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Search Results: 1 - 10 of 200685 matches for " P. Saggese "
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Analog read-out of the RPCs in the ARGO-YBJ experiment
M. Iacovacci,S. Catalanotti,P. Creti,G. Liguori,L. Saggese,for the ARGO-YBJ Collaboration
Physics , 2003,
Abstract: The ARGO-YBJ experiment, currently under construction at the Yangbaijing Laboratory (4300 m a.s.l.), consists of a single layer of about 2000 Resistive Plate Chambers (RPCs) for a total instrumented area of about 6700 m^2. The digital read-out, performed by means of pick-up electrodes 6.7 X 62 cm^2 ('strips'), allows one to measure the particle number of small size showers. To extend the size range up to the knee region it is necessary to implement the charge read-out of the detector chambers. In order to achieve this goal each RPC has been instrumented with two large size pads of dimensions 140 X 125 cm^2. In this paper the performance of the prototype circuit devoted to the charge read-out is reported.
Medicina de la conservación, enfermedades y aves rapaces
Saggese,Miguel D.;
El hornero , 2007,
Abstract: the explosive rate of growth of human populations and human related environmental changes have lead to increased exposure of humans, domestic animals and wildlife to each other's macroparasites (helminths and arthropods) and microparasites (bacteria, viruses, fungi and protozoa). this contributes to the emergence of new diseases in all of them. when combined with other classically considered factors (habitat loss, species introductions, extinction chains, and direct human persecution), parasites may cause severe demographic changes and declines in raptor and other wildlife populations. as a response to this problem, a new discipline has appeared in recent years: conservation medicine. its goals include the conservation of biodiversity and the re-establishment of the health of natural ecosystems and of all of its components. as an important difference with previous approaches that considered conservation and the health of wildlife, domestic animals and humans as separated issues, conservation medicine considers them all together, given that the presence of diseases in any one of them could have an impact on the others. conservation of argentine birds of prey in the frame of sustained development requires the collaborative work of professionals coming not only from medical and biological sciences but also from the fields of social, political and economic sciences. conservation medicine could be the most adequate framework to approach these difficult issues.
Mariano Bacigalupo Saggese
Revista d'Estudis Autonòmics i Federals , 2010,
Abstract: This paper aims to examine the distribution of powers between the stateand the autonomous communities in regard to renewable energy. Based onthe delimitation of powers under state law, the first part of the paper describesthe distribution of responsibilities in reference to special regime productionof electrical energy. The second part examines a number of practicalassumptions that provide insight into some current problems. The first refersto the right of access of special regime producers to distribution networksand, in particular, how some autonomic procedures can affect the exerciseof said right from state competition. The paper also analyzes the case ofcertain autonomic awarding of wind power using mechanisms of dubiouscompatibility with the order of distribution of powers and some of the substantiveprinciples that inform existing regulation of the energy sector. Followingalong with a recent ruling by the Constitutional Court (STC 136/2009),we also examine the distribution of jurisdictional distribution on matters ofsubsidies for renewable energy. Finally, we address two controversial issues:the inspection of photovoltaic plants by the National Energy Commission,and the creation of the Registry for the Pre-assignment of Remuneration.
Fatty Acid Composition of Human Colostrums of Burkinabe Women
Carbone Virginia,Musumeci Maria,Simpore Jacques,Saggese Paola
Pakistan Journal of Biological Sciences , 2006,
Abstract: The aim of this study is to compare/contrast the colostrum lipid composition of 53 Burkinabe women, collected in 2005 at the Maternity of Centre Medical Saint Camille in Ouagadougou (Burkina Faso), with similar data obtained in breast milk, five years ago and then to show the evolution of this important aliment. The fatty acid composition of colostrum samples was determined by Gas-liquid Chromatography-Mass Spectrometry. Saturated lipids (C8:0-C:14-0) showed a progressive increasing trend in the Burkinabe woman colostrum with respect those already measured five years ago. The C15:0-C24:0 fractions were found costantly higher, but their trends were in progressive decrement. The 18:2n-6 fraction (linoleic acid) reached the highest value in the third day post partum. The 18:3n-3 was constantly higher in the second and third days. The 20:4n-6 (arachidonic acid) and LC n-6 PUFA were lower ever since the first day, but with a trend to increase. Also 22: 6n-3 and LC n-3 PUFA were costantly lower. The 18:2n-6/18:3n-3 and LC n-6/LC n-3 ratios were lower and higher, respectively, if compared with those already measured five years ago. These results suggest the need to improve alimentary habits of mothers in order to restore the balanced n-6/n3 PUFA ratio in their colostrums.
Chemical Biomarkers of Human Breast Milk Pollution
Francesco Massart,Giulia Gherarducci,Benedetta Marchi,Giuseppe Saggese
Biomarker Insights , 2008,
Abstract: Human milk is, without question, the best source of nutrition for infants containing the optimal balance of fats, carbohydrates and proteins for developing babies. Breastfeeding provides a range of benefits for growth, immunity and development building a powerful bond between mother and her child. Recognition of the manifold benefits of breast milk has led to the adoption of breast-feeding policies by numerous health and professional organizations such as the World Health Organization and American Academy of Pediatrics.In industrially developed as well as in developing nations, human milk contamination by toxic chemicals such as heavy metals, dioxins and organohalogen compounds, however, is widespread and is the consequence of decades of inadequately controlled pollution. Through breastfeeding, the mother may transfer to the suckling infant potentially toxic chemicals to which the mother has previously been exposed.In the present review, environmental exposure, acquisition and current levels of old and emerging classes of breast milk pollutants are systematically presented. Although scientific evidences indicated that the advantages of breast-feeding outweigh any risks from contaminants, it is important to identify contaminant trends, to locate disproportionately exposed populations, and to take public health measures to improve chemical BM pollution as possible.
Advanced gastric cancer: Is there enough evidence to call second-line therapy standard?
Hendrik-Tobias Arkenau,Matilde Saggese,Charlotte Lemech
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i44.6376
Abstract: Gastric cancer and cancer of the gastro-oesophageal junction (GOJ) are the 4th most common cancer diagnoses worldwide with regional differences in incidence rates. The treatment of gastric and GOJ cancers is complex and requires multimodality treatment including chemotherapy treatment, surgery, and radiotherapy. During the past decade considerable improvements were achieved by advanced surgical techniques, tailored chemotherapies/radiotherapy and technical innovations in clinical diagnostics. In patients with advanced or metastatic gastric/GOJ cancer systemic chemotherapy with fluoropyrimidine/platinum-based regimens (+/-human epidermal growth factor receptor-2 antibody) is the mainstay of treatment. Despite these improvements, the clinical outcome for patients with advanced or metastatic disease is generally poor with 5-year survival rates ranging between 5%-15%. These poor survival rates may to some extent be related that standard therapies beyond first-line therapies have never been defined. Considering that this patient population is often not fit enough to receive further treatments there is an increasing body of evidence from phase-2 studies that in fact second-line therapies may have a positive impact in terms of overall survival. Moreover two recently published phase-3 studies support the use of second-line chemotherapy. A South Korean study compared either, irinotecan or docetaxel with best supportive care and a German study compared irinotecan with best supportive care-both studies met their primary endpoint overall survival. In this “Field of Vision” article, we review these recently published phase-3 studies and put them into the context of clinical prognostic factors helping to guide treatment decisions in patients who most likely benefit.
Development of a method for the measurement of primary cilia length in 3D
Taryn Saggese, Alistair A Young, Chaobo Huang, Kevin Braeckmans, Susan R McGlashan
Cilia , 2012, DOI: 10.1186/2046-2530-1-11
Abstract: Point spread functions and experimental resolutions were calculated from subresolution microspheres embedded in 3D agarose gels for both wide-field fluorescence and confocal laser scanning microscopes. The degree of axial smearing and spherical aberration was calculated from xy:xz diameter ratios of 3D image data sets of 4 μm microspheres that had undergone deconvolution and/or Gaussian blurring. Custom-made 18 and 50 μm fluorescent microfibers were also used as calibration objects to test the suitability of processed image sets for 3D skeletonization. Microfiber length in 2D was first measured to establish an original population mean. Fibers were then embedded in 3D agarose gels to act as ciliary models. 3D image sets of microfibers underwent deconvolution and Gaussian blurring. Length measurements within 1 standard deviation of the original 2D population mean were deemed accurate. Finally, the combined method of deconvolution, Gaussian blurring and skeletonization was compared to previously published methods using images of immunofluorescently labeled renal and chondrocyte primary cilia.Deconvolution significantly improved contrast and resolution but did not restore the xy:xz diameter ratio (0.80). Only the additional step of Gaussian blurring equalized xy and xz resolutions and yielded a diameter ratio of 1.02. Following image processing, skeletonization successfully estimated microfiber boundaries and allowed reliable and repeatable measurement of fiber lengths in 3D. We also found that the previously published method of calculating length from 2D maximum projection images significantly underestimated ciliary length.This study used commercial and public domain image processing software to rectify a long-standing problem of 3D microscopy. We have shown that a combination of deconvolution and Gaussian blurring rectifies optical distortions inherent in 3D images and allows accurate skeletonization and length measurement of microfibers and primary cilia that are ben
Sensitivity of the ARGO-YBJ strip size spectrum to different models of the primary cosmic ray composition in the energy range 10 - 500 TeV
L. Saggese,G. Di Sciascio,M. Iacovacci,S. Mastroianni,S. Vernetto,for the ARGO-YBJ Collaboration
Physics , 2003,
Abstract: The ARGO-YBJ experiment is currently under construction at the Yangbajing Cosmic Ray Laboratory (4300 m a.s.l.). The detector will cover 74 X 78 m^2 with a single layer of Resistive Plate Counters (RPCs), surrounded by a partially instrumented guard ring. Signals from each RPC are picked-up with 80 read out strips 6 cm wide and 62 cm long. These strips allow one to count the particle number of small size air showers. In this paper we discuss the digital response of the detector for showers with core located in a small fiducial area inside the carpet. The results enable us to assess the sensitivity of the strip size spectrum measurement to discriminate between different models of the Primary Cosmic Ray composition in the energy range 10 - 500 TeV.
Non-monotonic dependence of the friction coefficient on heterogeneous stiffness
Ferdinando Giacco,Luigi Saggese,Lucilla de Arcangelis,Massimo Pica Ciamarra,Eugenio Lippiello
Physics , 2015, DOI: 10.1038/srep06772
Abstract: The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining pressure. Here we show, by means of numerical simulations of a 2D Burridge-Knopoff model with a simple local friction law, that the macroscopic friction coefficient depends non-monotonically on the bulk elasticity of the system. This occurs because elastic constants control the geometrical features of the rupture fronts during the stick-slip dynamics, leading to four different ordering regimes characterized by different orientations of the rupture fronts with respect to the external shear direction. We rationalize these results by means of an energetic balance argument.
Soliton Turbulence in Shallow Water Ocean Surface Waves
Andrea Costa,Alfred R. Osborne,Donald T. Resio,Silvia Alessio,Elisabetta Chrivì,Enrica Saggese,Katinka Bellomo,Chuck E. Long
Physics , 2014, DOI: 10.1103/PhysRevLett.113.108501
Abstract: We analyze shallow water wind waves in Currituck Sound, North Carolina and experimentally confirm, for the first time, the presence of $soliton$ $turbulence$ in ocean waves. Soliton turbulence is an exotic form of nonlinear wave motion where low frequency energy may also be viewed as a $dense$ $soliton$ $gas$, described theoretically by the soliton limit of the Korteweg-deVries (KdV) equation, a $completely$ $integrable$ $soliton$ $system$: Hence the phrase "soliton turbulence" is synonymous with "integrable soliton turbulence." For periodic/quasiperiodic boundary conditions the $ergodic$ $solutions$ of KdV are exactly solvable by $finite$ $gap$ $theory$ (FGT), the basis of our data analysis. We find that large amplitude measured wave trains near the energetic peak of a storm have low frequency power spectra that behave as $\sim\omega^{-1}$. We use the linear Fourier transform to estimate this power law from the power spectrum and to filter $densely$ $packed$ $soliton$ $wave$ $trains$ from the data. We apply FGT to determine the $soliton$ $spectrum$ and find that the low frequency $\sim\omega^{-1}$ region is $soliton$ $dominated$. The solitons have $random$ $FGT$ $phases$, a $soliton$ $random$ $phase$ $approximation$, which supports our interpretation of the data as soliton turbulence. From the $probability$ $density$ $of$ $the$ $solitons$ we are able to demonstrate that the solitons are $dense$ $in$ $time$ and $highly$ $non$ $Gaussian$.
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