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Search Results: 1 - 10 of 6902 matches for " Paolo ODDO "
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The Adriatic basin forecasting system
Paolo ODDO,Nadia PINARDI,Marco ZAVATARELLI,Alessandro COLUCCELLI
Acta Adriatica , 2006,
Abstract: A regional ocean forecasting system has been implemented in the framework of the ADRIatic sea integrated COastal areaS and river basin Management system Pilot Project (ADRICOSM). The system is composed of a 5 km horizontal resolution model and an observing system collecting coastal and open ocean hydrological data. The numerical model is based on the Princeton Ocean Model using a SMOLARKIEWICZ iterative advection scheme, interactive air-sea flux computation, Po and other Adriatic rivers flow rates and is one-way nested to a general circulation model of the Mediterranean Sea. In this study the data from the observing system are used only for model validation. The results of the first operational year are shown and the model performance has been assessed based on root mean square (RMS) criteria.
Vocal cord palsy after vincristine treatment in a child and the inefficacy of glutamic acid in the prevention of relapse: a case report
Piero Farruggia, Serena Tropia, Sonia Cannella, Giuseppa Bruno, Gaspare Oddo, Paolo D'Angelo
Journal of Medical Case Reports , 2012, DOI: 10.1186/1752-1947-6-128
Abstract: The larynx paralysis presented with hoarseness and stridor in a Caucasian 18-month-old girl and spontaneously resolved in about a month. In order to administer a subsequent full dose of vincristine, our patient received oral glutamic acid whose efficacy against vincristine neurological side effects has been previously reported.Since in our patient the amino acid proved to be ineffective in the prevention of laryngeal paralysis relapse, we suggest that a dose reduction of vincristine should be preferred by oncologists as an initial approach after a case of drug-induced vocal cord palsy.
A Study of the hydrographic conditions in the Adriatic Sea from numerical modelling and direct observations (2000–2008)
P. Oddo,A. Guarnieri
Ocean Science Discussions (OSD) , 2011, DOI: 10.5194/osd-8-565-2011
Abstract: The inter-annual variability of Adriatic Sea hydrographic characteristics is investigated by means of numerical simulation and direct observation. The period investigated runs from the beginning of 2000 to the end of 2008. The model used to carry out the simulation is derived from the primitive equation component of the Adriatic Forecasting System (AFS). The model is based on the Princeton Ocean Model (POM) adapted in order to reproduce the features of the Adriatic. Both numerical findings and observations agree in depicting a strong inter-annual variability in the entire Adriatic Sea and its sub-basins. The dense water formation process has been found to be intermittent. In addition to inter-annual variability, a long-scale signal has been observed in the salinity content of the basin as a consequence of a prolonged period of reduced Po river runoff and high evaporation rates. As a result, the temperature and salinity of the northern Adriatic dense water vary considerably between the beginning and the end of the period investigated.
Operational ocean models in the Adriatic Sea: a skill assessment
J. Chiggiato,P. Oddo
Ocean Science Discussions (OSD) , 2006,
Abstract: In the framework of the Mediterranean Forecasting System project (MFS) sub-regional and regional numerical ocean forecasting systems performance are assessed by mean of model-model and model-data comparison. Three different operational systems have been considered in this study: the Adriatic REGional Model (AREG); the AdriaROMS and the Mediterranean Forecasting System general circulation model (MFS model). AREG and AdriaROMS are regional implementations (with some dedicated variations) of POM (Blumberg and Mellor, 1987) and ROMS (Shchepetkin and McWilliams, 2005) respectively, while MFS model is based on OPA (Madec et al., 1998) code. The assessment has been done by means of standard scores. The data used for operational systems assessment derive from in-situ and remote sensing measurements. In particular a set of CTDs covering the whole western Adriatic, collected in January 2006, one year of SST from space born sensors and six months of buoy data. This allowed to have a full three-dimensional picture of the operational forecasting systems quality during January 2006 and some preliminary considerations on the temporal fluctuation of scores estimated on surface (or near surface) quantities between summer 2005 and summer 2006. In general, the regional models are found to be colder and fresher than observations. They eventually outperform the large scale model in the shallowest locations, as expected. Results on amplitude and phase errors are also much better in locations shallower than 50 m, while degraded in deeper locations, where the models tend to have a higher homogeneity along the vertical column compared to observations. In a basin-wide overview, the two regional models show some dissimilarities in the local displacement of errors, something suggested by the full three-dimensional picture depicted using CTDs, but also confirmed by the comparison with SSTs. In locations where the regional models are mutually correlated, the aggregated mean-square-error has been found to be lower, which is a useful outcome of having several operational systems in the same region.
A study of the hydrographic conditions in the Adriatic Sea from numerical modelling and direct observations (2000–2008)
P. Oddo,A. Guarnieri
Ocean Science (OS) & Discussions (OSD) , 2011, DOI: 10.5194/os-7-549-2011
Abstract: The inter-annual variability of Adriatic Sea hydrographic characteristics is investigated by means of numerical simulation and direct observation. The period under investigation runs from the beginning of 2000 to the end of 2008. The model used to carry out the simulation is derived from the primitive equation component of the Adriatic Forecasting System (AFS). The model is based on the Princeton Ocean Model (POM) adapted in order to reproduce the features of the Adriatic. Both numerical findings and observations agree in depicting a strong inter-annual variability in the entire Adriatic Sea and its sub-basins. Nevertheless, two model deficiencies are identified: an excessive vertical/horizontal mixing and an inaccurate representation of the thermohaline properties of the entering Mediterranean Waters. The dense water formation process has been found to be intermittent. In addition to inter-annual variability, a long-scale signal has been observed in the salinity content of the basin as a consequence of a prolonged period of reduced Po river runoff and high evaporation rates. As a result, the temperature and salinity of the northern Adriatic dense water vary considerably between the beginning and the end of the period investigated.
Operational ocean models in the Adriatic Sea: a skill assessment
J. Chiggiato,P. Oddo
Ocean Science (OS) & Discussions (OSD) , 2008,
Abstract: In the framework of the Mediterranean Forecasting System (MFS) project, the performance of regional numerical ocean forecasting systems is assessed by means of model-model and model-data comparison. Three different operational systems considered in this study are: the Adriatic REGional Model (AREG); the Adriatic Regional Ocean Modelling System (AdriaROMS) and the Mediterranean Forecasting System General Circulation Model (MFS-GCM). AREG and AdriaROMS are regional implementations (with some dedicated variations) of POM and ROMS, respectively, while MFS-GCM is an OPA based system. The assessment is done through standard scores. In situ and remote sensing data are used to evaluate the system performance. In particular, a set of CTD measurements collected in the whole western Adriatic during January 2006 and one year of satellite derived sea surface temperature measurements (SST) allow to asses a full three-dimensional picture of the operational forecasting systems quality during January 2006 and to draw some preliminary considerations on the temporal fluctuation of scores estimated on surface quantities between summer 2005 and summer 2006. The regional systems share a negative bias in simulated temperature and salinity. Nonetheless, they outperform the MFS-GCM in the shallowest locations. Results on amplitude and phase errors are improved in areas shallower than 50 m, while degraded in deeper locations, where major models deficiencies are related to vertical mixing overestimation. In a basin-wide overview, the two regional models show differences in the local displacement of errors. In addition, in locations where the regional models are mutually correlated, the aggregated mean squared error was found to be smaller, that is a useful outcome of having several operational systems in the same region.
El Maestro de la medicina platense Christofredo Jakob, discípulo y amigo de Adolf von Strümpell.
Vicente Oddo,Mariela Szirko
Electroneurobiología , 2006,
Abstract: The friendly ties linking Christfried Jakob (1866-1956) and his illustrious teacher and good friend, Adolf von Strümpell (1853-1925), never resented the separation imposed by distance and time elapsing. Who was von Strümpell? Laín Entralgo placed the Leipzig master (together with Naunyn, Nothnagel and von Strümpell's immediate predecessor in Leipzig, Curschmann) into the third generation of the "Heroic Age of German medicine", utilizing this expression by Magnus Levy in order to designate the years among 1848 and 1914. Von Strümpell was among the German intellectual blacksmiths beating into shape such a neurology usually termed "classic" – anatomoclinical and localizationist – whose values' scale still shapes the Argentinian tradition. Besides these axiological appreciations and attitudes, von Strümpell as well received from his own family and intellectual atmosphere in Dorpat (Tartu), Estonia, and developed later in Erlangen, Breslau and Leipzig, a rich heritage of deep insights and conflictive perspectives which he bequeathed to his friend and disciple Jakob and hence played fecund roles in the Argentinian-German neurobiological tradition. --CASTELLANO: Los vínculos de amistad que unían a Christofredo Jakob (1866-1956) con su ilustre maestro y buen amigo Adolf von Strümpell (1853-1925) nunca se resintieron por la separación que les impusiera la distancia y el tiempo. Quién fue von Strümpell? Laín Entralgo ubica al maestro lipsiense (junto con Naunyn, Nothnagel y el inmediato predecesor allí de von Strümpell, Curschmann) en la tercera generación de la "edad heroica de la medicina alemana", utilizando tal expresión de Magnus Levy para se alar los a os comprendidos entre 1848 y 1914. Von Strümpell fue uno de los artífices ideológicos alemanes de esa neurología que solemos llamar "clásica" –anatomoclínica y localizatoria– cuyos valores aún informan la tradición argentina. Junto a estas apreciaciones axiológicas y actitudes, von Strümpell también recibió de su propia familia y de la atmósfera intelectual en Dorpat (Tartu, Estonia), y desarrolló luego en Erlangen, Breslau y Leipzig, una rica herencia de profundas comprensiones y perspectivas conflictivas que transmitió a su amigo y discípulo Jakob y, por medio de éste, jugaron fecundos roles en el itinerario conceptual de la tradición neurobiológica argentino-germana. (Article in Spanish).
Too cold may not be so cool: spontaneous hypothermia as a marker of poor outcome after cardiac arrest
Jakobea W?rner, Mauro Oddo
Critical Care , 2010, DOI: 10.1186/cc9270
Abstract: den Hartog and colleagues prospectively analyzed data from 105 consecutive comatose patients resuscitated from cardiac arrest (CA) and treated with therapeutic hypothermia (TH) over a 2-year period [1]. They observed that the percentage of patients with unfavourable outcome (including death, vegetative state and severe disability) was significantly higher in patients with spontaneous hypothermia (69%) than in those with a body temperature ≥35°C on admission to the ICU (50%, P = 0.05). Using multivariable analysis, and adjusting for age, initial arrest rhythm, and APACHE II and SOFA scores, the association between spontaneous hypothermia and outcome at 6 months was confirmed.In this single centre prospective cohort of more than 100 patients, spontaneous hypothermia remained significantly associated with long-term outcome, even when adjusted for APACHE II and SOFA scores. This indicates that low body temperature <35°C on admission after CA is a strong marker of neurological recovery.Previous studies have shown that spontaneous hypothermia is associated with increased mortality after severe trauma and haemorrhage [2]. TH has improved prognosis of hypoxic-ischemic encephalopathy [3], and might have an impact on our ability to predict final patient prognosis [4]. den Hartog and colleagues identify spontaneous hypothermia as a new prognostic marker of CA.However, in accordance with Utstein's style registry [5], arrest conditions (that is, witnessed versus un-witnessed arrest), initial arrest rhythm (that is, ventricular fibrillation versus non-ventricular fibrillation) and duration of circulatory arrest (that is, time from collapse to return of spontaneous circulation) are other well-known predictors of prognosis [6]. These parameters, and particularly time to return of spontaneous circulation, were not entered in the logistic regression; thus, it remains to be further established whether spontaneous hypothermia is an independent predictor of outcome. Furthermore, body te
Rol del sistema kallicreína kinina y su interrelación con sistemas vasoactivos durante la pre?ez
Oddo,Elisabet; Arrizurieta,Elvira E.;
Medicina (Buenos Aires) , 2011,
Abstract: glomerular hyperfiltration and increased sodium reabsorption are key factors for the development of the fetus and placenta in pregnancy. these adjustments result from hemodynamic and renal factors involving vasoactive systems. it was demonstrated in rats that activation of kks precedes the installation of glomerular hyperfiltration as aprotinin prevents the increase in glomerular filtration. in addition, individual or associated inhibition of specific kallikrein kinin system effectors, prostaglandins (pgs) and nitric oxide (no), confirm the glomerular filtration rate dependence of kks during pregnancy. it was also found that the renin-angiotensin system (ras) contributes to glomerular hyperfiltration as this is affected by the administration of ras blockers. the peak of hyperfiltration maximum inhibition was obtained by the blockade of both systems (kks and ras). in addition, strategies used to alter the glomerular hyperfiltration and increased sodium reabsorption during pregnancy, showed abnormalities in the development of the fetus and placenta, fewer offspring, more fetus resorptions and intrauterine growth retardation. kks inhibitors associated with ras or nitric oxide blockers showed the greatest impact. as a consequence, it was demonstrated that kks plays a central role in the adaptation phenomenom that accompanies normal pregnancy. the interplay of kks with several vasoactive systems, seem to arrange a network involved in the hemodynamic adaptations to allow the proper development of pregnancy and the fetus and placenta.
Rol del sistema kallicreína kinina y su interrelación con sistemas vasoactivos durante la pre ez Role of the kallikrein kinin system and its interrelationship with vasoactive systems in pregnancy
Elisabet Oddo,Elvira E. Arrizurieta
Medicina (Buenos Aires) , 2011,
Abstract: La hiperfiltración glomerular y el aumento de la reabsorción de sodio son factores fundamentales para el desarrollo de la unidad feto placentaria. Dichos factores resultan de adaptaciones hemodinámicas y renales en las que participan sistemas vasoactivos. Se pudo demostrar en ratas que la activación del sistema kallicreína kinina (SKK) precede a la instalación de la hiperfiltración glomerular, dado que su inhibición por aprotinina previene el aumento del filtrado glomerular. Además, la inhibición individual o asociada de los efectores específicos del SKK, las prostaglandinas (PGs) y el óxido nítrico (ON), confirman la dependencia del filtrado glomerular del SKK durante la pre ez. Encontramos también que el sistema renina angiotensina (SRA) participa en la generación de la hiperfiltración glomerular dado que ésta es afectada por la administración de bloqueantes del SRA. La inhibición máxima sobre el pico de hiperfiltración se obtuvo con el bloqueo de ambos sistemas (SKK y SRA). Además, estrategias para alterar la hiperfiltración glomerular y la reabsorción de sodio de la pre ez evidenciaron alteraciones en el desarrollo de la unidad feto placentaria, menor número de crías, mayor cantidad de reabsorciones intrauterinas y retardo en el crecimiento. El tratamiento combinado de inhibidores del SKK asociados a bloqueantes del SRA o de óxido nítrico mostraron los mayores efectos. En consecuencia, demostramos que el SKK juega un rol central en los fenómenos de adaptación que acompa an la pre ez normal. La interrelación del SKK con varios sistemas vasoactivos parecería formar una red que participa en las adaptaciones hemodinámicas para un adecuado desarrollo de la gestación y de la unidad feto-placentaria. Glomerular hyperfiltration and increased sodium reabsorption are key factors for the development of the fetus and placenta in pregnancy. These adjustments result from hemodynamic and renal factors involving vasoactive systems. It was demonstrated in rats that activation of KKS precedes the installation of glomerular hyperfiltration as aprotinin prevents the increase in glomerular filtration. In addition, individual or associated inhibition of specific kallikrein kinin system effectors, prostaglandins (PGs) and nitric oxide (NO), confirm the glomerular filtration rate dependence of KKS during pregnancy. It was also found that the renin-angiotensin system (RAS) contributes to glomerular hyperfiltration as this is affected by the administration of RAS blockers. The peak of hyperfiltration maximum inhibition was obtained by the blockade of both systems (KKS and RA
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