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Search Results: 1 - 10 of 804 matches for " PRATEEK bhatia "
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Robust Regression via Hard Thresholding
Kush Bhatia,Prateek Jain,Purushottam Kar
Computer Science , 2015,
Abstract: We study the problem of Robust Least Squares Regression (RLSR) where several response variables can be adversarially corrupted. More specifically, for a data matrix X \in R^{p x n} and an underlying model w*, the response vector is generated as y = X'w* + b where b \in R^n is the corruption vector supported over at most C.n coordinates. Existing exact recovery results for RLSR focus solely on L1-penalty based convex formulations and impose relatively strict model assumptions such as requiring the corruptions b to be selected independently of X. In this work, we study a simple hard-thresholding algorithm called TORRENT which, under mild conditions on X, can recover w* exactly even if b corrupts the response variables in an adversarial manner, i.e. both the support and entries of b are selected adversarially after observing X and w*. Our results hold under deterministic assumptions which are satisfied if X is sampled from any sub-Gaussian distribution. Finally unlike existing results that apply only to a fixed w*, generated independently of X, our results are universal and hold for any w* \in R^p. Next, we propose gradient descent-based extensions of TORRENT that can scale efficiently to large scale problems, such as high dimensional sparse recovery and prove similar recovery guarantees for these extensions. Empirically we find TORRENT, and more so its extensions, offering significantly faster recovery than the state-of-the-art L1 solvers. For instance, even on moderate-sized datasets (with p = 50K) with around 40% corrupted responses, a variant of our proposed method called TORRENT-HYB is more than 20x faster than the best L1 solver.
INCIDENCE OF COMMON FUSION TRANSCRIPTS IN ADULT AND PEDIATRIC ACUTE MYELOID LEUKEMIA (AML) CASES: EXPERIENCE OF A TERTIARY CARE RESEARCH INSTITUTE
PRATEEK bhatia,Jogeshwar Binota,Neelam Varma,RK Marwaha
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Introduction: The incidence of common fusion transcripts in AML is 40-45%, but data from Indian sub-continent is limited. Aims & Objectives: The aim of the present study is to note the incidence of common fusion transcripts of AML1-ETO, PML-RARA and CBFβ-MYH11 in adult and pediatric AML cases. Materials & Methods: A total of 116 AML cases diagnosed on bone marrow, cytochemistry and Flow-cytometry over a period of 1.5 year were enrolled and bone marrow samples in EDTA were processed by Multiplex RT-PCR assay. Results: Of 116 cases, 96 (83%) were adult and 20 (17%) pediatric cases. A total of 39/116 (33.6%) cases showed positivity for fusion transcripts of which 28/96 (29.16%) were adult and 11/20 (55%) pediatric cases. Of the 28 positive adult cases, 14/96 (14.58%) were positive for AML1-ETO, 12/96 (12.5%) for PML-RARA and 2/96 (2.08%) for CBFβ-MYH11. In the 11 positive pediatric cases, 6/20 (30%) were positive for AML1-ETO, 3/20 (15%) for PML-RARA and 2/20 (10%) for CBFβ-MYH11. Discussion & Conclusion: The incidence of the common fusion transcripts in our pilot study is in accordance with that described in western studies. It is important to identify these transcripts as they provide useful prognostic information to the treating clinician.
A CASE SERIES HIGHLIGHTING THE RELATIVE FREQUENCY OF COMMON, UNCOMMON AND ATYPICAL/UNUSUAL HEMATOLOGICAL FINDINGS ON BONE MARROW EXAMINATION IN CASES OF VISCERAL LEISHMANIASIS
Prateek Bhatia,Dipanjan Haldar,Neelam Varma,RK Marwaha
Mediterranean Journal of Hematology and Infectious Diseases , 2011, DOI: 10.4084/mjhid.2011.
Abstract: Introduction: Bone marrow aspiration and biopsy still remains as one of the vital tests for confirmation of diagnosis of visceral Leishmaniasis. The aim of the present study is to assess the relative frequency of common, uncommon and atypical hematological findings in cases of Visceral Leishmaniasis. Materials & Methods: A total of 16 cases of Leishmaniasis diagnosed on Bone marrow examination over a period of two years (2008-2010), were retrieved from the archives and the peripheral blood smear, bone marrow aspiration smears and trephine biopsies were examined for the common, uncommon and atypical features as described in the literature. Results: Out of the total of 16 cases, 10 were pediatric and 6 adult cases. The common findings like pancytopenia, peripheral blood monocytosis, increased histiocytes on aspirate smears and granulomas on biopsies were noted in 12/16 (75%), 9/16 (56.25%), 13/16 (81.2%) and 11/16 (69%) cases respectively. Amongst the uncommon findings, hemophagocytosis was noted in 12/ 16 (75%) cases, plasma cells with inclusions in 6/16 (37.5%) and LD bodies in cells other than histiocytes in 4/16 (25%) cases. The atypical findings included organism aggregates noted in 9/16 (56%) cases, Pelger-Heut cells seen in 4/16 (25%) cases and increased focal vascularity on biopsies in 10/16 (62.5%) cases. The average parasite density (APD) on smears was 3+ and the range of positivity was 1+ to 5+. Conclusion: The knowledge of these morphological clues can assist us in searching for LD bodies and correctly diagnosing the condition without excessive dependence on unnecessary and sophisticated tests.
A STUDY ON THE EXPRESSION OF BCR-ABL TRANSCRIPT IN MIXED PHENOTYPE ACUTE LEUKEMIA (MPAL) CASES USING THE REVERSE TRANSCRIPTASE POLYMERASE REACTION ASSAY (RT-PCR) AND ITS CORRELATION WITH HEMATOLOGICAL REMISSION STATUS POST INITIAL INDUCTION THERAPY
PRATEEK bhatia,JOGESHWAR BINOTA,Neelam Varma,DEEPAK BANSAL
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Introduction: The MPAL comprise 2-5% of all acute leukemia. The present WHO 2008 classification has separated two groups in MPAL based on t(9;22) positivity and MLL rearrangement. Aims & Objectives: The aim of the present pilot study is to note the incidence of BCR-ABL transcript in MPAL cases using the RT-PCR assay and to correlate the status with hematological remission post induction. Materials & Methods: A total of 10 MPAL cases classified on Flow-cytometry based on the current WHO 2008 criteria were enrolled. In all the cases Bone marrow or peripheral blood sample in EDTA was processed for molecular studies and the RT-PCR reaction carried out using primers specific to the t (9;22) and t(4;11) translocation. The post induction check marrow slides were also reviewed. Results: Out of the total 10 MPAL cases, 7/10 (70%) were adult and 3/10 (30%) pediatric cases. A total of 4/10 (40%) cases showed positivity for the t(9;22) transcript and none for t (4;11). Of the 4 positive cases, 3/10(30%) were adult cases and 1/10(10%) pediatric case. The BCR-ABL transcript type in adult cases was b3a2 (p210) in 2/3 (66%) and e1a2 (p190) in 1/3 (33.3%) case. The single pediatric case was positive for b3a2 transcript. Discussion & Conclusion: All the 4 positive MPAL cases presented with high TLC and low platelet count (p<0.05). The positive cases also showed hematological remission at post induction check marrow (blasts<5%). This could partly be explained due to good response to the imatinib added to the treatment protocol.
Acute leukemia / myelodysplastic syndrome as a sequelae of carcinoma breast: A report of five cases from north India
Bhatia Prateek,Das Reena,Ahluwalia Jasmina,Malhotra Pankaj
Indian Journal of Pathology and Microbiology , 2009,
Abstract: A second malignant neoplasm has been found to be more frequent than might be expected from the general population rates. Therapy-related myelodysplastic syndrome and acute leukemia are dreaded long-term complications of five cases of hematological malignancies following treatment for successful breast cancer therapy (therapeutic drugs or radiotherapy). We encountered carcinoma from north India over a 7-year period from 1999 to 2005. The patients presented 2-5 years after treatment of breast carcinoma. Three patients underwent surgery and received chemoradiotherapy. One patient received chemotherapy after surgery. One patient underwent only surgery and after 3 years presented with acute myeloid leukemia and bone marrow metastasis of carcinoma of the breast. At the time of presentation, all the patients had either bicytopenia or pancytopenia. A close follow-up with complete blood cell counts of the patients who previously had carcinoma of the breast is suggested for early detection of hematological abnormalities. However, the poor prognosis, limited financial resources and poor health insurance coverage results in few patients and their family members opting for treatment.
Locally Non-linear Embeddings for Extreme Multi-label Learning
Kush Bhatia,Himanshu Jain,Purushottam Kar,Prateek Jain,Manik Varma
Mathematics , 2015,
Abstract: The objective in extreme multi-label learning is to train a classifier that can automatically tag a novel data point with the most relevant subset of labels from an extremely large label set. Embedding based approaches make training and prediction tractable by assuming that the training label matrix is low-rank and hence the effective number of labels can be reduced by projecting the high dimensional label vectors onto a low dimensional linear subspace. Still, leading embedding approaches have been unable to deliver high prediction accuracies or scale to large problems as the low rank assumption is violated in most real world applications. This paper develops the X-One classifier to address both limitations. The main technical contribution in X-One is a formulation for learning a small ensemble of local distance preserving embeddings which can accurately predict infrequently occurring (tail) labels. This allows X-One to break free of the traditional low-rank assumption and boost classification accuracy by learning embeddings which preserve pairwise distances between only the nearest label vectors. We conducted extensive experiments on several real-world as well as benchmark data sets and compared our method against state-of-the-art methods for extreme multi-label classification. Experiments reveal that X-One can make significantly more accurate predictions then the state-of-the-art methods including both embeddings (by as much as 35%) as well as trees (by as much as 6%). X-One can also scale efficiently to data sets with a million labels which are beyond the pale of leading embedding methods.
RETRACTED: Reference Points as Information Frames  [PDF]
Prateek Goorha
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.53047
Abstract:

Short Retraction Notice

The paper does not meet the standards of \"Theoretical Economics Letters\".

This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.

Editor guiding this retraction: Prof. Moawia Alghalith (EiC of TEL)

The full retraction notice in PDF is preceding the original paper, which is marked \"RETRACTED\".
RETRACTED: Garbling in the Principal’s Monitoring Device  [PDF]
Prateek Goorha
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.63047
Abstract:

Short Retraction Notice

The paper does not meet the standards of \"Theoretical Economics Letters\".

This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.

Editor guiding this retraction: Prof. Moawia Alghalith (EiC of TEL)

The full retraction notice in PDF is preceding the original paper, which is marked \"RETRACTED\".

Defining “Context” with Institutions as Fuzzy Rule Bases  [PDF]
Prateek Goorha, Jason Potts
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.51003
Abstract: We propose considering an institutional context as a fuzzy control system, and, thereby, the role of any given institution to be akin to a database of fuzzy rules. We develop this analogy for a hierarchical institutional system and provide an overview of the method for designing the database structure using a hierarchical system of linguistic rules. This, we submit, is as an interesting way of looking at institutional development with nested institutions.
RETRACTED: Defining “Context” with Institutions as Fuzzy Rule Bases  [PDF]
Prateek Goorha, Jason Potts
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.51003
Abstract: Short Retraction Notice


The paper does not meet the standards of \"Theoretical Economics Letters\".

This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.

Editor guiding this retraction: Prof. Moawia Alghalith (EiC of TEL)

The full retraction notice in PDF is preceding the original paper, which is marked \"RETRACTED\".

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