dissatisfaction and adverse work environments?
Bhan Anant
Indian Journal of Medical Sciences , 2009,
Abstract:
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