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Search Results: 1 - 10 of 6875 matches for " Paolo Marullo Reedtz "
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The treatment of SMEs loans in the New Basel Capital Accord: some evaluations
Fabrizio Fabi,Sebastiano Laviola,Paolo Marullo Reedtz
PSL Quarterly Review , 2004,
Abstract: In April 2003 the Basel Committee on Banking Supervision issued a third consultative paper on the new Basel Capital Accord (Basel II). The document contains substantial changes with respect to the previous proposal of January 2001, on which improvements were requested, among other aspects, regarding the too severetreatment foreseen for loans to small and medium sized enterprises (SMEs). The aim of this paper is to analyse the treatment of SME loans under the Basel II framework and to provide an empirical evaluation of the impact of the different proposals on a large hypothetical portfolio of Italian corporations. Our simulations indicate that the prudential treatment of SME loans foreseen in the last consultative document of theBasel Committee is not penalizing with respect to the current situation. Therefore, we should not expect a reduction of credit or an increase in interest rates on loans to this type of borrowers.
A simple clinical model for planning transfusion quantities in heart surgery
Felicetta Simeone, Federico Franchi, Gabriele Cevenini, Antonino Marullo, Vittorio Fossombroni, Sabino Scolletta, Bonizella Biagioli, Pierpaolo Giomarelli, Paolo Barbini
BMC Medical Informatics and Decision Making , 2011, DOI: 10.1186/1472-6947-11-44
Abstract: We performed an observational study on 3315 consecutive patients who underwent cardiac surgery between January 2000 and December 2007. To estimate the number of packs of red blood cells (PRBC) transfused during heart surgery, we developed a multivariate regression model with discrete coefficients by selecting dummy variables as regressors in a stepwise manner. Model performance was assessed statistically by splitting cases into training and testing sets of the same size, and clinically by investigating the clinical course details of about one quarter of the patients in whom the difference between model estimates and actual number of PRBC transfused was higher than the root mean squared error.Ten preoperative and intraoperative dichotomous variables were entered in the model. Approximating the regression coefficients to the nearest half unit, each dummy regressor equal to one gave a number of half PRBC. The model assigned 4 units for kidney failure requiring preoperative dialysis, 2.5 units for cardiogenic shock, 2 units for minimum hematocrit at cardiopulmonary bypass less than or equal to 20%, 1.5 units for emergency operation, 1 unit for preoperative hematocrit less than or equal to 40%, cardiopulmonary bypass time greater than 130 minutes and type of surgery different from isolated artery bypass grafting, and 0.5 units for urgent operation, age over 70 years and systemic arterial hypertension.The regression model proved reliable for quantitative planning of number of PRBC in patients undergoing heart surgery. Besides enabling more rational resource allocation of costly blood-conservation strategies and blood bank resources, the results indicated a strong association between some essential postoperative variables and differences between the model estimate and the actual number of packs transfused.Despite published blood conservation and transfusion guidelines, transfusion practices in heart-surgery patients differ widely between physicians and institutions. For ex
Cryptic Behaviour of Juvenile Turbot Psetta maxima L. and European Flounder Platichthys flesus L.  [PDF]
Louise Dahl Kristensen, Claus Reedtz Sparrevohn, Jens Tang Christensen, Josianne Gatt St?ttrup
Open Journal of Marine Science (OJMS) , 2014, DOI: 10.4236/ojms.2014.43018
Abstract:
The aim of this study was to examine the burying behaviour of hatchery-reared European flounder Platichthys flesus and turbot Psetta maxima, and whether conditioning on a sandy substrate would improve burying efficiency. Both species buried shortly after release on a sandy substrate. However, the study revealed interspecies differences; the flounder buried immediately after release, while the turbot buried gradually. No significant difference in burying efficiency was observed between naïve and conditioned flounder and turbot. An effect of size on burial efficiency was observed for both flounder and turbot with a tendency for larger fish to bury more efficiently than smaller fish, despite previous conditioning. Size at settlement was found to be >2 cm for flounder and >3 cm for turbot.
Sperimentazioni di catalogazione digitale di fonti documentarie e iconografiche Trials of digital cataloging of documentary and iconographical sources.
Carlo Alberto Gemignani,Daniele Grignani,Eleana Marullo
Reti Medievali Rivista , 2007, DOI: 10.6092/1593-2214/121
Abstract: Il contributo offre una vasta riflessione sulla possibilità di creare archivi digitali funzionali alla ricerca storica, che sinora, sia a causa delle scarse possibilità di profitto, sia per via del carattere “dinamico” dell’indagine storica, sono state poco sviluppate. In particolare vengono indagate le potenzialità dell’Open Source, che, oltre a costituire una fonte di software a buon mercato, riesce a coniugare la salvaguardia del “principio di provenienza” con la creazione di conoscenze collettive. In una seconda sezione, l’articolo presenta i progetti in corso presso il Dipartimento di Storia Moderna e Contemporanea dell’Università di Genova (DISMEC). L’attenzione è soffermata sull’utilizzo di DSpace Federation, un dispositivo Open Source efficace nella catalogazione della documentazione. In particolare esso è stato applicato su una precedente banca dati di circa 30000 carte dell’Archivio Ligure di Scrittura Popolare e sulle fonti di varia natura (anche fotogratiche e cartografiche) del Laboratorio di Archeologia e Storia Ambientale. The contribution offers an extensive reflection on the opportunity to create digital cataloguing archives functional to historical research, which have been scarcely developed so far, both for the limited possibilities of profit and the “dynamic” character of historical research. The paper focuses particularly on the potentialities of the Open Source, which, besides being an inexpensive source of software, manages to combine the safeguard of the “principle of provenance” with the creation of collective knowledge. In the second section the paper outlines the projects under way at the Modern and Contemporary History Department of Genoa University (DISMEC). Special attention is given to the use of DSpace Federation, an Open Source tool effective in cataloguing documentation . In particular, it has been applied on a previous data bank of about 30,000 papers of the Archivio Ligure di Scrittura Popolare (Ligurian Archives of Popular Writing) and on sources of a different kind (even photographic and cartographic ones) of the Laboratorio di Archeologia e Storia Ambientale (Laboratory of Archaeology and Environmental History).
Surgical management of chronic proximal hamstring tendinopathy in athletes: a 2 to 11 years of follow-up
Francesco Benazzo,Matteo Marullo,Giacomo Zanon,Cristian Indino,Francesco Pelillo
Journal of Orthopaedics and Traumatology , 2013, DOI: 10.1007/s10195-013-0226-2
Abstract: Surgical treatment to manage chronic proximal hamstring tendinopathy in high-level athletes showed excellent results in terms of relief from symptoms and return to previous sport level.
Observing the Mediterranean Sea from space: 21 years of Pathfinder-AVHRR sea surface temperatures (1985 to 2005): re-analysis and validation
S. Marullo,B. Buongiorno Nardelli,M. Guarracino,R. Santoleri
Ocean Science (OS) & Discussions (OSD) , 2007,
Abstract: The time series of satellite infrared AVHRR data from 1985 to 2005 has been used to produce a daily series of optimally interpolated SST maps over the regular grid of the operational MFSTEP OGCM model of the Mediterranean basin. A complete validation of this OISST (Optimally Interpolated Sea Surface Temperature) product with in situ measurements has been performed in order to exclude any possibility of spurious trends due to instrumental calibration errors/shifts or algorithms malfunctioning related to local geophysical factors. The validation showed that satellite OISST is able to reproduce in situ measurements with a mean bias of less than 0.1 K and RMSE of about 0.5 K and that errors do not drift with time or with the percent interpolation error.
Observing The Mediterranean Sea from space: 21 years of Pathfinder-AVHRR Sea Surface Temperatures (1985 to 2005). Re-analysis and validation
S. Marullo,B. Buongiorno Nardelli,M. Guarracino,R. Santoleri
Ocean Science Discussions (OSD) , 2006,
Abstract: The time series of satellite infrared AVHRR data from 1985 to 2005 has been used to produce a daily series of optimally interpolated SST maps over the regular grid of the operational MFSTEP OGCM model of the Mediterranean basin. A complete validation of this OISST (Optimally Interpolated Sea Surface Temperature) product with in situ measurements has been performed in order to exclude any possibility of spurious trends due to instrumental calibration errors/shifts or algorithms malfunctioning related to local geophysical factors. The validation showed that satellite OISST is able to reproduce in situ measurements with a mean bias of less than 0.1°C and RMSE of about 0.5°C and that errors do not drift with time or with the percent interpolation error.
Antibiotic susceptibility of haemolytic E. coli strains isolated from diarrhoeic faeces of buffalo calves
Sandra Nizza,Karina Mallardo,Annarosaria Marullo,Valentina Iovane
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2010.e26
Abstract: We investigated the antibiotic resistance of a collection of 94 strains (55.6%) of haemolytic Escherichia coli (E. coli) isolated in 169 diarrhoeic faecal samples from buffalo (Bubalus Bubalis) calves. Bacterial colonies on McConkey and EHLY agar that showed the morphology of E. coli were biochemically tested and then, furtherly classified as haemolytic, using PCR-based assays for enterohemorrhagic E. coli hly (hlyEHEC) virulence gene. When the pathogenic isolates were tested for their susceptibility to 13 different antibiotics, each tested isolate was found to be highly resistant to more than three antibiotics. In fact, absolute resistance (100% of resistance) to penicillin G, lincomycin, neomycin, was detected. Amoxicillin/clavulonic acid and ampicillin were found to be moderately effective against the majority of isolates (46.8% of resistance). Thirty-two (34%) of the haemolytic E. coli strains were phenotypically resistant to tetracycline. None of the isolated strains of E. coli was resistant to colistin sulfate. We conclude that the high prevalence of antimicrobial resistance detected in our study is a source of concern, and cautious use of antibiotics in food producing animals is highly recommended.
Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease
Thomas Lindebo Holm,Steen Seier Poulsen,Helle Markholst,Stine Reedtz-Runge
International Journal of Inflammation , 2012, DOI: 10.1155/2012/412178
Abstract: Animal models are important tools in the development of new drug candidates against the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis. In order to increase the translational value of these models, it is important to increase knowledge relating to standard drugs. Using the SCID adoptive transfer colitis model, we have evaluated the effect of currently used IBD drugs and IBD drug candidates, that is, anti-TNF-α, TNFR-Fc, anti-IL-12p40, anti-IL-6, CTLA4-Ig, anti-α4β7 integrin, enrofloxacin/metronidazole, and cyclosporine. We found that anti-TNF-α, antibiotics, anti-IL-12p40, anti-α4β7 integrin, CTLA4-Ig, and anti-IL-6 effectively prevented onset of colitis, whereas TNFR-Fc and cyclosporine did not. In intervention studies, antibiotics, anti-IL-12p40, and CTLA4-Ig induced remission, whereas the other compounds did not. The data suggest that the adoptive transfer model and the inflammatory bowel diseases have some main inflammatory pathways in common. The finding that some well-established IBD therapeutics do not have any effect in the model highlights important differences between the experimental model and the human disease. 1. Introduction The two inflammatory bowel diseases (IBDs) ulcerative colitis (UC) and Crohn’s disease (CD) affect more than 3.6 million people in the Western world, resulting in a marked decrease in the patients’ quality of life [1, 2]. The aetiology is poorly understood, but it has become clear that genetic, microbial, and environmental factors all play a role [3]. A massive effort is taking place to develop new and better therapeutics, and the development of tumor necrosis factor-α (TNF-α) antagonists has ameliorated the disease in a large proportion of especially CD patients [4]. However, about one third of the CD patients do not respond to anti-TNF-α treatment and among the primary responders, about one third loose response or become intolerant to the treatment [5], thus leaving many IBD patients with inadequate therapeutic options. New IBD drugs and drug candidates include anti-interleukin (IL)-12/-23 (e.g., ustekinumab, briakinumab), cytotoxic T-lymphocyte antigen 4 immunoglobulin (CTLA4-Ig, abatacept), anti-IL-6R (tocilizumab), anti-interferon γ ((IFN-γ), fontolizumab), anti-α4β7 (vedolizumab), anti-α4 integrin (natalizumab), anti-IL-2-Rα (daclizumab, basiliximab), antigranulocyte macrophage colony-stimulating factor (anti-GM-CSF, sagramostim), anti-intercellular adhesion molecule 1 (anti-ICAM-1, alicaforsen), rIL-18 binding protein (tadekinig-α), IP-10/CXCL10 (MDX-1100), anti-CD3 (visilizumab), and
A Field Experiment on the Recurrence of Large Waves in Wind Seas  [PDF]
Paolo Boccotti
Open Journal of Marine Science (OJMS) , 2011, DOI: 10.4236/ojms.2011.13007
Abstract: Wind generated sea waves are generally regarded as an example of pure randomness in nature. Here we give a proof that the matter is not exactly so: some identical sequences of relatively large waves were found many hours apart from one another. This finding supports the theory of quasi determinism of sea waves.
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