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Search Results: 1 - 10 of 200619 matches for " P.Prathyusha "
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CONTRAST ADVERSE EFFECT STUDY OF ASPIRIN AND CLOPIDOGREL IN STROKE PATIENTS USING COMBINATION AND INDIVIDUAL MEDICATION
V.S. Giri Prasad,A.P. Ranjith kumar,Narender Karra,P.Prathyusha
International Research Journal of Pharmacy , 2012,
Abstract: Ischemia and hemorrhage are the conditions which may lead to stroke. As stroke is a medical emergency, treated with medications such as aspirin, clopidogrel and dipyridamole. In the present study the combination and individual adverse effects of aspirin and clopidogrel medication were studied. The study during was around nine months in one of the private hospital at Hyderabad, Andhra Pradesh, India. Adverse effects evaluation was based on WHO guide lines and Naranjo’s Algorithm. Total 69 stroke patients were taken in to studies. 46 (66.66%) were males and 23 (33.33%) were females. The number of ischemic stroke patients was 39(56.5%) and hemorrhage stroke was 30(43.4%). Among 41 patients, 19 patients was on Aspirin (46.34%), 10 patients was on clopidogral (24.34%) and 12 patients was on combinations medication (29.26%). Adverse effects reported among the antiplatelate users were 6 patients. Among these 6 patients 4 patients were observed with upper gastrointestinal bleeding (UGI) the overall percentage was 66.66% and 2 patients were observed with Vomiting, the overall percentage was 33.33%. In this study, the relative risk reduction for secondary stroke prevention was 37% with use of a combination of extended- release dipyridamole and aspirin. Importantly, the risk of major bleeding attributable to the combination therapy was no greater than that seen with aspirin alone. The benefit of clopidogrel over aspirin for the prevention of vascular events was a relative risk reduction of 8.7%.In addition, there was less major bleeding in the clopidogrel group, yielding a relative net benefit of about 10%. This study revels clopidogrel is the safe drug when compared with Aspirin and as well as combination therapy.
Variations of TEC over Bangalore Station During The Year 2003
N.VENKATESWARA RAO,T.MADHU,SK.BIBIBATHULA,P.PRATHYUSHA
International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering , 2013,
Abstract: Satellite-Based Augmentation Systems (SBAS s) are useful to aid the civil aviation in precision approach and other applications. India is developing its own navigation system, GAGAN (GPS Aided GEO Augmented Navigation), which is expected to become operational by 2014. A major concern that compromises accuracy in these systems is the fluctuating TEC at low latitudes which also displays steep horizontal gradients. The TEC values obtained from the SOPAC (Scripps Orbits and Permanent Array Center) data archive of the IGS (International GNSS (Global Navigation Satellite Systems) Service) for Bangalore Station(13.030N,77.510E),India show large variations, which can adversely affect the Indian GAGAN requirements. The TEC variations for quiet & storm days, their comparison with the IRI (International Reference Ionosphere) obtained over a period of one year (2003) give important features of the Indian low latitude region
Power optimization of BIST circuit using low power LFSR
PRATHYUSHA NAYINENI
International Journal of Computer Trends and Technology , 2011,
Abstract: In most number of electronic systems that are used in safety critical applications circuit testing has to be performed periodically. For these systems power dissipation due to BIST [built in self test] represents a significant percentage of overall power dissipation. The power dissipation during the test mode is 200% more than in normal mode. So, to reduce the power dissipation during the test mode for BIST circuit, we are using a low power LFSR. The correlation between consecutive patterns are higher in normal mode than during testing so, by using LPLFSR we are reducing the transitions between consecutive patterns generated by the conventional LFSR
The Gaussian Two-way Diamond Channel
Prathyusha V,Srikrishna Bhashyam,Andrew Thangaraj
Computer Science , 2013,
Abstract: We consider two-way relaying in a Gaussian diamond channel, where two terminal nodes wish to exchange information using two relays. A simple baseline protocol is obtained by time-sharing between two one-way protocols. To improve upon the baseline performance, we propose two compute-and-forward (CF) protocols: Compute-and-forward Compound multiple access channel (CF-CMAC) and Compute-and-forward-Broadcast (CF-BC). These protocols mix the two flows through the two relays and achieve rates better than the simple time-sharing protocol. We derive an outer bound to the capacity region that is satisfied by any relaying protocol, and observe that the proposed protocols provide rates close to the outer bound in certain channel conditions. Both the CF-CMAC and CF-BC protocols use nested lattice codes in the compute phases. In the CF-CMAC protocol, both relays simultaneously forward to the destinations over a Compound Multiple Access Channel (CMAC). In the simpler CF-BC protocol's forward phase, one relay is selected at a time for Broadcast Channel (BC) transmission depending on the rate-pair to be achieved. We also consider the diamond channel with direct source-destination link and the diamond channel with interfering relays. Outer bounds and achievable rate regions are compared for these two channels as well. Mixing of flows using the CF-CMAC protocol is shown to be good for symmetric two-way rates.
Countering Selective Jamming Attacks in Wireless Networks .
Prathyusha,Y.R.K.Paramahamsa
International Journal of Engineering Sciences & Research Technology , 2013,
Abstract: Wireless Networks constituting a large number of nodes are becoming viable solution to many challenging commercial, domestic, and military applications. Wireless Networks collect and disseminate information from the fields where ordinary networks are unreachable for various environmental and strategic reasons. Wireless networking has emerged as one of the most promising concept for auto-configurable and self-organizing wireless networking to provide flexible and adaptive wireless connectivity to mobile users. Wireless networks can be vulnerable to active and also passive attacks. These types of attacks include Denial- of- Service (DoS), Man- in- the- Middle (MITM), spoofing, jamming, war driving, network hijacking, packet sniffing, and many more. This paper presents a way for countering selective jamming attacks in wireless networks.
Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats
Ramaswamy Ramaswamy,Prathyusha Nettam,Saranya Ruthiramoorthi,Sumathy Haridass
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-190
Abstract: Background Nuna Kadugu (NK), a Siddha medicine prepared from leaves and fruits of Morinda Pubescens, used for the treatment of various skin diseases. Though NK has been widely used for several decades, no scientific report was available on its safety. Present study was undertaken to demonstrate the oral toxicity of NK in Sprague Dawley rats. Methods Acute and 28-day repeated oral toxicity studies were performed following OECD test guidelines 423 and 407, respectively, with minor modifications. In acute oral toxicity study, NK was administered at 2000mg/kg b.wt., p.o and animals were observed for toxic signs at 0, 0.5, 1, 4, 24 h and for next 14 days. Gross pathology was performed at the end of the study. In repeated dose, the 28- day oral toxicity study, NK was administered at 300, 600 and 900 mg/kg b.wt./p.o/day. Two satellite groups (control and high dose) were also maintained to determine the delayed onset toxicity of NK. Animals were observed for mortality, morbidity, body weight changes, feed and water intake. Haematology, clinical biochemistry, electrolytes, gross pathology, relative organ weight and histopathological examination were performed. Results In acute toxicity study, no treatment related death or toxic signs were observed with NK administration. In the repeated dose study, no significant differences in body weight changes, food / water intake, haematology, clinical biochemistry and electrolytes content were observed between control and NK groups. No gross pathological findings and difference in relative organ weights were observed between control and NK treated rats. Histopathological examination revealed no abnormalities with NK treatment. Conclusion Acute study reveals that the LD50 of NK is greater than 2000mg/kg, b.wt. in fasted female rats and can be classified as Category 5. 28-day repeated oral toxicity demonstrates that the No Observed Adverse Effect Level of NK is greater than 900 mg/kg b.wt./day, p.o in rats. There were no delayed effects in NK satellite group. In conclusion, NK was found to be non-toxic in the tested doses and experimental conditions.
IN VITRO SOLUBLE EPOXIDE HYDROLASE ENZYME INHIBITORY ACTIVITY OF SOME NOVEL CHALCONE DERIVATIVES
Kuppusamy Asokkumar,Lokeswari Prathyusha Tangella,Muthusamy Umamaheshwari,Thirumalaisamy Shivashanmugam
International Journal of Phytopharmacy , 2012, DOI: 10.7439/ijpp.v2i4.705
Abstract: Objective Soluble epoxide hydrolase (sEH) belongs to the α/β -hydrolase superfamily, a subclass of α/β proteins. Chalcones are chemical compounds that show hopeful obliging efficacy in controlling numerous diseases. The main objective of the study is to evaluate the sEH inhibitory activity of some synthesized chalcone derivatives and identification of its mode of inhibition. Methods Four different chalcone derivatives (PC-1 to PC-4) were selected for synthesis by Claisen-Schmidt method. The in vitro sEH inhibitory activity was performed for the synthesized compounds by fluorimetric assay. The percentage of sEH activity and IC50 values were calculated for the synthesized compounds. Dissociation constant were determined by following the method described by Lineweaver-Burks plot. Results and Conclusions The IC50 value obtained for PC-1, PC-2, PC-3, and PC-4 were found to be 0.8213 μg/mL, 2.64 μg/mL, 0.2490 μg/mL and 0.5238 μg/mL respectively. The order of potency (IC50) of the chalcone and chalcone oxide in sEH inhibition assay was PC-3 > PC-4 > PC-1 >PC-2. All the compounds (PC-1, PC-2, PC-3) showed mixed type of inhibition except PC-4 which showed non-competitive type of inhibition. Further in vivo studies are to be carried out for these compounds to confirm their activity and explore the mechanism by which these compounds act and rationalize their use.
DESIGN, ADMET AND DOCKING STUDIES ON SOME NOVEL CHALCONE DERIVATIVES AS SOLUBLE EPOXIDE HYDROLASE ENZYME INHIBITORS
KUPPUSAMY ASOKKUMAR,LOKESWARI TANGELLA PRATHYUSHA,MUTHUSAMY UMAMAHESHWARI,THIRUMALAISAMY SIVASHANMUGAM
Journal of the Chilean Chemical Society , 2012,
Abstract: Drug discovery is a lengthy and costly process which aims at bringing in a novel therapeutic molecule for the treatment of various diseases. In the present study, a novel series of eighty chalcone derivatives [(4-substituted)- (4'-substituted)-3' substituted sulphonyl (2E)- 1,3-diphenylprop-2-en-1-one] were designed to inhibit soluble epoxide hydrolase enzyme (sEH). Lipinski's rule of 5 and absorption, distribution, metabolism, elimination and toxicity (ADMET) properties of the compounds were calculated using Molinspiration server and Accord for excel software respectively. All 80 compounds have passed the Lipinski's rule of 5 and only 20 compounds showed considerable ADMET properties. These 20 compounds were subjected to molecular docking studies using AutoDock 4.2 in order to rationalize the possible interactions between test compounds and the active site of human soluble epoxide hydrolase enzyme (1ZD3). Binding energy, intermolecular energy and inhibition constant were the main parameters taken into consideration in this study. The binding energies ranged from -6.07 to -7.89 kcal/mol, the inhibition constant ranging from 1.64 μΜ to 35.45 μΜ and intermolecular energy ranging between -9.38 kcal/mol to -6.97 kcal/mol. Hence, further pharmacophore optimization and in vivo studies are necessary to develop potent chemical entities that could inhibit the sEH enzyme.
Outer Bounds for the Capacity Region of a Gaussian Two-way Relay Channel
Ishaque Ashar K.,Prathyusha V.,Srikrishna Bhashyam,Andrew Thangaraj
Mathematics , 2012,
Abstract: We consider a three-node half-duplex Gaussian relay network where two nodes (say $a$, $b$) want to communicate with each other and the third node acts as a relay for this twoway communication. Outer bounds and achievable rate regions for the possible rate pairs $(R_a, R_b)$ for two-way communication are investigated. The modes (transmit or receive) of the halfduplex nodes together specify the state of the network. A relaying protocol uses a specific sequence of states and a coding scheme for each state. In this paper, we first obtain an outer bound for the rate region of all achievable $(R_a,R_b)$ based on the half-duplex cut-set bound. This outer bound can be numerically computed by solving a linear program. It is proved that at any point on the boundary of the outer bound only four of the six states of the network are used. We then compare it with achievable rate regions of various known protocols. We consider two kinds of protocols: (1) protocols in which all messages transmitted in a state are decoded with the received signal in the same state, and (2) protocols where information received in one state can also be stored and used as side information to decode messages in future states. Various conclusions are drawn on the importance of using all states, use of side information, and the choice of processing at the relay. Then, two analytical outer bounds (as opposed to an optimization problem formulation) are derived. Using an analytical outer bound, we obtain the symmetric capacity within 0.5 bits for some channel conditions where the direct link between nodes a and b is weak.
The bovine QTL viewer: a web accessible database of bovine Quantitative Trait Loci
Pavana Polineni, Prathyusha Aragonda, Suresh R Xavier, Richard Furuta, David L Adelson
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-283
Abstract: The QTL (Quantitative Trait Locus) data and related information for bovine QTL are gathered from published work and from existing databases. An integrated database schema was designed and the database (MySQL) populated with the gathered data. The bovine QTL Viewer was developed for the integration of QTL data available for cattle. The tool consists of an integrated database of bovine QTL and the QTL viewer to display QTL and their chromosomal position.We present a web accessible, integrated database of bovine (dairy and beef cattle) QTL for use by animal geneticists. The viewer and database are of general applicability to any livestock species for which there are public QTL data. The viewer can be accessed at http://bovineqtl.tamu.edu webcite.Many important agricultural traits such as weight gain, milk fat content and intramuscular fat (marbling) in cattle are quantitative traits. While significant information regarding the mode of inheritance of these traits is available, most of this information is not integrated into a genomic context. As large amounts of genomic sequence data become available (estimated completion time of the bovine genome sequence is early 2006), they require livestock genome researchers to integrate sequence data not only with existing gene maps, but more importantly with Quantitative Trait Locus (QTL) and phenotype data. Without integration, application of these data to agricultural enterprise productivity will remain slow and inefficient. In order to facilitate this overall integration, there is a requirement for an integrated database of QTL of cattle and an analytical tool for this database such as a visualization component.While there are livestock genetic map viewers [1,2] and at least one QTL database [3], to the best of our knowledge there is only one other bovine QTL viewer available [4], but it is not dynamic and is restricted to one meta-analysis of dairy QTL data [5]. Our inspiration for this effort was RatMap [6], but our code and
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