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Search Results: 1 - 10 of 31417 matches for " PEI Dong "
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Possible roles of electrical synapse in temporal information processing: A computational study  [PDF]
Xu-Long Wang, Xiao-Dong Jiang, Pei-Ji Liang
Journal of Biomedical Science and Engineering (JBiSE) , 2008, DOI: 10.4236/jbise.2008.11005
Abstract: Temporal information processing in the range of tens to hundreds of milliseconds is critical in many forms of sensory and motor tasks. However, little has been known about the neural mechanisms of temporal information processing. Experimental observations indicate that sensory neurons of the nervous system do not show selective response to temporal properties of external stimuli. On the other hand, temporal selective neurons in the cortex have been reported in many species. Thus, processes which realize the temporal-to-spatial transformation of neuronal activities might be required for temporal information processing. In the present study, we propose a computational model to explore possible roles of electrical synapses in processing the duration of external stimuli. Firstly, we construct a small-scale network with neurons interconnected by electrical synapses in addition to chemical synapses. Basic properties of this small-scale neural network in processing duration information are analyzed. Secondly, a large-scale neural network which is more biologically realistic is further explored. Our results suggest that neural networks with electrical synapses functioning together with chemical synapses can effectively work for the temporal-to-spatial transformation of neuronal activities, and the spatially distributed sequential neural activities can potentially represent temporal information.
A Cohomological Characterization of Leibniz Central Extensions of Lie Algebras
Naihong Hu,Yufeng Pei,Dong Liu
Mathematics , 2006, DOI: 10.1090/S0002-9939-07-08985-X
Abstract: Mainly motivated by Pirashvili's spectral sequences on a Leibniz algebra, a cohomological characterization of Leibniz central extensions of Lie algebras is given based on Corollary 3.3 and Theorem 3.5. In particular, as applications, we obtain the cohomological version of Gao's main Theorem in \cite{Gao2} for Kac-Moody algebras and answer a question in \cite{LH}.
Lie bialgebra structures on the twisted Heisenberg-Virasoro algebra
Dong Liu,Yufeng Pei,Linsheng Zhu
Mathematics , 2010,
Abstract: In this paper we investigate Lie bialgebra structures on the twisted Heisenberg-Virasoro algebra. With the classifications of Lie bialgebra structures on the Virasoro algebra, we determined such structures on the twisted Heisenberg-Virasoro algebra. Moreover, some general and useful results are obtained. With our methods and results we also can easily to determine such structures on some Lie algebras related to the twisted Heisenberg-Virasoro algebra.
Perfect Sampling of GI/GI/c Queues
Jose Blanchet,Jing Dong,Yanan Pei
Mathematics , 2015,
Abstract: We introduce the first class of perfect sampling algorithms for the steady-state distribution of multi-server queues with general interarrival time and service time distributions. Our algorithm is built on the classical dominated coupling from the past protocol. In particular, we use a coupled multi-server vacation system as the upper bound process and develop an algorithm to simulate the vacation system backwards in time from stationarity at time zero. The algorithm has finite expected termination time with mild moment assumptions on the interarrival time and service time distributions.
Molten-Salt Depleted-Uranium Reactor
Bao-Guo Dong,Pei Dong,Ji-Yuan Gu
Physics , 2015,
Abstract: The supercritical, reactor core melting and nuclear fuel leaking accidents have troubled fission reactors for decades, and greatly limit their extensive applications. Now these troubles are still open. Here we first show a possible perfect reactor, Molten-Salt Depleted-Uranium Reactor which is no above accident trouble. We found this reactor could be realized in practical applications in terms of all of the scientific principle, principle of operation, technology, and engineering. Our results demonstrate how these reactors can possess and realize extraordinary excellent characteristics, no prompt critical, long-term safe and stable operation with negative feedback, closed uranium-plutonium cycle chain within the vessel, normal operation only with depleted-uranium, and depleted-uranium high burnup in reality, to realize with fission nuclear energy sufficiently satisfying humanity long-term energy resource needs, as well as thoroughly solve the challenges of nuclear criticality safety, uranium resource insufficiency and low-carbon development. They could provide safe, cheap, abundant, and clean energy resource and electric power lasting thousands years for humanity.
A Facile One-Pot Process for the Formation of Hindered Tertiary Amines
Zhouyu Wang,Dong Pei,Yu Zhang,Chao Wang,Jian Sun
Molecules , 2012, DOI: 10.3390/molecules17055151
Abstract: A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic Lewis base activator. A broad range of ketones were reacted with N-methylaniline to afford the corresponding tertiary amine products in high yield. An open transition model was proposed for the reductive step.
Reduction of the amount of intestinal secretory IgA in fulminant hepatic failure
Dong-yan, Liu;Weiguo, Jiang;Pei, Liu;
Brazilian Journal of Medical and Biological Research , 2011, DOI: 10.1590/S0100-879X2011007500051
Abstract: intestinal barrier dysfunction plays an important role in spontaneous bacterial peritonitis. in the present study, changes in the intestinal barrier with regard to levels of secretory immunoglobulin a (siga) and its components were studied in fulminant hepatic failure (fhf). immunohistochemistry and double immunofluorescent staining were used to detect intestinal iga, the secretory component (sc) and siga in patients with fhf (20 patients) and in an animal model with fhf (120 mice). real-time pcr was used to detect intestinal sc mrna in the animal model with fhf. intestinal siga, iga, and sc staining in patients with fhf was significantly weaker than in the normal control group (30 patients). intestinal iga and sc staining was significantly weaker in the animal model with fhf than in the control groups (normal saline: 30 mice; lipopolysaccharide: 50 mice; d-galactosamine: 50 mice; fhf: 120 mice). sc mrna of the animal model with fhf at 2, 6, and 9 h after injection was 0.4 ± 0.02, 0.3 ± 0.01, 0.09 ± 0.01, respectively. sc mrna of the animal model with fhf was significantly decreased compared to the normal saline group (1.0 ± 0.02) and lipopolysaccharide group (0.89 ± 0.01). the decrease in intestinal siga and sc induced failure of the intestinal immunologic barrier and the attenuation of gut immunity in the presence of fhf.
PX domain and CD domain play different roles in localization and vacuolation of Sorting Nexin 10
Dong Yao,Bin Wu,BaoMing Qin,DuanQing Pei
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0529-0
Abstract: Sorting nexins (SNXs) are PX domain containing proteins and essential for intracellular protein sorting, trafficking and signal transduction. The PX domains of SNXs can bind to various phosphorelated phosphoinositides (PIs) and target the host proteins to endosomes. Recently, we have reported that overexpression of SNX10 in mammalian cells could induce giant vacuoles. In this study, we aimed to identify regions in SNX10 critical for the vacuolation activity. We found that both the PX domain and the CD1 region were essential for vacuolation. We provided evidence that the PX domain was able to specifically bind to PtdIns(3)P and target SNX10 to endosomes. A mutation in the β1 region of the PX domain (V15A) disrupted the PtdIns(3)P binding ability and the endosomal localization of SNX10. However, correct subcellular localization alone was not sufficient for SNX10 to induce vacuoles. We found that the CD1 region, which was not required for the localization, was indispensable for the vacuolation activity of SNX10. In summary, both the PX domain and the CD1 region are necessary for SNX10 to induce vacuoles but they play different roles in this process.
Cloning, ligand-binding, and temporal expression of ecdysteroid receptors in the diamondback moth, Plutella xylostella
Tang Baozhen,Dong Wei,Liang Pei,Zhou Xuguo
BMC Molecular Biology , 2012, DOI: 10.1186/1471-2199-13-32
Abstract: Background The diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), is a devastating pest of cruciferous crops worldwide, and has developed resistance to a wide range of insecticides, including diacylhydrazine-based ecdysone agonists, a highly selective group of molt-accelerating biopesticides targeting the ecdysone receptors. Result In this study, we cloned and characterized the ecdysone receptors from P. xylostella, including the two isoforms of EcR and a USP. Sequence comparison and phylogenetic analysis showed striking conservations among insect ecdysone receptors, especially between P. xylostella and other lepidopterans. The binding affinity of ecdysteroids to in vitro-translated receptor proteins indicated that PxEcRB isoform bound specifically to ponasterone A, and the binding affinity was enhanced by co-incubation with PxUSP (Kd =3.0±1.7 nM). In contrast, PxEcRA did not bind to ponasterone A, even in the presence of PxUSP. The expression of PxEcRB were consistently higher than that of PxEcRA across each and every developmental stage, while the pattern of PxUSP expression is more or less ubiquitous. Conclusions Target site insensitivity, in which the altered binding of insecticides (ecdysone agonists) to their targets (ecdysone receptors) leads to an adaptive response (resistance), is one of the underlying mechanisms of diacylhydrazine resistance. Given the distinct differences at expression level and the ligand-binding capacity, we hypothesis that PxEcRB is the ecdysone receptor that controls the remodeling events during metamorphosis. More importantly, PxEcRB is the potential target site which is modified in the ecdysone agonist-resistant P. xylostella.
Retroperitoneal schwannoma mimicking metastatic seminoma: case report and literature review
Shi-Qiang Zhang,Song Wu,Kai Yao,Pei Dong
Chinese Journal of Cancer , 2013, DOI: 10.5732/cjc.012.10110
Abstract: If a testicular cancer patient has a mass in the retroperitoneum, a metastasis is often the first suspicion, probably leading to improper diagnosis and overtreatment. Here we report a case of retroperitoneal schwannoma mimicking metastatic seminoma. A 29-year-old man, who had a history of seminoma, presented with a single retroperitoneal mass suspected to be a metastasis. Because the patient refused radiotherapy, 3 cycles of cisplatin, etoposide, and bleomycin were offered. Post-chemotherapy computed tomography scan revealed persistence of the retroperitoneal mass, with no change in tumor size or characteristics. Subsequently, retroperitoneal lymph node dissection was performed. The dissected tissue contained negative lymph nodes but a single mass in the attached fat. Pathology revealed retroperitoneal schwannoma, which was confirmed by immunohistochemistry. Thus, clinicians should be aware of retroperitoneal schwannoma and its distinction from metastatic seminoma to avoid misdiagnosis and ensure proper treatment.
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