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Search Results: 1 - 10 of 1885 matches for " Pamela Deans "
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Use of Eye Movement Tracking in the Differential Diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) and Reading Disability  [PDF]
Pamela Deans, Liz O’Laughlin, Brad Brubaker, Nathan Gay, Damon Krug
Psychology (PSYCH) , 2010, DOI: 10.4236/psych.2010.14032
Abstract: The present study examined the clinical utility of eye movement tracking in the differential diagnosis of Attention Deficit/Hyperactivity Disorder (ADHD) and Reading Disorder (RD). It was anticipated that eye movement tracking would provide a better understanding of the underlying deficits that potentially contribute to reading difficulties among children with ADHD and RD. Participants included 27 children diagnosed with ADHD, 20 that met criteria for a reading disorder and 30 Control children with no clinical diagnosis. All participants were between the ages of 6 to 12. Consistent with previous research, children in the RD group displayed slower reading time, longer fixation duration and more atypical eye movements as compared to Control children. Children with ADHD also displayed more atypical eye movement as compared to Control children. The only significant difference between the ADHD and RD groups was in total reading time. Results of a discriminant analysis revealed that less than 60% of participants were given the correct diagnostic classification based on total reading time and proportion of left to right saccades indicating limited support for this measure in diagnosis of ADHD versus RD.
Progress in the NNPDF global analysis
Deans, Christopher S.
High Energy Physics - Phenomenology , 2013,
Abstract: We report on recent progress in the NNPDF framework of global PDF analysis. The NNPDF2.3 set is the first and only available PDF set with includes LHC data. A recent benchmark comparison of NNPDF2.3 and all other modern NNLO PDF sets with LHC data was performed. We have also studied theoretical uncertainties due to heavy quark renormalization schemes, higher twists and deuterium corrections in PDFs. Finally, we report on the release of positive definite PDF sets, based on the NNPDF2.3 analysis, specially suited for use in Monte Carlo event generators.
Masner, a new genus of Ceraphronidae (Hymenoptera, Ceraphronoidea) described using controlled vocabularies
Istvan Miko,Andrew Deans
ZooKeys , 2009, DOI: 10.3897/zookeys.20.119
Abstract: A ceraphronid wasp genus, Masner Mikó & Deans, gen. n., with one species, M. lubomirus Deans & Mikó, sp. n. is described from Australia and Fiji based on male specimens. This new genus challenges previous definitions of the two extant ceraphronoid families by sharing some character states with Megaspilidae (the presence of an expanded pterostigma and an occipital depression) and other character states with Ceraphronidae (the presence of uniramous anterior protibial spur, presence of a comb of the spur on the pro- and mesotibial spurs, a single mesotibial spur, an undivided synsternite, the presence of axillular setae, presence of Waterston’s evaporatorium and the fusion of the parossiculus with the gonostipes). Masner is distinguishable from all other Ceraphronoidea by the sensillar patch present on flagellomere 5 but absent from flagellomeres 6–9 and the presence of a dorsally visible depression surrounding anterior part of the petiole. The limits of Ceraphronidae and Megaspilidae are reviewed, and we provide new characters for family level diagnosis and classification. We also hypothesize that Masner is sister to the remaining Ceraphronidae.
Review: Forgotten Firebrand: James Redpath and the Making of Nineteenth-Century America, by John R. McKivigan
Halloran, Fiona Deans
Journal of Historical Biography , 2008,
Reproductive Late Effects in Female Survivors of Childhood Cancer
Shivany Gnaneswaran,Rebecca Deans,Richard J. Cohn
Obstetrics and Gynecology International , 2012, DOI: 10.1155/2012/564794
Abstract: Childhood cancer treatments can cause female reproductive late effects. Radiation to the hypothalamic-pituitary-ovarian axis is associated with altered menarche, miscarriage, and implantation failure. Patients who receive chemotherapy and/or ovarian radiation are at risk of premature ovarian failure; the risk increases with increasing radiation dose, alkylating agent score, combination therapy, and older age at treatment. Ovarian reserve may be assessed using antimullerian hormone assay and ultrasound measurements of ovarian volume and antral follicle count; however, their efficacy is poorly established in this cohort. Fertility preservation options including cryopreservation, oophoropexy, and gonadotropin-releasing hormone analogues may be initiated prior to treatment, although most are still considered experimental. Uterine radiation has been linked to pregnancy complications including miscarriage, premature delivery, stillbirth, low-birth-weight and small-for-gestational-age infants. This paper summarises the literature on female reproductive late effects. The information should facilitate counseling and management of female survivors throughout their reproductive lives. 1. Introduction Cancer is the second commonest cause of death in children in developed countries [1]. Common childhood cancers include leukaemia, lymphoma, rhabdomyosarcoma, neuroblastoma, Wilms’ tumour, central nervous system tumours, and germ cell tumours [2, 3]. Most of these cancers are curable using chemotherapy, radiotherapy, or surgery, either alone or in combination [2, 4]. More aggressive or treatment-refractory cancers require intensive multimodal therapies involving multiagent chemotherapy [4]. As a result of advances in paediatric cancer treatment protocols, survival rates from childhood cancers have improved dramatically over the past 3 decades [2]. The expected 5-year survival rate for newly diagnosed patients is at least 70% [2, 5]. Despite being highly successful in treating cancers, therapies such as chemotherapy and radiotherapy have also produced complications referred to as late effects [6]. Late effects can either arise during treatment or shortly thereafter to persist as chronic conditions. They may also manifest years after the completion of therapy [4]. Late effects encompass a range of clinical conditions including neurocognitive deficits, skeletal deformities, cardiopulmonary, and renal and hepatic damage, as well as endocrine and reproductive dysfunction. It is estimated that 60–75% of survivors of childhood cancer will develop at least one late effect as a
The second axillary in Hymenoptera
István Mikó,Andy R Deans
PeerJ , 2015, DOI: 10.7287/peerj.preprints.428v1
Abstract: The wing base of basal hymenopterans (Insecta) have never been properly described perhaps due to the difficulties of its visualization and understanding the 3D relationships between wing base components. Novel 3D visualization techniques such as microCT and Confocal Laser Scanning Microscopy (CLSM) allow us to provide easily digestible morphological data. The wing base of four basal Hymenoptera and 10 apocritan species have been imaged with CLSM and dissected under a stereomicroscope. The second axillary is composed of two sclerites (on on the dorsal wing membrane and one on the ventral in Macroxyela, Xyela and Athalia whereas it is represented by a single sclerite traversing the wing in other Hymenoptera. Consequences related to this observation as well are drawn and future directions in Hymenoptera wing base studies are provided.
Variable size computer-aided detection prompts and mammography film reader decisions
Fiona J Gilbert, Susan M Astley, Caroline RM Boggis, Magnus A McGee, Pamela M Griffiths, Stephen W Duffy, Olorunsola F Agbaje, Maureen GC Gillan, Mary Wilson, Anil K Jain, Nicola Barr, Ursula M Beetles, Miriam A Griffiths, Jill Johnson, Rita M Roberts, Heather E Deans, Karen A Duncan, Geeta Iyengar
Breast Cancer Research , 2008, DOI: 10.1186/bcr2137
Abstract: Local research ethics committee approval was obtained; informed consent was not required. Mammograms were obtained from women attending routine mammography at two breast screening centres in 1996. Films, previously double read, were re-read by a different reader using CAD. The study material included 315 cancer cases comprising all screen-detected cancer cases, all subsequent interval cancers and 861 normal cases randomly selected from 10,267 cases. Ground truth data were used to assess the efficacy of CAD prompting. Associations between prompt attributes and tumour features or reader recall decisions were assessed by chi-squared tests.There was a highly significant relationship between prompting and a decision to recall for cancer cases and for a random sample of normal cases (P < 0.001). Sixty-four per cent of all cases contained at least one CAD prompt. In cancer cases, larger prompts were more likely to be recalled (P = 0.02) for masses but there was no such association for calcifications (P = 0.9). In a random sample of 861 normal cases, larger prompts were more likely to be recalled (P = 0.02) for both mass and calcification prompts. Significant associations were observed with prompting and breast density (p = 0.009) for cancer cases but not for normal cases (P = 0.05).For both normal cases and cancer cases, prompted mammograms were more likely to be recalled and the prompt size was also associated with a recall decision.In a breast screening programme, film readers are required to read large volumes of mammograms to detect a relatively small number of cancers (<1.0%). The radiographic complexity of breast tissue, the subtle nature of the mammographic features in early breast cancers and reader fatigue or distraction make this a challenging task [1]. The performance level of readers is known to vary widely between general radiologists and breast imaging experts [2], and even among experienced mammography film readers [3-5]. Retrospective evaluation of interval
Mammalian Otolin: A Multimeric Glycoprotein Specific to the Inner Ear that Interacts with Otoconial Matrix Protein Otoconin-90 and Cerebellin-1
Michael R. Deans,Jonathan M. Peterson,G. William Wong
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012765
Abstract: The mammalian otoconial membrane is a dense extracellular matrix containing bio-mineralized otoconia. This structure provides the mechanical stimulus necessary for hair cells of the vestibular maculae to respond to linear accelerations and gravity. In teleosts, Otolin is required for the proper anchoring of otolith crystals to the sensory maculae. Otoconia detachment and subsequent entrapment in the semicircular canals can result in benign paroxysmal positional vertigo (BPPV), a common form of vertigo for which the molecular basis is unknown. Several cDNAs encoding protein components of the mammalian otoconia and otoconial membrane have recently been identified, and mutations in these genes result in abnormal otoconia formation and balance deficits.
Efficient isolation of highly purified tonsil B lymphocytes using RosetteSep with allogeneic human red blood cells
Jonathan Zuccolo, Tammy L Unruh, Julie P Deans
BMC Immunology , 2009, DOI: 10.1186/1471-2172-10-30
Abstract: B cell enrichment from tonsils was achieved using RosetteSep with no modification to the whole blood procedure; however, the degree of purity depended on the extent of red blood cell contamination of the starting tonsil cell suspension. Addition of a 50-fold excess of allogeneic human red blood cells, but not sheep red blood cells, reproducibly resulted in high levels of purity. Depletion of mononuclear cells from the donor red blood cells eliminated potential contamination with allogeneic B cells.RosetteSep reagent can be used in combination with allogeneic human red blood cells to reproducibly isolate tonsil B lymphocytes to high levels of purity with no change in phenotype or loss of cells. This method provides considerable time and cost savings compared to other methods.Human tonsils are a rich source of B lymphocytes exhibiting a variety of phenotypes and activation states. A well-established method for enriching B lymphocytes from tonsils involves the addition of 2-aminoethylisothiouronium bromide (AET) modified sheep red blood cells (RBCs) to deplete T lymphocytes by rosetting [1-3]. This is a relatively inefficient method, requiring advance acquisition and treatment of sheep RBCs, and several time-consuming steps on the day of cell separation. Additionally, while this method results in significant enrichment of B lymphocytes, there is often up to 8% contaminating T cells [2]. Magnetic cell separation techniques can yield highly purified populations of either negatively or positively selected B lymphocytes, but the high cost of reagents can be prohibitive when isolating very large numbers of cells.In this study we describe a rapid and cost-effective approach for purifying large numbers of B lymphocytes from tonsils using a commercially available reagent, RosetteSep, which was designed for purifying cells from whole blood. The RosetteSep Human B cell Enrichment Cocktail consists of tetrameric antibody complexes with specificities for CD2, CD3, CD16, CD36, CD56
Third Screen Communication and the Adoption of Mobile Marketing: A Malaysia Perspective
Geoffrey Harvey Tanakinjal,Kenneth R. Deans,Brendan J. Gray
International Journal of Marketing Studies , 2010, DOI: 10.5539/ijms.v2n1p36
Abstract: This study integrates innovation characteristics of the Innovation-Diffusion Theory (IDT), perceived risk, trustworthiness, and permissibility constructs to investigate what determines user intention to adopt mobile marketing. The proposed model in this study was empirically tested using data collected from a survey of mobile users. The structural equation modelling (SEM) technique was used to evaluate the causal model. The research findings suggested that relative advantage of mobile marketing is the strongest influence in building consumers’ intention decision to adopt mobile marketing. All other constructs were statistically significant in influencing behavioural intent to adopt mobile marketing. This study’s findings support Rogers’ (2003) perceived characteristics of innovation attributes that form a favourable or unfavourable attitude toward the innovation.
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