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Search Results: 1 - 10 of 9507 matches for " PATRICIA; PLAVNIK "
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Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
MORIEL,PATRICIA; PLAVNIK,FRIDA L; ZANELLA,MARIA T; BERTOLAMI,MARCELO C; ABDALLA,DULCINEIA SP;
Biological Research , 2000, DOI: 10.4067/S0716-97602000000200010
Abstract: lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. to clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of ldl, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (hc), hypertensive (h), hypercholesterolemic/hypertensive (hh) and normolipidemic/normotensive subjects (n). plasma ascorbate and lipid-soluble antioxidants were lower, while ldl oxidizability, ce-ooh and tl-ooh were higher in h, hc, and hh groups than in the n group. no difference was observed among groups for pl-ooh and isoprostanes. in summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the ldl susceptibility to oxidation were higher; 2) total cholesterol, ldl-cholesterol, apob and ce-ooh were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of ldl to oxidation; and 4) ce-ooh and tl-ooh were positively correlated with total cholesterol and ldl-cholesterol.
Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
PATRICIA MORIEL,FRIDA L PLAVNIK,MARIA T ZANELLA,MARCELO C BERTOLAMI
Biological Research , 2000,
Abstract: Lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. To clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of LDL, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (HC), hypertensive (H), hypercholesterolemic/hypertensive (HH) and normolipidemic/normotensive subjects (N). Plasma ascorbate and lipid-soluble antioxidants were lower, while LDL oxidizability, CE-OOH and TL-OOH were higher in H, HC, and HH groups than in the N group. No difference was observed among groups for PL-OOH and isoprostanes. In summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the LDL susceptibility to oxidation were higher; 2) total cholesterol, LDL-cholesterol, apoB and CE-OOH were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of LDL to oxidation; and 4) CE-OOH and TL-OOH were positively correlated with total cholesterol and LDL-cholesterol.
On fusion categories with few irreducible degrees
Sonia Natale,Julia Yael Plavnik
Mathematics , 2011,
Abstract: We prove some results on the structure of certain classes of integral fusion categories and semisimple Hopf algebras under restrictions on the set of its irreducible degrees.
Solvability of a class of braided fusion categories
Sonia Natale,Julia Yael Plavnik
Mathematics , 2012,
Abstract: We show that a weakly integral braided fusion category C such that every simple object of C has Frobenius-Perron dimension at most 2 is solvable. In addition, we prove that such a fusion category is group-theoretical in the extreme case where the universal grading group of C is trivial.
A multicenter, open-label study of the efficacy and safety of telmisartan in mild to moderate hypertensive patients
Plavnik, Frida Liane;Ribeiro, Artur Beltrame;
Arquivos Brasileiros de Cardiologia , 2002, DOI: 10.1590/S0066-782X2002001300002
Abstract: objective: to evaluate the efficacy and tolerability of telmisartan, given once a day to patients with mild to moderate hypertension, as well as to assess the 24-hour blood pressure profile with abpm. methods: initially, 163 patients over 18 were selected, regardless of sex, with blood pressure levels >140/90mmhg at visit 1, which was confirmed at visit 2. one hundred thirty-four patients completed the study. after a 4-week placebo run-in phase, telmisartan 40mg/daily was given for 6 weeks. in those patients whose blood pressure (bp) levels were lower than 140/90mmhg, the same dosage was kept for an additional period of 6 weeks. for those who had bp higher than 140/90mmhg, the dosage was increased to 80mg/daily. sixty-two patients were included in a subgroup that underwent abpm 3 different times during the study. results: in the overall group, blood pressure reduction ranged from 162.3±14.5/101.3±5.75 mmhg (baseline) to 147.3±20.1/90.8±10.9 mmhg (week 12) (p<0.05). mean blood pressure decreases were 14.4mmhg for systolic bp and 10.3mmhg for diastolic bp, after 12 weeks of active treatment. a subanalysis showed that 47 (35%) patients took telmisartan 40mg throughout the study and 81 (65%) had the dosage increased to 80mg daily. using abpm, an 8-mmhg reduction in systolic bp as well as a 5-mmhg reduction in diastolic bp were observed, when compared with baseline values in the final 6 hours (18-24 hours after the last dose of study medication). conclusion: our results confirm that telmisartan given once a day is effective in reducing blood pressure levels in mild to moderate hypertensive patients. this reduction occurs in a sustained and gradual manner during a 24-hour period confirmed by abpm.
Validation study of an automated wrist monitor, omron model HEM-608, compared with the standard methods for blood pressure measurement
Plavnik, Frida Liane;Zanella, Maria Teresa;
Arquivos Brasileiros de Cardiologia , 2001, DOI: 10.1590/S0066-782X2001001200004
Abstract: objective - the aim of our study was to assess the profile of a wrist monitor, the omron model hem-608, compared with the indirect method for blood pressure measurement. methods - our study population consisted of 100 subjects, 29 being normotensive and 71 being hypertensive. participants had their blood pressure checked 8 times with alternate techniques, 4 by the indirect method and 4 with the omron wrist monitor. the validation criteria used to test this device were based on the internationally recognized protocols. results - our data showed that the omron hem-608 reached a classification b for systolic and a for diastolic blood pressure, according to the one protocol. the mean differences between blood pressure values obtained with each of the methods were -2.3 +7.9mmhg for systolic and 0.97+5.5mmhg for diastolic blood pressure. therefore, we considered this type of device approved according to the criteria selected. conclusion - our study leads us to conclude that this wrist monitor is not only easy to use, but also produces results very similar to those obtained by the standard indirect method.
Validation study of an automated wrist monitor, omron model HEM-608, compared with the standard methods for blood pressure measurement
Plavnik Frida Liane,Zanella Maria Teresa
Arquivos Brasileiros de Cardiologia , 2001,
Abstract: OBJECTIVE - The aim of our study was to assess the profile of a wrist monitor, the Omron Model HEM-608, compared with the indirect method for blood pressure measurement. METHODS - Our study population consisted of 100 subjects, 29 being normotensive and 71 being hypertensive. Participants had their blood pressure checked 8 times with alternate techniques, 4 by the indirect method and 4 with the Omron wrist monitor. The validation criteria used to test this device were based on the internationally recognized protocols. RESULTS - Our data showed that the Omron HEM-608 reached a classification B for systolic and A for diastolic blood pressure, according to the one protocol. The mean differences between blood pressure values obtained with each of the methods were -2.3 +7.9mmHg for systolic and 0.97+5.5mmHg for diastolic blood pressure. Therefore, we considered this type of device approved according to the criteria selected. CONCLUSION - Our study leads us to conclude that this wrist monitor is not only easy to use, but also produces results very similar to those obtained by the standard indirect method.
A multicenter, open-label study of the efficacy and safety of telmisartan in mild to moderate hypertensive patients
Plavnik Frida Liane,Ribeiro Artur Beltrame
Arquivos Brasileiros de Cardiologia , 2002,
Abstract: OBJECTIVE: To evaluate the efficacy and tolerability of telmisartan, given once a day to patients with mild to moderate hypertension, as well as to assess the 24-hour blood pressure profile with ABPM. METHODS: Initially, 163 patients over 18 were selected, regardless of sex, with blood pressure levels >140/90mmHg at visit 1, which was confirmed at visit 2. One hundred thirty-four patients completed the study. After a 4-week placebo run-in phase, telmisartan 40mg/daily was given for 6 weeks. In those patients whose blood pressure (BP) levels were lower than 140/90mmHg, the same dosage was kept for an additional period of 6 weeks. For those who had BP higher than 140/90mmHg, the dosage was increased to 80mg/daily. Sixty-two patients were included in a subgroup that underwent ABPM 3 different times during the study. RESULTS: In the overall group, blood pressure reduction ranged from 162.3±14.5/101.3±5.75 mmHg (baseline) to 147.3±20.1/90.8±10.9 mmHg (week 12) (p<0.05). Mean blood pressure decreases were 14.4mmHg for systolic BP and 10.3mmHg for diastolic BP, after 12 weeks of active treatment. A subanalysis showed that 47 (35%) patients took telmisartan 40mg throughout the study and 81 (65%) had the dosage increased to 80mg daily. Using ABPM, an 8-mmHg reduction in systolic BP as well as a 5-mmHg reduction in diastolic BP were observed, when compared with baseline values in the final 6 hours (18-24 hours after the last dose of study medication). CONCLUSION: Our results confirm that telmisartan given once a day is effective in reducing blood pressure levels in mild to moderate hypertensive patients. This reduction occurs in a sustained and gradual manner during a 24-hour period confirmed by ABPM.
Tensor functors between Morita duals of fusion categories
César Galindo,Julia Yael Plavnik
Mathematics , 2014,
Abstract: Given a fusion category $\mathcal{C}$ and an indecomposable $\mathcal{C}$-module category $\mathcal{M}$, the fusion category $\mathcal{C}^*_\mathcal{M}$ of $\mathcal{C}$-module endofunctors of $\mathcal{M}$ is called the (Morita) dual fusion category of $\mathcal{C}$ with respect to $\mathcal{M}$. We describe tensor functors between two arbitrary duals $\mathcal{C}^*_\mathcal{M}$ and $\mathcal{D}^*_\mathcal{N}$ in terms of data associated to $\mathcal{C}$ and $\mathcal{D}$. We apply the results to $G$-equivariantizations of fusion categories and group-theoretical fusion categories. We describe the orbits of the action of the Brauer-Picard group on the set of module categories and we propose a categorification of the Rosenberg-Zelinsky sequence for fusion category.
Monitoring Recreational Waters: How to Integrate Environmental Determinants  [PDF]
Patricia Turgeon
Journal of Environmental Protection (JEP) , 2012, DOI: 10.4236/jep.2012.328095
Abstract: Recreational waters are associated with a higher risk of disease for people engaged in activities that bring them into contact with these waters. The primary cause of contamination of recreational waters is fecal microorganisms, which may originate from various sources and involve several modulating factors, making it a complex public health and en- vironmental issue. Monitoring recreational water quality should include two key components: Microbial water testing and monitoring environmental determinants associated with higher risks of contamination. Conducting both activities provides the foundation for a comprehensive assessment according to risk and the actual level of fecal pollution and thus could promote good management actions to ensure safe water quality. Nevertheless, monitoring of environmental determinants is rarely fully integrated in monitoring programs and is also harder to achieve, especially when water pol- lution is mainly associated with nonpoint sources. In order to achieve identification and monitoring of environmental determinants associated with fecal contamination of recreational waters, some specific steps should be followed and some questions must be answered. The objective of this review article is to present current knowledge on this topic and to suggest and discuss recommendations. Potential sources of contamination and factors able to modulate them should be identified and measured after the geographical area influencing fecal contamination of recreational water has been delineated. Statistical models have been developed to identify the relative importance of these environmental characteristics on fecal pollution of recreational waters but they do not allow for a full comprehension of the exact processes leading to this pollution, thus other methods should also be used to better understand these processes.
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